Latest Sio Capital Management, LLC Stock Portfolio
Sio Capital Management, LLC Performance:
2025 Q3: 8.86%YTD: -2.39%2024: -3.27%
Performance for 2025 Q3 is 8.86%, and YTD is -2.39%, and 2024 is -3.27%.
About Sio Capital Management, LLC and 13F Hedge Fund Stock Holdings
In it's latest 13F Holdings report, Sio Capital Management, LLC reported an equity portfolio of $395.2 Millions as of 30 Sep, 2025.
The top stock holdings of Sio Capital Management, LLC are MMS, CELC, . The fund has invested 12.9% of it's portfolio in MAXIMUS INC and 9.8% of portfolio in CELCUITY INC.
The fund managers got completely rid off GLOBUS MED INC (GMED), NEUROCRINE BIOSCIENCES INC (NBIX) and ANNEXON INC (ANNX) stocks. They significantly reduced their stock positions in SEPTERNA INC, APREA THERAPEUTICS INC (APRE) and SENSEONICS HOLDINGS INC (SENS). Sio Capital Management, LLC opened new stock positions in CELCUITY INC (CELC), ALKERMES PLC (ALKS) and HENRY SCHEIN INC (HSIC). The fund showed a lot of confidence in some stocks as they added substantially to SANOFI SA, AQUESTIVE THERAPEUTICS INC (AQST) and CENTENE CORP DEL (CNC).
The top stock holdings of Sio Capital Management, LLC are MMS, CELC, . The fund has invested 12.9% of it's portfolio in MAXIMUS INC and 9.8% of portfolio in CELCUITY INC.
The fund managers got completely rid off GLOBUS MED INC (GMED), NEUROCRINE BIOSCIENCES INC (NBIX) and ANNEXON INC (ANNX) stocks. They significantly reduced their stock positions in SEPTERNA INC, APREA THERAPEUTICS INC (APRE) and SENSEONICS HOLDINGS INC (SENS). Sio Capital Management, LLC opened new stock positions in CELCUITY INC (CELC), ALKERMES PLC (ALKS) and HENRY SCHEIN INC (HSIC). The fund showed a lot of confidence in some stocks as they added substantially to SANOFI SA, AQUESTIVE THERAPEUTICS INC (AQST) and CENTENE CORP DEL (CNC).
Sio Capital Management, LLC Annual Return Estimates Vs S&P 500
Our best estimate is that Sio Capital Management, LLC made a return of 8.86% in the last quarter. In trailing 12 months, it's portfolio return was -9.24%.
New Buys
| Ticker | $ Bought |
|---|---|
| celcuity inc | 38,854,400 |
| alkermes plc | 20,245,200 |
| henry schein inc | 14,548,800 |
| kenvue inc | 13,698,100 |
| gsk plc | 11,604,600 |
| haemonetics corp mass | 9,652,230 |
| kalvista pharmaceuticals inc | 8,328,920 |
| crinetics pharmaceuticals in | 7,282,130 |
New stocks bought by Sio Capital Management, LLC
Additions
| Ticker | % Inc. |
|---|---|
| sanofi sa | 200 |
| dianthus therapeutics inc | 144 |
| aquestive therapeutics inc | 58.11 |
| centene corp del | 47.66 |
| merck & co inc | 1.93 |
| maximus inc | 1.74 |
Additions to existing portfolio by Sio Capital Management, LLC
Reductions
| Ticker | % Reduced |
|---|---|
| septerna inc | -67.63 |
| bright minds biosciences inc | -62.77 |
| aprea therapeutics inc | -59.83 |
| senseonics holdings inc | -52.28 |
| ani pharmaceuticals inc | -50.65 |
| edgewise therapeutics inc | -43.09 |
| ventyx biosciences inc | -36.61 |
| tyra biosciences inc | -36.45 |
Sio Capital Management, LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| annexon inc | -9,829,830 |
| alector inc | -1,183,740 |
| astria therapeutics inc | -1,705,850 |
| avanos med inc | -3,535,510 |
| globus med inc | -14,493,500 |
| mbx biosciences inc | -2,749,810 |
| enanta pharmaceuticals inc | -1,351,530 |
| artivion inc | -4,936,690 |
Sio Capital Management, LLC got rid off the above stocks
Sector Distribution
Sio Capital Management, LLC has about 53.5% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 53.5 |
| Others | 33.6 |
| Industrials | 12.9 |
Market Cap. Distribution
Sio Capital Management, LLC has about 11.6% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| UNALLOCATED | 33.6 |
| MID-CAP | 28.2 |
| SMALL-CAP | 21.8 |
| LARGE-CAP | 7.8 |
| MEGA-CAP | 3.8 |
| MICRO-CAP | 3 |
| NANO-CAP | 1.8 |
Stocks belong to which Index?
About 57.5% of the stocks held by Sio Capital Management, LLC either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| RUSSELL 2000 | 45.3 |
| Others | 42.5 |
| S&P 500 | 12.2 |
Sio Capital Management, LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Sio Capital Management, LLC
Sio Capital Management, LLC has 51 stocks in it's portfolio. About 59.5% of the portfolio is in top 10 stocks. CNC proved to be the most loss making stock for the portfolio. MMS was the most profitable stock for Sio Capital Management, LLC last quarter.
Last Reported on: 13 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ALEC | alector inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ALGS | aligos therapeutics inc | 0.83 | 335,937 | 3,292,180 | unchanged | 0.00 | ||
| ALKS | alkermes plc | 5.12 | 674,840 | 20,245,200 | new | |||
| ANIP | ani pharmaceuticals inc | 1.29 | 55,723 | 5,104,230 | reduced | -50.65 | ||
| ANNX | annexon inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AORT | artivion inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| APRE | aprea therapeutics inc | 0.04 | 112,223 | 165,529 | reduced | -59.83 | ||
| AQST | aquestive therapeutics inc | 2.12 | 1,498,100 | 8,374,350 | added | 58.11 | ||
| ATXS | astria therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AVNS | avanos med inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AVTX | avalo therapeutics inc | 0.23 | 72,173 | 917,319 | unchanged | 0.00 | ||
| BMRN | biomarin pharmaceutical inc | 3.08 | 225,114 | 12,192,200 | unchanged | 0.00 | ||
| CELC | celcuity inc | 9.83 | 786,526 | 38,854,400 | new | |||
| CNC | centene corp del | 3.50 | 387,600 | 13,829,600 | added | 47.66 | ||
| CNTX | context therapeutics inc | 0.33 | 1,341,640 | 1,299,780 | unchanged | 0.00 | ||
| CRNX | crinetics pharmaceuticals in | 1.84 | 174,841 | 7,282,130 | new | |||
| EMBC | embecta corp | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ENTA | enanta pharmaceuticals inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ERAS | erasca inc | 0.76 | 1,369,750 | 2,986,050 | unchanged | 0.00 | ||
| EWTX | edgewise therapeutics inc | 1.26 | 307,181 | 4,982,480 | reduced | -43.09 | ||