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Latest Casdin Capital, LLC Stock Portfolio

$1.32Billion– No. of Holdings #40

Casdin Capital, LLC Performance:
2026 Q1: -15.64%YTD: -15.64%2025: 27.41%
Performance for 2026 Q1 is -15.64%, and YTD is -15.64%, and 2025 is 27.41%.

About Casdin Capital, LLC and 13F Hedge Fund Stock Holdings

Casdin Capital, LLC is a hedge fund based in New York, NY. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, Casdin Capital, LLC reported an equity portfolio of $1.3 Billions as of 31 Mar, 2026.

The top stock holdings of Casdin Capital, LLC are RVMD, SMFR, RLAY. The fund has invested 19% of it's portfolio in REVOLUTION MEDICINES INC and 14.6% of portfolio in GENEDX HOLDINGS CORP.

The fund managers got completely rid off AVIDITY BIOSCIENCES INC (RNA), ARS PHARMACEUTICALS INC (SBTX) and UNITEDHEALTH GROUP INC (UNH) stocks. They significantly reduced their stock positions in PACIFIC BIOSCIENCES CALIF IN (PACB), GUARDANT HEALTH INC (GH) and BEAM THERAPEUTICS INC (BEAM). Casdin Capital, LLC opened new stock positions in AGOMAB THERAPEUTICS NV, QIAGEN NV (QGEN) and PERSONALIS INC (PSNL). The fund showed a lot of confidence in some stocks as they added substantially to TAYSHA GENE THERAPIES INC (TSHA), MONTE ROSA THERAPEUTICS INC (GLUE) and HIMS & HERS HEALTH INC (HIMS).
Casdin Capital, LLC Equity Portfolio Value
Last Reported on: 15 May, 2026

Casdin Capital, LLC Annual Return Estimates Vs S&P 500

Our best estimate is that Casdin Capital, LLC made a return of -15.64% in the last quarter. In trailing 12 months, it's portfolio return was 29.34%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
agomab therapeutics nv16,259,500
qiagen nv14,414,400
grail inc11,886,400
personalis inc10,192,000
moonlake immunotherapeutics8,388,000
intellia therapeutics inc4,551,100
disc medicine inc4,156,100
moderna inc3,810,000
New stocks bought by Casdin Capital, LLC

Additions

Ticker% Inc.
taysha gene therapies inc116
monte rosa therapeutics inc116
hims & hers health inc81.82
10x genomics inc62.5
scholar rock hldg corp34.62
relay therapeutics inc10.88
neurogene inc9.65
Additions to existing portfolio by Casdin Capital, LLC

Reductions

Ticker% Reduced
pacific biosciences calif in-82.86
guardant health inc-17.11
beam therapeutics inc-15.62
illumina inc-11.67
Casdin Capital, LLC reduced stake in above stock

Sold off

Ticker$ Sold
ars pharmaceuticals inc-18,640,000
avidity biosciences inc-72,130,000
legend biotech corp-4,674,100
dexcom inc-11,614,800
incyte corp-9,877,000
unitedhealth group inc-16,505,500
the cigna group-11,009,200
Casdin Capital, LLC got rid off the above stocks

Sector Distribution

Casdin Capital, LLC has about 69.1% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
  • Consumer Defensive
Sector%
Healthcare69.1
Others15.2
14.6
Consumer Defensive1.1

Market Cap. Distribution

Casdin Capital, LLC has about 29% of it's portfolio invested in the large-cap and mega-cap stocks.

  • SMALL-CAP
  • LARGE-CAP
  • MID-CAP
  • UNALLOCATED
Category%
SMALL-CAP29.1
LARGE-CAP29
MID-CAP26.5
UNALLOCATED15.2

Stocks belong to which Index?

About 55.8% of the stocks held by Casdin Capital, LLC either belong to S&P 500 or RUSSELL 2000 index.

  • RUSSELL 2000
  • Others
  • S&P 500
Index%
RUSSELL 200049.8
Others44.3
S&P 5006
Top 5 Winners (%)%
IPSC
century therapeutics inc
127.2 %
TXG
10x genomics inc
23.0 %
RVMD
revolution medicines inc
22.1 %
RLAY
relay therapeutics inc
16.6 %
DNLI
denali therapeutics inc
16.3 %
Top 5 Winners ($)$
RVMD
revolution medicines inc
45.4 M
RLAY
relay therapeutics inc
20.4 M
TXG
10x genomics inc
9.0 M
DNLI
denali therapeutics inc
4.9 M
SRRK
scholar rock hldg corp
1.6 M
Top 5 Losers (%)%
SMFR
genedx holdings corp
-50.6 %
structure therapeutics inc
-30.7 %
HIMS
hims & hers health inc
-30.4 %
bridgebio oncology therapeut
-28.5 %
LAB
standard biotools inc
-28.2 %
Top 5 Losers ($)$
SMFR
genedx holdings corp
-198.0 M
LAB
standard biotools inc
-32.0 M
BLFS
biolife solutions inc
-30.4 M
structure therapeutics inc
-25.1 M
maze therapeutics inc
-8.8 M

Casdin Capital, LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Casdin Capital, LLC

Casdin Capital, LLC has 40 stocks in it's portfolio. About 77.3% of the portfolio is in top 10 stocks. SMFR proved to be the most loss making stock for the portfolio. RVMD was the most profitable stock for Casdin Capital, LLC last quarter.

Last Reported on: 15 May, 2026
TickerNamesorted ascending% PortfolioShares Held$ ValueType% ChangeOptions