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Latest Palo Alto Investors LP Stock Portfolio

$653Million | No. of Holdings #51

Palo Alto Investors LP Performance

2026 Q1-2.10%
YTD-2.10%
2025+31.91%

About Palo Alto Investors LP and 13F Hedge Fund Stock Holdings

Palo Alto Investors LP is a hedge fund based in Palo Alto, CA. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, Palo Alto Investors LP reported an equity portfolio of $653.9 Millions as of 31 Mar, 2026. <br><br> The top stock holdings of Palo Alto Investors LP are INSM, ACAD, PTCT. The fund has invested 10.4% of it's portfolio in INSMED INC and 9.8% of portfolio in ACADIA PHARMACEUTICALS INC. <br><br> The fund managers got completely rid off GOSSAMER BIO INC (GOSS), GENERATION BIO CO (GBIO) and AKARI THERAPEUTICS PLC-ADR (AKTX) stocks. They significantly reduced their stock positions in AMICUS THERAPEUTICS INC (FOLD), DENALI THERAPEUTICS INC (DNLI) and XENON PHARMACEUTICALS INC (XENE). Palo Alto Investors LP opened new stock positions in CELLDEX THERAPEUTICS INC (CLDX), CYTOKINETICS INC (CYTK) and VERASTEM INC (VSTM). The fund showed a lot of confidence in some stocks as they added substantially to TRAVERE THERAPEUTICS INC (TVTX), MIRUM PHARMACEUTICALS INC (MIRM) and BICARA THERAPEUTICS INC.
Palo Alto Investors LP Equity Portfolio Value
Last Reported on: 15 May, 2026
$653Million
  as of May 15, 2026

Palo Alto Investors LP Annual Return Estimates Vs S&P 500

Our best estimate is that Palo Alto Investors LP made a return of -2.1% in the last quarter. In trailing 12 months, it's portfolio return was 40.34%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
celldex therapeutics inc9,402,060
cytokinetics inc2,121,970
verastem inc1,304,290
madrigal pharmaceuticals inc935,441
xeris biopharma holdings inc605,578
New stocks bought by Palo Alto Investors LP

Additions

Ticker% Inc.
travere therapeutics inc108
mirum pharmaceuticals inc107
bicara therapeutics inc84.34
ultragenyx pharmaceutical in29.31
disc medicine inc26.54
annexon inc23.65
taysha gene therapies inc17.6
stoke therapeutics inc17.51
Additions to existing portfolio by Palo Alto Investors LP

Reductions

Ticker% Reduced
amicus therapeutics inc-78.62
denali therapeutics inc-63.42
xenon pharmaceuticals inc-46.8
compass therapeutics inc-40.2
aldeyra therapeutics inc-30.94
biogen inc-23.34
insmed inc-15.16
iovance biotherapeutics inc-10.78
Palo Alto Investors LP reduced stake in above stock

Sold off

Ticker$ Sold
gossamer bio inc-13,861,900
akari therapeutics plc-adr-42,201
generation bio co-85,467
Palo Alto Investors LP got rid off the above stocks

Sector Distribution

Palo Alto Investors LP has about 93.3% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
Sector%
Healthcare93.3
Others6.4

Market Cap. Distribution

Palo Alto Investors LP has about 28.1% of it's portfolio invested in the large-cap and mega-cap stocks.

  • MID-CAP
  • SMALL-CAP
  • LARGE-CAP
  • UNALLOCATED
Category%
MID-CAP35.1
SMALL-CAP29.8
LARGE-CAP28.1
UNALLOCATED6.4

Stocks belong to which Index?

About 74.1% of the stocks held by Palo Alto Investors LP either belong to S&P 500 or RUSSELL 2000 index.

  • RUSSELL 2000
  • Others
  • S&P 500
Index%
RUSSELL 200068.5
Others26
S&P 5005.6
Top 5 Winners (%)%
oruka therapeutics inc
61.8 %
IOVA
iovance biotherapeutics inc
27.0 %
PYXS
pyxis oncology inc
26.6 %
ALKS
alkermes plc
26.4 %
AGIO
agios pharmaceuticals inc
24.2 %
Top 5 Winners ($)$
UTHR
united therapeutics corp
6.4 M
IOVA
iovance biotherapeutics inc
5.3 M
ANAB
anaptysbio inc
4.6 M
MIRM
mirum pharmaceuticals inc
3.2 M
SNDX
syndax pharmaceuticals inc
1.9 M
Top 5 Losers (%)%
EHTH
ehealth inc
-70.8 %
ALDX
aldeyra therapeutics inc
-57.0 %
NUVB
nuvation bio inc
-50.7 %
INSP
inspire medical systems inc
-44.1 %
BCYC
bicycle therapeutics plc-adr
-33.0 %
Top 5 Losers ($)$
ACAD
acadia pharmaceuticals inc
-11.9 M
PTCT
ptc therapeutics inc
-7.1 M
disc medicine inc
-5.6 M
EHTH
ehealth inc
-5.0 M
INSM
insmed inc
-4.8 M

Palo Alto Investors LP Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Palo Alto Investors LP

Palo Alto Investors LP has 51 stocks in it's portfolio. About 63.8% of the portfolio is in top 10 stocks. ACAD proved to be the most loss making stock for the portfolio. UTHR was the most profitable stock for Palo Alto Investors LP last quarter.

$653.86MTotal Value
54.00Positions
15 May, 2026Last Reported
Current holdings of Current Stock Holdings of Palo Alto Investors LP, last reported on 15 May, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change
AKTX
Akari Therapeutics Plc-Adr

Akari Therapeutics Plc-Adr

AKTX
Palo Alto Investors LP's holding in Akari Therapeutics Plc-Adr over time
0%0.00
$0.00
0%
decreased 100 percentsold off
BNTX
Biontech Se-Adr

Biontech Se-Adr

BNTX
Palo Alto Investors LP's holding in Biontech Se-Adr over time
0.27%19,614
$1.74M
0.27%
unchanged 0 percentunchanged
CMPS
Compass Pathways Plc Adr

Compass Pathways Plc Adr

CMPS
Palo Alto Investors LP's holding in Compass Pathways Plc Adr over time
0.1%115,616
$639.4K
0.1%
unchanged 0 percentunchanged