Latest COMMODORE CAPITAL LP Stock Portfolio
COMMODORE CAPITAL LP Performance:
2025 Q3: 29.07%YTD: 14.42%2024: 7.99%
Performance for 2025 Q3 is 29.07%, and YTD is 14.42%, and 2024 is 7.99%.
About COMMODORE CAPITAL LP and 13F Hedge Fund Stock Holdings
Commodore Capital LP is a hedge fund based in NEW YORK, NY. On 24-Mar-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $814.6 Millions. In it's latest 13F Holdings report, Commodore Capital LP reported an equity portfolio of $2 Billions as of 30 Sep, 2025.
The top stock holdings of Commodore Capital LP are MRUS, NUVL, XENE. The fund has invested 16.2% of it's portfolio in MERUS N V and 5.9% of portfolio in NUVALENT INC.
The fund managers got completely rid off SCHOLAR ROCK HLDG CORP (SRRK), VERA THERAPEUTICS INC (VERA) and NEUROGENE INC stocks. They significantly reduced their stock positions in CIDARA THERAPEUTICS INC (CDTX), MIND MEDICINE MINDMED INC (MNMD) and VIRIDIAN THERAPEUTICS INC (VRDN). Commodore Capital LP opened new stock positions in AMYLYX PHARMACEUTICALS INC (AMLX), TERNS PHARMACEUTICALS INC (TERN) and ASSEMBLY BIOSCIENCES INC (ASMB). The fund showed a lot of confidence in some stocks as they added substantially to COGENT BIOSCIENCES INC (COGT), SOLENO THERAPEUTICS INC (SLNO) and RELAY THERAPEUTICS INC (RLAY).
The top stock holdings of Commodore Capital LP are MRUS, NUVL, XENE. The fund has invested 16.2% of it's portfolio in MERUS N V and 5.9% of portfolio in NUVALENT INC.
The fund managers got completely rid off SCHOLAR ROCK HLDG CORP (SRRK), VERA THERAPEUTICS INC (VERA) and NEUROGENE INC stocks. They significantly reduced their stock positions in CIDARA THERAPEUTICS INC (CDTX), MIND MEDICINE MINDMED INC (MNMD) and VIRIDIAN THERAPEUTICS INC (VRDN). Commodore Capital LP opened new stock positions in AMYLYX PHARMACEUTICALS INC (AMLX), TERNS PHARMACEUTICALS INC (TERN) and ASSEMBLY BIOSCIENCES INC (ASMB). The fund showed a lot of confidence in some stocks as they added substantially to COGENT BIOSCIENCES INC (COGT), SOLENO THERAPEUTICS INC (SLNO) and RELAY THERAPEUTICS INC (RLAY).
COMMODORE CAPITAL LP Annual Return Estimates Vs S&P 500
Our best estimate is that Commodore Capital LP made a return of 29.07% in the last quarter. In trailing 12 months, it's portfolio return was 0.51%.
New Buys
| Ticker | $ Bought |
|---|---|
| amylyx pharmaceuticals inc | 55,385,700 |
| terns pharmaceuticals inc | 42,807,000 |
| assembly biosciences inc | 25,600,000 |
| lb pharmaceuticals inc | 23,685,000 |
| pepgen inc | 10,890,800 |
| enanta pharmaceuticals inc | 9,576,000 |
| sab biotherapeutics inc | 8,847,020 |
New stocks bought by COMMODORE CAPITAL LP
Additions
| Ticker | % Inc. |
|---|---|
| cogent biosciences inc | 213 |
| soleno therapeutics inc | 121 |
| relay therapeutics inc | 27.34 |
| pharvaris n v | 26.53 |
| alkermes plc | 26.4 |
| oruka therapeutics inc | 23.48 |
| tyra biosciences inc | 8.87 |
| nuvalent inc | 1.82 |
Additions to existing portfolio by COMMODORE CAPITAL LP
Reductions
| Ticker | % Reduced |
|---|---|
| cidara therapeutics inc | -50.21 |
| mind medicine mindmed inc | -35.5 |
| viridian therapeutics inc | -34.36 |
| centessa pharmaceuticals plc | -13.59 |
| celldex therapeutics inc new | -12.22 |
| xenon pharmaceuticals inc | -10.74 |
| protagonist therapeutics inc | -4.65 |
| nurix therapeutics inc | -4.27 |
COMMODORE CAPITAL LP reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| scholar rock hldg corp | -51,359,000 |
| vera therapeutics inc | -18,848,000 |
| neurogene inc | -6,396,600 |
COMMODORE CAPITAL LP got rid off the above stocks
Sector Distribution
Commodore Capital LP has about 86.6% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 86.6 |
| Others | 13.4 |
Market Cap. Distribution
Commodore Capital LP has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| MID-CAP | 45.7 |
| SMALL-CAP | 31.3 |
| UNALLOCATED | 13.4 |
| MICRO-CAP | 8.4 |
| NANO-CAP | 1.2 |
Stocks belong to which Index?
About 47.5% of the stocks held by Commodore Capital LP either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| Others | 52.5 |
| RUSSELL 2000 | 47.5 |
COMMODORE CAPITAL LP Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of COMMODORE CAPITAL LP
Commodore Capital LP has 37 stocks in it's portfolio. About 58.9% of the portfolio is in top 10 stocks. SLNO proved to be the most loss making stock for the portfolio. MRUS was the most profitable stock for Commodore Capital LP last quarter.
Last Reported on: 14 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| AGIO | agios pharmaceuticals inc | 4.58 | 2,338,290 | 93,858,800 | added | 0.57 | ||
| AGLE | spyre therapeutics inc | 1.63 | 1,988,080 | 33,320,300 | unchanged | 0.00 | ||
| ALKS | alkermes plc | 4.54 | 3,096,750 | 92,902,600 | added | 26.4 | ||
| AMLX | amylyx pharmaceuticals inc | 2.70 | 4,075,480 | 55,385,700 | new | |||
| ASMB | assembly biosciences inc | 1.25 | 1,000,000 | 25,600,000 | new | |||
| AVTX | avalo therapeutics inc | 0.30 | 483,000 | 6,138,930 | unchanged | 0.00 | ||
| CDTX | cidara therapeutics inc | 2.73 | 585,000 | 56,019,600 | reduced | -50.21 | ||
| CLDX | celldex therapeutics inc new | 3.83 | 3,028,340 | 78,343,000 | reduced | -12.22 | ||
| CNTA | centessa pharmaceuticals plc | 3.37 | 2,850,000 | 69,112,500 | reduced | -13.59 | ||
| COGT | cogent biosciences inc | 5.08 | 7,250,000 | 104,110,000 | added | 213 | ||
| CTMX | cytomx therapeutics inc | 1.20 | 7,692,300 | 24,538,400 | unchanged | 0.00 | ||
| ENTA | enanta pharmaceuticals inc | 0.47 | 800,000 | 9,576,000 | new | |||
| IKT | inhibikase therapeutics inc | 0.43 | 5,397,490 | 8,743,930 | unchanged | 0.00 | ||
| KYMR | kymera therapeutics inc | 2.07 | 750,000 | 42,450,000 | unchanged | 0.00 | ||
| MNMD | mind medicine mindmed inc | 1.86 | 3,225,000 | 38,022,800 | reduced | -35.5 | ||
| MRUS | merus n v | 16.20 | 3,525,000 | 331,879,000 | unchanged | 0.00 | ||
| NRIX | nurix therapeutics inc | 1.71 | 3,780,060 | 34,927,700 | reduced | -4.27 | ||
| NUVL | nuvalent inc | 5.91 | 1,400,000 | 121,072,000 | added | 1.82 | ||
| PEPG | pepgen inc | 0.53 | 2,357,320 | 10,890,800 | new | |||
| PHVS | pharvaris n v | 2.95 | 2,418,480 | 60,341,000 | added | 26.53 | ||