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Latest Stonepine Capital Management, LLC Stock Portfolio

$249Million– No. of Holdings #66

Stonepine Capital Management, LLC Performance:
2026 Q1: -11.58%YTD: -11.58%2025: -31.98%
Performance for 2026 Q1 is -11.58%, and YTD is -11.58%, and 2025 is -31.98%.

About Stonepine Capital Management, LLC and 13F Hedge Fund Stock Holdings

Stonepine Capital Management, LLC is a hedge fund based in Bend, OR. On 2026-05-14, the fund reported it's updated stock portfolio. In the 13F Holdings report, Stonepine Capital Management, LLC reported an equity portfolio of $249.7 Millions as of 31 Mar, 2026.

The top stock holdings of Stonepine Capital Management, LLC are VSTM, TENX, EOLS. The fund has invested 7% of it's portfolio in VERASTEM INC and 6.2% of portfolio in TENAX THERAPEUTICS INC.

The fund managers got completely rid off INDIVIOR PLC, DAY ONE BIOPHARMACEUTICALS I (DAWN) and SPRUCE BIOSCIENCES INC (SPRB) stocks. They significantly reduced their stock positions in ELEDON PHARMACEUTICALS INC (ELDN), EDESA BIOTECH INC (EDSA) and MANNKIND CORP (MNKD). Stonepine Capital Management, LLC opened new stock positions in SOL-GEL TECHNOLOGIES LTD (SLGL), OKYO PHARMA LTD (OKYO) and CYTOMX THERAPEUTICS INC. (CTMX). The fund showed a lot of confidence in some stocks as they added substantially to TENAX THERAPEUTICS INC (TENX), CURIS INC (CRIS) and CAMP4 THERAPEUTICS CORP.
Stonepine Capital Management, LLC Equity Portfolio Value
Last Reported on: 14 May, 2026

Stonepine Capital Management, LLC Annual Return Estimates Vs S&P 500

Our best estimate is that Stonepine Capital Management, LLC made a return of -11.58% in the last quarter. In trailing 12 months, it's portfolio return was 5.52%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
sol-gel technologies ltd2,200,570
okyo pharma ltd1,368,500
cytomx therapeutics inc.940,000
connect biopharma hldgs ltd812,200
satellos bioscience inc563,000
phathom pharmaceuticals inc555,611
onkure therapeutics inc548,873
xilio therapeutics inc539,602
New stocks bought by Stonepine Capital Management, LLC

Additions

Ticker% Inc.
tenax therapeutics inc8,105
curis inc6,178
camp4 therapeutics corp507
processa pharmaceuticals inc346
in8bio inc302
pasithea therapeutics corp202
maxcyte inc114
codexis inc63.21
Additions to existing portfolio by Stonepine Capital Management, LLC

Reductions

Ticker% Reduced
eledon pharmaceuticals inc-96.08
edesa biotech inc-95.64
mannkind corp-81.13
omniab inc-76.6
verrica pharmaceuticals inc-71.8
surrozen inc-70.95
cabaletta bio inc-70.78
compugen ltd-65.85
Stonepine Capital Management, LLC reduced stake in above stock

Sold off

Ticker$ Sold
geron corp-1,063,660
milestone pharmaceuticals in-1,338,580
tenaya therapeutics inc-250,449
gossamer bio inc-634,787
day one biopharmaceuticals i-1,864,000
kezar life sciences inc-982,366
kiora pharmaceuticals inc-258,354
xilio therapeutics inc-80,838
Stonepine Capital Management, LLC got rid off the above stocks

Sector Distribution

Stonepine Capital Management, LLC has about 78.2% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
Sector%
Healthcare78.2
Others21.8

Market Cap. Distribution

Stonepine Capital Management, LLC has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.

  • MICRO-CAP
  • SMALL-CAP
  • UNALLOCATED
  • NANO-CAP
  • MID-CAP
Category%
MICRO-CAP39.1
SMALL-CAP23.4
UNALLOCATED21.8
NANO-CAP9.5
MID-CAP6.2

Stocks belong to which Index?

About 24.8% of the stocks held by Stonepine Capital Management, LLC either belong to S&P 500 or RUSSELL 2000 index.

  • Others
  • RUSSELL 2000
Index%
Others75.2
RUSSELL 200024.8
Top 5 Winners (%)%
ANTX
an2 therapeutics inc
167.7 %
EDSA
edesa biotech inc
140.0 %
NKTR
nektar therapeutics
70.2 %
ZNTL
zentalis pharmaceuticals inc
58.0 %
crescent biopharma inc.
54.0 %
Top 5 Winners ($)$
NKTR
nektar therapeutics
2.5 M
TENX
tenax therapeutics inc
1.9 M
ANTX
an2 therapeutics inc
1.5 M
EDSA
edesa biotech inc
1.4 M
ELDN
eledon pharmaceuticals inc
0.7 M
Top 5 Losers (%)%
CNSP
cns pharmaceuticals inc
-51.9 %
ADMA
adma biologics inc
-50.6 %
MXCT
maxcyte inc
-46.9 %
TELA
tela bio inc
-46.2 %
QNRX
quoin pharmaceuticals ltd
-45.7 %
Top 5 Losers ($)$
VSTM
verastem inc
-7.3 M
ADMA
adma biologics inc
-6.8 M
EOLS
evolus inc
-4.3 M
camp4 therapeutics corp
-1.4 M
TELA
tela bio inc
-1.4 M

Stonepine Capital Management, LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Stonepine Capital Management, LLC

Stonepine Capital Management, LLC has 66 stocks in it's portfolio. About 29.3% of the portfolio is in top 10 stocks. VSTM proved to be the most loss making stock for the portfolio. NKTR was the most profitable stock for Stonepine Capital Management, LLC last quarter.

Last Reported on: 14 May, 2026
TickerNamesorted ascending% PortfolioShares Held$ ValueType% ChangeOptions