Latest Samsara BioCapital, LLC Stock Portfolio
Samsara BioCapital, LLC Performance:
2025 Q4: 19.03%YTD: 26.2%2024: 3.02%
Performance for 2025 Q4 is 19.03%, and YTD is 26.2%, and 2024 is 3.02%.
About Samsara BioCapital, LLC and 13F Hedge Fund Stock Holdings
SAMSARA BIOCAPITAL, LLC is a hedge fund based in Palo Alto, CA. On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, SAMSARA BIOCAPITAL, LLC reported an equity portfolio of $969.3 Millions as of 31 Dec, 2025.
The top stock holdings of SAMSARA BIOCAPITAL, LLC are SRRK, , . The fund has invested 31.4% of it's portfolio in SCHOLAR ROCK HLDG CORP and 22% of portfolio in MINERALYS THERAPEUTICS INC.
The fund managers got completely rid off LENZ THERAPEUTICS INC, AURA BIOSCIENCES INC (AURA) and ZYMEWORKS INC (ZYME) stocks. They significantly reduced their stock positions in CONTINEUM THERAPEUTICS INC, ARCELLX INC (ACLX) and VTV THERAPEUTICS INC (VTVT). SAMSARA BIOCAPITAL, LLC opened new stock positions in INVENTIVA SA (IVA), RANI THERAPEUTICS HLDGS INC (RANI) and X4 PHARMACEUTICALS INC (XFOR). The fund showed a lot of confidence in some stocks as they added substantially to JADE BIOSCIENCES INC (AVTE), SCHOLAR ROCK HLDG CORP (SRRK) and ALUMIS INC.
The top stock holdings of SAMSARA BIOCAPITAL, LLC are SRRK, , . The fund has invested 31.4% of it's portfolio in SCHOLAR ROCK HLDG CORP and 22% of portfolio in MINERALYS THERAPEUTICS INC.
The fund managers got completely rid off LENZ THERAPEUTICS INC, AURA BIOSCIENCES INC (AURA) and ZYMEWORKS INC (ZYME) stocks. They significantly reduced their stock positions in CONTINEUM THERAPEUTICS INC, ARCELLX INC (ACLX) and VTV THERAPEUTICS INC (VTVT). SAMSARA BIOCAPITAL, LLC opened new stock positions in INVENTIVA SA (IVA), RANI THERAPEUTICS HLDGS INC (RANI) and X4 PHARMACEUTICALS INC (XFOR). The fund showed a lot of confidence in some stocks as they added substantially to JADE BIOSCIENCES INC (AVTE), SCHOLAR ROCK HLDG CORP (SRRK) and ALUMIS INC.
Samsara BioCapital, LLC Annual Return Estimates Vs S&P 500
Our best estimate is that SAMSARA BIOCAPITAL, LLC made a return of 19.03% in the last quarter. In trailing 12 months, it's portfolio return was 26.2%.
- Performance
- S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| inventiva sa | 24,155,800 |
| rani therapeutics hldgs inc | 11,475,000 |
| x4 pharmaceuticals inc | 7,840,000 |
| sutro biopharma inc | 2,366,100 |
New stocks bought by Samsara BioCapital, LLC
Additions
| Ticker | % Inc. |
|---|---|
| jade biosciences inc | 82.39 |
| scholar rock hldg corp | 22.89 |
| alumis inc | 19.9 |
| gossamer bio inc | 17.82 |
| kalaris therapeutics inc | 13.1 |
Additions to existing portfolio by Samsara BioCapital, LLC
Reductions
| Ticker | % Reduced |
|---|---|
| contineum therapeutics inc | -87.35 |
| palvella therapeutics inc ne | -50.00 |
| arcellx inc | -25.00 |
| upstream bio inc | -23.5 |
| vtv therapeutics inc | -20.29 |
| nkarta inc | -6.91 |
| nuvation bio inc | -6.91 |
| mineralys therapeutics inc | -6.26 |
Samsara BioCapital, LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| avadel pharmaceuticals plc | -10,314,900 |
| aura biosciences inc | -3,614,370 |
| lenz therapeutics inc | -15,977,500 |
| surrozen inc | -3,110,440 |
| sutro biopharma inc | -1,907,710 |
| zymeworks inc | -3,550,950 |
| terns pharmaceuticals inc | -1,018,150 |
| surrozen inc | -1,780 |
Samsara BioCapital, LLC got rid off the above stocks
Sector Distribution
SAMSARA BIOCAPITAL, LLC has about 58.6% of it's holdings in Others sector.
- Others
- Healthcare
| Sector | % |
|---|---|
| Others | 58.6 |
| Healthcare | 41.4 |
Market Cap. Distribution
SAMSARA BIOCAPITAL, LLC has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.
- UNALLOCATED
- MID-CAP
- SMALL-CAP
- MICRO-CAP
- NANO-CAP
| Category | % |
|---|---|
| UNALLOCATED | 58.6 |
| MID-CAP | 31.8 |
| SMALL-CAP | 5.5 |
| MICRO-CAP | 3 |
| NANO-CAP | 1.2 |
Stocks belong to which Index?
About 35% of the stocks held by SAMSARA BIOCAPITAL, LLC either belong to S&P 500 or RUSSELL 2000 index.
- Others
- RUSSELL 2000
| Index | % |
|---|---|
| Others | 65 |
| RUSSELL 2000 | 35 |
Samsara BioCapital, LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Samsara BioCapital, LLC
SAMSARA BIOCAPITAL, LLC has 21 stocks in it's portfolio. About 91.6% of the portfolio is in top 10 stocks. proved to be the most loss making stock for the portfolio. SRRK was the most profitable stock for SAMSARA BIOCAPITAL, LLC last quarter.
Last Reported on: 17 Feb, 2026| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ACLX | arcellx inc | 0.41 | 60,873 | 3,968,920 | reduced | -25.00 | ||
| AQST | aquestive therapeutics inc | 1.67 | 2,500,000 | 16,150,000 | unchanged | 0.00 | ||
| AURA | aura biosciences inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AVTE | jade biosciences inc | 1.54 | 968,798 | 14,948,600 | added | 82.39 | ||
| BOLT | bolt biotherapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| GOSS | gossamer bio inc | 2.31 | 7,222,560 | 22,389,900 | added | 17.82 | ||
| IVA | inventiva sa | 2.49 | 5,194,800 | 24,155,800 | new | |||
| NKTX | nkarta inc | 0.67 | 3,507,670 | 6,489,180 | reduced | -6.91 | ||
| NUVB | nuvation bio inc | 0.00 | 124,119 | 40,959 | reduced | -6.91 | ||
| RANI | rani therapeutics hldgs inc | 1.18 | 8,500,000 | 11,475,000 | new | |||
| RYTM | rhythm pharmaceuticals inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| SRRK | scholar rock hldg corp | 31.35 | 6,897,650 | 303,842,000 | added | 22.89 | ||
| SRZN | surrozen inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| SRZN | surrozen inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| STRO | sutro biopharma inc | 0.24 | 204,503 | 2,366,100 | new | |||
| STRO | sutro biopharma inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| TERN | terns pharmaceuticals inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| VTVT | vtv therapeutics inc | 1.23 | 298,496 | 11,936,900 | reduced | -20.29 | ||
| XFOR | x4 pharmaceuticals inc | 0.81 | 1,960,000 | 7,840,000 | new | |||
| ZYME | zymeworks inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||