Latest Avoro Capital Advisors LLC Stock Portfolio
Avoro Capital Advisors LLC Performance:
2025 Q3: 32.5%YTD: 23.48%2024: 5.93%
Performance for 2025 Q3 is 32.5%, and YTD is 23.48%, and 2024 is 5.93%.
About Avoro Capital Advisors LLC and 13F Hedge Fund Stock Holdings
Avoro Capital Advisors LLC is a hedge fund based in NEW YORK, NY. On 10-Mar-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $7.8 Billions. In it's latest 13F Holdings report, Avoro Capital Advisors LLC reported an equity portfolio of $7.7 Billions as of 30 Sep, 2025.
The top stock holdings of Avoro Capital Advisors LLC are , UTHR, MDGL. The fund has invested 13.1% of it's portfolio in ASCENDIS PHARMA and 11% of portfolio in UNITED THERAPEUTICS CORP.
The fund managers got completely rid off BLUEPRINT MEDICINES CORP (BPMC), MONTE ROSA THERAPEUTICS INC (GLUE) and ULTRAGENYX PHARMACEUTICAL INC (RARE) stocks. They significantly reduced their stock positions in BIOCRYST PHARMACEUTICALS INC (BCRX), MOONLAKE IMMUNOTHERAPEUTICS (MLTX) and MANNKIND CORP (MNKD). Avoro Capital Advisors LLC opened new stock positions in STRUCTURE THERAPEUTICS INC. and TANGO THERAPEUTICS INC (TNGX). The fund showed a lot of confidence in some stocks as they added substantially to CENTESSA PHARMACEUTICALS PLC (CNTA), OCULAR THERAPEUTIX INC (OCUL) and SOLENO THERAPEUTICS INC (SLNO).
The top stock holdings of Avoro Capital Advisors LLC are , UTHR, MDGL. The fund has invested 13.1% of it's portfolio in ASCENDIS PHARMA and 11% of portfolio in UNITED THERAPEUTICS CORP.
The fund managers got completely rid off BLUEPRINT MEDICINES CORP (BPMC), MONTE ROSA THERAPEUTICS INC (GLUE) and ULTRAGENYX PHARMACEUTICAL INC (RARE) stocks. They significantly reduced their stock positions in BIOCRYST PHARMACEUTICALS INC (BCRX), MOONLAKE IMMUNOTHERAPEUTICS (MLTX) and MANNKIND CORP (MNKD). Avoro Capital Advisors LLC opened new stock positions in STRUCTURE THERAPEUTICS INC. and TANGO THERAPEUTICS INC (TNGX). The fund showed a lot of confidence in some stocks as they added substantially to CENTESSA PHARMACEUTICALS PLC (CNTA), OCULAR THERAPEUTIX INC (OCUL) and SOLENO THERAPEUTICS INC (SLNO).
Avoro Capital Advisors LLC Annual Return Estimates Vs S&P 500
Our best estimate is that Avoro Capital Advisors LLC made a return of 32.5% in the last quarter. In trailing 12 months, it's portfolio return was 20.87%.
New Buys
| Ticker | $ Bought |
|---|---|
| structure therapeutics inc. | 144,356,000 |
| oruka therapeutics inc | 25,640,100 |
| tango therapeutics inc | 4,578,000 |
New stocks bought by Avoro Capital Advisors LLC
Additions
| Ticker | % Inc. |
|---|---|
| centessa pharmaceuticals plc | 116 |
| ocular therapeutix inc | 38.51 |
| soleno therapeutics inc | 25.75 |
| uniqure nv | 22.61 |
| akero therapeutics inc | 13.02 |
| merus n v | 12.26 |
| avidity biosciences inc | 8.44 |
| septerna inc | 8.08 |
Additions to existing portfolio by Avoro Capital Advisors LLC
Reductions
| Ticker | % Reduced |
|---|---|
| biocryst pharmaceuticals inc | -72.22 |
| moonlake immunotherapeutics | -51.81 |
| mannkind corp | -23.61 |
| alkermes plc | -22.76 |
| amicus therapeutics inc. | -16.53 |
| argenx se | -15.74 |
| united therapeutics corp | -14.67 |
| 89bio inc | -5.37 |
Avoro Capital Advisors LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| monte rosa therapeutics inc | -16,799,800 |
| blueprint medicines corp | -48,067,500 |
| ultragenyx pharmaceutical inc | -11,998,800 |
Avoro Capital Advisors LLC got rid off the above stocks
Sector Distribution
Avoro Capital Advisors LLC has about 73.3% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 73.3 |
| Others | 26.7 |
Market Cap. Distribution
Avoro Capital Advisors LLC has about 11% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| MID-CAP | 46.7 |
| UNALLOCATED | 26.7 |
| SMALL-CAP | 15.6 |
| LARGE-CAP | 11 |
Stocks belong to which Index?
About 41.5% of the stocks held by Avoro Capital Advisors LLC either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| Others | 58.5 |
| RUSSELL 2000 | 41.5 |
Avoro Capital Advisors LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Avoro Capital Advisors LLC
Avoro Capital Advisors LLC has 30 stocks in it's portfolio. About 72.4% of the portfolio is in top 10 stocks. MLTX proved to be the most loss making stock for the portfolio. UTHR was the most profitable stock for Avoro Capital Advisors LLC last quarter.
Last Reported on: 14 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| AADI | whitehawk therapeutics inc | 0.07 | 2,849,400 | 5,413,860 | unchanged | 0.00 | ||
| AKRO | akero therapeutics inc | 2.43 | 3,955,560 | 187,810,000 | added | 13.02 | ||
| ALKS | alkermes plc | 0.87 | 2,240,000 | 67,200,000 | reduced | -22.76 | ||
| APLS | apellis pharmaceuticals inc. | 3.58 | 12,222,200 | 276,589,000 | unchanged | 0.00 | ||
| ARWR | arrowhead pharmaceuticals inc. | 4.86 | 10,900,000 | 375,941,000 | added | 2.83 | ||
| BCRX | biocryst pharmaceuticals inc | 0.12 | 1,250,000 | 9,487,500 | reduced | -72.22 | ||
| BPMC | blueprint medicines corp | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| CNTA | centessa pharmaceuticals plc | 3.39 | 10,808,100 | 262,096,000 | added | 116 | ||
| ETNB | 89bio inc | 1.21 | 6,387,790 | 93,900,500 | reduced | -5.37 | ||
| FOLD | amicus therapeutics inc. | 1.53 | 15,025,000 | 118,397,000 | reduced | -16.53 | ||
| GLUE | monte rosa therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| KRYS | krystal biotech inc | 6.34 | 2,777,780 | 490,361,000 | added | 4.43 | ||
| KYMR | kymera therapeutics inc | 4.65 | 6,350,000 | 359,410,000 | reduced | -3.14 | ||
| MDGL | madrigal pharmaceuticals inc | 10.87 | 1,833,000 | 840,724,000 | reduced | -2.24 | ||
| MLTX | moonlake immunotherapeutics | 0.18 | 2,000,000 | 14,340,000 | reduced | -51.81 | ||
| MNKD | mannkind corp | 0.31 | 4,468,880 | 23,997,900 | reduced | -23.61 | ||
| MRUS | merus n v | 4.31 | 3,542,500 | 333,526,000 | added | 12.26 | ||
| OCUL | ocular therapeutix inc | 1.55 | 10,250,000 | 119,822,000 | added | 38.51 | ||
| QURE | uniqure nv | 3.35 | 4,444,440 | 259,422,000 | added | 22.61 | ||
| RARE | ultragenyx pharmaceutical inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||