Latest EcoR1 Capital, LLC Stock Portfolio
EcoR1 Capital, LLC Performance:
2024 Q4: -10.33%YTD: -21.23%2023: -0.17%
Performance for 2024 Q4 is -10.33%, and YTD is -21.23%, and 2023 is -0.17%.
About EcoR1 Capital, LLC and 13F Hedge Fund Stock Holdings
EcoR1 Capital, LLC is a hedge fund based in SAN FRANCISCO, CA. On 29-Mar-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $4.7 Billions. In it's latest 13F Holdings report, EcoR1 Capital, LLC reported an equity portfolio of $2.6 Billions as of 31 Dec, 2024.
The top stock holdings of EcoR1 Capital, LLC are APLS, ZYME, CRNX. The fund has invested 14.3% of it's portfolio in APELLIS PHARMACEUTICALS INC and 8.3% of portfolio in ZYMEWORKS INC.
The fund managers got completely rid off CENTESSA PHARMACEUTICALS PLC (CNTA), VIRIDIAN THERAPEUTICS INC (VRDN) and NUVATION BIO INC (NUVB) stocks. They significantly reduced their stock positions in ALLOVIR INC (ALVR), AADI BIOSCIENCE INC (AADI) and RELAY THERAPEUTICS INC (RLAY). EcoR1 Capital, LLC opened new stock positions in SAREPTA THERAPEUTICS INC (SRPT), UNIQURE NV (QURE) and SPRINGWORKS THERAPEUTICS INC (SWTX). The fund showed a lot of confidence in some stocks as they added substantially to DESIGN THERAPEUTICS INC (DSGN), ETON PHARMACEUTICALS INC (ETON) and XENCOR INC (XNCR).
The top stock holdings of EcoR1 Capital, LLC are APLS, ZYME, CRNX. The fund has invested 14.3% of it's portfolio in APELLIS PHARMACEUTICALS INC and 8.3% of portfolio in ZYMEWORKS INC.
The fund managers got completely rid off CENTESSA PHARMACEUTICALS PLC (CNTA), VIRIDIAN THERAPEUTICS INC (VRDN) and NUVATION BIO INC (NUVB) stocks. They significantly reduced their stock positions in ALLOVIR INC (ALVR), AADI BIOSCIENCE INC (AADI) and RELAY THERAPEUTICS INC (RLAY). EcoR1 Capital, LLC opened new stock positions in SAREPTA THERAPEUTICS INC (SRPT), UNIQURE NV (QURE) and SPRINGWORKS THERAPEUTICS INC (SWTX). The fund showed a lot of confidence in some stocks as they added substantially to DESIGN THERAPEUTICS INC (DSGN), ETON PHARMACEUTICALS INC (ETON) and XENCOR INC (XNCR).
EcoR1 Capital, LLC Annual Return Estimates Vs S&P 500
Our best estimate is that EcoR1 Capital, LLC made a return of -10.33% in the last quarter. In trailing 12 months, it's portfolio return was -21.23%.
New Buys
| Ticker | $ Bought |
|---|---|
| sarepta therapeutics inc | 93,624,300 |
| uniqure nv | 60,044,000 |
| springworks therapeutics inc | 56,362,800 |
| moonlake immunotherapeutics | 18,006,100 |
| ginkgo bioworks holdings inc | 17,119,600 |
| kymera therapeutics inc | 14,080,500 |
| fate therapeutics inc | 5,031,520 |
| upstream bio inc | 986,400 |
New stocks bought by EcoR1 Capital, LLC
Additions
| Ticker | % Inc. |
|---|---|
| design therapeutics inc | 692 |
| eton pharmaceuticals inc | 223 |
| xencor inc | 15.28 |
| atara biotherapeutics inc | 13.48 |
| zymeworks inc | 11.84 |
| mbx biosciences inc | 7.1 |
| anaptysbio inc | 1.01 |
Additions to existing portfolio by EcoR1 Capital, LLC
Reductions
| Ticker | % Reduced |
|---|---|
| allovir inc | -96.38 |
| aadi bioscience inc | -81.29 |
| relay therapeutics inc | -74.34 |
| mersana therapeutics inc | -41.5 |
| kura oncology inc | -38.74 |
| atea pharmaceuticals inc | -38.59 |
| hookipa pharma inc | -31.98 |
| avidity biosciences inc | -26.4 |
EcoR1 Capital, LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| nuvation bio inc | -43,990,100 |
| centessa pharmaceuticals plc | -51,549,400 |
| viridian therapeutics inc | -44,563,800 |
| proqr thrapeutics n v | -3,341,500 |
| iteos therapeutics inc | -16,424,000 |
| edgewise therapeutics inc | -33,372,800 |
| pharvaris n v | -16,668,000 |
| celldex therapeutics inc new | -22,093,500 |
EcoR1 Capital, LLC got rid off the above stocks
Sector Distribution
EcoR1 Capital, LLC has about 85.5% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 85.5 |
| Others | 14.5 |
Market Cap. Distribution
EcoR1 Capital, LLC has about 3.7% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| MID-CAP | 43.3 |
| SMALL-CAP | 35.3 |
| UNALLOCATED | 14.5 |
| LARGE-CAP | 3.7 |
| MICRO-CAP | 2.4 |
Stocks belong to which Index?
About 56.2% of the stocks held by EcoR1 Capital, LLC either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| RUSSELL 2000 | 56.2 |
| Others | 43.8 |
EcoR1 Capital, LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of EcoR1 Capital, LLC
EcoR1 Capital, LLC has 55 stocks in it's portfolio. About 65.6% of the portfolio is in top 10 stocks. ANAB proved to be the most loss making stock for the portfolio. QURE was the most profitable stock for EcoR1 Capital, LLC last quarter.
Last Reported on: 14 Feb, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| AADI | aadi bioscience inc | 0.04 | 345,253 | 1,089,270 | reduced | -81.29 | ||
| ADAP | adaptimmune therapeutics plc | 0.56 | 27,404,100 | 14,762,600 | unchanged | 0.00 | ||
| ALGS | aligos therapeutics inc | 0.38 | 255,573 | 10,182,000 | unchanged | 0.00 | ||
| ALLK | allakos inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ALVR | allovir inc | 0.15 | 17,769 | 3,947,930 | reduced | -96.38 | ||
| ANAB | anaptysbio inc | 3.94 | 7,873,450 | 104,244,000 | added | 1.01 | ||
| APLS | apellis pharmaceuticals inc | 14.35 | 11,890,800 | 379,437,000 | unchanged | 0.00 | ||
| ARVN | arvinas inc | 4.88 | 6,726,490 | 128,947,000 | unchanged | 0.00 | ||
| ATRA | atara biotherapeutics inc | 0.27 | 532,134 | 7,082,700 | added | 13.48 | ||
| AVIR | atea pharmaceuticals inc | 0.42 | 3,341,650 | 11,194,500 | reduced | -38.59 | ||
| BBIO | bridgebio pharma inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| BCYC | bicycle therapeutics plc | 0.48 | 910,000 | 12,740,000 | unchanged | 0.00 | ||
| CLDX | celldex therapeutics inc new | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| CMAX | caremax inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| CNTA | centessa pharmaceuticals plc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| CRNX | crinetics pharmaceuticals in | 8.29 | 4,288,120 | 219,252,000 | unchanged | 0.00 | ||
| CRSP | crispr therapeutics ag | 2.07 | 1,389,280 | 54,681,900 | unchanged | 0.00 | ||
| DAWN | day one biopharmaceuticals i | 0.41 | 862,068 | 10,922,400 | unchanged | 0.00 | ||
| DNA | ginkgo bioworks holdings inc | 0.65 | 1,743,340 | 17,119,600 | new | |||
| DSGN | design therapeutics inc | 0.10 | 426,683 | 2,632,630 | added | 692 | ||