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Latest RTW INVESTMENTS, LP Stock Portfolio

$11.71Billion | No. of Holdings #84

RTW INVESTMENTS, LP Performance

2026 Q2+16.10%
YTD+13.14%
2025+49.25%

About RTW INVESTMENTS, LP and 13F Hedge Fund Stock Holdings

RTW INVESTMENTS, LP is a hedge fund based in New York, NY. On 2026-08-14, the fund reported it's updated stock portfolio. In the 13F Holdings report, RTW INVESTMENTS, LP reported an equity portfolio of $11.7 Billions as of 30 Jun, 2026. <br><br> The top stock holdings of RTW INVESTMENTS, LP are MDGL, ARGX, PTCT. The fund has invested 9.1% of it's portfolio in MADRIGAL PHARMACEUTICALS INC and 5.6% of portfolio in ARGENX SE. <br><br> The fund managers got completely rid off APOGEE THERAPEUTICS INC, APELLIS PHARMACEUTICALS INC (APLS) and INTUITIVE SURGICAL INC (ISRG) stocks. They significantly reduced their stock positions in AVALO THERAPEUTICS INC (AVTX), HINGE HEALTH INC and COGENT BIOSCIENCES INC (COGT). RTW INVESTMENTS, LP opened new stock positions in KAILERA THERAPEUTICS INC, AXOGEN INC (AXGN) and DANAHER CORP DEL (DHR). The fund showed a lot of confidence in some stocks as they added substantially to ULTRAGENYX PHARMACEUTICAL IN (RARE), TENAX THERAPEUTICS INC (TENX) and LARIMAR THERAPEUTICS INC (LRMR).
RTW INVESTMENTS, LP Equity Portfolio Value
Last Reported on: 14 Aug, 2026
$11.71Billion
  as of Aug 14, 2026

RTW INVESTMENTS, LP Annual Return Estimates Vs S&P 500

Our best estimate is that RTW INVESTMENTS, LP made a return of 16.1% in the last quarter. In trailing 12 months, it's portfolio return was 64.8%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
kailera therapeutics inc237,413,000
structure therapeutics inc86,274,900
axogen inc46,724,700
danaher corp del43,810,400
solid biosciences inc38,890,300
ideaya biosciences inc13,803,700
allogene therapeutics inc6,760,000
maze therapeutics inc6,326,080
New stocks bought by RTW INVESTMENTS, LP

Additions

Ticker% Inc.
ultragenyx pharmaceutical in113
tenax therapeutics inc88.14
larimar therapeutics inc71.07
oruka therapeutics inc52.52
uniqure nv52.4
cullinan therapeutics inc38.59
definium therapeutics inc33.33
irhythm holdings inc30.81
Additions to existing portfolio by RTW INVESTMENTS, LP

Reductions

Ticker% Reduced
avalo therapeutics inc-79.58
hinge health inc-74.09
cogent biosciences inc-57.7
exagen inc-50.66
heartflow inc-40.4
beta bionics inc-25.00
natera inc-20.00
taysha gene therapies inc-0.88
RTW INVESTMENTS, LP reduced stake in above stock

Sold off

Ticker$ Sold
compass therapeutics inc-22,147,100
apellis pharmaceuticals inc-148,249,000
apogee therapeutics inc-234,169,000
centessa pharmaceuticals plc-81,591,800
waystar hldg corp-39,299,300
crinetics pharmaceuticals in-52,712,200
inventiva sa-7,207,800
fulgent genetics inc-20,495,100
RTW INVESTMENTS, LP got rid off the above stocks

Sector Distribution

RTW INVESTMENTS, LP has about 76.4% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
Sector%
Healthcare76.4
Others23.6

Market Cap. Distribution

RTW INVESTMENTS, LP has about 21% of it's portfolio invested in the large-cap and mega-cap stocks.

  • MID-CAP
  • UNALLOCATED
  • LARGE-CAP
  • SMALL-CAP
Category%
MID-CAP39.3
UNALLOCATED23.6
LARGE-CAP21
SMALL-CAP15.9

Stocks belong to which Index?

About 56.6% of the stocks held by RTW INVESTMENTS, LP either belong to S&P 500 or RUSSELL 2000 index.

  • RUSSELL 2000
  • Others
Index%
RUSSELL 200056.6
Others43
Top 5 Winners (%)%
CMPS
compass pathways plc
154.6 %
QURE
uniqure nv
114.7 %
CADL
candel therapeutics inc
110.2 %
definium therapeutics inc
109.8 %
URGN
urogen pharma ltd
104.7 %
Top 5 Winners ($)$
AGLE
spyre therapeutics inc
161.5 M
TNGX
tango therapeutics inc
140.6 M
ARGX
argenx se
140.1 M
oruka therapeutics inc
119.8 M
PTCT
ptc therapeutics inc
104.1 M
Top 5 Losers (%)%
RCKT
rocket pharmaceuticals inc
-83.5 %
evommune inc
-42.2 %
INSM
insmed inc
-34.8 %
kalaris therapeutics inc
-29.5 %
VSTM
verastem inc
-27.8 %
Top 5 Losers ($)$
INSM
insmed inc
-275.6 M
CELC
celcuity inc
-30.2 M
TARS
tarsus pharmaceuticals inc
-24.2 M
evommune inc
-14.6 M
VSTM
verastem inc
-9.8 M

RTW INVESTMENTS, LP Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of RTW INVESTMENTS, LP

RTW INVESTMENTS, LP has 84 stocks in it's portfolio. About 47.7% of the portfolio is in top 10 stocks. INSM proved to be the most loss making stock for the portfolio. AGLE was the most profitable stock for RTW INVESTMENTS, LP last quarter.

$11.71BTotal Value
97.00Positions
14 Aug, 2026Last Reported
Current holdings of Current Stock Holdings of RTW INVESTMENTS, LP, last reported on 14 Aug, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change
ARGX
Argenx Se

Argenx Se

ARGX
RTW INVESTMENTS, LP's holding in Argenx Se over time
5.62%709,446
$658.20M
5.62%
unchanged 0 percentunchanged
BLTE
Belite Bio Inc

Belite Bio Inc

BLTE
RTW INVESTMENTS, LP's holding in Belite Bio Inc over time
0.94%715,332
$110.15M
0.94%
unchanged 0 percentunchanged
CMPS
Compass Pathways Plc

Compass Pathways Plc

CMPS
RTW INVESTMENTS, LP's holding in Compass Pathways Plc over time
1.29%10,701,000
$151.42M
1.29%
increased 0.65 percentadded