Latest Sio Capital Management, LLC Stock Portfolio

Sio Capital Management, LLC Performance:

2025 Q4: 9.63%YTD: 4.48%2024: 0.38%

Performance for 2025 Q4 is 9.63%, and YTD is 4.48%, and 2024 is 0.38%.

About Sio Capital Management, LLC and 13F Hedge Fund Stock Holdings

On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, Sio Capital Management, LLC reported an equity portfolio of $635.7 Millions as of 31 Dec, 2025.

The top stock holdings of Sio Capital Management, LLC are CELC, CI, SNY. The fund has invested 7.5% of it's portfolio in CELCUITY INC and 7.5% of portfolio in THE CIGNA GROUP.

The fund managers got completely rid off MERCK & CO INC (MRK), HENRY SCHEIN INC (HSIC) and GSK PLC (GSK) stocks. They significantly reduced their stock positions in ALKERMES PLC (ALKS), DISC MEDICINE INC and BRIGHT MINDS BIOSCIENCES INC (DRUG). Sio Capital Management, LLC opened new stock positions in THE CIGNA GROUP (CI), ZIMMER BIOMET HOLDINGS INC (ZBH) and ORGANON & CO (OGN). The fund showed a lot of confidence in some stocks as they added substantially to TELEFLEX INCORPORATED (TFX), KENVUE INC and SANOFI SA (SNY).

Sio Capital Management, LLC Annual Return Estimates Vs S&P 500

Our best estimate is that Sio Capital Management, LLC made a return of 9.63% in the last quarter. In trailing 12 months, it's portfolio return was 4.48%.

Performance
S&P 500

New Buys

Ticker	$ Bought
the cigna group	47,395,400
zimmer biomet holdings inc	34,676,900
organon & co	24,534,100
icon plc	23,178,700
waystar hldg corp	20,099,500
livanova plc	19,836,200
biohaven ltd	14,053,400
structure therapeutics inc	14,014,300

New stocks bought by Sio Capital Management, LLC

Additions

Ticker	% Inc.
teleflex incorporated	116
kenvue inc	73.63
sanofi sa	72.68
ani pharmaceuticals inc	56.62
anteris technologies global	5.76
proqr therapeutics n v	4.29
biomarin pharmaceutical inc	3.36
tyra biosciences inc	2.15

Additions to existing portfolio by Sio Capital Management, LLC

Reductions

Ticker	% Reduced
alkermes plc	-85.87
disc medicine inc	-79.78
bright minds biosciences inc	-57.08
ventyx biosciences inc	-53.24
haemonetics corp mass	-53.22
neuroone med technologies co	-51.71
celcuity inc	-39.35
ideaya biosciences inc	-39.04

Sio Capital Management, LLC reduced stake in above stock

Sold off

Ticker	$ Sold
erasca inc	-2,986,050
kalvista pharmaceuticals inc	-8,328,920
novocure ltd	-5,346,670
simulations plus inc	-4,827,030
gsk plc	-11,604,600
henry schein inc	-14,548,800
septerna inc	-3,558,830
merck & co inc	-14,880,800

Sio Capital Management, LLC got rid off the above stocks

Sector Distribution

Sio Capital Management, LLC has about 55.3% of it's holdings in Healthcare sector.

Sector	%
Healthcare	55.3
Others	37.6
Industrials	7.2

Market Cap. Distribution

Sio Capital Management, LLC has about 19.5% of it's portfolio invested in the large-cap and mega-cap stocks.

Category	%
UNALLOCATED	36.7
MID-CAP	26.4
LARGE-CAP	19.5
SMALL-CAP	11.3
MICRO-CAP	5
NANO-CAP	1.1

Stocks belong to which Index?

About 50.6% of the stocks held by Sio Capital Management, LLC either belong to S&P 500 or RUSSELL 2000 index.

Index	%
Others	49.4
RUSSELL 2000	30.7
S&P 500	19.9

Top 5 Winners (%)		%
TERN	terns pharmaceuticals inc	437.9 %
NXTC	nextcure inc	142.2 %
VTYX	ventyx biosciences inc	139.7 %
TYRA	tyra biosciences inc	86.2 %
CELC	celcuity inc	81.9 %

Top 5 Winners ($)		$
CELC	celcuity inc	31.8 M
TYRA	tyra biosciences inc	6.4 M
HAE	haemonetics corp mass	4.6 M
VTYX	ventyx biosciences inc	3.6 M
DRUG	bright minds biosciences inc	2.4 M

Top 5 Losers (%)		%
HUMA	humacyte inc	-60.2 %
RCKT	rocket pharmaceuticals inc	-50.1 %
MODD	modular med inc	-48.0 %
TELA	tela bio inc	-20.8 %
ANIP	ani pharmaceuticals inc	-11.6 %

Top 5 Losers ($)		$
MMS	maximus inc	-2.7 M
ANIP	ani pharmaceuticals inc	-0.9 M
ALKS	alkermes plc	-0.8 M
PMVP	pmv pharmaceuticals inc	-0.4 M
MODD	modular med inc	-0.3 M

Sio Capital Management, LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Sio Capital Management, LLC

Sio Capital Management, LLC has 65 stocks in it's portfolio. About 52.4% of the portfolio is in top 10 stocks. MMS proved to be the most loss making stock for the portfolio. CELC was the most profitable stock for Sio Capital Management, LLC last quarter.

Last Reported on: 17 Feb, 2026

Ticker	Namesorted ascending	% Portfolio	Shares Held	$ Value	Type	% Change
ABC	cencora inc	0.84	15,900	5,370,220	new

ALGS	aligos therapeutics inc	0.49	335,937	3,130,930	unchanged	0.00

ALKS	alkermes plc	0.42	95,353	2,667,980	reduced	-85.87

ANIP	ani pharmaceuticals inc	1.08	87,272	6,889,250	added	56.62

APRE	aprea therapeutics inc	0.00	0.00	0.00	sold off	-100

AQST	aquestive therapeutics inc	1.01	993,095	6,415,390	reduced	-33.71

AVTX	avalo therapeutics inc	0.21	72,173	1,310,660	unchanged	0.00

BMRN	biomarin pharmaceutical inc	2.17	232,688	13,828,600	added	3.36

CCRN	cross ctry healthcare inc	1.36	1,068,820	8,657,450	new

CELC	celcuity inc	7.48	477,067	47,582,700	reduced	-39.35

CI	the cigna group	7.46	172,203	47,395,400	new

CNC	centene corp del	1.78	274,350	11,289,500	reduced	-29.22

CNTX	context therapeutics inc	0.31	1,341,640	1,972,200	unchanged	0.00

CRL	charles riv labs intl inc	1.73	54,985	10,968,400	new

CRNX	crinetics pharmaceuticals in	0.91	124,841	5,811,350	reduced	-28.6

DRUG	bright minds biosciences inc	1.00	81,883	6,390,150	reduced	-57.08

ENTA	enanta pharmaceuticals inc	0.10	40,000	630,800	new

ERAS	erasca inc	0.00	0.00	0.00	sold off	-100

EWTX	edgewise therapeutics inc	0.93	237,481	5,893,090	reduced	-22.69

FHTX	foghorn therapeutics inc	0.10	122,889	663,601	unchanged	0.00