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Latest Omega Fund Management, LLC Stock Portfolio

$163Million– No. of Holdings #10

Omega Fund Management, LLC Performance:
2026 Q1: -29.96%YTD: -29.96%2025: 35.56%
Performance for 2026 Q1 is -29.96%, and YTD is -29.96%, and 2025 is 35.56%.

About Omega Fund Management, LLC and 13F Hedge Fund Stock Holdings

Omega Fund Management, LLC is a hedge fund based in Boston, MA. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, Omega Fund Management, LLC reported an equity portfolio of $163.1 Millions as of 31 Mar, 2026.

The top stock holdings of Omega Fund Management, LLC are , NUVB, . The fund has invested 29.2% of it's portfolio in BICARA THERAPEUTICS INC. and 21.2% of portfolio in NUVATION BIO INC.

The fund managers got completely rid off UPSTREAM BIO INC. stocks. They significantly reduced their stock positions in ALUMIS INC.. The fund showed a lot of confidence in some stocks as they added substantially to BICARA THERAPEUTICS INC..
Omega Fund Management, LLC Equity Portfolio Value
Last Reported on: 15 May, 2026

Omega Fund Management, LLC Annual Return Estimates Vs S&P 500

Our best estimate is that Omega Fund Management, LLC made a return of -29.96% in the last quarter. In trailing 12 months, it's portfolio return was 25.07%.
  • Performance
  • S&P 500

New Buys

No new stocks were added by Omega Fund Management, LLC

Additions

Ticker% Inc.
bicara therapeutics inc.8.5
Additions to existing portfolio by Omega Fund Management, LLC

Reductions

Ticker% Reduced
alumis inc.-63.07
kestra med technologies ltd-25.59
Omega Fund Management, LLC reduced stake in above stock

Sold off

Ticker$ Sold
upstream bio inc.-36,008,900
Omega Fund Management, LLC got rid off the above stocks

Sector Distribution

Omega Fund Management, LLC has about 74.7% of it's holdings in Others sector.

  • Others
  • Healthcare
Sector%
Others74.7
Healthcare25.3

Market Cap. Distribution

Omega Fund Management, LLC has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.

  • UNALLOCATED
  • SMALL-CAP
  • MICRO-CAP
Category%
UNALLOCATED74.7
SMALL-CAP23.9
MICRO-CAP1.4

Stocks belong to which Index?

About 25.3% of the stocks held by Omega Fund Management, LLC either belong to S&P 500 or RUSSELL 2000 index.

  • Others
  • RUSSELL 2000
Index%
Others74.7
RUSSELL 200025.3
Top 5 Winners (%)%
alumis inc.
86.1 %
bicara therapeutics inc.
17.4 %
Top 5 Winners ($)$
bicara therapeutics inc.
7.0 M
alumis inc.
5.5 M
Top 5 Losers (%)%
beta bionics inc.
-67.1 %
NUVB
nuvation bio inc.
-52.1 %
SANA
sana biotechnology, inc.
-29.2 %
bridgebio oncology therapeutics inc.
-28.5 %
IKNA
imagenebio, inc.
-27.5 %
Top 5 Losers ($)$
NUVB
nuvation bio inc.
-37.7 M
beta bionics inc.
-26.9 M
bridgebio oncology therapeutics inc.
-11.7 M
kestra med technologies ltd
-7.9 M
engene holdings inc.
-1.9 M

Omega Fund Management, LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Omega Fund Management, LLC

Omega Fund Management, LLC has 10 stocks in it's portfolio. NUVB proved to be the most loss making stock for the portfolio. was the most profitable stock for Omega Fund Management, LLC last quarter.

Last Reported on: 15 May, 2026
TickerNamesorted ascending% PortfolioShares Held$ ValueType% ChangeOptions