Latest COMMODORE CAPITAL LP Stock Portfolio
$1.73Billion– No. of Holdings #36
COMMODORE CAPITAL LP Performance:
2026 Q1: 14.32%YTD: 14.32%2025: 47.07%
Performance for 2026 Q1 is 14.32%, and YTD is 14.32%, and 2025 is 47.07%.
About COMMODORE CAPITAL LP and 13F Hedge Fund Stock Holdings
Commodore Capital LP is a hedge fund based in New York, NY. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, Commodore Capital LP reported an equity portfolio of $1.7 Billions as of 31 Mar, 2026.
The top stock holdings of Commodore Capital LP are RLAY, ALKS, . The fund has invested 9.8% of it's portfolio in RELAY THERAPEUTICS INC and 8.6% of portfolio in ALKERMES PLC.
The fund managers got completely rid off TERNS PHARMACEUTICALS INC (TERN), ORUKA THERAPEUTICS INC and PROTAGONIST THERAPEUTICS INC (PTGX) stocks. They significantly reduced their stock positions in XENON PHARMACEUTICALS INC (XENE), SOLENO THERAPEUTICS INC (SLNO) and PALISADE BIO INC (PALI). Commodore Capital LP opened new stock positions in ERASCA INC (ERAS), DAMORA THERAPEUTICS INC (GLTO) and DEFINIUM THERAPEUTICS INC. The fund showed a lot of confidence in some stocks as they added substantially to NUVALENT INC (NUVL), ALTO NEUROSCIENCE INC and PEPGEN INC (PEPG).
The top stock holdings of Commodore Capital LP are RLAY, ALKS, . The fund has invested 9.8% of it's portfolio in RELAY THERAPEUTICS INC and 8.6% of portfolio in ALKERMES PLC.
The fund managers got completely rid off TERNS PHARMACEUTICALS INC (TERN), ORUKA THERAPEUTICS INC and PROTAGONIST THERAPEUTICS INC (PTGX) stocks. They significantly reduced their stock positions in XENON PHARMACEUTICALS INC (XENE), SOLENO THERAPEUTICS INC (SLNO) and PALISADE BIO INC (PALI). Commodore Capital LP opened new stock positions in ERASCA INC (ERAS), DAMORA THERAPEUTICS INC (GLTO) and DEFINIUM THERAPEUTICS INC. The fund showed a lot of confidence in some stocks as they added substantially to NUVALENT INC (NUVL), ALTO NEUROSCIENCE INC and PEPGEN INC (PEPG).
COMMODORE CAPITAL LP Equity Portfolio Value
Last Reported on: 15 May, 2026
COMMODORE CAPITAL LP Annual Return Estimates Vs S&P 500
Our best estimate is that Commodore Capital LP made a return of 14.32% in the last quarter. In trailing 12 months, it's portfolio return was 98.54%.
- Performance
- S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| erasca inc | 51,371,500 |
| damora therapeutics inc | 50,220,100 |
| definium therapeutics inc | 37,800,000 |
| eyepoint inc | 36,414,200 |
| corvus pharmaceuticals inc | 33,045,300 |
| perspective therapeutics inc | 26,424,400 |
| ocular therapeutix inc | 21,810,200 |
| century therapeutics inc | 19,652,200 |
New stocks bought by COMMODORE CAPITAL LP
Additions
| Ticker | % Inc. |
|---|---|
| nuvalent inc | 51.56 |
| alto neuroscience inc | 49.36 |
| pepgen inc | 31.62 |
| cogent biosciences inc | 31.46 |
| alkermes plc | 18.31 |
| celldex therapeutics inc new | 5.13 |
| pharvaris n v | 1.56 |
Additions to existing portfolio by COMMODORE CAPITAL LP
Reductions
| Ticker | % Reduced |
|---|---|
| xenon pharmaceuticals inc | -54.17 |
| soleno therapeutics inc | -45.63 |
| palisade bio inc | -37.26 |
| enliven therapeutics inc | -30.21 |
| tyra biosciences inc | -26.67 |
| spyre therapeutics inc | -19.93 |
COMMODORE CAPITAL LP reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| cytomx therapeutics inc | -32,769,200 |
| mind medicine mindmed inc | -26,780,000 |
| oruka therapeutics inc | -53,135,100 |
| terns pharmaceuticals inc | -59,590,000 |
| replimune group inc | -13,851,000 |
| centessa pharmaceuticals plc | -25,010,000 |
| contineum therapeutics inc | -9,330,610 |
| protagonist therapeutics inc | -39,303,000 |
COMMODORE CAPITAL LP got rid off the above stocks
Sector Distribution
Commodore Capital LP has about 78.6% of it's holdings in Healthcare sector.
- Healthcare
- Others
| Sector | % |
|---|---|
| Healthcare | 78.6 |
| Others | 21.4 |
Market Cap. Distribution
Commodore Capital LP has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.
- MID-CAP
- SMALL-CAP
- UNALLOCATED
- MICRO-CAP
- NANO-CAP
| Category | % |
|---|---|
| MID-CAP | 36.2 |
| SMALL-CAP | 34.1 |
| UNALLOCATED | 21.4 |
| MICRO-CAP | 4 |
| NANO-CAP | 3.6 |
Stocks belong to which Index?
About 58.9% of the stocks held by Commodore Capital LP either belong to S&P 500 or RUSSELL 2000 index.
- RUSSELL 2000
- Others
| Index | % |
|---|---|
| RUSSELL 2000 | 58.9 |
| Others | 41.1 |
COMMODORE CAPITAL LP Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of COMMODORE CAPITAL LP
Commodore Capital LP has 36 stocks in it's portfolio. About 61.3% of the portfolio is in top 10 stocks. PEPG proved to be the most loss making stock for the portfolio. was the most profitable stock for Commodore Capital LP last quarter.
Last Reported on: 15 May, 2026| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| AGLE | spyre therapeutics inc | 5.58 | 1,912,380 | 96,460,400 | reduced | -19.93 | ||
| ALKS | alkermes plc | 8.59 | 4,200,000 | 148,512,000 | added | 18.31 | ||
| AMLX | amylyx pharmaceuticals inc | 4.54 | 5,650,000 | 78,535,000 | unchanged | 0.00 | ||
| ANTX | an2 therapeutics inc | 0.46 | 2,333,710 | 7,981,300 | new | |||
| ASMB | assembly biosciences inc | 1.60 | 1,000,000 | 27,750,000 | unchanged | 0.00 | ||
| ATHA | leonabio inc | 0.28 | 46,908 | 4,774,010 | unchanged | 0.00 | ||
| AVTX | avalo therapeutics inc | 0.42 | 483,000 | 7,211,190 | unchanged | 0.00 | ||
| CLDX | celldex therapeutics inc new | 4.95 | 2,696,620 | 85,536,700 | added | 5.13 | ||
| CNTA | centessa pharmaceuticals plc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| COGT | cogent biosciences inc | 6.43 | 2,888,010 | 111,159,000 | added | 31.46 | ||
| CRVS | corvus pharmaceuticals inc | 1.91 | 2,258,740 | 33,045,300 | new | |||
| CTMX | cytomx therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| DRUG | bright minds biosciences inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ERAS | erasca inc | 2.97 | 3,175,000 | 51,371,500 | new | |||
| EYPT | eyepoint inc | 2.11 | 2,825,000 | 36,414,200 | new | |||
| GLTO | damora therapeutics inc | 2.90 | 1,939,000 | 50,220,100 | new | |||
| IKT | inhibikase therapeutics inc | 0.52 | 5,397,490 | 9,067,780 | unchanged | 0.00 | ||
| IPSC | century therapeutics inc | 1.14 | 8,695,650 | 19,652,200 | new | |||
| KPTI | karyopharm therapeutics inc | 0.63 | 1,950,000 | 10,861,500 | new | |||
| KYMR | kymera therapeutics inc | 3.61 | 750,000 | 62,467,500 | unchanged | 0.00 | ||