Latest SR ONE CAPITAL MANAGEMENT, LP Stock Portfolio
SR ONE CAPITAL MANAGEMENT, LP Performance:
2025 Q3: 11.91%YTD: 7.79%2024: 15.52%
Performance for 2025 Q3 is 11.91%, and YTD is 7.79%, and 2024 is 15.52%.
About SR ONE CAPITAL MANAGEMENT, LP and 13F Hedge Fund Stock Holdings
In it's latest 13F Holdings report, SR One Capital Management, LP reported an equity portfolio of $691.4 Millions as of 30 Sep, 2025.
The top stock holdings of SR One Capital Management, LP are ACLX, CRSP, . The fund has invested 27.9% of it's portfolio in ARCELLX, INC. and 19.1% of portfolio in CRISPR THERAPEUTICS AG.
The fund managers got completely rid off KALA BIO, INC. (KALA) stocks. They significantly reduced their stock positions in MINERALYS THERAPEUTICS INC.. The fund showed a lot of confidence in some stocks as they added substantially to CRISPR THERAPEUTICS AG (CRSP).
The top stock holdings of SR One Capital Management, LP are ACLX, CRSP, . The fund has invested 27.9% of it's portfolio in ARCELLX, INC. and 19.1% of portfolio in CRISPR THERAPEUTICS AG.
The fund managers got completely rid off KALA BIO, INC. (KALA) stocks. They significantly reduced their stock positions in MINERALYS THERAPEUTICS INC.. The fund showed a lot of confidence in some stocks as they added substantially to CRISPR THERAPEUTICS AG (CRSP).
SR ONE CAPITAL MANAGEMENT, LP Annual Return Estimates Vs S&P 500
Our best estimate is that SR One Capital Management, LP made a return of 11.91% in the last quarter. In trailing 12 months, it's portfolio return was -1.03%.
New Buys
Additions
| Ticker | % Inc. |
|---|---|
| crispr therapeutics ag | 94.36 |
Additions to existing portfolio by SR ONE CAPITAL MANAGEMENT, LP
Reductions
| Ticker | % Reduced |
|---|---|
| mineralys therapeutics inc. | -32.42 |
SR ONE CAPITAL MANAGEMENT, LP reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| kala bio, inc. | -2,850,950 |
SR ONE CAPITAL MANAGEMENT, LP got rid off the above stocks
Sector Distribution
SR One Capital Management, LP has about 62.9% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 62.9 |
| Others | 31.3 |
| 5.8 |
Market Cap. Distribution
SR One Capital Management, LP has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| MID-CAP | 47 |
| UNALLOCATED | 31.3 |
| SMALL-CAP | 14.7 |
| MICRO-CAP | 7.1 |
Stocks belong to which Index?
About 43.8% of the stocks held by SR One Capital Management, LP either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| Others | 56.2 |
| RUSSELL 2000 | 43.8 |
SR ONE CAPITAL MANAGEMENT, LP Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of SR ONE CAPITAL MANAGEMENT, LP
SR One Capital Management, LP has 12 stocks in it's portfolio. SBTX proved to be the most loss making stock for the portfolio. ACLX was the most profitable stock for SR One Capital Management, LP last quarter.
Last Reported on: 12 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ACLX | arcellx, inc. | 27.86 | 2,346,630 | 192,658,000 | unchanged | 0.00 | ||
| CRSP | crispr therapeutics ag | 19.11 | 2,038,760 | 132,132,000 | added | 94.36 | ||
| DSGN | design therapeutics, inc. | 7.11 | 6,526,480 | 49,144,400 | unchanged | 0.00 | ||
| KALA | kala bio, inc. | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| NKTX | nkarta, inc. | 1.00 | 3,333,330 | 6,900,000 | unchanged | 0.00 | ||
| ORIC | oric pharmaceuticals, inc. | 7.84 | 4,514,930 | 54,179,100 | unchanged | 0.00 | ||
| SBTX | ars pharmaceuticals, inc. | 5.83 | 4,012,900 | 40,329,700 | unchanged | 0.00 | ||
| zenas biopharma, inc | 15.77 | 4,911,540 | 109,036,000 | unchanged | 0.00 | |||
| mineralys therapeutics inc. | 11.59 | 2,113,930 | 80,160,300 | reduced | -32.42 | |||
| oruka therapeutics, inc | 1.20 | 430,330 | 8,275,250 | unchanged | 0.00 | |||
| alumis inc. | 1.13 | 1,959,900 | 7,819,980 | unchanged | 0.00 | |||
| oculis holding ag | 0.82 | 322,500 | 5,669,550 | unchanged | 0.00 | |||
| engene holdings inc. | 0.74 | 747,750 | 5,107,130 | unchanged | 0.00 | |||