Latest Palo Alto Investors LP Stock Portfolio

Palo Alto Investors LP Performance:

2025 Q2: -2.1%YTD: -9.2%2024: -7.25%

Performance for 2025 Q2 is -2.1%, and YTD is -9.2%, and 2024 is -7.25%.

About Palo Alto Investors LP and 13F Hedge Fund Stock Holdings

Palo Alto Investors LP is a hedge fund based in PALO ALTO, CA. On 02-Jun-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $1.3 Billions. In it's latest 13F Holdings report, Palo Alto Investors LP reported an equity portfolio of $470 Millions as of 30 Jun, 2025.

The top stock holdings of Palo Alto Investors LP are INSM, ACAD, BMRN. The fund has invested 18.5% of it's portfolio in INSMED INC and 11.8% of portfolio in ACADIA PHARMACEUTICALS INC.

The fund managers got completely rid off SAREPTA THERAPEUTICS INC (SRPT), ACELYRIN INC and VERVE THERAPEUTICS INC (VERV) stocks. They significantly reduced their stock positions in AMICUS THERAPEUTICS INC (FOLD), PROTHENA CORP PLC (PRTA) and DYNE THERAPEUTICS INC (DYN). Palo Alto Investors LP opened new stock positions in DISC MEDICINE INC, AVIDITY BIOSCIENCES INC (RNA) and DENALI THERAPEUTICS INC (DNLI). The fund showed a lot of confidence in some stocks as they added substantially to ACLARIS THERAPEUTICS INC (ACRS), STAAR SURGICAL CO (STAA) and IOVANCE BIOTHERAPEUTICS INC (IOVA).

Palo Alto Investors LP Annual Return Estimates Vs S&P 500

Our best estimate is that Palo Alto Investors LP made a return of -2.1% in the last quarter. In trailing 12 months, it's portfolio return was -17.04%.

New Buys

Ticker	$ Bought
disc medicine inc	7,715,800
avidity biosciences inc	3,376,360
denali therapeutics inc	3,354,930
crispr therapeutics ag	2,170,560
ultragenyx pharmaceutical in	1,772,550
karyopharm therapeutics inc	809,896
alumis inc	430,311

New stocks bought by Palo Alto Investors LP

Additions

Ticker	% Inc.
aclaris therapeutics inc	79.12
staar surgical co	50.83
iovance biotherapeutics inc	6.79
ptc therapeutics inc	0.56
biogen inc	0.41

Additions to existing portfolio by Palo Alto Investors LP

Reductions

Ticker	% Reduced
amicus therapeutics inc	-23.61
prothena corp plc	-23.2
dyne therapeutics inc	-20.52
anaptysbio inc	-20.37
biomarin pharmaceutical inc	-15.21
insmed inc	-12.36
taysha gene therapies inc	-12.22
alnylam pharmaceuticals inc	-9.53

Palo Alto Investors LP reduced stake in above stock

Sold off

Ticker	$ Sold
acelyrin inc	-4,428,450
verve therapeutics inc	-2,631,480
relmada therapeutics inc	-133,689
karyopharm therapeutics inc	-1,211,880
sarepta therapeutics inc	-13,418,700
instil bio inc	-193,824

Palo Alto Investors LP got rid off the above stocks

Sector Distribution

Palo Alto Investors LP has about 96.2% of it's holdings in Healthcare sector.

Sector	%
Healthcare	96.2
Others	2.3
Financial Services	1.5

Market Cap. Distribution

Palo Alto Investors LP has about 47.7% of it's portfolio invested in the large-cap and mega-cap stocks.

Category	%
LARGE-CAP	47.7
MID-CAP	33.8
SMALL-CAP	11.9
MICRO-CAP	4.1
UNALLOCATED	2.3

Stocks belong to which Index?

About 68.9% of the stocks held by Palo Alto Investors LP either belong to S&P 500 or RUSSELL 2000 index.

Index	%
RUSSELL 2000	61
Others	31.1
S&P 500	7.9

Top 5 Winners (%)		%
STOK	stoke therapeutics inc	70.7 %
TSHA	taysha gene therapies inc	66.2 %
INSM	insmed inc	31.9 %
ACAD	acadia pharmaceuticals inc	29.9 %
URGN	urogen pharma ltd	23.9 %

Top 5 Winners ($)		$
INSM	insmed inc	24.0 M
ACAD	acadia pharmaceuticals inc	13.2 M
ALNY	alnylam pharmaceuticals inc	4.7 M
ANAB	anaptysbio inc	3.7 M
TSHA	taysha gene therapies inc	1.3 M

Top 5 Losers (%)		%
PRTA	prothena corp plc	-51.0 %
IOVA	iovance biotherapeutics inc	-46.7 %
EHTH	ehealth inc	-34.9 %
ALDX	aldeyra therapeutics inc	-33.4 %
FOLD	amicus therapeutics inc	-29.8 %

Top 5 Losers ($)		$
FOLD	amicus therapeutics inc	-17.8 M
BMRN	biomarin pharmaceutical inc	-15.6 M
PRTA	prothena corp plc	-10.5 M
IOVA	iovance biotherapeutics inc	-5.2 M
EHTH	ehealth inc	-3.9 M

Palo Alto Investors LP Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Palo Alto Investors LP

Palo Alto Investors LP has 45 stocks in it's portfolio. About 75.2% of the portfolio is in top 10 stocks. FOLD proved to be the most loss making stock for the portfolio. INSM was the most profitable stock for Palo Alto Investors LP last quarter.

Last Reported on: 14 Aug, 2025

	Ticker	Namesorted descending	% Portfolio	Shares Held	$ Value	Type	% Change
	INSM	insmed inc	18.52	865,113	87,065,000	reduced	-12.36
Historical Trend of INSMED INC Position Held By Palo Alto Investors LP What % of Portfolio is INSM?: Number of INSM shares held: Change in No. of Shares Held:
	ACAD	acadia pharmaceuticals inc	11.76	2,563,210	55,288,400	reduced	-3.78

	BMRN	biomarin pharmaceutical inc	9.83	840,470	46,200,600	reduced	-15.21

	FOLD	amicus therapeutics inc	6.84	5,610,510	32,148,200	reduced	-23.61

	UTHR	united therapeutics corp	5.84	95,482	27,436,800	reduced	-9.26

	BIIB	biogen inc	5.50	205,759	25,841,300	added	0.41

	ALNY	alnylam pharmaceuticals inc	5.24	75,535	24,631,200	reduced	-9.53

	PTCT	ptc therapeutics inc	4.22	406,469	19,851,900	added	0.56

	ANAB	anaptysbio inc	3.84	812,821	18,044,600	reduced	-20.37

	NVCR	novocure ltd	3.64	962,396	17,130,600	reduced	-3.96

	STAA	staar surgical co	2.83	791,879	13,287,700	added	50.83

	AGIO	agios pharmaceuticals inc	1.90	268,783	8,939,720	reduced	-2.82

	PRTA	prothena corp plc	1.65	1,274,750	7,737,750	reduced	-23.2

		disc medicine inc	1.64	145,691	7,715,800	new

	ALGN	align technology inc	1.52	37,772	7,151,370	unchanged	0.00

	GOSS	gossamer bio inc	1.50	5,739,010	7,058,990	reduced	-8.57

	EHTH	ehealth inc	1.46	1,577,850	6,863,650	reduced	-6.32

	ALKS	alkermes plc	1.34	221,021	6,323,410	reduced	-0.22

	IOVA	iovance biotherapeutics inc	1.25	3,429,330	5,898,450	added	6.79

	SNDX	syndax pharmaceuticals inc	0.88	444,367	4,161,500	unchanged	0.00