Latest Casdin Capital, LLC Stock Portfolio

$2.00Billion | No. of Holdings #43

Casdin Capital, LLC Performance

2026 Q2+42.03%

YTD+19.82%

2025+27.41%

About Casdin Capital, LLC and 13F Hedge Fund Stock Holdings

Casdin Capital, LLC is a hedge fund based in New York, NY. On 2026-08-14, the fund reported it's updated stock portfolio. In the 13F Holdings report, Casdin Capital, LLC reported an equity portfolio of $2 Billions as of 30 Jun, 2026. <br><br> The top stock holdings of Casdin Capital, LLC are RVMD, RLAY, SMFR. The fund has invested 24.2% of it's portfolio in REVOLUTION MEDICINES INC and 15% of portfolio in RELAY THERAPEUTICS INC. <br><br> The fund managers got completely rid off QIAGEN NV (QGEN), TEMPUS AI INC and MOONLAKE IMMUNOTHERAPEUTICS (MLTX) stocks. They significantly reduced their stock positions in 10X GENOMICS INC (TXG), GUARDANT HEALTH INC (GH) and BIOLIFE SOLUTIONS INC (BLFS). Casdin Capital, LLC opened new stock positions in PARABILIS MEDICINES INC, SAREPTA THERAPEUTICS INC (SRPT) and UNIQURE NV (QURE). The fund showed a lot of confidence in some stocks as they added substantially to ADLAI NORTYE LTD, SCHOLAR ROCK HLDG CORP (SRRK) and PERSONALIS INC (PSNL).

Casdin Capital, LLC Equity Portfolio Value

Last Reported on: 14 Aug, 2026

$2.00Billion

as of Aug 14, 2026

Casdin Capital, LLC Annual Return Estimates Vs S&P 500

Our best estimate is that Casdin Capital, LLC made a return of 42.03% in the last quarter. In trailing 12 months, it's portfolio return was 78.47%.

Performance
S&P 500

New Buys

Ticker	$ Bought
parabilis medicines inc	17,672,500
sionna therapeutics inc	17,596,000
sarepta therapeutics inc	8,445,900
uniqure nv	6,909,000
editas medicine inc	1,441,800
kardigan inc	1,192,500

New stocks bought by Casdin Capital, LLC

Additions

Ticker	% Inc.
adlai nortye ltd	132
grail inc	108
scholar rock hldg corp	90.00
personalis inc	59.38
genedx holdings corp	23.28
relay therapeutics inc	11.21
maze therapeutics inc	11.2
denali therapeutics inc	11.14

Additions to existing portfolio by Casdin Capital, LLC

Reductions

Ticker	% Reduced
10x genomics inc	-53.85
guardant health inc	-41.27
biolife solutions inc	-21.86

Casdin Capital, LLC reduced stake in above stock

Sold off

Ticker	$ Sold
moonlake immunotherapeutics	-8,388,000
qiagen nv	-14,414,400
tempus ai inc	-13,300,400

Casdin Capital, LLC got rid off the above stocks

Sector Distribution

Casdin Capital, LLC has about 72% of it's holdings in Healthcare sector.

Healthcare
Others
Consumer Defensive

Sector	%
Healthcare	72
Others	14
	12.7
Consumer Defensive	1.2

Market Cap. Distribution

Casdin Capital, LLC has about 32.1% of it's portfolio invested in the large-cap and mega-cap stocks.

LARGE-CAP
SMALL-CAP
MID-CAP
UNALLOCATED

Category	%
LARGE-CAP	32.1
SMALL-CAP	27.6
MID-CAP	26.2
UNALLOCATED	14

Stocks belong to which Index?

About 62.3% of the stocks held by Casdin Capital, LLC either belong to S&P 500 or RUSSELL 2000 index.

RUSSELL 2000
Others
S&P 500

Index	%
RUSSELL 2000	56.8
Others	37.7
S&P 500	5.5

Top 5 Winners (%)		%
ABSI	absci corporation	286.3 %
RVMD	revolution medicines inc	92.6 %
VCYT	veracyte inc	82.3 %
RLAY	relay therapeutics inc	80.0 %
PSNL	personalis inc	74.5 %

Top 5 Winners ($)		$
RVMD	revolution medicines inc	232.0 M
RLAY	relay therapeutics inc	133.4 M
BLFS	biolife solutions inc	48.6 M
TXG	10x genomics inc	28.4 M
ILMN	illumina inc	27.9 M

Top 5 Losers (%)		%
	bridgebio oncology therapeut	-14.9 %
LAB	standard biotools inc	-10.5 %
ALNY	alnylam pharmaceuticals inc	-9.0 %
	maze therapeutics inc	-0.0 %

Top 5 Losers ($)		$
LAB	standard biotools inc	-8.6 M
ALNY	alnylam pharmaceuticals inc	-2.2 M
	bridgebio oncology therapeut	-0.4 M
	maze therapeutics inc	0.0 M

Casdin Capital, LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Casdin Capital, LLC

Casdin Capital, LLC has 43 stocks in it's portfolio. About 77.4% of the portfolio is in top 10 stocks. LAB proved to be the most loss making stock for the portfolio. RVMD was the most profitable stock for Casdin Capital, LLC last quarter.

$2.00BTotal Value

46.00Positions

14 Aug, 2026Last Reported

Current holdings of Current Stock Holdings of Casdin Capital, LLC, last reported on 14 Aug, 2026. Select a row with a linked ticker to view its historical trend.
Holdingsorted ascending	% Portfolio	Shares Held	$ Value	% Change
ABSI Absci Corporation Absci CorporationABSI Casdin Capital, LLC's holding in Absci Corporation over time	0.56%	973,260	$11.28M 0.56%	unchanged 0 percentunchanged

ALNY Alnylam Pharmaceuticals Inc Alnylam Pharmaceuticals IncALNY Casdin Capital, LLC's holding in Alnylam Pharmaceuticals Inc over time	1.13%	75,000	$22.58M 1.13%	unchanged 0 percentunchanged

BEAM Beam Therapeutics Inc Beam Therapeutics IncBEAM Casdin Capital, LLC's holding in Beam Therapeutics Inc over time	2.32%	1,350,000	$46.33M 2.32%	unchanged 0 percentunchanged

BLFS Biolife Solutions Inc Biolife Solutions IncBLFS Casdin Capital, LLC's holding in Biolife Solutions Inc over time	6.58%	4,655,000	$131.46M 6.58%	decreased 21.86 percentreduced

DGX Quest Diagnostics Inc Quest Diagnostics IncDGX Casdin Capital, LLC's holding in Quest Diagnostics Inc over time	0.53%	50,000	$10.60M 0.53%	unchanged 0 percentunchanged

DNA Ginkgo Bioworks Holdings Inc Ginkgo Bioworks Holdings IncDNA Casdin Capital, LLC's holding in Ginkgo Bioworks Holdings Inc over time	0.02%	36,493	$361.6K 0.02%	unchanged 0 percentunchanged

DNLI Denali Therapeutics Inc Denali Therapeutics IncDNLI Casdin Capital, LLC's holding in Denali Therapeutics Inc over time	2.63%	2,045,000	$52.60M 2.63%	increased 11.14 percentadded

EDIT Editas Medicine Inc Editas Medicine IncEDIT Casdin Capital, LLC's holding in Editas Medicine Inc over time	0.07%	445,000	$1.44M 0.07%	new position

GH Guardant Health Inc Guardant Health IncGH Casdin Capital, LLC's holding in Guardant Health Inc over time	1.39%	185,000	$27.76M 1.39%	decreased 41.27 percentreduced

GLUE Monte Rosa Therapeutics Inc Monte Rosa Therapeutics IncGLUE Casdin Capital, LLC's holding in Monte Rosa Therapeutics Inc over time	0.22%	186,014	$4.50M 0.22%	unchanged 0 percentunchanged

HIMS Hims & Hers Health Inc Hims & Hers Health IncHIMS Casdin Capital, LLC's holding in Hims & Hers Health Inc over time	1.22%	700,000	$24.27M 1.22%	unchanged 0 percentunchanged

ILMN Illumina Inc Illumina IncILMN Casdin Capital, LLC's holding in Illumina Inc over time	4.66%	530,000	$93.19M 4.66%	unchanged 0 percentunchanged

IPSC Century Therapeutics Inc Century Therapeutics IncIPSC Casdin Capital, LLC's holding in Century Therapeutics Inc over time	0.15%	1,228,190	$3.01M 0.15%	unchanged 0 percentunchanged

LAB Standard Biotools Inc Standard Biotools IncLAB Casdin Capital, LLC's holding in Standard Biotools Inc over time	3.66%	88,783,900	$73.04M 3.66%	unchanged 0 percentunchanged

MLTX Moonlake Immunotherapeutics Moonlake ImmunotherapeuticsMLTX Casdin Capital, LLC's holding in Moonlake Immunotherapeutics over time	0%	0.00	$0.00 0%	decreased 100 percentsold off

MRNA Moderna Inc Moderna IncMRNA Casdin Capital, LLC's holding in Moderna Inc over time	0.26%	75,000	$5.25M 0.26%	unchanged 0 percentunchanged

NTLA Intellia Therapeutics Inc Intellia Therapeutics IncNTLA Casdin Capital, LLC's holding in Intellia Therapeutics Inc over time	0.3%	355,000	$6.01M 0.3%	unchanged 0 percentunchanged

PACB Pacific Biosciences Calif In Pacific Biosciences Calif InPACB Casdin Capital, LLC's holding in Pacific Biosciences Calif In over time	0.06%	723,767	$1.22M 0.06%	unchanged 0 percentunchanged

PSNL Personalis Inc Personalis IncPSNL Casdin Capital, LLC's holding in Personalis Inc over time	1.71%	2,550,000	$34.17M 1.71%	increased 59.38 percentadded

QGEN Qiagen Nv Qiagen Nv QGEN Casdin Capital, LLC's holding in Qiagen Nv over time	0%	0.00	$0.00 0%	decreased 100 percentsold off