Latest Opaleye Management Inc. Stock Portfolio
$759Million– No. of Holdings #53
Opaleye Management Inc. Performance:
2026 Q1: 6.42%YTD: 6.42%2025: 26.95%
Performance for 2026 Q1 is 6.42%, and YTD is 6.42%, and 2025 is 26.95%.
About Opaleye Management Inc. and 13F Hedge Fund Stock Holdings
Opaleye Management Inc. is a hedge fund based in Boston, MA. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, Opaleye Management Inc. reported an equity portfolio of $759.2 Millions as of 31 Mar, 2026.
The top stock holdings of Opaleye Management Inc. are HROW, LQDA, ETON. The fund has invested 13.2% of it's portfolio in HARROW INC and 11.7% of portfolio in LIQUIDIA CORPORATION.
The fund managers got completely rid off ALKERMES PLC (ALKS), GOSSAMER BIO INC (GOSS) and KARYOPHARM THERAPEUTICS INC (KPTI) stocks. They significantly reduced their stock positions in PROTALIX BIOTHERAPEUTICS INC (PLX), CG ONCOLOGY INC and RHYTHM PHARMACEUTICALS INC (RYTM). Opaleye Management Inc. opened new stock positions in ASSERTIO HOLDINGS INC (ASRT), EDITAS MEDICINE INC (EDIT) and BIODESIX INC (BDSX). The fund showed a lot of confidence in some stocks as they added substantially to Q32 BIO INC, MEIRAGTX HLDGS PLC (MGTX) and UROGEN PHARMA LTD (URGN).
The top stock holdings of Opaleye Management Inc. are HROW, LQDA, ETON. The fund has invested 13.2% of it's portfolio in HARROW INC and 11.7% of portfolio in LIQUIDIA CORPORATION.
The fund managers got completely rid off ALKERMES PLC (ALKS), GOSSAMER BIO INC (GOSS) and KARYOPHARM THERAPEUTICS INC (KPTI) stocks. They significantly reduced their stock positions in PROTALIX BIOTHERAPEUTICS INC (PLX), CG ONCOLOGY INC and RHYTHM PHARMACEUTICALS INC (RYTM). Opaleye Management Inc. opened new stock positions in ASSERTIO HOLDINGS INC (ASRT), EDITAS MEDICINE INC (EDIT) and BIODESIX INC (BDSX). The fund showed a lot of confidence in some stocks as they added substantially to Q32 BIO INC, MEIRAGTX HLDGS PLC (MGTX) and UROGEN PHARMA LTD (URGN).
Opaleye Management Inc. Equity Portfolio Value
Last Reported on: 15 May, 2026
Opaleye Management Inc. Annual Return Estimates Vs S&P 500
Our best estimate is that Opaleye Management Inc. made a return of 6.42% in the last quarter. In trailing 12 months, it's portfolio return was 58.4%.
- Performance
- S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| assertio holdings inc | 5,064,380 |
| editas medicine inc | 4,759,680 |
| biodesix inc | 3,451,680 |
| intellia therapeutics inc | 3,140,900 |
| lyell immunopharma inc | 1,586,690 |
| nextcure inc | 1,507,810 |
| 4d molecular therapeutics in | 1,045,430 |
| bridgebio oncology therapeut | 476,874 |
New stocks bought by Opaleye Management Inc.
Additions
| Ticker | % Inc. |
|---|---|
| q32 bio inc | 488 |
| meiragtx hldgs plc | 443 |
| urogen pharma ltd | 432 |
| perspective therapeutics inc | 294 |
| disc medicine inc | 110 |
| atea pharmaceuticals inc | 79.41 |
| enanta pharmaceuticals inc | 66.67 |
| cabaletta bio inc | 53.33 |
Additions to existing portfolio by Opaleye Management Inc.
Reductions
| Ticker | % Reduced |
|---|---|
| protalix biotherapeutics inc | -86.28 |
| cg oncology inc | -76.88 |
| rhythm pharmaceuticals inc | -62.73 |
| ocular therapeutix inc | -62.38 |
| tectonic therapeutic inc | -42.72 |
| harrow inc | -27.47 |
| annexon inc | -10.32 |
| protagonist therapeutics inc | -4.76 |
Opaleye Management Inc. reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| gossamer bio inc | -8,432,000 |
| karyopharm therapeutics inc | -6,844,800 |
| alkermes plc | -13,710,200 |
| generation bio co | -1,760,800 |
| assertio holdings inc | -2,584,950 |
| ventyx biosciences inc | -2,274,950 |
| rapt therapeutics inc | -213,363 |
| zymeworks inc | -2,868,100 |
Opaleye Management Inc. got rid off the above stocks
Sector Distribution
Opaleye Management Inc. has about 71.9% of it's holdings in Healthcare sector.
- Healthcare
- Others
| Sector | % |
|---|---|
| Healthcare | 71.9 |
| Others | 28.1 |
Market Cap. Distribution
Opaleye Management Inc. has about 1.3% of it's portfolio invested in the large-cap and mega-cap stocks.
- SMALL-CAP
- UNALLOCATED
- MID-CAP
- MICRO-CAP
- LARGE-CAP
| Category | % |
|---|---|
| SMALL-CAP | 40.1 |
| UNALLOCATED | 28.1 |
| MID-CAP | 22.2 |
| MICRO-CAP | 8.1 |
| LARGE-CAP | 1.3 |
Stocks belong to which Index?
About 57.3% of the stocks held by Opaleye Management Inc. either belong to S&P 500 or RUSSELL 2000 index.
- RUSSELL 2000
- Others
| Index | % |
|---|---|
| RUSSELL 2000 | 57.3 |
| Others | 42.7 |
Opaleye Management Inc. Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Opaleye Management Inc.
Opaleye Management Inc. has 53 stocks in it's portfolio. About 61.5% of the portfolio is in top 10 stocks. HROW proved to be the most loss making stock for the portfolio. RYTM was the most profitable stock for Opaleye Management Inc. last quarter.
Last Reported on: 15 May, 2026| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ALKS | alkermes plc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ANNX | annexon inc | 1.70 | 2,331,760 | 12,918,000 | reduced | -10.32 | ||
| ASRT | assertio holdings inc | 0.67 | 265,707 | 5,064,380 | new | |||
| ASRT | assertio holdings inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AVIR | atea pharmaceuticals inc | 0.23 | 322,600 | 1,735,590 | added | 79.41 | ||
| AVTE | jade biosciences inc | 0.79 | 427,608 | 6,007,890 | unchanged | 0.00 | ||
| BBIO | bridgebio pharma inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| BDSX | biodesix inc | 0.46 | 238,047 | 3,451,680 | new | |||
| CABA | cabaletta bio inc | 0.49 | 1,380,000 | 3,712,200 | added | 53.33 | ||
| CDXS | codexis inc | 1.46 | 6,785,000 | 11,059,600 | reduced | -0.07 | ||
| DERM | journey med corp | 0.59 | 960,000 | 4,502,400 | reduced | -1.54 | ||
| EDIT | editas medicine inc | 0.63 | 1,927,000 | 4,759,680 | new | |||
| ENTA | enanta pharmaceuticals inc | 0.21 | 125,000 | 1,578,750 | added | 66.67 | ||
| ETON | eton pharmaceuticals inc | 9.30 | 2,860,000 | 70,584,800 | unchanged | 0.00 | ||
| EWTX | edgewise therapeutics inc | 2.07 | 500,000 | 15,750,000 | unchanged | 0.00 | ||
| FBIO | fortress biotech inc | 0.38 | 1,042,000 | 2,907,180 | reduced | -4.4 | ||
| FDMT | 4d molecular therapeutics in | 0.14 | 112,291 | 1,045,430 | new | |||
| GBIO | generation bio co | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| GOSS | gossamer bio inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| HROW | harrow inc | 13.15 | 2,832,230 | 99,864,400 | reduced | -27.47 | ||