Latest RTW INVESTMENTS, LP Stock Portfolio
$10.05Billion– No. of Holdings #88
RTW INVESTMENTS, LP Performance:
2026 Q1: -2.55%YTD: -2.55%2025: 49.25%
Performance for 2026 Q1 is -2.55%, and YTD is -2.55%, and 2025 is 49.25%.
About RTW INVESTMENTS, LP and 13F Hedge Fund Stock Holdings
RTW INVESTMENTS, LP is a hedge fund based in New York, NY. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, RTW INVESTMENTS, LP reported an equity portfolio of $10 Billions as of 31 Mar, 2026.
The top stock holdings of RTW INVESTMENTS, LP are MDGL, INSM, PTGX. The fund has invested 10.4% of it's portfolio in MADRIGAL PHARMACEUTICALS INC and 7.9% of portfolio in INSMED INC.
The fund managers got completely rid off PENUMBRA INC (PEN), AXSOME THERAPEUTICS INC (AXSM) and INSULET CORP (PODD) stocks. They significantly reduced their stock positions in JADE BIOSCIENCES INC (AVTE), STRYKER CORPORATION (SYK) and LARIMAR THERAPEUTICS INC (LRMR). RTW INVESTMENTS, LP opened new stock positions in WAYSTAR HLDG CORP, CANDEL THERAPEUTICS INC (CADL) and CENTURY THERAPEUTICS INC (IPSC). The fund showed a lot of confidence in some stocks as they added substantially to ERASCA INC (ERAS), TANGO THERAPEUTICS INC (TNGX) and CELCUITY INC (CELC).
The top stock holdings of RTW INVESTMENTS, LP are MDGL, INSM, PTGX. The fund has invested 10.4% of it's portfolio in MADRIGAL PHARMACEUTICALS INC and 7.9% of portfolio in INSMED INC.
The fund managers got completely rid off PENUMBRA INC (PEN), AXSOME THERAPEUTICS INC (AXSM) and INSULET CORP (PODD) stocks. They significantly reduced their stock positions in JADE BIOSCIENCES INC (AVTE), STRYKER CORPORATION (SYK) and LARIMAR THERAPEUTICS INC (LRMR). RTW INVESTMENTS, LP opened new stock positions in WAYSTAR HLDG CORP, CANDEL THERAPEUTICS INC (CADL) and CENTURY THERAPEUTICS INC (IPSC). The fund showed a lot of confidence in some stocks as they added substantially to ERASCA INC (ERAS), TANGO THERAPEUTICS INC (TNGX) and CELCUITY INC (CELC).
RTW INVESTMENTS, LP Equity Portfolio Value
Last Reported on: 15 May, 2026
RTW INVESTMENTS, LP Annual Return Estimates Vs S&P 500
Our best estimate is that RTW INVESTMENTS, LP made a return of -2.55% in the last quarter. In trailing 12 months, it's portfolio return was 47.88%.
- Performance
- S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| waystar hldg corp | 39,299,300 |
| candel therapeutics inc | 31,467,900 |
| aktis oncology inc | 28,481,600 |
| dianthus therapeutics inc | 20,817,400 |
| century therapeutics inc | 19,652,200 |
| avalo therapeutics inc | 12,794,400 |
| ocugen inc | 12,066,700 |
| ataibeckley inc | 7,080,000 |
New stocks bought by RTW INVESTMENTS, LP
Additions
| Ticker | % Inc. |
|---|---|
| erasca inc | 10,917 |
| tango therapeutics inc | 791 |
| celcuity inc | 452 |
| hinge health inc | 445 |
| cg oncology inc | 247 |
| milestone pharmaceuticals in | 152 |
| intuitive surgical inc | 117 |
| fulgent genetics inc | 82.83 |
Additions to existing portfolio by RTW INVESTMENTS, LP
Reductions
| Ticker | % Reduced |
|---|---|
| jade biosciences inc | -60.45 |
| stryker corporation | -59.18 |
| larimar therapeutics inc | -52.00 |
| apellis pharmaceuticals inc | -51.93 |
| exagen inc | -50.00 |
| uniqure nv | -30.31 |
| cogent biosciences inc | -28.1 |
| beta bionics inc | -20.00 |
RTW INVESTMENTS, LP reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| allurion technologies inc | -7,246,460 |
| atai beckley nv | -8,180,000 |
| rapt therapeutics inc | -55,450,800 |
| axsome therapeutics inc | -162,184,000 |
| penumbra inc | -269,403,000 |
| masimo corp | -88,869,200 |
| corvus pharmaceuticals inc | -3,446,570 |
| insulet corp | -92,264,300 |
RTW INVESTMENTS, LP got rid off the above stocks
Sector Distribution
RTW INVESTMENTS, LP has about 78.7% of it's holdings in Healthcare sector.
- Healthcare
- Others
| Sector | % |
|---|---|
| Healthcare | 78.7 |
| Others | 21.3 |
Market Cap. Distribution
RTW INVESTMENTS, LP has about 26.1% of it's portfolio invested in the large-cap and mega-cap stocks.
- MID-CAP
- LARGE-CAP
- UNALLOCATED
- SMALL-CAP
| Category | % |
|---|---|
| MID-CAP | 38.7 |
| LARGE-CAP | 26.1 |
| UNALLOCATED | 21.3 |
| SMALL-CAP | 13.3 |
Stocks belong to which Index?
About 62.4% of the stocks held by RTW INVESTMENTS, LP either belong to S&P 500 or RUSSELL 2000 index.
- RUSSELL 2000
- Others
- S&P 500
| Index | % |
|---|---|
| RUSSELL 2000 | 61.1 |
| Others | 37.6 |
| S&P 500 | 1.3 |
RTW INVESTMENTS, LP Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of RTW INVESTMENTS, LP
RTW INVESTMENTS, LP has 88 stocks in it's portfolio. About 50% of the portfolio is in top 10 stocks. MDGL proved to be the most loss making stock for the portfolio. was the most profitable stock for RTW INVESTMENTS, LP last quarter.
Last Reported on: 15 May, 2026| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ACAD | acadia pharmaceuticals inc | 1.58 | 7,144,520 | 159,037,000 | unchanged | 0.00 | ||
| AGLE | spyre therapeutics inc | 2.09 | 4,172,000 | 210,435,000 | unchanged | 0.00 | ||
| ALKS | alkermes plc | 0.59 | 1,672,360 | 59,134,500 | unchanged | 0.00 | ||
| APLS | apellis pharmaceuticals inc | 1.48 | 3,685,040 | 148,249,000 | reduced | -51.93 | ||
| AQST | aquestive therapeutics inc | 0.31 | 7,426,470 | 30,819,900 | added | 18.82 | ||
| ARGX | argenx se | 5.16 | 709,446 | 518,073,000 | added | 5.34 | ||
| ARWR | arrowhead pharmaceuticals in | 0.36 | 585,682 | 36,722,300 | added | 0.17 | ||
| ATAI | atai beckley nv | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AVTE | jade biosciences inc | 0.08 | 573,205 | 8,053,530 | reduced | -60.45 | ||
| AVTX | avalo therapeutics inc | 0.13 | 856,962 | 12,794,400 | new | |||
| AXSM | axsome therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| BEAM | beam therapeutics inc | 0.14 | 570,394 | 13,592,500 | unchanged | 0.00 | ||
| BLTE | belite bio inc | 1.14 | 715,332 | 114,053,000 | unchanged | 0.00 | ||
| CADL | candel therapeutics inc | 0.31 | 6,422,020 | 31,467,900 | new | |||
| CAPR | capricor therapeutics inc | 0.08 | 250,000 | 7,600,000 | unchanged | 0.00 | ||
| CELC | celcuity inc | 3.45 | 3,039,620 | 346,942,000 | added | 452 | ||
| CGEM | cullinan therapeutics inc | 0.24 | 1,705,960 | 24,241,700 | unchanged | 0.00 | ||
| CMPS | compass pathways plc | 0.58 | 10,632,400 | 58,797,100 | added | 21.41 | ||
| CMPX | compass therapeutics inc | 0.22 | 4,186,600 | 22,147,100 | added | 67.46 | ||
| CNTA | centessa pharmaceuticals plc | 0.81 | 2,054,180 | 81,591,800 | added | 14.7 | ||