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Latest BAKER BROS. ADVISORS LP Stock Portfolio

BAKER BROS. ADVISORS LP Performance:
2024 Q4: -2.73%YTD: 1.57%2023: -0.24%

Performance for 2024 Q4 is -2.73%, and YTD is 1.57%, and 2023 is -0.24%.

About BAKER BROS. ADVISORS LP and 13F Hedge Fund Stock Holdings

BAKER BROS. ADVISORS LP is a hedge fund based in NEW YORK, NY. On 24-Mar-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $23.2 Billions. In it's latest 13F Holdings report, BAKER BROS. ADVISORS LP reported an equity portfolio of $9.4 Billions as of 31 Dec, 2024.

The top stock holdings of BAKER BROS. ADVISORS LP are INCY, BGNE, ACAD. The fund has invested 22.7% of it's portfolio in INCYTE CORPORATION and 18.8% of portfolio in BEIGENE, LTD.

The fund managers got completely rid off TANGO THERAPEUTICS, INC. (TNGX), CRINETICS PHARMACEUTICALS, INC. (CRNX) and DBV TECHNOLOGIES S.A. (DBVT) stocks. They significantly reduced their stock positions in BIOMEA FUSION, INC. (BMEA), SAGIMET BIOSCIENCES INC. and BEIGENE, LTD. (BGNE). BAKER BROS. ADVISORS LP opened new stock positions in GRAIL, INC., CANDEL THERAPEUTICS, INC. (CADL) and VIR BIOTECHNOLOGY, INC. (VIR). The fund showed a lot of confidence in some stocks as they added substantially to STRUCTURE THERAPEUTICS INC., IONIS PHARMACEUTICALS, INC. (IONS) and CRISPR THERAPEUTICS AG (CRSP).

BAKER BROS. ADVISORS LP Annual Return Estimates Vs S&P 500

Our best estimate is that BAKER BROS. ADVISORS LP made a return of -2.73% in the last quarter. In trailing 12 months, it's portfolio return was 1.57%.

New Buys

Ticker$ Bought
ionis pharmaceuticals, inc.29,543,600
grail, inc.29,097,700
candel therapeutics, inc.25,883,600
vir biotechnology, inc.7,960,520
intellia therapeutics, inc.7,510,390
biontech se5,131,280
disc medicine, inc.4,884,970
dbv technologies s.a.4,515,800

New stocks bought by BAKER BROS. ADVISORS LP

Additions

Ticker% Inc.
structure therapeutics inc.322
ionis pharmaceuticals, inc.60.16
crispr therapeutics ag55.15
merus n.v.50.00
neurogene inc.47.9
celcuity inc.42.86
immunovant, inc.39.37
kala bio, inc.34.84

Additions to existing portfolio by BAKER BROS. ADVISORS LP

Reductions

Ticker% Reduced
biomea fusion, inc.-31.15
sagimet biosciences inc.-31.04
beigene, ltd.-9.81
rhythm pharmaceuticals, inc.-4.91

BAKER BROS. ADVISORS LP reduced stake in above stock

Sold off

Ticker$ Sold
dbv technologies s.a.-5,114,990
alector, inc.-4,321,050
tango therapeutics, inc.-5,775,000
aerovate therapeutics, inc.-1,314,480
crinetics pharmaceuticals, inc.-5,310,670
newamsterdam pharma company n.v.-1,605,400
biocryst pharmaceuticals, inc.-575,913
pfizer inc.-1,012,900

BAKER BROS. ADVISORS LP got rid off the above stocks

Sector Distribution

BAKER BROS. ADVISORS LP has about 96.7% of it's holdings in Healthcare sector.

Sector%
Healthcare96.7
Others3.3

Market Cap. Distribution

BAKER BROS. ADVISORS LP has about 45.8% of it's portfolio invested in the large-cap and mega-cap stocks.

Category%
MID-CAP31.2
LARGE-CAP26.7
MEGA-CAP19.1
SMALL-CAP15.6
UNALLOCATED3.8
MICRO-CAP3.4

Stocks belong to which Index?

About 70.4% of the stocks held by BAKER BROS. ADVISORS LP either belong to S&P 500 or RUSSELL 2000 index.

Index%
RUSSELL 200047.4
Others29.6
S&P 50023
Top 5 Winners (%)%
ALGS
aligos therapeutics, inc.
360.1 %
DBVT
dbv technologies s.a.
296.1 %
KOD
kodiak sciences inc.
281.2 %
TARA
protara therapeutics, inc.
188.5 %
SRZN
surrozen, inc.
107.8 %
Top 5 Winners ($)$
MDGL
madrigal pharmaceuticals, inc.
190.3 M
ACAD
acadia pharmaceuticals inc.
127.3 M
KOD
kodiak sciences inc.
127.1 M
INCY
incyte corporation
91.3 M
RYTM
rhythm pharmaceuticals, inc.
22.8 M
Top 5 Losers (%)%
IGMS
igm biosciences, inc.
-63.0 %
SANA
sana biotechnology, inc.
-60.8 %
GBIO
generation bio co.
-57.1 %
HOOK
hookipa pharma inc.
-53.3 %
FATE
fate therapeutics, inc.
-51.7 %
Top 5 Losers ($)$
BGNE
beigene, ltd.
-400.5 M
SMMT
summit therapeutics inc.
-99.0 M
BCYC
bicycle therapeutics plc
-92.6 M
IGMS
igm biosciences, inc.
-42.7 M
KYMR
kymera therapeutics, inc.
-42.6 M

BAKER BROS. ADVISORS LP Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of BAKER BROS. ADVISORS LP

BAKER BROS. ADVISORS LP has 93 stocks in it's portfolio. About 76.5% of the portfolio is in top 10 stocks. BGNE proved to be the most loss making stock for the portfolio. MDGL was the most profitable stock for BAKER BROS. ADVISORS LP last quarter.

Last Reported on: 14 Feb, 2025
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