Latest Sio Capital Management, LLC Stock Portfolio

Sio Capital Management, LLC Performance:

2025 Q2: -1.39%YTD: -10.33%2024: -3.27%

Performance for 2025 Q2 is -1.39%, and YTD is -10.33%, and 2024 is -3.27%.

About Sio Capital Management, LLC and 13F Hedge Fund Stock Holdings

In it's latest 13F Holdings report, Sio Capital Management, LLC reported an equity portfolio of $261.8 Millions as of 30 Jun, 2025.

The top stock holdings of Sio Capital Management, LLC are MMS, , GMED. The fund has invested 14.7% of it's portfolio in MAXIMUS INC and 5.8% of portfolio in DISC MEDICINE INC.

The fund managers got completely rid off ICON PLC, ZIMMER BIOMET HOLDINGS INC (ZBH) and TELEFLEX INCORPORATED (TFX) stocks. They significantly reduced their stock positions in EMBECTA CORP (EMBC), VENTYX BIOSCIENCES INC (VTYX) and NEUROCRINE BIOSCIENCES INC (NBIX). Sio Capital Management, LLC opened new stock positions in CENTENE CORP DEL (CNC), SANOFI and EDGEWISE THERAPEUTICS INC (EWTX). The fund showed a lot of confidence in some stocks as they added substantially to DISC MEDICINE INC, MODULAR MED INC (MODD) and AQUESTIVE THERAPEUTICS INC (AQST).

Sio Capital Management, LLC Annual Return Estimates Vs S&P 500

Our best estimate is that Sio Capital Management, LLC made a return of -1.39% in the last quarter. In trailing 12 months, it's portfolio return was -11.83%.

New Buys

Ticker	$ Bought
centene corp del	14,248,500
sanofi	9,058,120
edgewise therapeutics inc	7,075,860
merus n v	3,299,020
mbx biosciences inc	2,749,810
neuroone med technologies co	2,390,100
senseonics hldgs inc	2,311,640

New stocks bought by Sio Capital Management, LLC

Additions

Ticker	% Inc.
disc medicine inc	287
modular med inc	211
aquestive therapeutics inc	141
dianthus therapeutics inc	101
tyra biosciences inc	94.49
aligos therapeutics inc	85.89
biomarin pharmaceutical inc	59.5
artivion inc	30.99

Additions to existing portfolio by Sio Capital Management, LLC

Reductions

Ticker	% Reduced
embecta corp	-97.19
ventyx biosciences inc	-49.36
neurocrine biosciences inc	-46.3
merck & co inc	-35.72
septerna inc	-25.9
anteris technologies global	-22.4

Sio Capital Management, LLC reduced stake in above stock

Sold off

Ticker	$ Sold
vaxart inc	-2,272,460
protara therapeutics inc	-6,450,920
ironwood pharmaceuticals inc	-1,495,900
89bio inc	-3,635,000
icon plc	-35,577,400
zimmer biomet holdings inc	-21,242,200
haemonetics corp mass	-8,513,540
praxis precision medicines inc i	-4,260,380

Sio Capital Management, LLC got rid off the above stocks

Sector Distribution

Sio Capital Management, LLC has about 59.4% of it's holdings in Healthcare sector.

Sector	%
Healthcare	59.4
Others	25.1
Industrials	15.4

Market Cap. Distribution

Sio Capital Management, LLC has about 21.3% of it's portfolio invested in the large-cap and mega-cap stocks.

Category	%
UNALLOCATED	25.1
MID-CAP	23.6
SMALL-CAP	21.9
LARGE-CAP	15.8
MICRO-CAP	5.6
MEGA-CAP	5.5
NANO-CAP	2.5

Stocks belong to which Index?

About 52.6% of the stocks held by Sio Capital Management, LLC either belong to S&P 500 or RUSSELL 2000 index.

Index	%
Others	47.4
RUSSELL 2000	41.4
S&P 500	11.2

Top 5 Winners (%)		%
VTYX	ventyx biosciences inc	86.1 %
TELA	tela bio inc	58.1 %
ENTA	enanta pharmaceuticals inc	36.5 %
TERN	terns pharmaceuticals inc	34.7 %
FHTX	foghorn therapeutics inc	28.4 %

Top 5 Winners ($)		$
NBIX	neurocrine biosciences inc	2.8 M
VTYX	ventyx biosciences inc	2.6 M
ANNX	annexon inc	1.6 M
MMS	maximus inc	0.9 M
AORT	artivion inc	0.8 M

Top 5 Losers (%)		%
AVTX	avalo therapeutics inc	-37.5 %
EMBC	embecta corp	-24.0 %
VIR	vir biotechnology inc	-22.1 %
RCKT	rocket pharmaceuticals inc	-20.4 %
SVRA	savara inc	-17.6 %

Top 5 Losers ($)		$
EMBC	embecta corp	-3.4 M
GMED	globus med inc	-2.9 M
MRK	merck & co inc	-2.9 M
BMRN	biomarin pharmaceutical inc	-2.2 M
VIR	vir biotechnology inc	-0.7 M

Sio Capital Management, LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Sio Capital Management, LLC

Sio Capital Management, LLC has 49 stocks in it's portfolio. About 58.6% of the portfolio is in top 10 stocks. EMBC proved to be the most loss making stock for the portfolio. NBIX was the most profitable stock for Sio Capital Management, LLC last quarter.

Last Reported on: 13 Aug, 2025

	Ticker	Namesorted descending	% Portfolio	Shares Held	$ Value	Type	% Change
	MMS	maximus inc	14.69	548,086	38,475,600	added	17.02
Historical Trend of MAXIMUS INC Position Held By Sio Capital Management, LLC What % of Portfolio is MMS?: Number of MMS shares held: Change in No. of Shares Held:
		disc medicine inc	5.76	284,787	15,082,300	added	287

	GMED	globus med inc	5.54	245,570	14,493,500	added	18.63

	CNC	centene corp del	5.44	262,500	14,248,500	new

	MRK	merck & co inc	5.26	173,951	13,770,000	reduced	-35.72

		bright minds biosciences inc	5.11	512,338	13,377,100	added	0.94

	NBIX	neurocrine biosciences inc	4.84	100,725	12,660,100	reduced	-46.3

	BMRN	biomarin pharmaceutical inc	4.73	225,114	12,374,500	added	59.5

	ANNX	annexon inc	3.75	4,095,760	9,829,830	added	20.54

		sanofi	3.46	187,500	9,058,120	new

	TYRA	tyra biosciences inc	2.96	810,274	7,754,320	added	94.49

	ANIP	ani pharmaceuticals inc	2.81	112,923	7,368,230	added	29.35

	EWTX	edgewise therapeutics inc	2.70	539,730	7,075,860	new

		anteris technologies global	2.66	1,839,020	6,969,890	reduced	-22.4

		septerna inc	2.36	584,435	6,177,480	reduced	-25.9

	AORT	artivion inc	1.89	158,736	4,936,690	added	30.99

		dianthus therapeutics inc	1.68	236,070	4,397,980	added	101

		proqr therapeutics n v	1.62	2,075,140	4,233,280	added	1.00

	PMVP	pmv pharmaceuticals inc	1.51	3,735,400	3,959,520	unchanged	0.00

	AVNS	avanos med inc	1.35	288,849	3,535,510	added	1.00