Latest Opaleye Management Inc. Stock Portfolio
Opaleye Management Inc. Performance:
2024 Q4: 0.12%YTD: 48.15%2023: 11.95%
Performance for 2024 Q4 is 0.12%, and YTD is 48.15%, and 2023 is 11.95%.
About Opaleye Management Inc. and 13F Hedge Fund Stock Holdings
Opaleye Management Inc. is a hedge fund based in BOSTON, MA. On 27-Mar-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $422 Millions. In it's latest 13F Holdings report, Opaleye Management Inc. reported an equity portfolio of $571.4 Millions as of 31 Dec, 2024.
The top stock holdings of Opaleye Management Inc. are HROW, TGTX, CDXS. The fund has invested 23.4% of it's portfolio in HARROW HEALTH INC and 11.9% of portfolio in TG THERAPEUTICS INC.
The fund managers got completely rid off KEROS THERAPEUTICS INC (KROS), APPLIED THERAPEUTICS INC' (APLT) and CYTOKINETICS INC (CYTK) stocks. They significantly reduced their stock positions in UROGEN PHARMA LTD (URGN), PEPGEN INC (PEPG) and OCULAR THERAPEUTIX INC (OCUL). Opaleye Management Inc. opened new stock positions in ESSA PHARMA INC (EPIX), IMMATICS NV and REGENXBIO INC (RGNX). The fund showed a lot of confidence in some stocks as they added substantially to ZENTALIS PHARMACEUTICALS INC (ZNTL), IMMUNOME INC (IMNM) and GINKGO BIOWORKS HOLDINGS (DNA).
The top stock holdings of Opaleye Management Inc. are HROW, TGTX, CDXS. The fund has invested 23.4% of it's portfolio in HARROW HEALTH INC and 11.9% of portfolio in TG THERAPEUTICS INC.
The fund managers got completely rid off KEROS THERAPEUTICS INC (KROS), APPLIED THERAPEUTICS INC' (APLT) and CYTOKINETICS INC (CYTK) stocks. They significantly reduced their stock positions in UROGEN PHARMA LTD (URGN), PEPGEN INC (PEPG) and OCULAR THERAPEUTIX INC (OCUL). Opaleye Management Inc. opened new stock positions in ESSA PHARMA INC (EPIX), IMMATICS NV and REGENXBIO INC (RGNX). The fund showed a lot of confidence in some stocks as they added substantially to ZENTALIS PHARMACEUTICALS INC (ZNTL), IMMUNOME INC (IMNM) and GINKGO BIOWORKS HOLDINGS (DNA).
Opaleye Management Inc. Annual Return Estimates Vs S&P 500
Our best estimate is that Opaleye Management Inc. made a return of 0.12% in the last quarter. In trailing 12 months, it's portfolio return was 48.15%.
New Buys
| Ticker | $ Bought |
|---|---|
| essa pharma inc | 3,955,900 |
| immatics nv | 1,173,150 |
| lexeo therapeutics inc | 855,400 |
| regenxbio inc | 618,400 |
| ventyx biosciences | 613,200 |
| stoke therapeutics inc | 275,750 |
New stocks bought by Opaleye Management Inc.
Additions
| Ticker | % Inc. |
|---|---|
| zentalis pharmaceuticals inc | 82.78 |
| immunome inc | 64.85 |
| ginkgo bioworks holdings | 46.31 |
| gossamer bio inc | 43.75 |
| cargo therapeutics inc | 38.52 |
| arvinas inc | 29.48 |
| gossamer bio inc | 22.51 |
| abcellera biologics inc | 20.62 |
Additions to existing portfolio by Opaleye Management Inc.
Reductions
| Ticker | % Reduced |
|---|---|
| urogen pharma ltd | -45.56 |
| pepgen inc | -38.62 |
| ocular therapeutix inc | -13.58 |
| vaxcyte inc | -11.76 |
| nurix therapeutics inc | -9.88 |
| trevi therapeutics inc | -9.75 |
| biodesix inc | -9.17 |
| nuvalent inc | -8.59 |
Opaleye Management Inc. reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| allakos inc | -1,572,640 |
| lyell immunopharma inc | -1,925,100 |
| applied therapeutics inc' | -11,220,000 |
| syros pharmaceuticals inc | -1,408,130 |
| regulus therapeutics inc | -839,950 |
| relmada therapeutics inc | -1,555,200 |
| aerovate therapeutics inc | -919,600 |
| keros therapeutics inc | -22,953,700 |
Opaleye Management Inc. got rid off the above stocks
Sector Distribution
Opaleye Management Inc. has about 96.4% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 96.4 |
| Others | 3.6 |
Market Cap. Distribution
Opaleye Management Inc. has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| SMALL-CAP | 50.7 |
| MICRO-CAP | 22.5 |
| MID-CAP | 19.8 |
| UNALLOCATED | 5.1 |
| NANO-CAP | 1.9 |
Stocks belong to which Index?
About 75.5% of the stocks held by Opaleye Management Inc. either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| RUSSELL 2000 | 75.5 |
| Others | 24.5 |
Opaleye Management Inc. Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Opaleye Management Inc.
Opaleye Management Inc. has 37 stocks in it's portfolio. About 76.2% of the portfolio is in top 10 stocks. HROW proved to be the most loss making stock for the portfolio. ETON was the most profitable stock for Opaleye Management Inc. last quarter.
Last Reported on: 14 Feb, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ABCL | abcellera biologics inc | 0.50 | 965,000 | 2,827,450 | added | 20.62 | ||
| ALLK | allakos inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| APLT | applied therapeutics inc' | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ARVN | arvinas inc | 5.89 | 1,625,000 | 33,643,400 | added | 29.48 | ||
| AVTE | aerovate therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| BDSX | biodesix inc | 0.93 | 3,465,000 | 5,301,450 | reduced | -9.17 | ||
| CDXS | codexis inc | 7.38 | 8,840,000 | 42,166,800 | added | 0.8 | ||
| CPRX | catalyst pharmaceuticals inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| CYTK | cytokinetics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| DNA | ginkgo bioworks holdings | 2.06 | 1,200,000 | 11,784,000 | added | 46.31 | ||
| EPIX | essa pharma inc | 0.69 | 2,210,000 | 3,955,900 | new | |||
| ETON | eton pharmaceuticals inc | 6.65 | 2,852,070 | 37,989,600 | added | 2.59 | ||
| EWTX | edgewise therapeutics inc | 2.24 | 480,000 | 12,816,000 | reduced | -8.13 | ||
| GOSS | gossamer bio inc | 1.07 | 11,500,000 | 6,090,400 | added | 43.75 | ||
| GOSS | gossamer bio inc | 0.71 | 4,490,000 | 4,061,650 | added | 22.51 | ||
| HROW | harrow health inc | 23.43 | 3,990,000 | 133,864,000 | unchanged | 0.00 | ||
| IBIO | ibio inc | 0.16 | 375,000 | 918,750 | unchanged | 0.00 | ||
| IMNM | immunome inc | 3.79 | 2,040,000 | 21,664,800 | added | 64.85 | ||
| JSPR | jasper therapeutics inc | 1.50 | 400,000 | 8,552,000 | added | 13.15 | ||
| KPTI | karyopharm therapeutics inc | 0.82 | 6,000,000 | 4,669,560 | unchanged | 0.00 | ||