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Latest COMMODORE CAPITAL LP Stock Portfolio

$1.68Billion | No. of Holdings #33

COMMODORE CAPITAL LP Performance

2026 Q2+23.67%
YTD+41.38%
2025+47.07%

About COMMODORE CAPITAL LP and 13F Hedge Fund Stock Holdings

Commodore Capital LP is a hedge fund based in New York, NY. On 2026-08-14, the fund reported it's updated stock portfolio. In the 13F Holdings report, Commodore Capital LP reported an equity portfolio of $1.7 Billions as of 30 Jun, 2026. <br><br> The top stock holdings of Commodore Capital LP are RLAY, , ALKS. The fund has invested 13.4% of it's portfolio in RELAY THERAPEUTICS INC and 9.9% of portfolio in ENLIVEN THERAPEUTICS INC. <br><br> The fund managers got completely rid off ERASCA INC (ERAS), XENON PHARMACEUTICALS INC (XENE) and NURIX THERAPEUTICS INC (NRIX) stocks. They significantly reduced their stock positions in NUVALENT INC (NUVL), KYMERA THERAPEUTICS INC (KYMR) and SPYRE THERAPEUTICS INC (AGLE). Commodore Capital LP opened new stock positions in TANGO THERAPEUTICS INC (TNGX), EDITAS MEDICINE INC (EDIT) and INFLARX NV (IFRX). The fund showed a lot of confidence in some stocks as they added substantially to LEONABIO INC (ATHA), RELMADA THERAPEUTICS INC (RLMD) and AVALO THERAPEUTICS INC (AVTX).
COMMODORE CAPITAL LP Equity Portfolio Value
Last Reported on: 14 Aug, 2026
$1.68Billion
  as of Aug 14, 2026

COMMODORE CAPITAL LP Annual Return Estimates Vs S&P 500

Our best estimate is that Commodore Capital LP made a return of 23.67% in the last quarter. In trailing 12 months, it's portfolio return was 134.54%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
tango therapeutics inc70,335,000
editas medicine inc28,800,400
inflarx nv16,352,000
research alliance corp iii5,350,000
vistagen therapeutics inc630,228
New stocks bought by COMMODORE CAPITAL LP

Additions

Ticker% Inc.
leonabio inc890
relmada therapeutics inc124
avalo therapeutics inc110
eyepoint inc62.83
assembly biosciences inc41.5
an2 therapeutics inc25.71
cogent biosciences inc5.61
Additions to existing portfolio by COMMODORE CAPITAL LP

Reductions

Ticker% Reduced
nuvalent inc-88.00
kymera therapeutics inc-66.67
spyre therapeutics inc-55.72
celldex therapeutics inc new-49.94
sab biotherapeutics inc-34.79
relay therapeutics inc-29.41
alkermes plc-28.57
pharvaris n v-25.74
COMMODORE CAPITAL LP reduced stake in above stock

Sold off

Ticker$ Sold
palisade bio inc-12,566,900
erasca inc-51,371,500
ocular therapeutix inc-21,810,200
nurix therapeutics inc-35,262,500
corvus pharmaceuticals inc-33,045,300
karyopharm therapeutics inc-10,861,500
xenon pharmaceuticals inc-47,973,800
soleno therapeutics inc-21,843,400
COMMODORE CAPITAL LP got rid off the above stocks

Sector Distribution

Commodore Capital LP has about 70.3% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
Sector%
Healthcare70.3
Others29.7

Market Cap. Distribution

Commodore Capital LP has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.

  • MID-CAP
  • UNALLOCATED
  • SMALL-CAP
  • MICRO-CAP
Category%
MID-CAP49.9
UNALLOCATED29.7
SMALL-CAP15.8
MICRO-CAP4.4

Stocks belong to which Index?

About 56.4% of the stocks held by Commodore Capital LP either belong to S&P 500 or RUSSELL 2000 index.

  • RUSSELL 2000
  • Others
Index%
RUSSELL 200056.4
Others43.6
Top 5 Winners (%)%
definium therapeutics inc
148.9 %
RLAY
relay therapeutics inc
75.1 %
AGLE
spyre therapeutics inc
54.8 %
ALKS
alkermes plc
41.3 %
ANTX
an2 therapeutics inc
35.8 %
Top 5 Winners ($)$
RLAY
relay therapeutics inc
127.0 M
ALKS
alkermes plc
61.3 M
definium therapeutics inc
56.3 M
AGLE
spyre therapeutics inc
52.9 M
enliven therapeutics inc
37.8 M
Top 5 Losers (%)%
ATHA
leonabio inc
-84.7 %
perspective therapeutics inc
-18.2 %
TYRA
tyra biosciences inc
-14.6 %
zura bio ltd
-0.8 %
ASMB
assembly biosciences inc
-0.8 %
Top 5 Losers ($)$
ATHA
leonabio inc
-23.7 M
TYRA
tyra biosciences inc
-13.8 M
perspective therapeutics inc
-4.8 M
ASMB
assembly biosciences inc
-0.3 M
zura bio ltd
-0.2 M

COMMODORE CAPITAL LP Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of COMMODORE CAPITAL LP

Commodore Capital LP has 33 stocks in it's portfolio. About 68.2% of the portfolio is in top 10 stocks. ATHA proved to be the most loss making stock for the portfolio. RLAY was the most profitable stock for Commodore Capital LP last quarter.

$1.68BTotal Value
41.00Positions
14 Aug, 2026Last Reported
Current holdings of Current Stock Holdings of COMMODORE CAPITAL LP, last reported on 14 Aug, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change
IFRX
Inflarx Nv

Inflarx Nv

IFRX
COMMODORE CAPITAL LP's holding in Inflarx Nv over time
0.97%7,300,000
$16.35M
0.97%
new position