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Latest Sio Capital Management, LLC Stock Portfolio

$697Million– No. of Holdings #74

Sio Capital Management, LLC Performance:
2026 Q1: -2.86%YTD: -2.86%2025: 4.48%
Performance for 2026 Q1 is -2.86%, and YTD is -2.86%, and 2025 is 4.48%.

About Sio Capital Management, LLC and 13F Hedge Fund Stock Holdings

On 2026-05-14, the fund reported it's updated stock portfolio. In the 13F Holdings report, Sio Capital Management, LLC reported an equity portfolio of $697.3 Millions as of 31 Mar, 2026.

The top stock holdings of Sio Capital Management, LLC are MMS, , ICLR. The fund has invested 7.1% of it's portfolio in MAXIMUS INC and 5.7% of portfolio in WAYSTAR HLDG CORP.

The fund managers got completely rid off THE CIGNA GROUP (CI), KENVUE INC and CHARLES RIV LABS INTL INC (CRL) stocks. They significantly reduced their stock positions in ZIMMER BIOMET HOLDINGS INC (ZBH), SANOFI SA (SNY) and ORGANON & CO (OGN). Sio Capital Management, LLC opened new stock positions in CORCEPT THERAPEUTICS INC (CORT), GSK PLC (GSK) and ABBOTT LABORATORIES (ABT). The fund showed a lot of confidence in some stocks as they added substantially to CENCORA INC (ABC), ABIVAX SA and VIR BIOTECHNOLOGY INC (VIR).
Sio Capital Management, LLC Equity Portfolio Value
Last Reported on: 14 May, 2026

Sio Capital Management, LLC Annual Return Estimates Vs S&P 500

Our best estimate is that Sio Capital Management, LLC made a return of -2.86% in the last quarter. In trailing 12 months, it's portfolio return was 20.28%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
corcept therapeutics inc27,199,500
gsk plc21,296,700
abbott laboratories19,155,600
embecta corp16,335,000
sionna therapeutics inc11,800,100
monopar therapeutics inc9,506,390
eyepoint inc9,303,810
compass pathways plc8,331,080
New stocks bought by Sio Capital Management, LLC

Additions

Ticker% Inc.
cencora inc534
abivax sa214
vir biotechnology inc213
ani pharmaceuticals inc204
anteris technologies global187
waystar hldg corp167
icon plc140
haemonetics corp mass138
Additions to existing portfolio by Sio Capital Management, LLC

Reductions

Ticker% Reduced
zimmer biomet holdings inc-83.76
sanofi sa-75.33
organon & co-74.69
celcuity inc-59.37
neuroone med technologies co-56.44
hyperfine inc-50.00
context therapeutics inc-31.58
dianthus therapeutics inc-22.01
Sio Capital Management, LLC reduced stake in above stock

Sold off

Ticker$ Sold
xilio therapeutics inc-1,366,530
kenvue inc-25,278,900
ventyx biosciences inc-3,501,390
fulcrum therapeutics inc-4,320,420
brightspring health svcs inc-11,535,000
the cigna group-47,395,400
alkermes plc-2,667,980
ideaya biosciences inc-2,617,990
Sio Capital Management, LLC got rid off the above stocks

Sector Distribution

Sio Capital Management, LLC has about 50.2% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
  • Industrials
Sector%
Healthcare50.2
Others42.7
Industrials7.1

Market Cap. Distribution

Sio Capital Management, LLC has about 9.7% of it's portfolio invested in the large-cap and mega-cap stocks.

  • UNALLOCATED
  • MID-CAP
  • SMALL-CAP
  • LARGE-CAP
  • MICRO-CAP
Category%
UNALLOCATED38.1
MID-CAP25
SMALL-CAP20.5
LARGE-CAP9.7
MICRO-CAP5.6

Stocks belong to which Index?

About 45.1% of the stocks held by Sio Capital Management, LLC either belong to S&P 500 or RUSSELL 2000 index.

  • Others
  • RUSSELL 2000
  • S&P 500
Index%
Others54.9
RUSSELL 200039.9
S&P 5005.2
Top 5 Winners (%)%
dianthus therapeutics inc
92.2 %
CNTX
context therapeutics inc
65.9 %
oruka therapeutics inc
56.6 %
TYRA
tyra biosciences inc
41.4 %
OVID
ovid therapeutics inc
34.0 %
Top 5 Winners ($)$
dianthus therapeutics inc
18.0 M
TYRA
tyra biosciences inc
6.8 M
CELC
celcuity inc
4.8 M
VIR
vir biotechnology inc
2.9 M
oruka therapeutics inc
2.3 M
Top 5 Losers (%)%
TELA
tela bio inc
-47.5 %
nyxoah s a
-36.5 %
ICLR
icon plc
-31.4 %
structure therapeutics inc
-30.3 %
AQST
aquestive therapeutics inc
-29.7 %
Top 5 Losers ($)$
ICLR
icon plc
-15.5 M
MMS
maximus inc
-14.1 M
waystar hldg corp
-9.7 M
structure therapeutics inc
-4.4 M
HAE
haemonetics corp mass
-3.7 M

Sio Capital Management, LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Sio Capital Management, LLC

Sio Capital Management, LLC has 74 stocks in it's portfolio. About 45.1% of the portfolio is in top 10 stocks. ICLR proved to be the most loss making stock for the portfolio. was the most profitable stock for Sio Capital Management, LLC last quarter.

Last Reported on: 14 May, 2026
TickerNamesorted ascending% PortfolioShares Held$ ValueType% ChangeOptions