Latest BAKER BROS. ADVISORS LP Stock Portfolio
$8.79Billion
Equity Portfolio Value
Last Reported on: 14 Feb, 2024
About BAKER BROS. ADVISORS LP and it’s 13F Hedge Fund Stock Holdings
BAKER BROS. ADVISORS LP is a hedge fund based in New York, NY. On 24-Mar-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $23.2 Billions. In it's latest 13F Holdings report, BAKER BROS. ADVISORS LP reported an equity portfolio of $8.8 Billions as of 31 Dec, 2023.
The top stock holdings of BAKER BROS. ADVISORS LP are INCY, BGNE, ACAD. The fund has invested 25.9% of it's portfolio in INCYTE CORPORATION and 21.7% of portfolio in BEIGENE, LTD.
The fund managers got completely rid off SEAGEN INC. (SGEN), BIOMARIN PHARMACEUTICAL INC. (BMRN) and SPRINGWORKS THERAPEUTICS, INC. (SWTX) stocks. They significantly reduced their stock positions in CABALETTA BIO, INC. (CABA), PRAXIS PRECISION MEDICINES, INC. (PRAX) and AADI BIOSCIENCE, INC. (AADI). BAKER BROS. ADVISORS LP opened new stock positions in CEREVEL THERAPEUTICS HOLDINGS, INC. (CERE), CELLDEX THERAPEUTICS, INC. (CLDX) and NEUROGENE INC.. The fund showed a lot of confidence in some stocks as they added substantially to SERA PROGNOSTICS, INC. (SERA), EDGEWISE THERAPEUTICS, INC. (EWTX) and MIRATI THERAPEUTICS, INC. (MRTX).
The top stock holdings of BAKER BROS. ADVISORS LP are INCY, BGNE, ACAD. The fund has invested 25.9% of it's portfolio in INCYTE CORPORATION and 21.7% of portfolio in BEIGENE, LTD.
The fund managers got completely rid off SEAGEN INC. (SGEN), BIOMARIN PHARMACEUTICAL INC. (BMRN) and SPRINGWORKS THERAPEUTICS, INC. (SWTX) stocks. They significantly reduced their stock positions in CABALETTA BIO, INC. (CABA), PRAXIS PRECISION MEDICINES, INC. (PRAX) and AADI BIOSCIENCE, INC. (AADI). BAKER BROS. ADVISORS LP opened new stock positions in CEREVEL THERAPEUTICS HOLDINGS, INC. (CERE), CELLDEX THERAPEUTICS, INC. (CLDX) and NEUROGENE INC.. The fund showed a lot of confidence in some stocks as they added substantially to SERA PROGNOSTICS, INC. (SERA), EDGEWISE THERAPEUTICS, INC. (EWTX) and MIRATI THERAPEUTICS, INC. (MRTX).
New Buys
| Ticker | $ Bought |
|---|---|
| CEREVEL THERAPEUTICS HOLDINGS, INC. | 67,840,000 |
| CELLDEX THERAPEUTICS, INC. | 9,821,560 |
| NEUROGENE INC. | 8,789,140 |
| PFIZER INC. | 1,007,650 |
| TYRA BIOSCIENCES, INC. | 146,907 |
New stocks bought by BAKER BROS. ADVISORS LP
Additions
| Ticker | % Inc. |
|---|---|
| SERA PROGNOSTICS, INC. | 258 |
| EDGEWISE THERAPEUTICS, INC. | 196 |
| MIRATI THERAPEUTICS, INC. | 192 |
| BICYCLE THERAPEUTICS PLC | 112 |
| REPLIMUNE GROUP, INC. | 108 |
| GRACELL BIOTECHNOLOGIES INC. | 108 |
| XENCOR, INC. | 99.33 |
| REVOLUTION MEDICINES, INC. | 91.29 |
Additions to existing portfolio by BAKER BROS. ADVISORS LP
Reductions
| Ticker | % Reduced |
|---|---|
| CABALETTA BIO, INC. | -99.16 |
| PRAXIS PRECISION MEDICINES, INC. | -93.00 |
| AADI BIOSCIENCE, INC. | -74.57 |
| ATRECA, INC. | -38.36 |
| ROIVANT SCIENCES LTD. | -36.07 |
| CENTURY THERAPEUTICS, INC. | -30.62 |
| BIOCRYST PHARMACEUTICALS, INC. | -20.33 |
| ACHILLES THERAPEUTICS PLC | -17.77 |
BAKER BROS. ADVISORS LP reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| SEAGEN INC. | -9,452,170,000 |
| HERON THERAPEUTICS, INC. | -8,375,630 |
| INSTIL BIO, INC. | -2,013,480 |
| AFFIMED N.V. | -2,126,010 |
| BIOMARIN PHARMACEUTICAL INC. | -337,131,000 |
| SUMMIT THERAPEUTICS INC. | -5,872,680 |
| GERON CORPORATION | -6,489,800 |
| SPRINGWORKS THERAPEUTICS, INC. | -69,356,400 |
BAKER BROS. ADVISORS LP got rid off the above stocks
Current Stock Holdings of BAKER BROS. ADVISORS LP
Last Reported on: 14 Feb, 2024| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options |
|---|---|---|---|---|---|---|---|
| AADI | AADI BIOSCIENCE, INC. | 0.01 | 251,727 | 508,489 | REDUCED | -74.57 | |
| ABCL | ABCELLERA BIOLOGICS INC. | 1.49 | 22,909,800 | 130,815,000 | ADDED | 10.34 | |
| ACAD | ACADIA PHARMACEUTICALS INC. | 15.27 | 42,864,600 | 1,342,090,000 | UNCHANGED | 0.00 | |
| ACHL | ACHILLES THERAPEUTICS PLC | 0.02 | 2,102,790 | 1,869,380 | REDUCED | -17.77 | |
| ADAP | ADAPTIMMUNE THERAPEUTICS PLC | 0.10 | 10,969,300 | 8,698,640 | UNCHANGED | 0.00 | |
| AFMD | AFFIMED N.V. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| AKRO | AKERO THERAPEUTICS, INC. | 0.63 | 2,368,380 | 55,301,600 | UNCHANGED | 0.00 | |
| ALEC | ALECTOR, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| ALGS | ALIGOS THERAPEUTICS, INC. | 0.02 | 2,076,400 | 1,378,730 | UNCHANGED | 0.00 | |
| ANAB | ANAPTYSBIO, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| ARGX | ARGENX SE | 0.66 | 151,215 | 57,526,700 | UNCHANGED | 0.00 | |
| ARVN | ARVINAS, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| ATHA | ATHIRA PHARMA, INC. | 0.09 | 3,153,810 | 7,663,750 | UNCHANGED | 0.00 | |
| AVTE | AEROVATE THERAPEUTICS, INC. | 0.43 | 1,680,520 | 38,030,100 | REDUCED | -14.41 | |
| BCEL | ATRECA, INC. | 0.00 | 2,177,500 | 287,430 | REDUCED | -38.36 | |
| BCRX | BIOCRYST PHARMACEUTICALS, INC. | 0.69 | 10,126,200 | 60,655,800 | REDUCED | -20.33 | |
| BCYC | BICYCLE THERAPEUTICS PLC | 0.37 | 1,790,390 | 32,370,300 | ADDED | 112 | |
| BGNE | BEIGENE, LTD. | 21.69 | 10,568,900 | 1,906,210,000 | REDUCED | -9.43 | |
| BLUE | BLUEBIRD BIO, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| BMEA | BIOMEA FUSION, INC. | 0.35 | 2,108,950 | 30,621,900 | UNCHANGED | 0.00 | |
| BMRN | BIOMARIN PHARMACEUTICAL INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| CABA | CABALETTA BIO, INC. | 0.00 | 13,331 | 302,614 | REDUCED | -99.16 | |
| CELC | CELCUITY INC. | 0.09 | 535,478 | 7,801,910 | UNCHANGED | 0.00 | |
| CERE | CEREVEL THERAPEUTICS HOLDINGS, INC. | 0.77 | 1,600,000 | 67,840,000 | NEW | ||
| CERS | CERUS CORPORATION | 0.48 | 19,477,300 | 42,071,100 | ADDED | 12.98 | |
| CLDX | CELLDEX THERAPEUTICS, INC. | 0.11 | 247,644 | 9,821,560 | NEW | ||
| CMPX | COMPASS THERAPEUTICS, INC. | 0.03 | 1,557,630 | 2,429,900 | UNCHANGED | 0.00 | |
| COGT | COGENT BIOSCIENCES, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| DAWN | DAY ONE BIOPHARMACEUTICALS, INC. | 0.17 | 1,000,000 | 14,600,000 | UNCHANGED | 0.00 | |
| DBVT | DBV TECHNOLOGIES S.A. | 0.16 | 14,614,300 | 13,924,500 | UNCHANGED | 0.00 | |
| DNLI | DENALI THERAPEUTICS INC. | 0.64 | 2,607,200 | 55,950,400 | ADDED | 13.75 | |
| DSGN | DESIGN THERAPEUTICS, INC. | 0.04 | 1,500,000 | 3,975,000 | UNCHANGED | 0.00 | |
| EWTX | EDGEWISE THERAPEUTICS, INC. | 0.39 | 3,112,790 | 34,053,900 | ADDED | 196 | |
| FHTX | FOGHORN THERAPEUTICS INC. | 0.00 | 45,027 | 290,424 | UNCHANGED | 0.00 | |
| GERN | GERON CORPORATION | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| GLUE | MONTE ROSA THERAPEUTICS, INC. | 0.32 | 4,916,100 | 27,775,900 | UNCHANGED | 0.00 | |
| GRCL | GRACELL BIOTECHNOLOGIES INC. | 0.24 | 2,080,000 | 20,883,200 | ADDED | 108 | |
| GTH | GENETRON HOLDINGS LIMITED | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| HOOK | HOOKIPA PHARMA INC. | 0.07 | 8,128,150 | 6,583,800 | ADDED | 0.78 | |
| HRTX | HERON THERAPEUTICS, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| IDYA | IDEAYA BIOSCIENCES, INC. | 0.43 | 1,062,120 | 37,790,300 | UNCHANGED | 0.00 | |
| IGMS | IGM BIOSCIENCES, INC. | 0.35 | 3,691,010 | 30,672,300 | ADDED | 16.89 | |
| IMCR | IMMUNOCORE HOLDINGS PLC | 1.96 | 2,520,730 | 172,216,000 | UNCHANGED | 0.00 | |
| IMTX | IMMATICS N.V. | 0.70 | 5,838,850 | 61,483,100 | ADDED | 3.51 | |
| IMVT | IMMUNOVANT, INC. | 0.20 | 425,009 | 17,905,600 | UNCHANGED | 0.00 | |
| INCY | INCYTE CORPORATION | 25.85 | 36,179,100 | 2,271,690,000 | ADDED | 0.00 | |
| INSM | INSMED INCORPORATED | 0.12 | 343,000 | 10,629,600 | UNCHANGED | 0.00 | |
| IPSC | CENTURY THERAPEUTICS, INC. | 0.03 | 797,460 | 2,647,570 | REDUCED | -30.62 | |
| ITOS | ITEOS THERAPEUTICS, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| KALA | KALA BIO, INC. | 0.02 | 266,613 | 1,866,290 | UNCHANGED | 0.00 | |
| KNSA | KINIKSA PHARMACEUTICALS, LTD. | 0.56 | 2,809,580 | 49,280,000 | UNCHANGED | 0.00 | |
| KOD | KODIAK SCIENCES INC. | 0.60 | 17,310,500 | 52,623,900 | UNCHANGED | 0.00 | |
| KRYS | KRYSTAL BIOTECH, INC. | 0.24 | 169,934 | 21,082,000 | UNCHANGED | 0.00 | |
| KYMR | KYMERA THERAPEUTICS, INC. | 1.74 | 5,995,930 | 152,656,000 | ADDED | 26.22 | |
| LPTX | LEAP THERAPEUTICS, INC. | 0.06 | 1,172,180 | 4,858,660 | UNCHANGED | 0.00 | |
| MDGL | MADRIGAL PHARMACEUTICALS, INC. | 5.19 | 1,969,800 | 455,772,000 | ADDED | 27.49 | |
| MIRM | MIRUM PHARMACEUTICALS, INC. | 0.06 | 190,476 | 5,622,850 | UNCHANGED | 0.00 | |
| MORF | MORPHIC HOLDING, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| MRSN | MERSANA THERAPEUTICS, INC. | 0.03 | 1,086,120 | 2,519,790 | UNCHANGED | 0.00 | |
| MRTX | MIRATI THERAPEUTICS, INC. | 2.76 | 4,121,440 | 242,135,000 | ADDED | 192 | |
| NLTX | NEOLEUKIN THERAPEUTICS, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| NRIX | NURIX THERAPEUTICS, INC. | 0.46 | 3,882,120 | 40,063,500 | UNCHANGED | 0.00 | |
| NTRA | NATERA, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| NVTA | INVITAE CORPORATION | 1.49 | 300,000,000 | 131,152,000 | UNCHANGED | 0.00 | |
| NVTA | INVITAE CORPORATION | 0.07 | 9,274,000 | 6,272,700 | UNCHANGED | 0.00 | |
| NVTA | INVITAE CORPORATION | 0.01 | 1,764,550 | 1,106,020 | UNCHANGED | 0.00 | |
| OPT | OPTHEA LIMITED | 0.09 | 2,588,640 | 7,636,500 | REDUCED | -3.8 | |
| PACB | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| PCVX | VAXCYTE, INC. | 0.04 | 48,885 | 3,069,980 | UNCHANGED | 0.00 | |
| PFE | PFIZER INC. | 0.01 | 35,000 | 1,007,650 | NEW | ||
| PMVP | PMV PHARMACEUTICALS, INC. | 0.01 | 322,024 | 998,274 | UNCHANGED | 0.00 | |
| PNT | POINT BIOPHARMA GLOBAL INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| PRAX | PRAXIS PRECISION MEDICINES, INC. | 0.03 | 131,533 | 2,930,560 | REDUCED | -93.00 | |
| PRLD | PRELUDE THERAPEUTICS INC. | 0.49 | 10,123,800 | 43,228,700 | UNCHANGED | 0.00 | |
| RARE | ULTRAGENYX PHARMACEUTICAL INC. | 0.80 | 1,466,550 | 70,130,300 | ADDED | 7.32 | |
| REPL | REPLIMUNE GROUP, INC. | 0.92 | 9,545,340 | 80,467,200 | ADDED | 108 | |
| RLAY | RELAY THERAPEUTICS, INC. | 0.14 | 1,160,120 | 12,772,900 | UNCHANGED | 0.00 | |
| RNA | AVIDITY BIOSCIENCES, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| ROIV | ROIVANT SCIENCES LTD. | 0.97 | 7,593,020 | 85,269,700 | REDUCED | -36.07 | |
| RVMD | REVOLUTION MEDICINES, INC. | 1.68 | 5,148,660 | 147,663,000 | ADDED | 91.29 | |
| RYTM | RHYTHM PHARMACEUTICALS, INC. | 3.35 | 6,398,360 | 294,133,000 | REDUCED | -4.54 | |
| SANA | SANA BIOTECHNOLOGY, INC. | 0.09 | 2,000,000 | 8,160,000 | UNCHANGED | 0.00 | |
| SBTX | ARS PHARMACEUTICALS, INC. | 0.12 | 2,006,450 | 10,995,400 | UNCHANGED | 0.00 | |
| SERA | SERA PROGNOSTICS, INC. | 0.37 | 5,434,400 | 32,497,700 | ADDED | 258 | |
| SGEN | SEAGEN INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| SMMT | SUMMIT THERAPEUTICS INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| SRZN | SURROZEN, INC. | 0.00 | 833,333 | 16,167 | UNCHANGED | 0.00 | |
| STOK | STOKE THERAPEUTICS, INC. | 0.12 | 2,030,130 | 10,678,500 | ADDED | 36.63 | |
| SWTX | SPRINGWORKS THERAPEUTICS, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| TARA | PROTARA THERAPEUTICS, INC. | 0.00 | 199,671 | 374,403 | UNCHANGED | 0.00 | |
| TCRX | TSCAN THERAPEUTICS, INC. | 0.18 | 2,784,790 | 16,235,300 | UNCHANGED | 0.00 | |
| TIL | INSTIL BIO, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| TLIS | TALIS BIOMEDICAL CORPORATION | 0.04 | 508,323 | 3,787,010 | UNCHANGED | 0.00 | |
| TNGX | TANGO THERAPEUTICS, INC. | 0.08 | 750,000 | 7,425,000 | UNCHANGED | 0.00 | |
| TRDA | ENTRADA THERAPEUTICS, INC. | 0.84 | 4,865,820 | 73,425,200 | UNCHANGED | 0.00 | |
| TSHA | TAYSHA GENE THERAPIES, INC. | 0.08 | 4,004,760 | 7,088,420 | ADDED | 59.89 | |
| TSVT | 2SEVENTY BIO, INC. | 0.12 | 2,497,530 | 10,664,400 | UNCHANGED | 0.00 | |
| TYRA | TYRA BIOSCIENCES, INC. | 0.00 | 10,607 | 146,907 | NEW | ||
| VERV | VERVE THERAPEUTICS, INC. | 0.27 | 1,691,530 | 23,579,900 | ADDED | 19.41 | |
| VOR | VOR BIOPHARMA INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| XENE | XENON PHARMACEUTICALS INC. | 0.52 | 993,679 | 45,768,900 | ADDED | 32.2 | |
| XNCR | XENCOR, INC. | 0.06 | 245,431 | 5,210,500 | ADDED | 99.33 | |
| PRIME MEDICINE, INC. | 0.10 | 1,028,470 | 9,112,210 | UNCHANGED | 0.00 | ||
| NEUROGENE INC. | 0.10 | 453,516 | 8,789,140 | NEW | |||
| SAGIMET BIOSCIENCES INC. | 0.09 | 1,456,520 | 7,894,330 | ADDED | 78.64 | ||
| PERSPECTIVE THERAPEUTICS, INC. | 0.04 | 7,639,700 | 3,071,160 | UNCHANGED | 0.00 |