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Latest COMMODORE CAPITAL LP Stock Portfolio

$1.73Billion | No. of Holdings #36

COMMODORE CAPITAL LP Performance

2026 Q1+14.32%
YTD+14.32%
2025+47.07%

About COMMODORE CAPITAL LP and 13F Hedge Fund Stock Holdings

Commodore Capital LP is a hedge fund based in New York, NY. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, Commodore Capital LP reported an equity portfolio of $1.7 Billions as of 31 Mar, 2026. <br><br> The top stock holdings of Commodore Capital LP are RLAY, ALKS, . The fund has invested 9.8% of it's portfolio in RELAY THERAPEUTICS INC and 8.6% of portfolio in ALKERMES PLC. <br><br> The fund managers got completely rid off TERNS PHARMACEUTICALS INC (TERN), ORUKA THERAPEUTICS INC and PROTAGONIST THERAPEUTICS INC (PTGX) stocks. They significantly reduced their stock positions in XENON PHARMACEUTICALS INC (XENE), SOLENO THERAPEUTICS INC (SLNO) and PALISADE BIO INC (PALI). Commodore Capital LP opened new stock positions in ERASCA INC (ERAS), DAMORA THERAPEUTICS INC (GLTO) and DEFINIUM THERAPEUTICS INC. The fund showed a lot of confidence in some stocks as they added substantially to NUVALENT INC (NUVL), ALTO NEUROSCIENCE INC and PEPGEN INC (PEPG).
COMMODORE CAPITAL LP Equity Portfolio Value
Last Reported on: 15 May, 2026
$1.73Billion
  as of May 15, 2026

COMMODORE CAPITAL LP Annual Return Estimates Vs S&P 500

Our best estimate is that Commodore Capital LP made a return of 14.32% in the last quarter. In trailing 12 months, it's portfolio return was 98.54%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
erasca inc51,371,500
damora therapeutics inc50,220,100
definium therapeutics inc37,800,000
eyepoint inc36,414,200
corvus pharmaceuticals inc33,045,300
perspective therapeutics inc26,424,400
ocular therapeutix inc21,810,200
century therapeutics inc19,652,200
New stocks bought by COMMODORE CAPITAL LP

Additions

Ticker% Inc.
nuvalent inc51.56
alto neuroscience inc49.36
pepgen inc31.62
cogent biosciences inc31.46
alkermes plc18.31
celldex therapeutics inc new5.13
pharvaris n v1.56
Additions to existing portfolio by COMMODORE CAPITAL LP

Reductions

Ticker% Reduced
xenon pharmaceuticals inc-54.17
soleno therapeutics inc-45.63
palisade bio inc-37.26
enliven therapeutics inc-30.21
tyra biosciences inc-26.67
spyre therapeutics inc-19.93
COMMODORE CAPITAL LP reduced stake in above stock

Sold off

Ticker$ Sold
cytomx therapeutics inc-32,769,200
mind medicine mindmed inc-26,780,000
oruka therapeutics inc-53,135,100
terns pharmaceuticals inc-59,590,000
replimune group inc-13,851,000
centessa pharmaceuticals plc-25,010,000
contineum therapeutics inc-9,330,610
protagonist therapeutics inc-39,303,000
COMMODORE CAPITAL LP got rid off the above stocks

Sector Distribution

Commodore Capital LP has about 78.6% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
Sector%
Healthcare78.6
Others21.4

Market Cap. Distribution

Commodore Capital LP has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.

  • MID-CAP
  • SMALL-CAP
  • UNALLOCATED
  • MICRO-CAP
  • NANO-CAP
Category%
MID-CAP36.2
SMALL-CAP34.1
UNALLOCATED21.4
MICRO-CAP4
NANO-CAP3.6

Stocks belong to which Index?

About 58.9% of the stocks held by Commodore Capital LP either belong to S&P 500 or RUSSELL 2000 index.

  • RUSSELL 2000
  • Others
Index%
RUSSELL 200058.9
Others41.1
Top 5 Winners (%)%
enliven therapeutics inc
131.2 %
AGLE
spyre therapeutics inc
48.6 %
TYRA
tyra biosciences inc
39.6 %
ATHA
leonabio inc
35.8 %
ALKS
alkermes plc
23.9 %
Top 5 Winners ($)$
enliven therapeutics inc
94.8 M
AGLE
spyre therapeutics inc
38.0 M
TYRA
tyra biosciences inc
35.1 M
ALKS
alkermes plc
28.6 M
RLAY
relay therapeutics inc
25.3 M
Top 5 Losers (%)%
PEPG
pepgen inc
-70.2 %
SLNO
soleno therapeutics inc
-21.4 %
PALI
palisade bio inc
-20.8 %
ASMB
assembly biosciences inc
-18.4 %
NRIX
nurix therapeutics inc
-18.3 %
Top 5 Losers ($)$
PEPG
pepgen inc
-18.7 M
SLNO
soleno therapeutics inc
-11.9 M
NRIX
nurix therapeutics inc
-7.9 M
ASMB
assembly biosciences inc
-6.3 M
PALI
palisade bio inc
-5.6 M

COMMODORE CAPITAL LP Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of COMMODORE CAPITAL LP

Commodore Capital LP has 36 stocks in it's portfolio. About 61.3% of the portfolio is in top 10 stocks. PEPG proved to be the most loss making stock for the portfolio. was the most profitable stock for Commodore Capital LP last quarter.

$1.73BTotal Value
46.00Positions
15 May, 2026Last Reported
Current holdings of Current Stock Holdings of COMMODORE CAPITAL LP, last reported on 15 May, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change
DRUG
Bright Minds Biosciences Inc

Bright Minds Biosciences Inc

DRUG
COMMODORE CAPITAL LP's holding in Bright Minds Biosciences Inc over time
0%0.00
$0.00
0%
decreased 100 percentsold off