Latest RTW INVESTMENTS, LP Stock Portfolio
RTW INVESTMENTS, LP Performance:
2025 Q4: 17.16%YTD: 49.25%2024: 2.41%
Performance for 2025 Q4 is 17.16%, and YTD is 49.25%, and 2024 is 2.41%.
About RTW INVESTMENTS, LP and 13F Hedge Fund Stock Holdings
RTW INVESTMENTS, LP is a hedge fund based in New York, NY. On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, RTW INVESTMENTS, LP reported an equity portfolio of $10 Billions as of 31 Dec, 2025.
The top stock holdings of RTW INVESTMENTS, LP are MDGL, INSM, PTCT. The fund has invested 11.6% of it's portfolio in MADRIGAL PHARMACEUTICALS INC and 8.4% of portfolio in INSMED INC .
The fund managers got completely rid off AVIDITY BIOSCIENCES INC (RNA), AKERO THERAPEUTICS INC (AKRO) and MERUS N V (MRUS) stocks. They significantly reduced their stock positions in CORVUS PHARMACEUTICALS INC (CRVS), EXAGEN INC (XGN) and STRYKER CORPORATION (SYK). RTW INVESTMENTS, LP opened new stock positions in IRHYTHM TECHNOLOGIES INC (IRTC), APELLIS PHARMACEUTICALS INC (APLS) and REPLIGEN CORP (RGEN). The fund showed a lot of confidence in some stocks as they added substantially to ZAI LAB LTD (ZLAB), ALLURION TECHNOLOGIES INC and BELITE BIO INC (BLTE).
The top stock holdings of RTW INVESTMENTS, LP are MDGL, INSM, PTCT. The fund has invested 11.6% of it's portfolio in MADRIGAL PHARMACEUTICALS INC and 8.4% of portfolio in INSMED INC .
The fund managers got completely rid off AVIDITY BIOSCIENCES INC (RNA), AKERO THERAPEUTICS INC (AKRO) and MERUS N V (MRUS) stocks. They significantly reduced their stock positions in CORVUS PHARMACEUTICALS INC (CRVS), EXAGEN INC (XGN) and STRYKER CORPORATION (SYK). RTW INVESTMENTS, LP opened new stock positions in IRHYTHM TECHNOLOGIES INC (IRTC), APELLIS PHARMACEUTICALS INC (APLS) and REPLIGEN CORP (RGEN). The fund showed a lot of confidence in some stocks as they added substantially to ZAI LAB LTD (ZLAB), ALLURION TECHNOLOGIES INC and BELITE BIO INC (BLTE).
RTW INVESTMENTS, LP Annual Return Estimates Vs S&P 500
Our best estimate is that RTW INVESTMENTS, LP made a return of 17.16% in the last quarter. In trailing 12 months, it's portfolio return was 49.25%.
- Performance
- S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| irhythm technologies inc | 209,732,000 |
| apellis pharmaceuticals inc | 192,589,000 |
| repligen corp | 174,347,000 |
| insulet corp | 92,264,300 |
| castle biosciences inc | 82,282,700 |
| immunovant inc | 80,780,900 |
| celcuity inc | 54,873,000 |
| kodiak sciences inc | 41,602,600 |
New stocks bought by RTW INVESTMENTS, LP
Additions
| Ticker | % Inc. |
|---|---|
| zai lab ltd | 203 |
| allurion technologies inc | 131 |
| belite bio inc | 128 |
| cogent biosciences inc | 118 |
| insmed inc | 57.00 |
| crinetics pharmaceuticals in | 54.9 |
| wave life sciences ltd | 50.00 |
| radnet inc | 39.88 |
Additions to existing portfolio by RTW INVESTMENTS, LP
Reductions
| Ticker | % Reduced |
|---|---|
| corvus pharmaceuticals inc | -83.29 |
| exagen inc | -53.42 |
| intuitive surgical inc | -50.00 |
| stryker corporation | -50.00 |
| taysha gene therapies inc | -32.67 |
| natera inc | -25.00 |
| beta bionics inc | -24.22 |
| centessa pharmaceuticals plc | -21.86 |
RTW INVESTMENTS, LP reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| avidity biosciences inc | -495,514,000 |
| alector inc | -20,692,800 |
| akero therapeutics inc | -260,075,000 |
| cytomx therapeutics inc | -11,042,200 |
| dyne therapeutics inc | -36,565,700 |
| merus n v | -190,680,000 |
| pepgen inc | -6,930,000 |
| lenz therapeutics inc | -40,216,700 |
RTW INVESTMENTS, LP got rid off the above stocks
Sector Distribution
RTW INVESTMENTS, LP has about 83.3% of it's holdings in Healthcare sector.
- Healthcare
- Others
| Sector | % |
|---|---|
| Healthcare | 83.3 |
| Others | 16.7 |
Market Cap. Distribution
RTW INVESTMENTS, LP has about 32.9% of it's portfolio invested in the large-cap and mega-cap stocks.
- MID-CAP
- LARGE-CAP
- UNALLOCATED
- SMALL-CAP
| Category | % |
|---|---|
| MID-CAP | 37.6 |
| LARGE-CAP | 32.9 |
| UNALLOCATED | 16.7 |
| SMALL-CAP | 12.5 |
Stocks belong to which Index?
About 61.8% of the stocks held by RTW INVESTMENTS, LP either belong to S&P 500 or RUSSELL 2000 index.
- RUSSELL 2000
- Others
- S&P 500
| Index | % |
|---|---|
| RUSSELL 2000 | 59.3 |
| Others | 38.2 |
| S&P 500 | 2.5 |
RTW INVESTMENTS, LP Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of RTW INVESTMENTS, LP
RTW INVESTMENTS, LP has 91 stocks in it's portfolio. About 50.5% of the portfolio is in top 10 stocks. QURE proved to be the most loss making stock for the portfolio. MDGL was the most profitable stock for RTW INVESTMENTS, LP last quarter.
Last Reported on: 17 Feb, 2026| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ACAD | acadia pharmaceuticals inc | 1.91 | 7,144,520 | 190,830,000 | unchanged | 0.00 | ||
| AGLE | spyre therapeutics inc | 1.37 | 4,172,000 | 136,675,000 | added | 15.18 | ||
| AKRO | akero therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ALEC | alector inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ALKS | alkermes plc | 0.47 | 1,672,360 | 46,792,500 | unchanged | 0.00 | ||
| APLS | apellis pharmaceuticals inc | 1.93 | 7,666,760 | 192,589,000 | new | |||
| AQST | aquestive therapeutics inc | 0.40 | 6,250,000 | 40,375,000 | unchanged | 0.00 | ||
| ARGX | argenx se | 5.67 | 673,497 | 566,377,000 | unchanged | 0.00 | ||
| ARWR | arrowhead pharmaceuticals in | 0.39 | 584,716 | 38,819,300 | new | |||
| ATAI | atai beckley nv | 0.08 | 2,000,000 | 8,180,000 | new | |||
| AVTE | jade biosciences inc | 0.22 | 1,449,270 | 22,362,300 | unchanged | 0.00 | ||
| AXSM | axsome therapeutics inc | 1.62 | 888,001 | 162,184,000 | reduced | -20.64 | ||
| BEAM | beam therapeutics inc | 0.16 | 570,394 | 15,811,300 | new | |||
| BLTE | belite bio inc | 1.15 | 715,332 | 114,425,000 | added | 128 | ||
| CAPR | capricor therapeutics inc | 0.07 | 250,000 | 7,215,000 | new | |||
| CELC | celcuity inc | 0.55 | 550,160 | 54,873,000 | new | |||
| CGEM | cullinan therapeutics inc | 0.18 | 1,705,960 | 17,656,700 | unchanged | 0.00 | ||
| CMPS | compass pathways plc | 0.60 | 8,757,390 | 60,426,000 | added | 0.57 | ||
| CMPX | compass therapeutics inc | 0.13 | 2,500,000 | 13,425,000 | unchanged | 0.00 | ||
| CNTA | centessa pharmaceuticals plc | 0.45 | 1,790,840 | 44,788,800 | reduced | -21.86 | ||