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Latest Opaleye Management Inc. Stock Portfolio

$759Million | No. of Holdings #53

Opaleye Management Inc. Performance

2026 Q1+6.42%
YTD+6.42%
2025+26.95%

About Opaleye Management Inc. and 13F Hedge Fund Stock Holdings

Opaleye Management Inc. is a hedge fund based in Boston, MA. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, Opaleye Management Inc. reported an equity portfolio of $759.2 Millions as of 31 Mar, 2026. <br><br> The top stock holdings of Opaleye Management Inc. are HROW, LQDA, ETON. The fund has invested 13.2% of it's portfolio in HARROW INC and 11.7% of portfolio in LIQUIDIA CORPORATION. <br><br> The fund managers got completely rid off ALKERMES PLC (ALKS), GOSSAMER BIO INC (GOSS) and KARYOPHARM THERAPEUTICS INC (KPTI) stocks. They significantly reduced their stock positions in PROTALIX BIOTHERAPEUTICS INC (PLX), CG ONCOLOGY INC and RHYTHM PHARMACEUTICALS INC (RYTM). Opaleye Management Inc. opened new stock positions in ASSERTIO HOLDINGS INC (ASRT), EDITAS MEDICINE INC (EDIT) and BIODESIX INC (BDSX). The fund showed a lot of confidence in some stocks as they added substantially to Q32 BIO INC, MEIRAGTX HLDGS PLC (MGTX) and UROGEN PHARMA LTD (URGN).
Opaleye Management Inc. Equity Portfolio Value
Last Reported on: 15 May, 2026
$759Million
  as of May 15, 2026

Opaleye Management Inc. Annual Return Estimates Vs S&P 500

Our best estimate is that Opaleye Management Inc. made a return of 6.42% in the last quarter. In trailing 12 months, it's portfolio return was 58.4%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
assertio holdings inc5,064,380
editas medicine inc4,759,680
biodesix inc3,451,680
intellia therapeutics inc3,140,900
lyell immunopharma inc1,586,690
nextcure inc1,507,810
4d molecular therapeutics in1,045,430
bridgebio oncology therapeut476,874
New stocks bought by Opaleye Management Inc.

Additions

Ticker% Inc.
q32 bio inc488
meiragtx hldgs plc443
urogen pharma ltd432
perspective therapeutics inc294
disc medicine inc110
atea pharmaceuticals inc79.41
enanta pharmaceuticals inc66.67
cabaletta bio inc53.33
Additions to existing portfolio by Opaleye Management Inc.

Reductions

Ticker% Reduced
protalix biotherapeutics inc-86.28
cg oncology inc-76.88
rhythm pharmaceuticals inc-62.73
ocular therapeutix inc-62.38
tectonic therapeutic inc-42.72
harrow inc-27.47
annexon inc-10.32
protagonist therapeutics inc-4.76
Opaleye Management Inc. reduced stake in above stock

Sold off

Ticker$ Sold
gossamer bio inc-8,432,000
karyopharm therapeutics inc-6,844,800
alkermes plc-13,710,200
generation bio co-1,760,800
assertio holdings inc-2,584,950
ventyx biosciences inc-2,274,950
rapt therapeutics inc-213,363
zymeworks inc-2,868,100
Opaleye Management Inc. got rid off the above stocks

Sector Distribution

Opaleye Management Inc. has about 71.9% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
Sector%
Healthcare71.9
Others28.1

Market Cap. Distribution

Opaleye Management Inc. has about 1.3% of it's portfolio invested in the large-cap and mega-cap stocks.

  • SMALL-CAP
  • UNALLOCATED
  • MID-CAP
  • MICRO-CAP
  • LARGE-CAP
Category%
SMALL-CAP40.1
UNALLOCATED28.1
MID-CAP22.2
MICRO-CAP8.1
LARGE-CAP1.3

Stocks belong to which Index?

About 57.3% of the stocks held by Opaleye Management Inc. either belong to S&P 500 or RUSSELL 2000 index.

  • RUSSELL 2000
  • Others
Index%
RUSSELL 200057.3
Others42.7
Top 5 Winners (%)%
alumis inc
121.9 %
RYTM
rhythm pharmaceuticals inc
115.5 %
STRO
sutro biopharma inc
115.3 %
SLGL
sol-gel technologies ltd
80.6 %
ZNTL
zentalis pharmaceuticals inc
72.8 %
Top 5 Winners ($)$
RYTM
rhythm pharmaceuticals inc
40.8 M
ETON
eton pharmaceuticals inc
22.2 M
SLGL
sol-gel technologies ltd
17.7 M
crescent biopharma inc.
8.1 M
alumis inc
6.7 M
Top 5 Losers (%)%
SNWV
sanuwave health inc
-42.1 %
DERM
journey med corp
-38.9 %
RIGL
rigel pharmaceuticals inc
-36.9 %
HROW
harrow inc
-24.2 %
FBIO
fortress biotech inc
-23.3 %
Top 5 Losers ($)$
HROW
harrow inc
-46.3 M
SNWV
sanuwave health inc
-12.3 M
disc medicine inc
-4.8 M
URGN
urogen pharma ltd
-4.6 M
OCUL
ocular therapeutix inc
-4.0 M

Opaleye Management Inc. Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Opaleye Management Inc.

Opaleye Management Inc. has 53 stocks in it's portfolio. About 61.5% of the portfolio is in top 10 stocks. HROW proved to be the most loss making stock for the portfolio. RYTM was the most profitable stock for Opaleye Management Inc. last quarter.

$758.39MTotal Value
63.00Positions
15 May, 2026Last Reported
Current holdings of Current Stock Holdings of Opaleye Management Inc., last reported on 15 May, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change