Latest Avoro Capital Advisors LLC Stock Portfolio
Avoro Capital Advisors LLC Performance:
2025 Q4: 20.32%YTD: 48.57%2024: 5.93%
Performance for 2025 Q4 is 20.32%, and YTD is 48.57%, and 2024 is 5.93%.
About Avoro Capital Advisors LLC and 13F Hedge Fund Stock Holdings
Avoro Capital Advisors LLC is a hedge fund based in New York, NY. On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, Avoro Capital Advisors LLC reported an equity portfolio of $10.2 Billions as of 31 Dec, 2025.
The top stock holdings of Avoro Capital Advisors LLC are UTHR, ASND, MDGL. The fund has invested 12.5% of it's portfolio in UNITED THERAPEUTICS CORP and 10.7% of portfolio in ASCENDIS PHARMA.
The fund managers got completely rid off MERUS N V (MRUS), AKERO THERAPEUTICS INC (AKRO) and TOURMALINE BIO INC stocks. They significantly reduced their stock positions in ALKERMES PLC (ALKS), AVIDITY BIOSCIENCES INC (RNA) and VERA THERAPEUTICS INC (VERA). Avoro Capital Advisors LLC opened new stock positions in CELCUITY INC (CELC), SPDR SERIES TRUST - S&P BIOTECH (BIL) and REVOLUTION MEDICINES INC (RVMD). The fund showed a lot of confidence in some stocks as they added substantially to UNIQURE NV (QURE), CENTESSA PHARMACEUTICALS PLC (CNTA) and UNITED THERAPEUTICS CORP (UTHR).
The top stock holdings of Avoro Capital Advisors LLC are UTHR, ASND, MDGL. The fund has invested 12.5% of it's portfolio in UNITED THERAPEUTICS CORP and 10.7% of portfolio in ASCENDIS PHARMA.
The fund managers got completely rid off MERUS N V (MRUS), AKERO THERAPEUTICS INC (AKRO) and TOURMALINE BIO INC stocks. They significantly reduced their stock positions in ALKERMES PLC (ALKS), AVIDITY BIOSCIENCES INC (RNA) and VERA THERAPEUTICS INC (VERA). Avoro Capital Advisors LLC opened new stock positions in CELCUITY INC (CELC), SPDR SERIES TRUST - S&P BIOTECH (BIL) and REVOLUTION MEDICINES INC (RVMD). The fund showed a lot of confidence in some stocks as they added substantially to UNIQURE NV (QURE), CENTESSA PHARMACEUTICALS PLC (CNTA) and UNITED THERAPEUTICS CORP (UTHR).
Avoro Capital Advisors LLC Annual Return Estimates Vs S&P 500
Our best estimate is that Avoro Capital Advisors LLC made a return of 20.32% in the last quarter. In trailing 12 months, it's portfolio return was 48.57%.
- Performance
- S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| celcuity inc | 310,302,000 |
| spdr series trust - s&p biotech | 256,053,000 |
| revolution medicines inc | 172,840,000 |
| mind medicine (mindmed) inc | 66,950,000 |
| ptc therapeutics inc | 52,032,600 |
| viridian therapeutics inc | 46,680,000 |
| apogee therapeutics inc | 37,740,000 |
| lexeo therapeutics inc | 32,769,000 |
New stocks bought by Avoro Capital Advisors LLC
Additions
| Ticker | % Inc. |
|---|---|
| uniqure nv | 38.38 |
| centessa pharmaceuticals plc | 34.67 |
| united therapeutics corp | 28.87 |
| structure therapeutics inc | 27.16 |
| kymera therapeutics inc | 17.71 |
| soleno therapeutics inc | 12.5 |
| ocular therapeutix inc | 5.15 |
| krystal biotech inc | 4.00 |
Additions to existing portfolio by Avoro Capital Advisors LLC
Reductions
| Ticker | % Reduced |
|---|---|
| alkermes plc | -37.5 |
| avidity biosciences inc | -28.65 |
| vera therapeutics inc | -5.17 |
| arrowhead pharmaceuticals inc | -2.52 |
| madrigal pharmaceuticals inc | -1.39 |
| mannkind corp | -0.55 |
Avoro Capital Advisors LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| amicus therapeutics inc. | -118,397,000 |
| 89bio inc | -93,900,500 |
| akero therapeutics inc | -187,810,000 |
| merus n v | -333,526,000 |
| tourmaline bio inc | -122,232,000 |
| moonlake immunotherapeutics | -14,340,000 |
| biocryst pharmaceuticals inc | -9,487,500 |
| tango therapeutics inc | -4,578,000 |
Avoro Capital Advisors LLC got rid off the above stocks
Sector Distribution
Avoro Capital Advisors LLC has about 71.8% of it's holdings in Healthcare sector.
- Healthcare
- Others
| Sector | % |
|---|---|
| Healthcare | 71.8 |
| Others | 28.2 |
Market Cap. Distribution
Avoro Capital Advisors LLC has about 29.2% of it's portfolio invested in the large-cap and mega-cap stocks.
- MID-CAP
- LARGE-CAP
- UNALLOCATED
- SMALL-CAP
| Category | % |
|---|---|
| MID-CAP | 37.6 |
| LARGE-CAP | 29.2 |
| UNALLOCATED | 28.2 |
| SMALL-CAP | 4.9 |
Stocks belong to which Index?
About 45% of the stocks held by Avoro Capital Advisors LLC either belong to S&P 500 or RUSSELL 2000 index.
- Others
- RUSSELL 2000
| Index | % |
|---|---|
| Others | 54.9 |
| RUSSELL 2000 | 45 |
Avoro Capital Advisors LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Avoro Capital Advisors LLC
Avoro Capital Advisors LLC has 31 stocks in it's portfolio. About 73.3% of the portfolio is in top 10 stocks. QURE proved to be the most loss making stock for the portfolio. ARWR was the most profitable stock for Avoro Capital Advisors LLC last quarter.
Last Reported on: 17 Feb, 2026| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| AADI | whitehawk therapeutics inc | 0.07 | 2,849,400 | 6,895,550 | unchanged | 0.00 | ||
| AKRO | akero therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ALKS | alkermes plc | 0.38 | 1,400,000 | 39,172,000 | reduced | -37.5 | ||
| APLS | apellis pharmaceuticals inc | 3.02 | 12,222,200 | 307,022,000 | unchanged | 0.00 | ||
| ARGX | argenx se | 8.18 | 990,000 | 832,540,000 | unchanged | 0.00 | ||
| ARWR | arrowhead pharmaceuticals inc | 6.93 | 10,625,000 | 705,394,000 | reduced | -2.52 | ||
| ASND | ascendis pharma | 10.71 | 5,111,110 | 1,089,890,000 | added | 0.02 | ||
| BCRX | biocryst pharmaceuticals inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| BIL | spdr series trust - s&p biotech | 2.52 | 2,100,000 | 256,053,000 | new | |||
| CELC | celcuity inc | 3.05 | 3,111,110 | 310,302,000 | new | |||
| CNTA | centessa pharmaceuticals plc | 3.58 | 14,555,600 | 364,034,000 | added | 34.67 | ||
| ETNB | 89bio inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| FOLD | amicus therapeutics inc. | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| GHRS | gh research plc | 0.22 | 1,800,000 | 22,860,000 | new | |||
| INCY | incyte corp | 0.13 | 135,000 | 13,334,000 | new | |||
| KRYS | krystal biotech inc | 7.00 | 2,888,890 | 712,226,000 | added | 4.00 | ||
| KYMR | kymera therapeutics inc | 5.72 | 7,474,750 | 581,610,000 | added | 17.71 | ||
| MDGL | madrigal pharmaceuticals inc | 10.35 | 1,807,500 | 1,052,580,000 | reduced | -1.39 | ||
| MLTX | moonlake immunotherapeutics | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| MNKD | mannkind corp | 0.25 | 4,444,440 | 25,200,000 | reduced | -0.55 | ||