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Latest DAFNA Capital Management LLC Stock Portfolio

$439Million | No. of Holdings #82

DAFNA Capital Management LLC Performance

2026 Q1+2.56%
YTD+2.56%
2025+34.86%

About DAFNA Capital Management LLC and 13F Hedge Fund Stock Holdings

DAFNA Capital Management LLC is a hedge fund based in Los Angeles, CA. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, DAFNA Capital Management LLC reported an equity portfolio of $439.6 Millions as of 31 Mar, 2026. <br><br> The top stock holdings of DAFNA Capital Management LLC are RVMD, BIL, STXS. The fund has invested 12.8% of it's portfolio in REVOLUTION MEDICINES INC and 9.3% of portfolio in SPDR S&P BIOTECH ETF. <br><br> The fund managers got completely rid off ASTRIA THERAPEUTICS INC (ATXS), ERASCA INC (ERAS) and BRAINSWAY LTD (BWAY) stocks. They significantly reduced their stock positions in ANNEXON INC (ANNX), AXOGEN INC (AXGN) and CYTOKINETICS INC (CYTK). DAFNA Capital Management LLC opened new stock positions in FULCRUM THERAPEUTICS INC (FULC), ORTHOPEDIATRICS CORP (KIDS) and CYTOMX THERAPEUTICS INC (CTMX). The fund showed a lot of confidence in some stocks as they added substantially to ULTRAGENYX PHARMACEUTICAL INC (RARE), COMPASS PATHWAYS PLC (CMPS) and NEKTAR THERAPEUTICS (NKTR).
DAFNA Capital Management LLC Equity Portfolio Value
Last Reported on: 15 May, 2026
$439Million
  as of May 15, 2026

DAFNA Capital Management LLC Annual Return Estimates Vs S&P 500

Our best estimate is that DAFNA Capital Management LLC made a return of 2.56% in the last quarter. In trailing 12 months, it's portfolio return was 59.72%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
fulcrum therapeutics inc1,572,350
orthopediatrics corp1,518,110
cytomx therapeutics inc1,081,000
maze therapeutics inc1,044,750
scynexis inc996,630
zenas biopharma inc830,875
newamsterdam pharma co640,200
pliant therapeutics inc613,620
New stocks bought by DAFNA Capital Management LLC

Additions

Ticker% Inc.
ultragenyx pharmaceutical inc281
compass pathways plc198
nektar therapeutics120
larimar therapeutics inc116
inspire medical systems inc111
neurogene inc102
bicara therapeutics inc61.22
insulet corp58.22
Additions to existing portfolio by DAFNA Capital Management LLC

Reductions

Ticker% Reduced
annexon inc-56.82
axogen inc-47.58
cytokinetics inc-41.37
oric pharmaceuticals inc-30.01
edgewise therapeutics inc-29.74
ars pharmaceuticals inc-26.72
kalvista pharmaceuticals inc-25.06
syndax pharmaceuticals inc-21.77
DAFNA Capital Management LLC reduced stake in above stock

Sold off

Ticker$ Sold
astria therapeutics inc-3,989,500
erasca inc-946,502
perspective therapeutics inc-137,500
brainsway ltd-246,594
DAFNA Capital Management LLC got rid off the above stocks

Sector Distribution

DAFNA Capital Management LLC has about 74.1% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
Sector%
Healthcare74.1
Others25.6

Market Cap. Distribution

DAFNA Capital Management LLC has about 17.6% of it's portfolio invested in the large-cap and mega-cap stocks.

  • SMALL-CAP
  • UNALLOCATED
  • LARGE-CAP
  • MID-CAP
  • MICRO-CAP
Category%
SMALL-CAP27.5
UNALLOCATED25.6
LARGE-CAP17.6
MID-CAP17.2
MICRO-CAP11.7

Stocks belong to which Index?

About 53.6% of the stocks held by DAFNA Capital Management LLC either belong to S&P 500 or RUSSELL 2000 index.

  • RUSSELL 2000
  • Others
  • S&P 500
Index%
RUSSELL 200051.2
Others46.4
S&P 5002.4
Top 5 Winners (%)%
DAWN
day one biopharmaceuticals i
128.7 %
IPSC
century therapeutics inc
119.0 %
ALLO
allogene therapeutics inc
77.8 %
NKTR
nektar therapeutics
42.8 %
CGEN
compugen ltd
38.2 %
Top 5 Winners ($)$
DAWN
day one biopharmaceuticals i
12.0 M
RVMD
revolution medicines inc
10.4 M
XENE
xenon pharmaceuticals inc
3.6 M
NKTR
nektar therapeutics
3.6 M
IPSC
century therapeutics inc
3.3 M
Top 5 Losers (%)%
ARAY
accuray inc
-50.7 %
TELA
tela bio inc
-47.5 %
lexeo therapeutics inc
-41.0 %
CYBN
cybin inc
-40.3 %
INSP
inspire medical systems inc
-36.7 %
Top 5 Losers ($)$
ATRC
atricure inc
-6.6 M
STXS
stereotaxis inc
-6.3 M
biohaven ltd
-2.5 M
CMPS
compass pathways plc
-2.2 M
CYBN
cybin inc
-1.6 M

DAFNA Capital Management LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of DAFNA Capital Management LLC

DAFNA Capital Management LLC has 82 stocks in it's portfolio. About 52.4% of the portfolio is in top 10 stocks. ATRC proved to be the most loss making stock for the portfolio. DAWN was the most profitable stock for DAFNA Capital Management LLC last quarter.

$439.59MTotal Value
87.00Positions
15 May, 2026Last Reported
Current holdings of Current Stock Holdings of DAFNA Capital Management LLC, last reported on 15 May, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change
ADCT
Adc Therapeutics Sa

Adc Therapeutics Sa

ADCT
DAFNA Capital Management LLC's holding in Adc Therapeutics Sa over time
0.06%72,081
$270.3K
0.06%
decreased 6.49 percentreduced
ASND
Ascendis Pharma A/S

Ascendis Pharma A/S

ASND
DAFNA Capital Management LLC's holding in Ascendis Pharma A/S over time
1.35%4,000,000
$5.92M
1.35%
unchanged 0 percentunchanged
ASND
Ascendis Pharma A/S

Ascendis Pharma A/S

ASND
DAFNA Capital Management LLC's holding in Ascendis Pharma A/S over time
1.21%23,177
$5.30M
1.21%
decreased 17.74 percentreduced
AUTL
Autolus Therapeutics Ltd

Autolus Therapeutics Ltd

AUTL
DAFNA Capital Management LLC's holding in Autolus Therapeutics Ltd over time
0.06%179,316
$247.5K
0.06%
unchanged 0 percentunchanged
BIL
Spdr S&P Biotech Etf

Spdr S&P Biotech Etf

BIL
DAFNA Capital Management LLC's holding in Spdr S&P Biotech Etf over time
9.26%318,505
$40.68M
9.26%
decreased 5.35 percentreduced
BNTX
Biontech Se

Biontech Se

BNTX
DAFNA Capital Management LLC's holding in Biontech Se over time
0.14%7,000
$622.2K
0.14%
unchanged 0 percentunchanged
BWAY
Brainsway Ltd

Brainsway Ltd

BWAY
DAFNA Capital Management LLC's holding in Brainsway Ltd over time
0%0.00
$0.00
0%
decreased 100 percentsold off