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Latest DAFNA Capital Management LLC Stock Portfolio

$524Million | No. of Holdings #88

DAFNA Capital Management LLC Performance

2026 Q2+23.87%
YTD+27.04%
2025+34.86%

About DAFNA Capital Management LLC and 13F Hedge Fund Stock Holdings

DAFNA Capital Management LLC is a hedge fund based in Los Angeles, CA. On 2026-08-14, the fund reported it's updated stock portfolio. In the 13F Holdings report, DAFNA Capital Management LLC reported an equity portfolio of $524.4 Millions as of 30 Jun, 2026. <br><br> The top stock holdings of DAFNA Capital Management LLC are RVMD, BIL, CMPS. The fund has invested 20.1% of it's portfolio in REVOLUTION MEDICINES INC and 5.9% of portfolio in SPDR S&P BIOTECH ETF. <br><br> The fund managers got completely rid off DAY ONE BIOPHARMACEUTICALS I (DAWN), KALVISTA PHARMACEUTICALS INC (KALV) and ASCENDIS PHARMA A/S (ASND) stocks. They significantly reduced their stock positions in MBX BIOSCIENCES INC, VERRICA PHARMACEUTICALS INC (VRCA) and KURA ONCOLOGY INC (KURA). DAFNA Capital Management LLC opened new stock positions in ASCENDIS PHARMA A/S, KYMERA THERAPEUTICS INC (KYMR) and DESIGN THERAPEUTICS INC (DSGN). The fund showed a lot of confidence in some stocks as they added substantially to INSULET CORP (PODD), ANNEXON INC (ANNX) and DENALI THERAPEUTICS INC (DNLI).
DAFNA Capital Management LLC Equity Portfolio Value
Last Reported on: 14 Aug, 2026
$524Million
  as of Aug 14, 2026

DAFNA Capital Management LLC Annual Return Estimates Vs S&P 500

Our best estimate is that DAFNA Capital Management LLC made a return of 23.87% in the last quarter. In trailing 12 months, it's portfolio return was 88.85%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
ascendis pharma a/s12,927,700
kymera therapeutics inc3,096,090
adlai nortye ltd2,754,860
nervgen pharma corp2,163,000
atrium therapeutics inc1,721,600
eupraxia pharmaceuticals inc1,491,220
design therapeutics inc1,484,620
corbus pharmaceuticals hldgs1,010,910
New stocks bought by DAFNA Capital Management LLC

Additions

Ticker% Inc.
insulet corp469
annexon inc152
denali therapeutics inc132
edgewise therapeutics inc102
orthopediatrics corp97.71
nektar therapeutics92.75
cytomx therapeutics inc90.61
maze therapeutics inc85.71
Additions to existing portfolio by DAFNA Capital Management LLC

Reductions

Ticker% Reduced
mbx biosciences inc-93.27
verrica pharmaceuticals inc-84.55
biohaven ltd-83.73
kura oncology inc-48.88
immatics nv-48.22
spdr s&p biotech etf-38.3
compugen ltd-34.74
bicara therapeutics inc-32.43
DAFNA Capital Management LLC reduced stake in above stock

Sold off

Ticker$ Sold
ascendis pharma a/s-5,916,500
day one biopharmaceuticals i-20,978,200
kalvista pharmaceuticals inc-5,382,800
fulcrum therapeutics inc-1,572,350
engene holdings inc-1,275,870
scynexis inc-996,630
oric pharmaceuticals inc-945,460
neumora therapeutics inc-136,500
DAFNA Capital Management LLC got rid off the above stocks

Sector Distribution

DAFNA Capital Management LLC has about 78.7% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
Sector%
Healthcare78.7
Others21

Market Cap. Distribution

DAFNA Capital Management LLC has about 25.3% of it's portfolio invested in the large-cap and mega-cap stocks.

  • MID-CAP
  • LARGE-CAP
  • UNALLOCATED
  • SMALL-CAP
  • MICRO-CAP
Category%
MID-CAP28
LARGE-CAP25.3
UNALLOCATED21
SMALL-CAP18.3
MICRO-CAP7

Stocks belong to which Index?

About 57.1% of the stocks held by DAFNA Capital Management LLC either belong to S&P 500 or RUSSELL 2000 index.

  • RUSSELL 2000
  • Others
  • S&P 500
Index%
RUSSELL 200053.7
Others42.9
S&P 5003.4
Top 5 Winners (%)%
CMPS
compass pathways plc
142.8 %
FATE
fate therapeutics inc
122.2 %
RVMD
revolution medicines inc
91.1 %
maplight therapeutics inc
76.3 %
IMVT
immunovant inc
54.9 %
Top 5 Winners ($)$
RVMD
revolution medicines inc
51.5 M
CMPS
compass pathways plc
19.1 M
BIL
spdr s&p biotech etf
7.9 M
RCUS
arcus biosciences inc
4.1 M
CYTK
cytokinetics inc
3.8 M
Top 5 Losers (%)%
ADCT
adc therapeutics sa
-70.8 %
ARAY
accuray inc
-33.6 %
LRMR
larimar therapeutics inc
-32.1 %
TNDM
tandem diabetes care inc
-21.3 %
lexeo therapeutics inc
-18.9 %
Top 5 Losers ($)$
LRMR
larimar therapeutics inc
-2.9 M
PODD
insulet corp
-2.1 M
STXS
stereotaxis inc
-1.6 M
TNDM
tandem diabetes care inc
-1.4 M
ALLO
allogene therapeutics inc
-0.6 M

DAFNA Capital Management LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of DAFNA Capital Management LLC

DAFNA Capital Management LLC has 88 stocks in it's portfolio. About 56.2% of the portfolio is in top 10 stocks. LRMR proved to be the most loss making stock for the portfolio. RVMD was the most profitable stock for DAFNA Capital Management LLC last quarter.

$524.36MTotal Value
100Positions
14 Aug, 2026Last Reported
Current holdings of Current Stock Holdings of DAFNA Capital Management LLC, last reported on 14 Aug, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change
ADCT
Adc Therapeutics Sa

Adc Therapeutics Sa

ADCT
DAFNA Capital Management LLC's holding in Adc Therapeutics Sa over time
0.02%77,081
$82.5K
0.02%
increased 6.94 percentadded
ASND
Ascendis Pharma A/S

Ascendis Pharma A/S

ASND
DAFNA Capital Management LLC's holding in Ascendis Pharma A/S over time
0%0.00
$0.00
0%
decreased 100 percentsold off
ASND
Ascendis Pharma A/S

Ascendis Pharma A/S

ASND
DAFNA Capital Management LLC's holding in Ascendis Pharma A/S over time
0%0.00
$0.00
0%
decreased 100 percentsold off
AUTL
Autolus Therapeutics Ltd

Autolus Therapeutics Ltd

AUTL
DAFNA Capital Management LLC's holding in Autolus Therapeutics Ltd over time
0.06%179,316
$286.9K
0.06%
unchanged 0 percentunchanged
BIL
Spdr S&P Biotech Etf

Spdr S&P Biotech Etf

BIL
DAFNA Capital Management LLC's holding in Spdr S&P Biotech Etf over time
5.93%196,505
$31.10M
5.93%
decreased 38.3 percentreduced
BNTX
Biontech Se

Biontech Se

BNTX
DAFNA Capital Management LLC's holding in Biontech Se over time
0.12%7,000
$651.4K
0.12%
unchanged 0 percentunchanged
CGEN
Compugen Ltd

Compugen Ltd

CGEN
DAFNA Capital Management LLC's holding in Compugen Ltd over time
0.07%168,232
$360.0K
0.07%
decreased 34.74 percentreduced