Latest COMMODORE CAPITAL LP Stock Portfolio
COMMODORE CAPITAL LP Performance:
2025 Q4: 28.53%YTD: 47.07%2024: 7.99%
Performance for 2025 Q4 is 28.53%, and YTD is 47.07%, and 2024 is 7.99%.
About COMMODORE CAPITAL LP and 13F Hedge Fund Stock Holdings
Commodore Capital LP is a hedge fund based in New York, NY. On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, Commodore Capital LP reported an equity portfolio of $1.5 Billions as of 31 Dec, 2025.
The top stock holdings of Commodore Capital LP are RLAY, ALKS, TYRA. The fund has invested 9.6% of it's portfolio in RELAY THERAPEUTICS INC and 6.6% of portfolio in ALKERMES PLC.
The fund managers got completely rid off MERUS N V (MRUS), AGIOS PHARMACEUTICALS INC (AGIO) and VIRIDIAN THERAPEUTICS INC (VRDN) stocks. They significantly reduced their stock positions in BRIGHT MINDS BIOSCIENCES INC (DRUG), TERNS PHARMACEUTICALS INC (TERN) and COGENT BIOSCIENCES INC (COGT). Commodore Capital LP opened new stock positions in ALTO NEUROSCIENCE INC, PALISADE BIO INC (PALI) and REPLIMUNE GROUP INC (REPL). The fund showed a lot of confidence in some stocks as they added substantially to PEPGEN INC (PEPG), AMYLYX PHARMACEUTICALS INC (AMLX) and SPYRE THERAPEUTICS INC (AGLE).
The top stock holdings of Commodore Capital LP are RLAY, ALKS, TYRA. The fund has invested 9.6% of it's portfolio in RELAY THERAPEUTICS INC and 6.6% of portfolio in ALKERMES PLC.
The fund managers got completely rid off MERUS N V (MRUS), AGIOS PHARMACEUTICALS INC (AGIO) and VIRIDIAN THERAPEUTICS INC (VRDN) stocks. They significantly reduced their stock positions in BRIGHT MINDS BIOSCIENCES INC (DRUG), TERNS PHARMACEUTICALS INC (TERN) and COGENT BIOSCIENCES INC (COGT). Commodore Capital LP opened new stock positions in ALTO NEUROSCIENCE INC, PALISADE BIO INC (PALI) and REPLIMUNE GROUP INC (REPL). The fund showed a lot of confidence in some stocks as they added substantially to PEPGEN INC (PEPG), AMYLYX PHARMACEUTICALS INC (AMLX) and SPYRE THERAPEUTICS INC (AGLE).
COMMODORE CAPITAL LP Annual Return Estimates Vs S&P 500
Our best estimate is that Commodore Capital LP made a return of 28.53% in the last quarter. In trailing 12 months, it's portfolio return was 47.07%.
- Performance
- S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| alto neuroscience inc | 32,452,900 |
| palisade bio inc | 26,895,800 |
| replimune group inc | 13,851,000 |
| contineum therapeutics inc | 9,330,610 |
| rapt therapeutics inc | 8,467,500 |
| athira pharma inc | 3,515,490 |
New stocks bought by COMMODORE CAPITAL LP
Additions
| Ticker | % Inc. |
|---|---|
| pepgen inc | 44.23 |
| amylyx pharmaceuticals inc | 38.63 |
| spyre therapeutics inc | 20.13 |
| alkermes plc | 14.64 |
Additions to existing portfolio by COMMODORE CAPITAL LP
Reductions
| Ticker | % Reduced |
|---|---|
| bright minds biosciences inc | -96.23 |
| terns pharmaceuticals inc | -74.12 |
| cogent biosciences inc | -69.7 |
| centessa pharmaceuticals plc | -64.91 |
| nuvalent inc | -60.71 |
| protagonist therapeutics inc | -56.1 |
| nurix therapeutics inc | -39.82 |
| mind medicine mindmed inc | -37.98 |
COMMODORE CAPITAL LP reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| merus n v | -331,879,000 |
| viridian therapeutics inc | -69,056,000 |
| agios pharmaceuticals inc | -93,858,800 |
| vistagen therapeutics inc | -5,591,250 |
| tango therapeutics inc | -12,600,000 |
| enanta pharmaceuticals inc | -9,576,000 |
| perceptive cap solutions cor | -7,920,000 |
| cidara therapeutics inc | -56,019,600 |
COMMODORE CAPITAL LP got rid off the above stocks
Sector Distribution
Commodore Capital LP has about 83.1% of it's holdings in Healthcare sector.
- Healthcare
- Others
| Sector | % |
|---|---|
| Healthcare | 83.1 |
| Others | 16.9 |
Market Cap. Distribution
Commodore Capital LP has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.
- MID-CAP
- SMALL-CAP
- UNALLOCATED
- MICRO-CAP
| Category | % |
|---|---|
| MID-CAP | 41.9 |
| SMALL-CAP | 36.7 |
| UNALLOCATED | 16.9 |
| MICRO-CAP | 4.2 |
Stocks belong to which Index?
About 56.4% of the stocks held by Commodore Capital LP either belong to S&P 500 or RUSSELL 2000 index.
- RUSSELL 2000
- Others
| Index | % |
|---|---|
| RUSSELL 2000 | 56.4 |
| Others | 43.6 |
COMMODORE CAPITAL LP Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of COMMODORE CAPITAL LP
Commodore Capital LP has 33 stocks in it's portfolio. About 55.8% of the portfolio is in top 10 stocks. SLNO proved to be the most loss making stock for the portfolio. TERN was the most profitable stock for Commodore Capital LP last quarter.
Last Reported on: 17 Feb, 2026| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| AGIO | agios pharmaceuticals inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AGLE | spyre therapeutics inc | 5.21 | 2,388,240 | 78,238,900 | added | 20.13 | ||
| ALKS | alkermes plc | 6.61 | 3,550,000 | 99,329,000 | added | 14.64 | ||
| AMLX | amylyx pharmaceuticals inc | 4.54 | 5,650,000 | 68,252,000 | added | 38.63 | ||
| ASMB | assembly biosciences inc | 2.26 | 1,000,000 | 34,010,000 | unchanged | 0.00 | ||
| ATHA | athira pharma inc | 0.23 | 464,398 | 3,515,490 | new | |||
| AVTX | avalo therapeutics inc | 0.58 | 483,000 | 8,771,280 | unchanged | 0.00 | ||
| CDTX | cidara therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| CLDX | celldex therapeutics inc new | 4.64 | 2,565,000 | 69,665,400 | reduced | -15.3 | ||
| CNTA | centessa pharmaceuticals plc | 1.67 | 1,000,000 | 25,010,000 | reduced | -64.91 | ||
| COGT | cogent biosciences inc | 5.19 | 2,196,840 | 78,031,900 | reduced | -69.7 | ||
| CTMX | cytomx therapeutics inc | 2.18 | 7,692,300 | 32,769,200 | unchanged | 0.00 | ||
| DRUG | bright minds biosciences inc | 0.10 | 18,851 | 1,471,130 | reduced | -96.23 | ||
| ENTA | enanta pharmaceuticals inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| IKT | inhibikase therapeutics inc | 0.74 | 5,397,490 | 11,064,800 | unchanged | 0.00 | ||
| KYMR | kymera therapeutics inc | 3.88 | 750,000 | 58,357,500 | unchanged | 0.00 | ||
| MNMD | mind medicine mindmed inc | 1.78 | 2,000,000 | 26,780,000 | reduced | -37.98 | ||
| MRUS | merus n v | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| NRIX | nurix therapeutics inc | 2.87 | 2,275,000 | 43,156,800 | reduced | -39.82 | ||
| NUVL | nuvalent inc | 3.68 | 550,000 | 55,324,500 | reduced | -60.71 | ||