Latest Opaleye Management Inc. Stock Portfolio
Opaleye Management Inc. Performance:
2025 Q3: 35.87%YTD: 22.57%2024: 46.08%
Performance for 2025 Q3 is 35.87%, and YTD is 22.57%, and 2024 is 46.08%.
About Opaleye Management Inc. and 13F Hedge Fund Stock Holdings
Opaleye Management Inc. is a hedge fund based in BOSTON, MA. On 27-Mar-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $422 Millions. In it's latest 13F Holdings report, Opaleye Management Inc. reported an equity portfolio of $707.3 Millions as of 30 Sep, 2025.
The top stock holdings of Opaleye Management Inc. are HROW, ETON, LQDA. The fund has invested 26.6% of it's portfolio in HARROW HEALTH INC and 8.8% of portfolio in ETON PHARMACEUTICALS INC.
The fund managers got completely rid off VIGIL NEUROSCIENCES INC (VIGL), ANIKA THERAPEUTICS INC (ANIK) and GINKGO BIOWORKS HOLDINGS (DNA) stocks. They significantly reduced their stock positions in ZENTALIS PHARMACEUTICALS INC (ZNTL), PEPGEN INC (PEPG) and ZYMEWORKS INC (ZYME). Opaleye Management Inc. opened new stock positions in APOGEE THERAPEUTICS INC, ALKERMES PLC (ALKS) and ANNEXON INC (ANNX). The fund showed a lot of confidence in some stocks as they added substantially to JOURNEY MEDICAL CORP (DERM), CG ONCOLOGY INC and STOKE THERAPEUTICS INC (STOK).
The top stock holdings of Opaleye Management Inc. are HROW, ETON, LQDA. The fund has invested 26.6% of it's portfolio in HARROW HEALTH INC and 8.8% of portfolio in ETON PHARMACEUTICALS INC.
The fund managers got completely rid off VIGIL NEUROSCIENCES INC (VIGL), ANIKA THERAPEUTICS INC (ANIK) and GINKGO BIOWORKS HOLDINGS (DNA) stocks. They significantly reduced their stock positions in ZENTALIS PHARMACEUTICALS INC (ZNTL), PEPGEN INC (PEPG) and ZYMEWORKS INC (ZYME). Opaleye Management Inc. opened new stock positions in APOGEE THERAPEUTICS INC, ALKERMES PLC (ALKS) and ANNEXON INC (ANNX). The fund showed a lot of confidence in some stocks as they added substantially to JOURNEY MEDICAL CORP (DERM), CG ONCOLOGY INC and STOKE THERAPEUTICS INC (STOK).
Opaleye Management Inc. Annual Return Estimates Vs S&P 500
Our best estimate is that Opaleye Management Inc. made a return of 35.87% in the last quarter. In trailing 12 months, it's portfolio return was 21%.
New Buys
| Ticker | $ Bought |
|---|---|
| apogee therapeutics inc | 14,432,200 |
| alkermes plc | 13,500,000 |
| annexon inc | 7,930,000 |
| sol gel technologies | 5,970,940 |
| protalix biotherapeutics inc | 5,728,830 |
| treace medical concepts inc | 4,712,060 |
| adc therapeutics sa | 2,730,120 |
| cabaletta bio inc | 1,892,780 |
New stocks bought by Opaleye Management Inc.
Additions
| Ticker | % Inc. |
|---|---|
| journey medical corp | 922 |
| cg oncology inc | 54.14 |
| stoke therapeutics inc | 21.33 |
| sarepta therapeutics inc | 17.00 |
| mbx biosciences inc | 5.72 |
| liquidia corporation | 5.66 |
| disc medicine inc | 3.95 |
| edgewise therapeutics inc | 2.04 |
Additions to existing portfolio by Opaleye Management Inc.
Reductions
| Ticker | % Reduced |
|---|---|
| zentalis pharmaceuticals inc | -83.55 |
| pepgen inc | -68.75 |
| zymeworks inc | -52.38 |
| arvinas inc | -41.2 |
| gossamer bio inc | -23.13 |
| alumis inc | -14.19 |
| opus genetics inc | -9.84 |
| immunome inc | -9.76 |
Opaleye Management Inc. reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| gossamer bio inc | -5,948,970 |
| essa pharma inc | -3,757,000 |
| elevation oncology inc | -529,381 |
| vigil neurosciences inc | -7,950,000 |
| protara therapeutics inc | -2,590,650 |
| cargo therapeutics inc | -2,745,990 |
| anika therapeutics inc | -6,229,470 |
| ginkgo bioworks holdings | -5,625,000 |
Opaleye Management Inc. got rid off the above stocks
Sector Distribution
Opaleye Management Inc. has about 86.3% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 86.3 |
| Others | 13.7 |
Market Cap. Distribution
Opaleye Management Inc. has about 1.6% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| SMALL-CAP | 51.6 |
| MICRO-CAP | 19.4 |
| UNALLOCATED | 14.1 |
| MID-CAP | 13 |
| LARGE-CAP | 1.6 |
Stocks belong to which Index?
About 66.7% of the stocks held by Opaleye Management Inc. either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| RUSSELL 2000 | 66.7 |
| Others | 33.3 |
Opaleye Management Inc. Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Opaleye Management Inc.
Opaleye Management Inc. has 42 stocks in it's portfolio. About 73% of the portfolio is in top 10 stocks. LRMR proved to be the most loss making stock for the portfolio. HROW was the most profitable stock for Opaleye Management Inc. last quarter.
Last Reported on: 14 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ADCT | adc therapeutics sa | 0.39 | 682,529 | 2,730,120 | new | |||
| AGLE | spyre therapeutics inc | 0.15 | 65,000 | 1,089,400 | new | |||
| ALKS | alkermes plc | 1.91 | 450,000 | 13,500,000 | new | |||
| ANIK | anika therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ANNX | annexon inc | 1.12 | 2,600,000 | 7,930,000 | new | |||
| ARVN | arvinas inc | 1.19 | 987,818 | 8,416,210 | reduced | -41.2 | ||
| CABA | cabaletta bio inc | 0.27 | 808,882 | 1,892,780 | new | |||
| CDXS | codexis inc | 4.41 | 12,795,000 | 31,219,800 | added | 1.55 | ||
| DERM | journey medical corp | 0.98 | 971,064 | 6,913,980 | added | 922 | ||
| DNA | ginkgo bioworks holdings | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ELEV | elevation oncology inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| EPIX | essa pharma inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ETON | eton pharmaceuticals inc | 8.79 | 2,860,000 | 62,147,800 | unchanged | 0.00 | ||
| EWTX | edgewise therapeutics inc | 1.15 | 500,000 | 8,110,000 | added | 2.04 | ||
| GOSS | gossamer bio inc | 1.01 | 2,725,000 | 7,166,750 | reduced | -23.13 | ||
| GOSS | gossamer bio inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| HROW | harrow health inc | 26.60 | 3,905,000 | 188,143,000 | unchanged | 0.00 | ||
| IBIO | ibio inc | 0.04 | 375,000 | 310,425 | unchanged | 0.00 | ||
| IMNM | immunome inc | 5.27 | 3,185,000 | 37,296,400 | reduced | -9.76 | ||
| KPTI | karyopharm therapeutics inc | 0.66 | 6,000,000 | 4,630,840 | unchanged | 0.00 | ||