Grufity logo
Grufity logo

Latest SR ONE CAPITAL MANAGEMENT, LP Stock Portfolio

$1.04Billion | No. of Holdings #15

SR ONE CAPITAL MANAGEMENT, LP Performance

2026 Q2+24.79%
YTD+33.14%
2025+37.52%

About SR ONE CAPITAL MANAGEMENT, LP and 13F Hedge Fund Stock Holdings

On 2026-08-12, the fund reported it's updated stock portfolio. In the 13F Holdings report, SR One Capital Management, LP reported an equity portfolio of $1 Billions as of 30 Jun, 2026. <br><br> The top stock holdings of SR One Capital Management, LP are , , CRSP. The fund has invested 28.4% of it's portfolio in VERADERMICS, INC. and 12.3% of portfolio in ZENAS BIOPHARMA, INC. <br><br> The fund managers got completely rid off ARCELLX, INC. (ACLX) and ORUKA THERAPEUTICS, INC stocks. SR One Capital Management, LP opened new stock positions in AVALYN PHARMA, INC. The fund showed a lot of confidence in some stocks as they added substantially to ORIC PHARMACEUTICALS, INC. (ORIC).
SR ONE CAPITAL MANAGEMENT, LP Equity Portfolio Value
Last Reported on: 12 Aug, 2026
$1.04Billion
  as of Aug 12, 2026

SR ONE CAPITAL MANAGEMENT, LP Annual Return Estimates Vs S&P 500

Our best estimate is that SR One Capital Management, LP made a return of 24.79% in the last quarter. In trailing 12 months, it's portfolio return was 91.55%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
avalyn pharma, inc108,921,000
odyssey therapeutics, inc.71,002,300
mobia medical, inc26,613,400
New stocks bought by SR ONE CAPITAL MANAGEMENT, LP

Additions

Ticker% Inc.
oric pharmaceuticals, inc.2.22
Additions to existing portfolio by SR ONE CAPITAL MANAGEMENT, LP

Reductions

None of the existing positions were reduced by SR ONE CAPITAL MANAGEMENT, LP

Sold off

Ticker$ Sold
arcellx, inc.-269,440,000
oruka therapeutics, inc-21,107,700
SR ONE CAPITAL MANAGEMENT, LP got rid off the above stocks

Sector Distribution

SR One Capital Management, LP has about 71% of it's holdings in Others sector.

  • Others
  • Healthcare
Sector%
Others71
Healthcare26
3.1

Market Cap. Distribution

SR One Capital Management, LP has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.

  • UNALLOCATED
  • SMALL-CAP
  • MID-CAP
Category%
UNALLOCATED71
SMALL-CAP17
MID-CAP11.1

Stocks belong to which Index?

About 14.8% of the stocks held by SR One Capital Management, LP either belong to S&P 500 or RUSSELL 2000 index.

  • Others
  • RUSSELL 2000
Index%
Others85.2
RUSSELL 200014.8
Top 5 Winners (%)%
veradermics, inc.
94.7 %
RARE
ultragenyx pharmaceutical inc.
59.4 %
DSGN
design therapeutics, inc.
36.0 %
NKTX
nkarta, inc.
34.1 %
zenas biopharma, inc
29.8 %
Top 5 Winners ($)$
veradermics, inc.
143.6 M
zenas biopharma, inc
29.4 M
DSGN
design therapeutics, inc.
25.0 M
CRSP
crispr therapeutics ag
14.2 M
alumis inc.
12.0 M
Top 5 Losers (%)%
engene holdings inc.
-74.6 %
oculis holding ag
-47.8 %
ORIC
oric pharmaceuticals, inc.
-16.2 %
mineralys therapeutics inc.
-0.4 %
SBTX
ars pharmaceuticals, inc.
-0.3 %
Top 5 Losers ($)$
ORIC
oric pharmaceuticals, inc.
-9.7 M
oculis holding ag
-8.2 M
engene holdings inc.
-3.8 M
mineralys therapeutics inc.
-0.2 M
SBTX
ars pharmaceuticals, inc.
-0.1 M

SR ONE CAPITAL MANAGEMENT, LP Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of SR ONE CAPITAL MANAGEMENT, LP

SR One Capital Management, LP has 15 stocks in it's portfolio. About 95.1% of the portfolio is in top 10 stocks. ORIC proved to be the most loss making stock for the portfolio. was the most profitable stock for SR One Capital Management, LP last quarter.

$1.04BTotal Value
17.00Positions
12 Aug, 2026Last Reported
Current holdings of Current Stock Holdings of SR ONE CAPITAL MANAGEMENT, LP, last reported on 12 Aug, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change
Common Stock
Veradermics, Inc.

Veradermics, Inc.

SR ONE CAPITAL MANAGEMENT, LP's holding in Veradermics, Inc. over time
28.42%2,401,870
$295.29M
28.42%
unchanged 0 percentunchanged
Common Stock
Zenas Biopharma, Inc

Zenas Biopharma, Inc

SR ONE CAPITAL MANAGEMENT, LP's holding in Zenas Biopharma, Inc over time
12.31%5,037,850
$127.86M
12.31%
unchanged 0 percentunchanged
Common Stock
Avalyn Pharma, Inc

Avalyn Pharma, Inc

SR ONE CAPITAL MANAGEMENT, LP's holding in Avalyn Pharma, Inc over time
10.48%3,308,650
$108.92M
10.48%
new position
Common Stock
Odyssey Therapeutics, Inc.

Odyssey Therapeutics, Inc.

SR ONE CAPITAL MANAGEMENT, LP's holding in Odyssey Therapeutics, Inc. over time
6.83%3,794,880
$71.00M
6.83%
new position
Common Stock
Alumis Inc.

Alumis Inc.

SR ONE CAPITAL MANAGEMENT, LP's holding in Alumis Inc. over time
5.31%1,959,900
$55.15M
5.31%
unchanged 0 percentunchanged
Common Stock
Mineralys Therapeutics Inc.

Mineralys Therapeutics Inc.

SR ONE CAPITAL MANAGEMENT, LP's holding in Mineralys Therapeutics Inc. over time
4.06%1,563,970
$42.20M
4.06%
unchanged 0 percentunchanged
Common Stock
Mobia Medical, Inc

Mobia Medical, Inc

SR ONE CAPITAL MANAGEMENT, LP's holding in Mobia Medical, Inc over time
2.56%1,986,070
$26.61M
2.56%
new position
Ordinary Shares
Oculis Holding Ag

Oculis Holding Ag

SR ONE CAPITAL MANAGEMENT, LP's holding in Oculis Holding Ag over time
0.86%641,022
$8.89M
0.86%
unchanged 0 percentunchanged
Common Shares
Engene Holdings Inc.

Engene Holdings Inc.

SR ONE CAPITAL MANAGEMENT, LP's holding in Engene Holdings Inc. over time
0.12%747,750
$1.29M
0.12%
unchanged 0 percentunchanged
Common Stock
Oruka Therapeutics, Inc

Oruka Therapeutics, Inc

SR ONE CAPITAL MANAGEMENT, LP's holding in Oruka Therapeutics, Inc over time
0%0.00
$0.00
0%
decreased 100 percentsold off