Latest Foresite Capital Management IV, LLC Stock Portfolio

About Foresite Capital Management IV, LLC and 13F Hedge Fund Stock Holdings

On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, Foresite Capital Management IV, LLC reported an equity portfolio of $229.7 Millions as of 31 Dec, 2025.

The top stock holdings of Foresite Capital Management IV, LLC are PHVS, CYTK, LYEL. The fund has invested 57.7% of it's portfolio in PHARVARIS N.V. and 12.7% of portfolio in CYTOKINETICS INC.

Foresite Capital Management IV, LLC opened new stock positions in ALECTOR, INC. (ALEC).

Foresite Capital Management IV, LLC Annual Return Estimates Vs S&P 500

Performance

New Buys

Ticker	$ Bought
alector, inc.	6,064,030

New stocks bought by Foresite Capital Management IV, LLC

Additions

No additions were made to existing positions by Foresite Capital Management IV, LLC

Reductions

None of the existing positions were reduced by Foresite Capital Management IV, LLC

Sold off

None of the stocks were completely sold off by Foresite Capital Management IV, LLC

Sector Distribution

Sector	%
Others	67.2
Healthcare	32.8

Market Cap. Distribution

Category	%
UNALLOCATED	67.2
MID-CAP	15.8
SMALL-CAP	14.4
MICRO-CAP	2.6

Stocks belong to which Index?

Index	%
Others	70.3
RUSSELL 2000	29.7

Top 5 Winners (%)		%
LYEL	lyell immunopharma, inc.	89.5 %
RLAY	relay therapeutics, inc.	62.1 %
	maze therapeutics, inc.	59.8 %
CYTK	cytokinetics inc	15.6 %
XENE	xenon pharmaceuticals inc.	11.6 %

Top 5 Winners ($)		$
PHVS	pharvaris n.v.	13.4 M
LYEL	lyell immunopharma, inc.	11.6 M
	maze therapeutics, inc.	8.1 M
CYTK	cytokinetics inc	3.9 M
RLAY	relay therapeutics, inc.	3.2 M

Top 5 Losers (%)		%

Top 5 Losers ($)		$

Foresite Capital Management IV, LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Foresite Capital Management IV, LLC

Last Reported on: 17 Feb, 2026

Ticker	Namesorted ascending	% Portfolio	Shares Held	$ Value	Type	% Change
ALEC	alector, inc.	2.64	3,887,200	6,064,030	new

CYTK	cytokinetics inc	12.68	458,295	29,120,100	unchanged	0.00

LYEL	lyell immunopharma, inc.	10.72	800,399	24,636,300	unchanged	0.00

PHVS	pharvaris n.v.	57.73	4,778,580	132,606,000	unchanged	0.00

RLAY	relay therapeutics, inc.	3.68	1,000,000	8,460,000	unchanged	0.00

XENE	xenon pharmaceuticals inc.	3.12	160,000	7,171,200	unchanged	0.00

	maze therapeutics, inc.	9.43	522,657	21,653,700	unchanged	0.00