Latest EcoR1 Capital, LLC Stock Portfolio
About EcoR1 Capital, LLC and 13F Hedge Fund Stock Holdings
EcoR1 Capital, LLC is a hedge fund based in SAN FRANCISCO, CA. On 29-Mar-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $4.7 Billions. In it's latest 13F Holdings report, EcoR1 Capital, LLC reported an equity portfolio of $2.1 Billions as of 30 Sep, 2025.
The top stock holdings of EcoR1 Capital, LLC are ZYME, ANAB, QURE. The fund has invested 18.8% of it's portfolio in ZYMEWORKS INC and 11.6% of portfolio in ANAPTYSBIO INC.
The fund managers got completely rid off ITEOS THERAPEUTICS INC (ITOS), JANUX THERAPEUTICS INC (JANX) and AKERO THERAPEUTICS INC (AKRO) stocks. They significantly reduced their stock positions in VOYAGER THERAPEUTICS INC (VYGR), KURA ONCOLOGY INC (KURA) and APELLIS PHARMACEUTICALS INC (APLS). EcoR1 Capital, LLC opened new stock positions in BRIDGEBIO ONCOLOGY THERAPEUT, AQUESTIVE THERAPEUTICS INC (AQST) and CENTESSA PHARMACEUTICALS PLC (CNTA). The fund showed a lot of confidence in some stocks as they added substantially to ORIC PHARMACEUTICALS INC (ORIC), MBX BIOSCIENCES INC and AVIDITY BIOSCIENCES INC (RNA).
The top stock holdings of EcoR1 Capital, LLC are ZYME, ANAB, QURE. The fund has invested 18.8% of it's portfolio in ZYMEWORKS INC and 11.6% of portfolio in ANAPTYSBIO INC.
The fund managers got completely rid off ITEOS THERAPEUTICS INC (ITOS), JANUX THERAPEUTICS INC (JANX) and AKERO THERAPEUTICS INC (AKRO) stocks. They significantly reduced their stock positions in VOYAGER THERAPEUTICS INC (VYGR), KURA ONCOLOGY INC (KURA) and APELLIS PHARMACEUTICALS INC (APLS). EcoR1 Capital, LLC opened new stock positions in BRIDGEBIO ONCOLOGY THERAPEUT, AQUESTIVE THERAPEUTICS INC (AQST) and CENTESSA PHARMACEUTICALS PLC (CNTA). The fund showed a lot of confidence in some stocks as they added substantially to ORIC PHARMACEUTICALS INC (ORIC), MBX BIOSCIENCES INC and AVIDITY BIOSCIENCES INC (RNA).
EcoR1 Capital, LLC Annual Return Estimates Vs S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| bridgebio oncology therapeut | 32,691,800 |
| aquestive therapeutics inc | 14,673,800 |
| centessa pharmaceuticals plc | 13,337,500 |
| prime medicine inc | 8,550,030 |
| pepgen inc | 3,696,000 |
| compass pathways plc | 1,519,240 |
New stocks bought by EcoR1 Capital, LLC
Additions
| Ticker | % Inc. |
|---|---|
| oric pharmaceuticals inc | 315 |
| mbx biosciences inc | 84.69 |
| galapagos nv | 60.77 |
| avidity biosciences inc | 53.00 |
Additions to existing portfolio by EcoR1 Capital, LLC
Reductions
| Ticker | % Reduced |
|---|---|
| voyager therapeutics inc | -82.89 |
| kura oncology inc | -79.23 |
| apellis pharmaceuticals inc | -71.02 |
EcoR1 Capital, LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| adaptimmune therapeutics plc | -6,568,760 |
| iteos therapeutics inc | -106,569,000 |
| hillevax inc | -4,816,280 |
| macrogenics inc | -1,939,290 |
| janux therapeutics inc | -33,952,800 |
| whitehawk therapeutics inc | -2,040,950 |
| tectonic therapeutic inc | -18,580,900 |
| day one biopharmaceuticals i | -5,603,440 |
EcoR1 Capital, LLC got rid off the above stocks
Sector Distribution
| Sector | % |
|---|---|
| Healthcare | 72.9 |
| Others | 27.1 |
Market Cap. Distribution
| Category | % |
|---|---|
| SMALL-CAP | 38.9 |
| MID-CAP | 31.4 |
| UNALLOCATED | 27.1 |
| MICRO-CAP | 2.1 |
Stocks belong to which Index?
| Index | % |
|---|---|
| RUSSELL 2000 | 55.8 |
| Others | 44.2 |
EcoR1 Capital, LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of EcoR1 Capital, LLC
Last Reported on: 14 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| AADI | whitehawk therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ADAP | adaptimmune therapeutics plc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AKRO | akero therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ALKS | alkermes plc | 0.72 | 500,000 | 15,000,000 | unchanged | 0.00 | ||
| ANAB | anaptysbio inc | 11.58 | 7,880,090 | 241,288,000 | unchanged | 0.00 | ||
| APLS | apellis pharmaceuticals inc | 3.74 | 3,447,160 | 78,009,100 | reduced | -71.02 | ||
| AQST | aquestive therapeutics inc | 0.70 | 2,625,000 | 14,673,800 | new | |||
| ATRA | atara biotherapeutics inc | 0.39 | 573,183 | 8,213,710 | unchanged | 0.00 | ||
| CMPS | compass pathways plc | 0.07 | 265,137 | 1,519,240 | new | |||
| CNTA | centessa pharmaceuticals plc | 0.64 | 550,000 | 13,337,500 | new | |||
| CRNX | crinetics pharmaceuticals in | 8.57 | 4,288,120 | 178,600,000 | unchanged | 0.00 | ||
| CRSP | crispr therapeutics ag | 4.32 | 1,389,280 | 90,039,000 | unchanged | 0.00 | ||
| DAWN | day one biopharmaceuticals i | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ETON | eton pharmaceuticals inc | 2.12 | 2,030,540 | 44,123,700 | unchanged | 0.00 | ||
| HLVX | hillevax inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| IMNM | immunome inc | 2.29 | 4,079,420 | 47,770,000 | unchanged | 0.00 | ||
| ITOS | iteos therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| JANX | janux therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| JAZZ | jazz pharmaceuticals plc | 10.79 | 1,706,470 | 224,913,000 | unchanged | 0.00 | ||
| KURA | kura oncology inc | 0.37 | 872,500 | 7,721,620 | reduced | -79.23 | ||