Latest Crestline Management, LP Stock Portfolio
Crestline Management, LP Performance:
2025 Q4: 11.76%YTD: -12.32%2024: 5.88%
Performance for 2025 Q4 is 11.76%, and YTD is -12.32%, and 2024 is 5.88%.
About Crestline Management, LP and 13F Hedge Fund Stock Holdings
Crestline Management, LP is a hedge fund based in Fort Worth, TX. On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, Crestline Management, LP reported an equity portfolio of $53.3 Millions as of 31 Dec, 2025.
The top stock holdings of Crestline Management, LP are DNLI, SANA, EGHT. The fund has invested 87% of it's portfolio in DENALI THERAPEUTICS INC and 9.3% of portfolio in SANA BIOTECHNOLOGY INC.
They significantly reduced their stock positions in SANA BIOTECHNOLOGY INC (SANA) and DENALI THERAPEUTICS INC (DNLI).
The top stock holdings of Crestline Management, LP are DNLI, SANA, EGHT. The fund has invested 87% of it's portfolio in DENALI THERAPEUTICS INC and 9.3% of portfolio in SANA BIOTECHNOLOGY INC.
They significantly reduced their stock positions in SANA BIOTECHNOLOGY INC (SANA) and DENALI THERAPEUTICS INC (DNLI).
Crestline Management, LP Annual Return Estimates Vs S&P 500
Our best estimate is that Crestline Management, LP made a return of 11.76% in the last quarter. In trailing 12 months, it's portfolio return was -12.32%.
- Performance
- S&P 500
New Buys
Additions
Reductions
| Ticker | % Reduced |
|---|---|
| sana biotechnology inc | -32.95 |
| denali therapeutics inc | -17.59 |
Crestline Management, LP reduced stake in above stock
Sold off
Sector Distribution
Crestline Management, LP has about 96.3% of it's holdings in Healthcare sector.
- Healthcare
- Technology
| Sector | % |
|---|---|
| Healthcare | 96.3 |
| Technology | 3.7 |
Market Cap. Distribution
Crestline Management, LP has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.
- MID-CAP
- SMALL-CAP
| Category | % |
|---|---|
| MID-CAP | 87 |
| SMALL-CAP | 13 |
Stocks belong to which Index?
About 100% of the stocks held by Crestline Management, LP either belong to S&P 500 or RUSSELL 2000 index.
- RUSSELL 2000
| Index | % |
|---|---|
| RUSSELL 2000 | 100 |
Crestline Management, LP Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Crestline Management, LP
Crestline Management, LP has 3 stocks in it's portfolio. EGHT proved to be the most loss making stock for the portfolio. DNLI was the most profitable stock for Crestline Management, LP last quarter.
Last Reported on: 17 Feb, 2026