Latest RTW INVESTMENTS, LP Stock Portfolio
RTW INVESTMENTS, LP Performance:
2025 Q3: 21.67%YTD: 27.07%2024: 1.15%
Performance for 2025 Q3 is 21.67%, and YTD is 27.07%, and 2024 is 1.15%.
About RTW INVESTMENTS, LP and 13F Hedge Fund Stock Holdings
RTW INVESTMENTS, LP is a hedge fund based in NEW YORK, NY. On 30-May-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $7.2 Billions. In it's latest 13F Holdings report, RTW INVESTMENTS, LP reported an equity portfolio of $8.1 Billions as of 30 Sep, 2025.
The top stock holdings of RTW INVESTMENTS, LP are MDGL, , RNA. The fund has invested 11.3% of it's portfolio in MADRIGAL PHARMACEUTICALS INC and 6.1% of portfolio in ARGENX SE .
The fund managers got completely rid off VERONA PHARMA PLC (VRNA), ABBOTT LABS (ABT) and SOLENO THERAPEUTICS INC (SLNO) stocks. They significantly reduced their stock positions in ALKERMES PLC (ALKS), ZAI LAB LTD (ZLAB) and QUEST DIAGNOSTICS INC (DGX). RTW INVESTMENTS, LP opened new stock positions in COGENT BIOSCIENCES INC (COGT), AQUESTIVE THERAPEUTICS INC (AQST) and ABIVAX SA. The fund showed a lot of confidence in some stocks as they added substantially to REPLIMUNE GROUP INC (REPL), XENCOR INC (XNCR) and ULTRAGENYX PHARMACEUTICAL IN (RARE).
The top stock holdings of RTW INVESTMENTS, LP are MDGL, , RNA. The fund has invested 11.3% of it's portfolio in MADRIGAL PHARMACEUTICALS INC and 6.1% of portfolio in ARGENX SE .
The fund managers got completely rid off VERONA PHARMA PLC (VRNA), ABBOTT LABS (ABT) and SOLENO THERAPEUTICS INC (SLNO) stocks. They significantly reduced their stock positions in ALKERMES PLC (ALKS), ZAI LAB LTD (ZLAB) and QUEST DIAGNOSTICS INC (DGX). RTW INVESTMENTS, LP opened new stock positions in COGENT BIOSCIENCES INC (COGT), AQUESTIVE THERAPEUTICS INC (AQST) and ABIVAX SA. The fund showed a lot of confidence in some stocks as they added substantially to REPLIMUNE GROUP INC (REPL), XENCOR INC (XNCR) and ULTRAGENYX PHARMACEUTICAL IN (RARE).
RTW INVESTMENTS, LP Annual Return Estimates Vs S&P 500
Our best estimate is that RTW INVESTMENTS, LP made a return of 21.67% in the last quarter. In trailing 12 months, it's portfolio return was 26.69%.
New Buys
| Ticker | $ Bought |
|---|---|
| cogent biosciences inc | 49,793,100 |
| aquestive therapeutics inc | 34,937,500 |
| abivax sa | 29,715,000 |
| belite bio inc | 23,125,000 |
| alector inc | 20,692,800 |
| heartflow inc | 16,661,700 |
| larimar therapeutics inc | 10,093,800 |
| compass therapeutics inc | 8,750,000 |
New stocks bought by RTW INVESTMENTS, LP
Additions
| Ticker | % Inc. |
|---|---|
| replimune group inc | 209 |
| xencor inc | 158 |
| ultragenyx pharmaceutical in | 90.83 |
| crinetics pharmaceuticals in | 86.81 |
| guardant health inc | 72.92 |
| dyne therapeutics inc | 70.98 |
| centessa pharmaceuticals plc | 49.8 |
| verastem inc | 27.63 |
Additions to existing portfolio by RTW INVESTMENTS, LP
Reductions
| Ticker | % Reduced |
|---|---|
| alkermes plc | -64.28 |
| zai lab ltd | -58.62 |
| quest diagnostics inc | -50.00 |
| tempus ai inc | -50.00 |
| merus n v | -49.38 |
| ge healthcare technologies i | -37.14 |
| axsome therapeutics inc | -26.24 |
| natera inc | -22.89 |
RTW INVESTMENTS, LP reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| verona pharma plc | -288,647,000 |
| 89bio inc | -19,321,100 |
| cargo therapeutics inc | -4,995,760 |
| moonlake immunotherapeutics | -34,979,400 |
| abbott labs | -60,388,400 |
| soleno therapeutics inc | -35,556,900 |
| immunic inc | -280,470 |
| kestra med technologies ltd | -3,316,000 |
RTW INVESTMENTS, LP got rid off the above stocks
Sector Distribution
RTW INVESTMENTS, LP has about 85.9% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 85.9 |
| Others | 14.1 |
Market Cap. Distribution
RTW INVESTMENTS, LP has about 16.2% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| MID-CAP | 46.1 |
| SMALL-CAP | 19.3 |
| UNALLOCATED | 16.3 |
| LARGE-CAP | 16.2 |
| MICRO-CAP | 1.6 |
Stocks belong to which Index?
About 60.1% of the stocks held by RTW INVESTMENTS, LP either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| RUSSELL 2000 | 56.2 |
| Others | 39.8 |
| S&P 500 | 3.9 |
RTW INVESTMENTS, LP Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of RTW INVESTMENTS, LP
RTW INVESTMENTS, LP has 74 stocks in it's portfolio. About 52.6% of the portfolio is in top 10 stocks. AKRO proved to be the most loss making stock for the portfolio. MDGL was the most profitable stock for RTW INVESTMENTS, LP last quarter.
Last Reported on: 14 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ABT | abbott labs | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ACAD | acadia pharmaceuticals inc | 1.88 | 7,144,520 | 152,464,000 | reduced | -20.58 | ||
| AGLE | spyre therapeutics inc | 0.75 | 3,622,000 | 60,704,700 | unchanged | 0.00 | ||
| AKRO | akero therapeutics inc | 3.20 | 5,477,560 | 260,075,000 | unchanged | 0.00 | ||
| ALEC | alector inc | 0.26 | 6,990,810 | 20,692,800 | new | |||
| ALKS | alkermes plc | 0.62 | 1,672,360 | 50,170,700 | reduced | -64.28 | ||
| AQST | aquestive therapeutics inc | 0.43 | 6,250,000 | 34,937,500 | new | |||
| AVTE | jade biosciences inc | 0.15 | 1,449,270 | 12,507,200 | unchanged | 0.00 | ||
| AXSM | axsome therapeutics inc | 1.67 | 1,118,880 | 135,888,000 | reduced | -26.24 | ||
| CGEM | cullinan therapeutics inc | 0.12 | 1,705,960 | 10,116,300 | unchanged | 0.00 | ||
| CMPS | compass pathways plc | 0.62 | 8,707,390 | 49,893,300 | added | 5.9 | ||
| CMPX | compass therapeutics inc | 0.11 | 2,500,000 | 8,750,000 | new | |||
| CNTA | centessa pharmaceuticals plc | 0.69 | 2,291,750 | 55,574,900 | added | 49.8 | ||
| COGT | cogent biosciences inc | 0.61 | 3,467,490 | 49,793,100 | new | |||
| CRNX | crinetics pharmaceuticals in | 0.45 | 872,387 | 36,334,900 | added | 86.81 | ||
| CRVS | corvus pharmaceuticals inc | 0.24 | 2,679,480 | 19,747,800 | unchanged | 0.00 | ||
| CTMX | cytomx therapeutics inc | 0.14 | 3,461,500 | 11,042,200 | unchanged | 0.00 | ||
| CYTK | cytokinetics inc | 1.84 | 2,721,160 | 149,555,000 | unchanged | 0.00 | ||
| DGX | quest diagnostics inc | 0.59 | 250,000 | 47,645,000 | reduced | -50.00 | ||
| DYN | dyne therapeutics inc | 0.45 | 2,890,570 | 36,565,700 | added | 70.98 | ||