Latest Omega Fund Management, LLC Stock Portfolio

Omega Fund Management, LLC Performance:

2025 Q4: 39.51%YTD: 35.56%2024: -3.47%

Performance for 2025 Q4 is 39.51%, and YTD is 35.56%, and 2024 is -3.47%.

About Omega Fund Management, LLC and 13F Hedge Fund Stock Holdings

Omega Fund Management, LLC is a hedge fund based in Boston, MA. On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, Omega Fund Management, LLC reported an equity portfolio of $286.5 Millions as of 31 Dec, 2025.

The top stock holdings of Omega Fund Management, LLC are NUVB, , . The fund has invested 25.3% of it's portfolio in NUVATION BIO and 14.4% of portfolio in BRIDGEBIO ONCOLOGY THERAPEUTICS INC.

The fund managers got completely rid off ENGENE HOLDINGS INC. stocks. They significantly reduced their stock positions in BETA BIONICS INC. and NUVATION BIO (NUVB). The fund showed a lot of confidence in some stocks as they added substantially to ENGENE HOLDINGS INC..

Omega Fund Management, LLC Annual Return Estimates Vs S&P 500

Our best estimate is that Omega Fund Management, LLC made a return of 39.51% in the last quarter. In trailing 12 months, it's portfolio return was 35.56%.

Performance
S&P 500

New Buys

No new stocks were added by Omega Fund Management, LLC

Additions

Ticker	% Inc.
engene holdings inc.	66.49

Additions to existing portfolio by Omega Fund Management, LLC

Reductions

Ticker	% Reduced
beta bionics inc.	-31.45
kestra med technologies ltd	-16.54
nuvation bio	-8.49
upstream bio inc.	-2.21

Omega Fund Management, LLC reduced stake in above stock

Sold off

Ticker	$ Sold
engene holdings inc.	-63,438

Omega Fund Management, LLC got rid off the above stocks

Sector Distribution

Omega Fund Management, LLC has about 71.6% of it's holdings in Others sector.

Sector	%
Others	71.6
Healthcare	28.4

Market Cap. Distribution

Omega Fund Management, LLC has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.

Category	%
UNALLOCATED	71.6
SMALL-CAP	27.3
MICRO-CAP	1.1

Stocks belong to which Index?

About 28.4% of the stocks held by Omega Fund Management, LLC either belong to S&P 500 or RUSSELL 2000 index.

Index	%
Others	71.6
RUSSELL 2000	28.4

Top 5 Winners (%)		%
	alumis inc.	144.6 %
NUVB	nuvation bio	136.1 %
REPL	replimune group	132.0 %
	beta bionics inc.	45.0 %
	upstream bio inc.	43.9 %

Top 5 Winners ($)		$
NUVB	nuvation bio	44.5 M
	beta bionics inc.	17.2 M
	upstream bio inc.	11.2 M
	kestra med technologies ltd	4.2 M
	alumis inc.	3.8 M

Top 5 Losers (%)		%
IKNA	imagenebio, inc.	-15.3 %

Top 5 Losers ($)		$
IKNA	imagenebio, inc.	-0.6 M

Omega Fund Management, LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Omega Fund Management, LLC

Omega Fund Management, LLC has 11 stocks in it's portfolio. IKNA proved to be the most loss making stock for the portfolio. NUVB was the most profitable stock for Omega Fund Management, LLC last quarter.

Last Reported on: 17 Feb, 2026

Ticker	Namesorted ascending	% Portfolio	Shares Held	$ Value	Type	% Change
IKNA	imagenebio, inc.	1.10	455,361	3,141,990	unchanged	0.00

NUVB	nuvation bio	25.27	8,081,090	72,406,600	reduced	-8.49

REPL	replimune group	0.84	248,672	2,417,090	unchanged	0.00

SANA	sana biotechnology, inc.	1.20	843,750	3,434,060	unchanged	0.00

	bridgebio oncology therapeutics inc.	14.38	3,289,660	41,186,600	unchanged	0.00

	beta bionics inc.	14.00	1,316,180	40,104,100	reduced	-31.45

	bicara therapeutics inc.	12.95	2,204,650	37,104,300	unchanged	0.00

	kestra med technologies ltd	12.71	1,373,590	36,427,600	reduced	-16.54

	upstream bio inc.	12.57	1,326,290	36,008,900	reduced	-2.21

	engene holdings inc.	2.76	876,357	7,913,500	added	66.49

	alumis inc.	2.22	653,223	6,375,460	unchanged	0.00

	engene holdings inc.	0.00	0.00	0.00	sold off	-100