Latest Palo Alto Investors LP Stock Portfolio
Palo Alto Investors LP Performance:
2025 Q3: 20.69%YTD: 9.59%2024: -7.25%
Performance for 2025 Q3 is 20.69%, and YTD is 9.59%, and 2024 is -7.25%.
About Palo Alto Investors LP and 13F Hedge Fund Stock Holdings
Palo Alto Investors LP is a hedge fund based in PALO ALTO, CA. On 02-Jun-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $1.3 Billions. In it's latest 13F Holdings report, Palo Alto Investors LP reported an equity portfolio of $540.4 Millions as of 30 Sep, 2025.
The top stock holdings of Palo Alto Investors LP are INSM, PTCT, ACAD. The fund has invested 13.1% of it's portfolio in INSMED INC and 9.8% of portfolio in PTC THERAPEUTICS INC.
The fund managers got completely rid off STAAR SURGICAL CO (STAA), KARYOPHARM THERAPEUTICS INC (KPTI) and VYNE THERAPEUTICS INC PIPE (VYNE) stocks. They significantly reduced their stock positions in ALNYLAM PHARMACEUTICALS INC (ALNY), INSMED INC (INSM) and UNITED THERAPEUTICS CORP (UTHR). Palo Alto Investors LP opened new stock positions in CAREDX INC (CDNA) and ORUKA THERAPEUTICS INC. The fund showed a lot of confidence in some stocks as they added substantially to ULTRAGENYX PHARMACEUTICAL IN (RARE), DYNE THERAPEUTICS INC (DYN) and IOVANCE BIOTHERAPEUTICS INC (IOVA).
The top stock holdings of Palo Alto Investors LP are INSM, PTCT, ACAD. The fund has invested 13.1% of it's portfolio in INSMED INC and 9.8% of portfolio in PTC THERAPEUTICS INC.
The fund managers got completely rid off STAAR SURGICAL CO (STAA), KARYOPHARM THERAPEUTICS INC (KPTI) and VYNE THERAPEUTICS INC PIPE (VYNE) stocks. They significantly reduced their stock positions in ALNYLAM PHARMACEUTICALS INC (ALNY), INSMED INC (INSM) and UNITED THERAPEUTICS CORP (UTHR). Palo Alto Investors LP opened new stock positions in CAREDX INC (CDNA) and ORUKA THERAPEUTICS INC. The fund showed a lot of confidence in some stocks as they added substantially to ULTRAGENYX PHARMACEUTICAL IN (RARE), DYNE THERAPEUTICS INC (DYN) and IOVANCE BIOTHERAPEUTICS INC (IOVA).
Palo Alto Investors LP Annual Return Estimates Vs S&P 500
Our best estimate is that Palo Alto Investors LP made a return of 20.69% in the last quarter. In trailing 12 months, it's portfolio return was 1.21%.
New Buys
| Ticker | $ Bought |
|---|---|
| caredx inc | 4,597,610 |
| oruka therapeutics inc | 791,310 |
| proqr therapeutics nv | 402,159 |
New stocks bought by Palo Alto Investors LP
Additions
| Ticker | % Inc. |
|---|---|
| ultragenyx pharmaceutical in | 658 |
| dyne therapeutics inc | 376 |
| iovance biotherapeutics inc | 122 |
| ptc therapeutics inc | 112 |
| denali therapeutics inc | 70.14 |
| disc medicine inc | 53.96 |
| syndax pharmaceuticals inc | 47.38 |
| neurocrine biosciences inc | 35.87 |
Additions to existing portfolio by Palo Alto Investors LP
Reductions
| Ticker | % Reduced |
|---|---|
| alnylam pharmaceuticals inc | -57.21 |
| insmed inc | -43.15 |
| united therapeutics corp | -39.06 |
| biontech se-adr | -22.19 |
| anaptysbio inc | -17.14 |
| alkermes plc | -16.78 |
| stoke therapeutics inc | -16.24 |
| edwards lifesciences corp | -14.78 |
Palo Alto Investors LP reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| staar surgical co | -13,287,700 |
| vyne therapeutics inc pipe | -734,966 |
| karyopharm therapeutics inc | -809,896 |
| alumis inc | -430,311 |
Palo Alto Investors LP got rid off the above stocks
Sector Distribution
Palo Alto Investors LP has about 95.4% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 95.4 |
| Others | 3.3 |
| Financial Services | 1.2 |
Market Cap. Distribution
Palo Alto Investors LP has about 34.9% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| MID-CAP | 43.9 |
| LARGE-CAP | 34.9 |
| SMALL-CAP | 12.6 |
| MICRO-CAP | 5.2 |
| UNALLOCATED | 3.3 |
Stocks belong to which Index?
About 71.5% of the stocks held by Palo Alto Investors LP either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| RUSSELL 2000 | 65 |
| Others | 28.4 |
| S&P 500 | 6.5 |
Palo Alto Investors LP Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Palo Alto Investors LP
Palo Alto Investors LP has 44 stocks in it's portfolio. About 67.2% of the portfolio is in top 10 stocks. NVCR proved to be the most loss making stock for the portfolio. INSM was the most profitable stock for Palo Alto Investors LP last quarter.
Last Reported on: 14 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ABEO | abeona therapeutics inc | 0.11 | 108,865 | 574,807 | unchanged | 0.00 | ||
| ACAD | acadia pharmaceuticals inc | 9.74 | 2,466,680 | 52,639,000 | reduced | -3.77 | ||
| ACRS | aclaris therapeutics inc | 0.55 | 1,566,840 | 2,977,000 | added | 12.72 | ||
| AGIO | agios pharmaceuticals inc | 1.97 | 265,497 | 10,657,000 | reduced | -1.22 | ||
| AKTX | akari therapeutics plc-adr | 0.03 | 146,024 | 147,484 | unchanged | 0.00 | ||
| ALDX | aldeyra therapeutics inc | 0.22 | 225,465 | 1,176,930 | unchanged | 0.00 | ||
| ALGN | align technology inc | 1.06 | 45,735 | 5,726,940 | added | 21.08 | ||
| ALKS | alkermes plc | 1.02 | 183,938 | 5,518,140 | reduced | -16.78 | ||
| ALNY | alnylam pharmaceuticals inc | 2.73 | 32,320 | 14,737,900 | reduced | -57.21 | ||
| ANAB | anaptysbio inc | 3.82 | 673,520 | 20,623,200 | reduced | -17.14 | ||
| BCYC | bicycle therapeutics plc-adr | 0.32 | 221,071 | 1,711,090 | reduced | -11.19 | ||
| BIIB | biogen inc | 4.81 | 185,661 | 26,007,400 | reduced | -9.77 | ||
| BMRN | biomarin pharmaceutical inc | 7.56 | 754,007 | 40,837,000 | reduced | -10.29 | ||
| CDNA | caredx inc | 0.85 | 316,204 | 4,597,610 | new | |||
| CRSP | crispr therapeutics ag | 0.49 | 41,226 | 2,671,860 | reduced | -7.62 | ||
| DNLI | denali therapeutics inc | 1.10 | 408,006 | 5,924,250 | added | 70.14 | ||
| DYN | dyne therapeutics inc | 2.96 | 1,262,670 | 15,972,800 | added | 376 | ||
| EHTH | ehealth inc | 1.23 | 1,544,620 | 6,657,310 | reduced | -2.11 | ||
| EW | edwards lifesciences corp | 0.48 | 33,640 | 2,616,180 | reduced | -14.78 | ||
| FOLD | amicus therapeutics inc | 7.83 | 5,367,800 | 42,298,200 | reduced | -4.33 | ||