Latest Omega Fund Management, LLC Stock Portfolio
$163Million | No. of Holdings #10
Omega Fund Management, LLC Performance
2026 Q1-29.96%
YTD-29.96%
2025+35.56%
About Omega Fund Management, LLC and 13F Hedge Fund Stock Holdings
Omega Fund Management, LLC is a hedge fund based in Boston, MA. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, Omega Fund Management, LLC reported an equity portfolio of $163.1 Millions as of 31 Mar, 2026. <br><br> The top stock holdings of Omega Fund Management, LLC are , NUVB, . The fund has invested 29.2% of it's portfolio in BICARA THERAPEUTICS INC. and 21.2% of portfolio in NUVATION BIO INC. <br><br> The fund managers got completely rid off UPSTREAM BIO INC. stocks. They significantly reduced their stock positions in ALUMIS INC.. The fund showed a lot of confidence in some stocks as they added substantially to BICARA THERAPEUTICS INC..
Omega Fund Management, LLC Equity Portfolio Value
Last Reported on: 15 May, 2026
$163Million
as of May 15, 2026Omega Fund Management, LLC Annual Return Estimates Vs S&P 500
Our best estimate is that Omega Fund Management, LLC made a return of -29.96% in the last quarter. In trailing 12 months, it's portfolio return was 25.07%.
- Performance
- S&P 500
New Buys
No new stocks were added by Omega Fund Management, LLC
Additions
| Ticker | % Inc. |
|---|---|
| bicara therapeutics inc. | 8.5 |
Additions to existing portfolio by Omega Fund Management, LLC
Reductions
| Ticker | % Reduced |
|---|---|
| alumis inc. | -63.07 |
| kestra med technologies ltd | -25.59 |
Omega Fund Management, LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| upstream bio inc. | -36,008,900 |
Omega Fund Management, LLC got rid off the above stocks
Sector Distribution
Omega Fund Management, LLC has about 74.7% of it's holdings in Others sector.
- Others
- Healthcare
| Sector | % |
|---|---|
| Others | 74.7 |
| Healthcare | 25.3 |
Market Cap. Distribution
Omega Fund Management, LLC has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.
- UNALLOCATED
- SMALL-CAP
- MICRO-CAP
| Category | % |
|---|---|
| UNALLOCATED | 74.7 |
| SMALL-CAP | 23.9 |
| MICRO-CAP | 1.4 |
Stocks belong to which Index?
About 25.3% of the stocks held by Omega Fund Management, LLC either belong to S&P 500 or RUSSELL 2000 index.
- Others
- RUSSELL 2000
| Index | % |
|---|---|
| Others | 74.7 |
| RUSSELL 2000 | 25.3 |
| Top 5 Winners (%) | % | |
|---|---|---|
alumis inc. | 86.1 % | |
bicara therapeutics inc. | 17.4 % | |
| Top 5 Winners ($) | $ | |
|---|---|---|
bicara therapeutics inc. | 7.0 M | |
alumis inc. | 5.5 M | |
| Top 5 Losers ($) | $ | |
|---|---|---|
| NUVB | nuvation bio inc. | -37.7 M |
beta bionics inc. | -26.9 M | |
bridgebio oncology therapeutics inc. | -11.7 M | |
kestra med technologies ltd | -7.9 M | |
engene holdings inc. | -1.9 M | |
Omega Fund Management, LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Omega Fund Management, LLC
Omega Fund Management, LLC has 10 stocks in it's portfolio. NUVB proved to be the most loss making stock for the portfolio. was the most profitable stock for Omega Fund Management, LLC last quarter.
$163.15MTotal Value
11.00Positions
15 May, 2026Last Reported
| Expand | Holdingsorted ascending | % Portfolio | Shares Held | $ Value | % Change |
|---|---|---|---|---|---|
 Imagenebio, Inc. Imagenebio, Inc.IKNA Omega Fund Management, LLC's holding in Imagenebio, Inc. over time | 1.4% | 455,361 | $2.28M 1.4% | 0%unchanged 0 percentunchanged | |
 Nuvation Bio Inc. Omega Fund Management, LLC's holding in Nuvation Bio Inc. over time | 21.25% | 8,081,090 | $34.67M 21.25% | 0%unchanged 0 percentunchanged | |
 Replimune Group Replimune GroupREPL Omega Fund Management, LLC's holding in Replimune Group over time | 1.17% | 248,672 | $1.91M 1.17% | 0%unchanged 0 percentunchanged | |
 Sana Biotechnology, Inc. Omega Fund Management, LLC's holding in Sana Biotechnology, Inc. over time | 1.49% | 843,750 | $2.43M 1.49% | 0%unchanged 0 percentunchanged | |
Common Stock Bicara Therapeutics Inc.Bicara Therapeutics Inc. | 29.16% | 2,392,150 | $47.58M 29.16% | 8.5%increased 8.5 percentadded | |
Common Stock Bridgebio Oncology Therapeutics Inc.Bridgebio Oncology Therapeutics Inc. | 18.05% | 3,289,660 | $29.44M 18.05% | 0%unchanged 0 percentunchanged | |
Common Stock Kestra Med Technologies LtdKestra Med Technologies Ltd | 12.49% | 1,022,150 | $20.37M 12.49% | 25.59%decreased 25.59 percentreduced | |
Common Stock Beta Bionics Inc.Beta Bionics Inc. | 8.08% | 1,316,180 | $13.19M 8.08% | 0%unchanged 0 percentunchanged | |
Common Stock Engene Holdings Inc.Engene Holdings Inc. | 3.66% | 876,357 | $5.97M 3.66% | 0%unchanged 0 percentunchanged | |
Common Stock Alumis Inc.Alumis Inc. | 3.26% | 241,255 | $5.31M 3.26% | 63.07%decreased 63.07 percentreduced | |
Common Stock Upstream Bio Inc.Upstream Bio Inc. | 0% | 0.00 | $0.00 0% | 100%decreased 100 percentsold off | |