Latest Casdin Capital, LLC Stock Portfolio
Casdin Capital, LLC Performance:
2025 Q4: 23.44%YTD: 27.41%2024: 19.68%
Performance for 2025 Q4 is 23.44%, and YTD is 27.41%, and 2024 is 19.68%.
About Casdin Capital, LLC and 13F Hedge Fund Stock Holdings
Casdin Capital, LLC is a hedge fund based in New York, NY. On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, Casdin Capital, LLC reported an equity portfolio of $1.6 Billions as of 31 Dec, 2025.
The top stock holdings of Casdin Capital, LLC are SMFR, RVMD, BLFS. The fund has invested 24.3% of it's portfolio in GENEDX HOLDINGS CORP and 12.8% of portfolio in REVOLUTION MEDICINES INC.
The fund managers got completely rid off EXACT SCIENCES CORP (EXAS) stocks. They significantly reduced their stock positions in AVIDITY BIOSCIENCES INC (RNA), STRUCTURE THERAPEUTICS INC and BIOLIFE SOLUTIONS INC (BLFS). Casdin Capital, LLC opened new stock positions in 10X GENOMICS INC (TXG), DEXCOM INC (DXCM) and SCHOLAR ROCK HLDG CORP (SRRK). The fund showed a lot of confidence in some stocks as they added substantially to PACIFIC BIOSCIENCES CALIF IN (PACB), GUARDANT HEALTH INC (GH) and DENALI THERAPEUTICS INC (DNLI).
The top stock holdings of Casdin Capital, LLC are SMFR, RVMD, BLFS. The fund has invested 24.3% of it's portfolio in GENEDX HOLDINGS CORP and 12.8% of portfolio in REVOLUTION MEDICINES INC.
The fund managers got completely rid off EXACT SCIENCES CORP (EXAS) stocks. They significantly reduced their stock positions in AVIDITY BIOSCIENCES INC (RNA), STRUCTURE THERAPEUTICS INC and BIOLIFE SOLUTIONS INC (BLFS). Casdin Capital, LLC opened new stock positions in 10X GENOMICS INC (TXG), DEXCOM INC (DXCM) and SCHOLAR ROCK HLDG CORP (SRRK). The fund showed a lot of confidence in some stocks as they added substantially to PACIFIC BIOSCIENCES CALIF IN (PACB), GUARDANT HEALTH INC (GH) and DENALI THERAPEUTICS INC (DNLI).
Casdin Capital, LLC Annual Return Estimates Vs S&P 500
Our best estimate is that Casdin Capital, LLC made a return of 23.44% in the last quarter. In trailing 12 months, it's portfolio return was 27.41%.
- Performance
- S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| 10x genomics inc | 22,834,000 |
| dexcom inc | 11,614,800 |
| scholar rock hldg corp | 11,453,000 |
| the cigna group | 11,009,200 |
| quest diagnostics inc | 8,676,500 |
| taysha gene therapies inc | 8,250,000 |
| legend biotech corp | 4,674,100 |
New stocks bought by Casdin Capital, LLC
Additions
Additions to existing portfolio by Casdin Capital, LLC
Reductions
| Ticker | % Reduced |
|---|---|
| avidity biosciences inc | -43.82 |
| structure therapeutics inc | -24.44 |
| biolife solutions inc | -11.18 |
| revolution medicines inc | -2.64 |
Casdin Capital, LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| exact sciences corp | -4,923,900 |
Casdin Capital, LLC got rid off the above stocks
Sector Distribution
Casdin Capital, LLC has about 61.8% of it's holdings in Healthcare sector.
- Healthcare
- Others
| Sector | % |
|---|---|
| Healthcare | 61.8 |
| 25.5 | |
| Others | 12 |
Market Cap. Distribution
Casdin Capital, LLC has about 28.9% of it's portfolio invested in the large-cap and mega-cap stocks.
- MID-CAP
- LARGE-CAP
- SMALL-CAP
- UNALLOCATED
| Category | % |
|---|---|
| MID-CAP | 32.6 |
| LARGE-CAP | 28.9 |
| SMALL-CAP | 25.4 |
| UNALLOCATED | 12 |
Stocks belong to which Index?
About 51.5% of the stocks held by Casdin Capital, LLC either belong to S&P 500 or RUSSELL 2000 index.
- Others
- RUSSELL 2000
- S&P 500
| Index | % |
|---|---|
| Others | 48.5 |
| RUSSELL 2000 | 43 |
| S&P 500 | 8.5 |
Casdin Capital, LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Casdin Capital, LLC
Casdin Capital, LLC has 38 stocks in it's portfolio. About 79.5% of the portfolio is in top 10 stocks. BLFS proved to be the most loss making stock for the portfolio. RVMD was the most profitable stock for Casdin Capital, LLC last quarter.
Last Reported on: 17 Feb, 2026| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ABSI | absci corporation | 0.21 | 973,260 | 3,396,680 | unchanged | 0.00 | ||
| ALNY | alnylam pharmaceuticals inc | 1.85 | 75,000 | 29,823,800 | added | 36.36 | ||
| BEAM | beam therapeutics inc | 2.76 | 1,600,000 | 44,352,000 | unchanged | 0.00 | ||
| BLFS | biolife solutions inc | 8.95 | 5,957,160 | 144,044,000 | reduced | -11.18 | ||
| CI | the cigna group | 0.68 | 40,000 | 11,009,200 | new | |||
| DGX | quest diagnostics inc | 0.54 | 50,000 | 8,676,500 | new | |||
| DNA | ginkgo bioworks holdings inc | 0.02 | 36,493 | 303,257 | unchanged | 0.00 | ||
| DNLI | denali therapeutics inc | 1.89 | 1,840,000 | 30,378,400 | added | 106 | ||
| DXCM | dexcom inc | 0.72 | 175,000 | 11,614,800 | new | |||
| EXAS | exact sciences corp | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| GH | guardant health inc | 2.41 | 380,000 | 38,813,200 | added | 280 | ||
| GLUE | monte rosa therapeutics inc | 0.08 | 86,014 | 1,348,700 | unchanged | 0.00 | ||
| HIMS | hims & hers health inc | 0.78 | 385,000 | 12,501,000 | added | 67.39 | ||
| ILMN | illumina inc | 4.89 | 600,000 | 78,696,000 | added | 14.29 | ||
| INCY | incyte corp | 0.61 | 100,000 | 9,877,000 | unchanged | 0.00 | ||
| IPSC | century therapeutics inc | 0.08 | 1,228,190 | 1,221,800 | unchanged | 0.00 | ||
| LAB | standard biotools inc | 7.06 | 88,783,900 | 113,643,000 | added | 14.47 | ||
| LEGN | legend biotech corp | 0.29 | 215,000 | 4,674,100 | new | |||
| PACB | pacific biosciences calif in | 0.49 | 4,223,770 | 7,898,440 | added | 483 | ||
| RLAY | relay therapeutics inc | 6.83 | 13,003,600 | 110,010,000 | added | 14.66 | ||