Latest Opaleye Management Inc. Stock Portfolio
Opaleye Management Inc. Performance:
2025 Q4: 3.56%YTD: 26.93%2024: 46.08%
Performance for 2025 Q4 is 3.56%, and YTD is 26.93%, and 2024 is 46.08%.
About Opaleye Management Inc. and 13F Hedge Fund Stock Holdings
Opaleye Management Inc. is a hedge fund based in Boston, MA. On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, Opaleye Management Inc. reported an equity portfolio of $758 Millions as of 31 Dec, 2025.
The top stock holdings of Opaleye Management Inc. are HROW, LQDA, ETON. The fund has invested 25.2% of it's portfolio in HARROW HEALTH INC and 11.2% of portfolio in LIQUIDIA CORPORATION.
The fund managers got completely rid off IMMUNOME INC (IMNM), SAREPTA THERAPEUTICS INC (SRPT) and LARIMAR THERAPEUTICS INC (LRMR) stocks. They significantly reduced their stock positions in CODEXIS INC (CDXS), RHYTHM PHARMACEUTICALS INC (RYTM) and ALUMIS INC. Opaleye Management Inc. opened new stock positions in CRESCENT BIOPHARMA INC, KARYOPHARM THERAPEUTICS INC (KPTI) and JADE BIOSCIENCES INC (AVTE). The fund showed a lot of confidence in some stocks as they added substantially to ALPHA COGNITION INC, REZOLUTE INC (RZLT) and ZENTALIS PHARMACEUTICALS INC (ZNTL).
The top stock holdings of Opaleye Management Inc. are HROW, LQDA, ETON. The fund has invested 25.2% of it's portfolio in HARROW HEALTH INC and 11.2% of portfolio in LIQUIDIA CORPORATION.
The fund managers got completely rid off IMMUNOME INC (IMNM), SAREPTA THERAPEUTICS INC (SRPT) and LARIMAR THERAPEUTICS INC (LRMR) stocks. They significantly reduced their stock positions in CODEXIS INC (CDXS), RHYTHM PHARMACEUTICALS INC (RYTM) and ALUMIS INC. Opaleye Management Inc. opened new stock positions in CRESCENT BIOPHARMA INC, KARYOPHARM THERAPEUTICS INC (KPTI) and JADE BIOSCIENCES INC (AVTE). The fund showed a lot of confidence in some stocks as they added substantially to ALPHA COGNITION INC, REZOLUTE INC (RZLT) and ZENTALIS PHARMACEUTICALS INC (ZNTL).
Opaleye Management Inc. Annual Return Estimates Vs S&P 500
Our best estimate is that Opaleye Management Inc. made a return of 3.56% in the last quarter. In trailing 12 months, it's portfolio return was 26.93%.
- Performance
- S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| crescent biopharma inc | 13,974,600 |
| karyopharm therapeutics inc | 6,844,800 |
| jade biosciences inc | 6,597,990 |
| urogen pharma ltd | 6,286,470 |
| perspective therapeutics inc | 4,989,880 |
| voyager therapeutics inc | 4,703,830 |
| relmada therapeutics inc | 4,516,050 |
| tectonic therapeutics inc | 4,479,620 |
New stocks bought by Opaleye Management Inc.
Additions
| Ticker | % Inc. |
|---|---|
| alpha cognition inc | 1,698 |
| rezolute inc | 595 |
| zentalis pharmaceuticals inc | 342 |
| sol gel technologies | 121 |
| rigel pharmaceuticals inc | 85.25 |
| xoma corp del | 14.7 |
| cabaletta bio inc | 11.26 |
| zymeworks inc | 8.93 |
Additions to existing portfolio by Opaleye Management Inc.
Reductions
| Ticker | % Reduced |
|---|---|
| codexis inc | -46.93 |
| rhythm pharmaceuticals inc | -28.53 |
| alumis inc | -19.55 |
| trevi therapeutics inc | -11.51 |
| liquidia corporation | -6.88 |
| protalix biotherapeutics inc | -3.97 |
| gossamer bio inc | -0.18 |
Opaleye Management Inc. reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| karyopharm therapeutics inc | -4,630,840 |
| larimar therapeutics inc | -10,564,900 |
| immunome inc | -37,296,400 |
| arvinas inc | -8,416,210 |
| treace medical concepts inc | -4,712,060 |
| adc therapeutics sa | -2,730,120 |
| sarepta therapeutics inc | -11,273,000 |
| ibio inc | -310,425 |
Opaleye Management Inc. got rid off the above stocks
Sector Distribution
Opaleye Management Inc. has about 78.2% of it's holdings in Healthcare sector.
- Healthcare
- Others
| Sector | % |
|---|---|
| Healthcare | 78.2 |
| Others | 21.8 |
Market Cap. Distribution
Opaleye Management Inc. has about 2.1% of it's portfolio invested in the large-cap and mega-cap stocks.
- SMALL-CAP
- MID-CAP
- UNALLOCATED
- MICRO-CAP
- LARGE-CAP
| Category | % |
|---|---|
| SMALL-CAP | 46.3 |
| MID-CAP | 22.6 |
| UNALLOCATED | 21.8 |
| MICRO-CAP | 6.9 |
| LARGE-CAP | 2.1 |
Stocks belong to which Index?
About 66.7% of the stocks held by Opaleye Management Inc. either belong to S&P 500 or RUSSELL 2000 index.
- RUSSELL 2000
- Others
| Index | % |
|---|---|
| RUSSELL 2000 | 66.7 |
| Others | 33.3 |
Opaleye Management Inc. Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Opaleye Management Inc.
Opaleye Management Inc. has 54 stocks in it's portfolio. About 65.5% of the portfolio is in top 10 stocks. RZLT proved to be the most loss making stock for the portfolio. LQDA was the most profitable stock for Opaleye Management Inc. last quarter.
Last Reported on: 17 Feb, 2026| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ADCT | adc therapeutics sa | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AGLE | spyre therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ALKS | alkermes plc | 1.81 | 490,000 | 13,710,200 | added | 8.89 | ||
| ANNX | annexon inc | 1.72 | 2,600,000 | 13,052,000 | unchanged | 0.00 | ||
| ARVN | arvinas inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ASRT | assertio holdings inc | 0.34 | 285,000 | 2,584,950 | new | |||
| AVIR | atea pharmaceuticals inc | 0.09 | 179,815 | 641,940 | new | |||
| AVTE | jade biosciences inc | 0.87 | 427,608 | 6,597,990 | new | |||
| BBIO | bridgebio pharma inc | 0.18 | 18,319 | 1,401,220 | new | |||
| CABA | cabaletta bio inc | 0.26 | 900,000 | 1,971,000 | added | 11.26 | ||
| CDXS | codexis inc | 1.46 | 6,789,740 | 11,067,300 | reduced | -46.93 | ||
| DERM | journey medical corp | 0.99 | 975,000 | 7,517,250 | added | 0.41 | ||
| ENTA | enanta pharmaceuticals inc | 0.16 | 75,000 | 1,182,750 | new | |||
| ETON | eton pharmaceuticals inc | 6.38 | 2,860,000 | 48,362,600 | unchanged | 0.00 | ||
| EWTX | edgewise therapeutics inc | 1.64 | 500,000 | 12,407,500 | unchanged | 0.00 | ||
| FBIO | fortress biotech inc | 0.53 | 1,090,000 | 3,989,400 | new | |||
| GBIO | generation bio co | 0.23 | 310,000 | 1,760,800 | new | |||
| GOSS | gossamer bio inc | 1.11 | 2,720,000 | 8,432,000 | reduced | -0.18 | ||
| HROW | harrow health inc | 25.24 | 3,905,000 | 191,345,000 | unchanged | 0.00 | ||
| IBIO | ibio inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||