Latest Sarissa Capital Management LP Stock Portfolio
Sarissa Capital Management LP Performance:
2025 Q4: 21.57%YTD: 3.94%2024: -23.27%
Performance for 2025 Q4 is 21.57%, and YTD is 3.94%, and 2024 is -23.27%.
About Sarissa Capital Management LP and 13F Hedge Fund Stock Holdings
On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, Sarissa Capital Management LP reported an equity portfolio of $222.9 Millions as of 31 Dec, 2025.
The top stock holdings of Sarissa Capital Management LP are INVA, IRWD, NBIX. The fund has invested 25.2% of it's portfolio in INNOVIVA INC and 24.1% of portfolio in IRONWOOD PHARMACEUTICALS INC.
They significantly reduced their stock positions in CYTOKINETICS INC (CYTK). Sarissa Capital Management LP opened new stock positions in BIOHAVEN LTD. The fund showed a lot of confidence in some stocks as they added substantially to AMARIN CORP PLC (AMRN).
The top stock holdings of Sarissa Capital Management LP are INVA, IRWD, NBIX. The fund has invested 25.2% of it's portfolio in INNOVIVA INC and 24.1% of portfolio in IRONWOOD PHARMACEUTICALS INC.
They significantly reduced their stock positions in CYTOKINETICS INC (CYTK). Sarissa Capital Management LP opened new stock positions in BIOHAVEN LTD. The fund showed a lot of confidence in some stocks as they added substantially to AMARIN CORP PLC (AMRN).
Sarissa Capital Management LP Annual Return Estimates Vs S&P 500
Our best estimate is that Sarissa Capital Management LP made a return of 21.57% in the last quarter. In trailing 12 months, it's portfolio return was 3.94%.
- Performance
- S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| biohaven ltd | 5,793,850 |
New stocks bought by Sarissa Capital Management LP
Additions
| Ticker | % Inc. |
|---|---|
| amarin corp plc | 34.68 |
Additions to existing portfolio by Sarissa Capital Management LP
Reductions
| Ticker | % Reduced |
|---|---|
| cytokinetics inc | -32.63 |
Sarissa Capital Management LP reduced stake in above stock
Sold off
Sector Distribution
Sarissa Capital Management LP has about 97.4% of it's holdings in Healthcare sector.
- Healthcare
- Others
| Sector | % |
|---|---|
| Healthcare | 97.4 |
| Others | 2.6 |
Market Cap. Distribution
Sarissa Capital Management LP has about 20.7% of it's portfolio invested in the large-cap and mega-cap stocks.
- SMALL-CAP
- MID-CAP
- LARGE-CAP
- UNALLOCATED
| Category | % |
|---|---|
| SMALL-CAP | 49.3 |
| MID-CAP | 27.2 |
| LARGE-CAP | 20.7 |
| UNALLOCATED | 2.6 |
Stocks belong to which Index?
About 67.7% of the stocks held by Sarissa Capital Management LP either belong to S&P 500 or RUSSELL 2000 index.
- RUSSELL 2000
- Others
- S&P 500
| Index | % |
|---|---|
| RUSSELL 2000 | 66.2 |
| Others | 32.4 |
| S&P 500 | 1.5 |
Sarissa Capital Management LP Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Sarissa Capital Management LP
Sarissa Capital Management LP has 9 stocks in it's portfolio. AMRN proved to be the most loss making stock for the portfolio. IRWD was the most profitable stock for Sarissa Capital Management LP last quarter.
Last Reported on: 17 Feb, 2026| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| AMRN | amarin corp plc | 10.48 | 1,673,400 | 23,352,200 | added | 34.68 | ||
| CYTK | cytokinetics inc | 11.30 | 396,357 | 25,184,500 | reduced | -32.63 | ||
| INVA | innoviva inc | 25.25 | 2,816,020 | 56,292,300 | unchanged | 0.00 | ||
| IRWD | ironwood pharmaceuticals inc | 24.07 | 15,919,400 | 53,648,500 | unchanged | 0.00 | ||
| LNTH | lantheus hldgs inc | 5.42 | 181,450 | 12,075,500 | unchanged | 0.00 | ||
| NBIX | neurocrine biosciences inc | 19.29 | 303,151 | 42,995,900 | unchanged | 0.00 | ||
| REGN | regeneron pharmaceuticals | 1.45 | 4,190 | 3,234,140 | unchanged | 0.00 | ||
| VOR | vor biopharma inc | 0.15 | 25,399 | 332,219 | unchanged | 0.00 | ||
| biohaven ltd | 2.60 | 513,184 | 5,793,850 | new | ||||