Grufity logo
Grufity logo

Latest RTW INVESTMENTS, LP Stock Portfolio

$10.05Billion | No. of Holdings #88

RTW INVESTMENTS, LP Performance

2026 Q1-2.55%
YTD-2.55%
2025+49.25%

About RTW INVESTMENTS, LP and 13F Hedge Fund Stock Holdings

RTW INVESTMENTS, LP is a hedge fund based in New York, NY. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, RTW INVESTMENTS, LP reported an equity portfolio of $10 Billions as of 31 Mar, 2026. <br><br> The top stock holdings of RTW INVESTMENTS, LP are MDGL, INSM, PTGX. The fund has invested 10.4% of it's portfolio in MADRIGAL PHARMACEUTICALS INC and 7.9% of portfolio in INSMED INC. <br><br> The fund managers got completely rid off PENUMBRA INC (PEN), AXSOME THERAPEUTICS INC (AXSM) and INSULET CORP (PODD) stocks. They significantly reduced their stock positions in JADE BIOSCIENCES INC (AVTE), STRYKER CORPORATION (SYK) and LARIMAR THERAPEUTICS INC (LRMR). RTW INVESTMENTS, LP opened new stock positions in WAYSTAR HLDG CORP, CANDEL THERAPEUTICS INC (CADL) and CENTURY THERAPEUTICS INC (IPSC). The fund showed a lot of confidence in some stocks as they added substantially to ERASCA INC (ERAS), TANGO THERAPEUTICS INC (TNGX) and CELCUITY INC (CELC).
RTW INVESTMENTS, LP Equity Portfolio Value
Last Reported on: 15 May, 2026
$10.05Billion
  as of May 15, 2026

RTW INVESTMENTS, LP Annual Return Estimates Vs S&P 500

Our best estimate is that RTW INVESTMENTS, LP made a return of -2.55% in the last quarter. In trailing 12 months, it's portfolio return was 47.88%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
waystar hldg corp39,299,300
candel therapeutics inc31,467,900
aktis oncology inc28,481,600
dianthus therapeutics inc20,817,400
century therapeutics inc19,652,200
avalo therapeutics inc12,794,400
ocugen inc12,066,700
ataibeckley inc7,080,000
New stocks bought by RTW INVESTMENTS, LP

Additions

Ticker% Inc.
erasca inc10,917
tango therapeutics inc791
celcuity inc452
hinge health inc445
cg oncology inc247
milestone pharmaceuticals in152
intuitive surgical inc117
fulgent genetics inc82.83
Additions to existing portfolio by RTW INVESTMENTS, LP

Reductions

Ticker% Reduced
jade biosciences inc-60.45
stryker corporation-59.18
larimar therapeutics inc-52.00
apellis pharmaceuticals inc-51.93
exagen inc-50.00
uniqure nv-30.31
cogent biosciences inc-28.1
beta bionics inc-20.00
RTW INVESTMENTS, LP reduced stake in above stock

Sold off

Ticker$ Sold
allurion technologies inc -7,246,460
atai beckley nv -8,180,000
rapt therapeutics inc -55,450,800
axsome therapeutics inc -162,184,000
penumbra inc -269,403,000
masimo corp -88,869,200
corvus pharmaceuticals inc -3,446,570
insulet corp -92,264,300
RTW INVESTMENTS, LP got rid off the above stocks

Sector Distribution

RTW INVESTMENTS, LP has about 78.7% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
Sector%
Healthcare78.7
Others21.3

Market Cap. Distribution

RTW INVESTMENTS, LP has about 26.1% of it's portfolio invested in the large-cap and mega-cap stocks.

  • MID-CAP
  • LARGE-CAP
  • UNALLOCATED
  • SMALL-CAP
Category%
MID-CAP38.7
LARGE-CAP26.1
UNALLOCATED21.3
SMALL-CAP13.3

Stocks belong to which Index?

About 62.4% of the stocks held by RTW INVESTMENTS, LP either belong to S&P 500 or RUSSELL 2000 index.

  • RUSSELL 2000
  • Others
  • S&P 500
Index%
RUSSELL 200061.1
Others37.6
S&P 5001.3
Top 5 Winners (%)%
ERAS
erasca inc
63.5 %
oruka therapeutics inc
61.8 %
crescent biopharma inc.
54.9 %
AGLE
spyre therapeutics inc
54.0 %
CNTA
centessa pharmaceuticals plc
53.0 %
Top 5 Winners ($)$
cg oncology inc
117.7 M
ERAS
erasca inc
101.6 M
PTGX
protagonist therapeutics inc
91.4 M
TNGX
tango therapeutics inc
89.2 M
APLS
apellis pharmaceuticals inc
85.8 M
Top 5 Losers (%)%
beta bionics inc
-60.4 %
WVE
wave life sciences ltd
-57.4 %
lumexa imaging holdings inc
-53.5 %
XGN
exagen inc
-38.0 %
CSTL
castle biosciences inc
-34.0 %
Top 5 Losers ($)$
MDGL
madrigal pharmaceuticals inc
-117.4 M
IRTC
irhythm holdings inc
-84.7 M
ARGX
argenx se
-76.5 M
RDNT
radnet inc
-63.6 M
PTCT
ptc therapeutics inc
-60.7 M

RTW INVESTMENTS, LP Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of RTW INVESTMENTS, LP

RTW INVESTMENTS, LP has 88 stocks in it's portfolio. About 50% of the portfolio is in top 10 stocks. MDGL proved to be the most loss making stock for the portfolio. was the most profitable stock for RTW INVESTMENTS, LP last quarter.

$10.05BTotal Value
100Positions
15 May, 2026Last Reported
Current holdings of Current Stock Holdings of RTW INVESTMENTS, LP, last reported on 15 May, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change
ARGX
Argenx Se

Argenx Se

ARGX
RTW INVESTMENTS, LP's holding in Argenx Se over time
5.16%709,446
$518.07M
5.16%
increased 5.34 percentadded
BLTE
Belite Bio Inc

Belite Bio Inc

BLTE
RTW INVESTMENTS, LP's holding in Belite Bio Inc over time
1.14%715,332
$114.05M
1.14%
unchanged 0 percentunchanged
CMPS
Compass Pathways Plc

Compass Pathways Plc

CMPS
RTW INVESTMENTS, LP's holding in Compass Pathways Plc over time
0.58%10,632,400
$58.80M
0.58%
increased 21.41 percentadded