Latest Foresite Capital Management IV, LLC Stock Portfolio

$237Million | No. of Holdings #8

Foresite Capital Management IV, LLC Performance

2026 Q1-1.21%

YTD-1.21%

2025+58.24%

About Foresite Capital Management IV, LLC and 13F Hedge Fund Stock Holdings

On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, Foresite Capital Management IV, LLC reported an equity portfolio of $237.1 Millions as of 31 Mar, 2026. <br><br> The top stock holdings of Foresite Capital Management IV, LLC are PHVS, CYTK, . The fund has invested 56.9% of it's portfolio in PHARVARIS N.V. and 14% of portfolio in CYTOKINETICS INC. <br><br> They significantly reduced their stock positions in MAZE THERAPEUTICS, INC.. Foresite Capital Management IV, LLC opened new stock positions in EIKON THERAPEUTICS, INC.. The fund showed a lot of confidence in some stocks as they added substantially to CYTOKINETICS INC (CYTK).

Foresite Capital Management IV, LLC Equity Portfolio Value

Last Reported on: 15 May, 2026

$237Million

as of May 15, 2026

Foresite Capital Management IV, LLC Annual Return Estimates Vs S&P 500

Our best estimate is that Foresite Capital Management IV, LLC made a return of -1.21% in the last quarter. In trailing 12 months, it's portfolio return was 84.7%.

Performance
S&P 500

New Buys

Ticker	$ Bought
eikon therapeutics, inc.	20,564,200

New stocks bought by Foresite Capital Management IV, LLC

Additions

Ticker	% Inc.
cytokinetics inc	9.82

Additions to existing portfolio by Foresite Capital Management IV, LLC

Reductions

Ticker	% Reduced
maze therapeutics, inc.	-69.98

Foresite Capital Management IV, LLC reduced stake in above stock

Sold off

None of the stocks were completely sold off by Foresite Capital Management IV, LLC

Sector Distribution

Foresite Capital Management IV, LLC has about 67.6% of it's holdings in Others sector.

Others
Healthcare

Sector	%
Others	67.6
Healthcare	32.4

Market Cap. Distribution

Foresite Capital Management IV, LLC has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.

UNALLOCATED
MID-CAP
SMALL-CAP
MICRO-CAP

Category	%
UNALLOCATED	67.6
MID-CAP	17.9
SMALL-CAP	11
MICRO-CAP	3.5

Stocks belong to which Index?

About 28.5% of the stocks held by Foresite Capital Management IV, LLC either belong to S&P 500 or RUSSELL 2000 index.

Others
RUSSELL 2000

Index	%
Others	71.5
RUSSELL 2000	28.5

Top 5 Winners (%)		%
ALEC	alector, inc.	37.8 %
XENE	xenon pharmaceuticals inc.	29.7 %
RLAY	relay therapeutics, inc.	17.6 %
CYTK	cytokinetics inc	3.6 %
PHVS	pharvaris n.v.	1.8 %

Top 5 Winners ($)		$
PHVS	pharvaris n.v.	2.4 M
ALEC	alector, inc.	2.3 M
XENE	xenon pharmaceuticals inc.	2.1 M
RLAY	relay therapeutics, inc.	1.5 M
CYTK	cytokinetics inc	1.1 M

Top 5 Losers (%)		%
LYEL	lyell immunopharma, inc.	-34.8 %
	maze therapeutics, inc.	-18.2 %

Top 5 Losers ($)		$
LYEL	lyell immunopharma, inc.	-8.6 M
	maze therapeutics, inc.	-3.9 M

Foresite Capital Management IV, LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Foresite Capital Management IV, LLC

Foresite Capital Management IV, LLC has 8 stocks in it's portfolio. LYEL proved to be the most loss making stock for the portfolio. PHVS was the most profitable stock for Foresite Capital Management IV, LLC last quarter.

$237.08MTotal Value

8.00Positions

15 May, 2026Last Reported

Current holdings of Current Stock Holdings of Foresite Capital Management IV, LLC, last reported on 15 May, 2026. Select a row with a linked ticker to view its historical trend.
Holdingsorted ascending	% Portfolio	Shares Held	$ Value	% Change
ALEC Alector, Inc. Alector, Inc.ALEC Foresite Capital Management IV, LLC's holding in Alector, Inc. over time	3.52%	3,887,200	$8.36M 3.52%	unchanged 0 percentunchanged

CYTK Cytokinetics Inc Cytokinetics IncCYTK Foresite Capital Management IV, LLC's holding in Cytokinetics Inc over time	13.99%	503,295	$33.17M 13.99%	increased 9.82 percentadded

LYEL Lyell Immunopharma, Inc. Lyell Immunopharma, Inc.LYEL Foresite Capital Management IV, LLC's holding in Lyell Immunopharma, Inc. over time	6.77%	800,399	$16.06M 6.77%	unchanged 0 percentunchanged

PHVS Pharvaris N.V. Pharvaris N.V. PHVS Foresite Capital Management IV, LLC's holding in Pharvaris N.V. over time	56.94%	4,778,580	$135.00M 56.94%	unchanged 0 percentunchanged

RLAY Relay Therapeutics, Inc. Relay Therapeutics, Inc.RLAY Foresite Capital Management IV, LLC's holding in Relay Therapeutics, Inc. over time	4.2%	1,000,000	$9.95M 4.2%	unchanged 0 percentunchanged

XENE Xenon Pharmaceuticals Inc. Xenon Pharmaceuticals Inc.XENE Foresite Capital Management IV, LLC's holding in Xenon Pharmaceuticals Inc. over time	3.92%	160,000	$9.30M 3.92%	unchanged 0 percentunchanged

Com Eikon Therapeutics, Inc. Eikon Therapeutics, Inc. Foresite Capital Management IV, LLC's holding in Eikon Therapeutics, Inc. over time	8.67%	1,943,680	$20.56M 8.67%	new position

Com Maze Therapeutics, Inc. Maze Therapeutics, Inc. Foresite Capital Management IV, LLC's holding in Maze Therapeutics, Inc. over time	1.98%	156,901	$4.68M 1.98%	decreased 69.98 percentreduced