Latest Stonepine Capital Management, LLC Stock Portfolio
Stonepine Capital Management, LLC Performance:
2025 Q3: 7.88%YTD: -7.16%2024: 54.38%
Performance for 2025 Q3 is 7.88%, and YTD is -7.16%, and 2024 is 54.38%.
About Stonepine Capital Management, LLC and 13F Hedge Fund Stock Holdings
Stonepine Capital Management, LLC is a hedge fund based in BEND, OR. On 08-Jun-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $271.5 Millions. In it's latest 13F Holdings report, Stonepine Capital Management, LLC reported an equity portfolio of $123 Millions as of 30 Sep, 2025.
The top stock holdings of Stonepine Capital Management, LLC are VSTM, ADMA, EOLS. The fund has invested 19.2% of it's portfolio in VERASTEM INC and 8.8% of portfolio in ADMA BIOLOGICS INC.
The fund managers got completely rid off ITEOS THERAPEUTICS INC (ITOS), ANI PHARMACEUTICALS INC (ANIP) and ANIKA THERAPEUTICS INC (ANIK) stocks. They significantly reduced their stock positions in REZOLUTE INC (RZLT), INDIVIOR PLC and ARDELYX INC (ARDX). Stonepine Capital Management, LLC opened new stock positions in X4 PHARMACEUTICALS INC (XFOR), OMNIAB INC and EDESA BIOTECH INC (EDSA). The fund showed a lot of confidence in some stocks as they added substantially to ABEONA THERAPEUTICS INC (ABEO), PULMONX CORP (LUNG) and ZENTALIS PHARMACEUTICALS INC (ZNTL).
The top stock holdings of Stonepine Capital Management, LLC are VSTM, ADMA, EOLS. The fund has invested 19.2% of it's portfolio in VERASTEM INC and 8.8% of portfolio in ADMA BIOLOGICS INC.
The fund managers got completely rid off ITEOS THERAPEUTICS INC (ITOS), ANI PHARMACEUTICALS INC (ANIP) and ANIKA THERAPEUTICS INC (ANIK) stocks. They significantly reduced their stock positions in REZOLUTE INC (RZLT), INDIVIOR PLC and ARDELYX INC (ARDX). Stonepine Capital Management, LLC opened new stock positions in X4 PHARMACEUTICALS INC (XFOR), OMNIAB INC and EDESA BIOTECH INC (EDSA). The fund showed a lot of confidence in some stocks as they added substantially to ABEONA THERAPEUTICS INC (ABEO), PULMONX CORP (LUNG) and ZENTALIS PHARMACEUTICALS INC (ZNTL).
Stonepine Capital Management, LLC Annual Return Estimates Vs S&P 500
Our best estimate is that Stonepine Capital Management, LLC made a return of 7.88% in the last quarter. In trailing 12 months, it's portfolio return was -11.44%.
New Buys
| Ticker | $ Bought |
|---|---|
| x4 pharmaceuticals inc | 3,612,680 |
| omniab inc | 3,428,570 |
| edesa biotech inc | 1,698,120 |
| soleno therapeutics inc | 1,622,400 |
| mannkind corp | 846,146 |
| maxcyte inc | 725,248 |
| ultragenyx pharmaceutical in | 601,600 |
| aquestive therapeutics inc | 562,354 |
New stocks bought by Stonepine Capital Management, LLC
Additions
| Ticker | % Inc. |
|---|---|
| abeona therapeutics inc | 902 |
| pulmonx corp | 359 |
| zentalis pharmaceuticals inc | 316 |
| boundless bio inc | 289 |
| dynavax technologies corp | 260 |
| kezar life sciences inc | 125 |
| verastem inc | 96.27 |
| in8bio inc | 93.4 |
Additions to existing portfolio by Stonepine Capital Management, LLC
Reductions
| Ticker | % Reduced |
|---|---|
| rezolute inc | -81.74 |
| indivior plc | -71.43 |
| ardelyx inc | -63.96 |
| aclaris therapeutics inc | -60.74 |
| syndax pharmaceuticals inc | -59.96 |
| enanta pharmaceuticals inc | -49.51 |
| savara inc | -29.41 |
| grace therapeutics inc | -27.86 |
Stonepine Capital Management, LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| myomo inc | -988,025 |
| achieve life sciences inc | -753,333 |
| iteos therapeutics inc | -3,091,030 |
| y-mabs therapeutics inc | -1,286,700 |
| hillevax inc | -449,758 |
| xeris biopharma holdings inc | -957,817 |
| anika therapeutics inc | -2,016,440 |
| theratechnologies inc | -446,160 |
Stonepine Capital Management, LLC got rid off the above stocks
Sector Distribution
Stonepine Capital Management, LLC has about 86% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 86 |
| Others | 14 |
Market Cap. Distribution
Stonepine Capital Management, LLC has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| MICRO-CAP | 42.3 |
| SMALL-CAP | 20.9 |
| MID-CAP | 14.1 |
| UNALLOCATED | 14 |
| NANO-CAP | 8.6 |
Stocks belong to which Index?
About 49.3% of the stocks held by Stonepine Capital Management, LLC either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| Others | 50.7 |
| RUSSELL 2000 | 49.3 |
Stonepine Capital Management, LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Stonepine Capital Management, LLC
Stonepine Capital Management, LLC has 58 stocks in it's portfolio. About 62.1% of the portfolio is in top 10 stocks. EOLS proved to be the most loss making stock for the portfolio. VSTM was the most profitable stock for Stonepine Capital Management, LLC last quarter.
Last Reported on: 13 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| AADI | whitehawk therapeutics inc | 0.05 | 35,253 | 66,981 | new | |||
| ABEO | abeona therapeutics inc | 1.94 | 450,970 | 2,381,120 | added | 902 | ||
| ACAD | acadia pharmaceuticals inc | 3.03 | 174,544 | 3,724,770 | reduced | -22.42 | ||
| ACHV | achieve life sciences inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ACRS | aclaris therapeutics inc | 0.30 | 192,900 | 366,510 | reduced | -60.74 | ||
| ADMA | adma biologics inc | 8.81 | 739,000 | 10,833,700 | reduced | -1.47 | ||
| ANGO | angiodynamics inc | 0.54 | 60,000 | 670,200 | reduced | -22.22 | ||
| ANIK | anika therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ANIP | ani pharmaceuticals inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ANTX | an2 therapeutics inc | 0.58 | 563,913 | 716,170 | added | 3.57 | ||
| AQST | aquestive therapeutics inc | 0.46 | 100,600 | 562,354 | new | |||
| ARDX | ardelyx inc | 0.90 | 200,000 | 1,102,000 | reduced | -63.96 | ||
| AYTU | aytu biopharma inc | 1.36 | 891,855 | 1,676,690 | added | 9.74 | ||
| CDXS | codexis inc | 0.17 | 88,264 | 215,364 | new | |||
| CHRS | coherus biosciences inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| COLL | collegium pharmaceutical inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| CTMX | cytomx therapeutics inc | 0.32 | 125,000 | 398,750 | new | |||
| DAWN | day one biopharmaceuticals i | 3.71 | 647,382 | 4,564,040 | added | 43.86 | ||
| DVAX | dynavax technologies corp | 0.87 | 108,094 | 1,073,370 | added | 260 | ||
| EDSA | edesa biotech inc | 1.38 | 687,500 | 1,698,120 | new | |||