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Latest Sio Capital Management, LLC Stock Portfolio

$604Million | No. of Holdings #58

Sio Capital Management, LLC Performance

2026 Q2+3.89%
YTD+0.92%
2025+4.48%

About Sio Capital Management, LLC and 13F Hedge Fund Stock Holdings

On 2026-08-14, the fund reported it's updated stock portfolio. In the 13F Holdings report, Sio Capital Management, LLC reported an equity portfolio of $604.3 Millions as of 30 Jun, 2026. <br><br> The top stock holdings of Sio Capital Management, LLC are , ABC, MMS. The fund has invested 9% of it's portfolio in ANTERIS TECHNOLOGIES GLOBAL and 8.1% of portfolio in CENCORA INC. <br><br> The fund managers got completely rid off CORCEPT THERAPEUTICS INC (CORT), LIVANOVA PLC (LIVN) and EMBECTA CORP (EMBC) stocks. They significantly reduced their stock positions in DIANTHUS THERAPEUTICS INC, ICON PUB LTD CO (ICLR) and ANI PHARMACEUTICALS INC (ANIP). Sio Capital Management, LLC opened new stock positions in ALLOGENE THERAPEUTICS INC (ALLO), GLOBUS MED INC (GMED) and IDEAYA BIOSCIENCES INC (IDYA). The fund showed a lot of confidence in some stocks as they added substantially to MODULAR MED INC (MODD), SENSEONICS HLDGS INC (SENS) and ZIMMER BIOMET HOLDINGS INC (ZBH).
Sio Capital Management, LLC Equity Portfolio Value
Last Reported on: 14 Aug, 2026
$604Million
  as of Aug 14, 2026

Sio Capital Management, LLC Annual Return Estimates Vs S&P 500

Our best estimate is that Sio Capital Management, LLC made a return of 3.89% in the last quarter. In trailing 12 months, it's portfolio return was 26.17%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
allogene therapeutics inc27,712,700
globus med inc23,846,500
ideaya biosciences inc17,903,900
the cigna group15,920,500
viatris inc15,154,300
regeneron pharmaceuticals11,223,700
bristol-myers squibb co11,149,500
medtronic plc11,147,800
New stocks bought by Sio Capital Management, LLC

Additions

Ticker% Inc.
modular med inc2,900
modular med inc2,900
senseonics hldgs inc1,275
zimmer biomet holdings inc109
cencora inc72.05
sanofi sa51.96
oruka therapeutics inc33.68
tyra biosciences inc14.84
Additions to existing portfolio by Sio Capital Management, LLC

Reductions

Ticker% Reduced
dianthus therapeutics inc-83.99
icon pub ltd co-71.21
ani pharmaceuticals inc-63.36
sionna therapeutics inc-56.58
adagio med hldgs inc-45.75
ocular therapeutix inc-44.3
waystar hldg corp-43.62
celcuity inc-43.24
Sio Capital Management, LLC reduced stake in above stock

Sold off

Ticker$ Sold
proqr therapeutics n v-3,166,640
embecta corp-16,335,000
compass pathways plc-8,331,080
biohaven ltd-9,846,810
hyperfine inc-1,080,000
context therapeutics inc-2,404,960
organon & co-5,186,790
replimune group inc-5,508,280
Sio Capital Management, LLC got rid off the above stocks

Sector Distribution

Sio Capital Management, LLC has about 51.4% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
  • Industrials
Sector%
Healthcare51.4
Others42
Industrials6.6

Market Cap. Distribution

Sio Capital Management, LLC has about 27.5% of it's portfolio invested in the large-cap and mega-cap stocks.

  • UNALLOCATED
  • LARGE-CAP
  • SMALL-CAP
  • MID-CAP
  • MICRO-CAP
Category%
UNALLOCATED33.6
LARGE-CAP27.5
SMALL-CAP20.3
MID-CAP13.7
MICRO-CAP4.4

Stocks belong to which Index?

About 47% of the stocks held by Sio Capital Management, LLC either belong to S&P 500 or RUSSELL 2000 index.

  • Others
  • RUSSELL 2000
  • S&P 500
Index%
Others53
RUSSELL 200032
S&P 50015
Top 5 Winners (%)%
anteris technologies global
75.5 %
oruka therapeutics inc
73.5 %
CCRN
cross ctry healthcare inc
40.5 %
ANTX
an2 therapeutics inc
37.5 %
ICLR
icon pub ltd co
36.7 %
Top 5 Winners ($)$
anteris technologies global
23.5 M
ICLR
icon pub ltd co
12.4 M
oruka therapeutics inc
7.1 M
CCRN
cross ctry healthcare inc
4.2 M
rapport therapeutics inc
3.5 M
Top 5 Losers (%)%
MODD
modular med inc
-94.6 %
MODD
modular med inc
-94.6 %
HUMA
humacyte inc
-89.6 %
RCKT
rocket pharmaceuticals inc
-78.9 %
adagio med hldgs inc
-33.4 %
Top 5 Losers ($)$
MMS
maximus inc
-7.7 M
waystar hldg corp
-4.6 M
ABC
cencora inc
-4.3 M
TYRA
tyra biosciences inc
-4.1 M
TARA
protara therapeutics inc
-2.7 M

Sio Capital Management, LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Sio Capital Management, LLC

Sio Capital Management, LLC has 58 stocks in it's portfolio. About 48.4% of the portfolio is in top 10 stocks. MMS proved to be the most loss making stock for the portfolio. was the most profitable stock for Sio Capital Management, LLC last quarter.

$583.53MTotal Value
88.00Positions
14 Aug, 2026Last Reported
Current holdings of Current Stock Holdings of Sio Capital Management, LLC, last reported on 14 Aug, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change
CMPS
Compass Pathways Plc

Compass Pathways Plc

CMPS
Sio Capital Management, LLC's holding in Compass Pathways Plc over time
0%0.00
$0.00
0%
decreased 100 percentsold off
CYBN
Cybin Inc

Cybin Inc

CYBN
Sio Capital Management, LLC's holding in Cybin Inc over time
1.42%1,300,000
$8.59M
1.42%
new position
DRUG
Bright Minds Biosciences Inc

Bright Minds Biosciences Inc

DRUG
Sio Capital Management, LLC's holding in Bright Minds Biosciences Inc over time
0.86%73,952
$5.19M
0.86%
decreased 14.09 percentreduced