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Latest TCG Crossover Management, LLC Stock Portfolio

$3.50Billion– No. of Holdings #49

TCG Crossover Management, LLC Performance:
2026 Q1: 7.7%YTD: 7.7%2025: 130.69%
Performance for 2026 Q1 is 7.7%, and YTD is 7.7%, and 2025 is 130.69%.

About TCG Crossover Management, LLC and 13F Hedge Fund Stock Holdings

On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, TCG Crossover Management, LLC reported an equity portfolio of $3.5 Billions as of 31 Mar, 2026.

The top stock holdings of TCG Crossover Management, LLC are , , TNGX. The fund has invested 20.6% of it's portfolio in ABIVAX SA AMERICAN DEPOSITARY SHARES and 7.1% of portfolio in CG ONCOLOGY INC.

The fund managers got completely rid off RAPT THERAPEUTICS INC (RAPT), EYEPOINT PHARMACEUTICALS INC (EYPT) and AGIOS PHARMACEUTICALS INC (AGIO) stocks. They significantly reduced their stock positions in STRUCTURE THERAPEUTICS INC, LIQUIDIA TECHNOLOGIES INC (LQDA) and OCULAR THERAPEUTIX INC (OCUL). TCG Crossover Management, LLC opened new stock positions in BIOCRYST PHARMACEUTICALS INC (BCRX), VOR BIOPHARMA INC (VOR) and DISC MEDICINE INC. The fund showed a lot of confidence in some stocks as they added substantially to MIRUM PHARMACEUTICALS INC (MIRM), IMMUNOVANT INC (IMVT) and AVALO THERAPEUTICS INC (AVTX).
TCG Crossover Management, LLC Equity Portfolio Value
Last Reported on: 15 May, 2026

TCG Crossover Management, LLC Annual Return Estimates Vs S&P 500

Our best estimate is that TCG Crossover Management, LLC made a return of 7.7% in the last quarter. In trailing 12 months, it's portfolio return was 241%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
biocryst pharmaceuticals inc104,920,000
vor biopharma inc96,499,100
disc medicine inc85,798,700
surrozen inc42,911,400
century therapeutics inc39,021,600
tectonic therapeutic inc37,243,200
perspective therapeutics inc33,007,900
alx oncology holdings inc26,088,800
New stocks bought by TCG Crossover Management, LLC

Additions

Ticker% Inc.
mirum pharmaceuticals inc1,611
immunovant inc168
avalo therapeutics inc52.87
relay therapeutics inc32.71
revolution medicines inc32.08
tyra biosciences inc12.11
entrada therapeutics inc9.53
lb pharmaceuticals inc5.41
Additions to existing portfolio by TCG Crossover Management, LLC

Reductions

Ticker% Reduced
structure therapeutics inc-84.75
liquidia technologies inc-76.43
upstream bio inc-75.66
ocular therapeutix inc-71.29
urogen pharma ltd-43.49
tango therapeutics inc-17.48
cogent biosciences inc-15.7
arvinas holding co llc-10.46
TCG Crossover Management, LLC reduced stake in above stock

Sold off

Ticker$ Sold
eyepoint pharmaceuticals inc-65,266,600
rapt therapeutics inc-87,466,200
agios pharmaceuticals inc-32,169,700
ventyx biosciences inc-2,855,240
maze therapeutics inc-7,201,200
TCG Crossover Management, LLC got rid off the above stocks

Sector Distribution

TCG Crossover Management, LLC has about 58.1% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
Sector%
Healthcare58.1
Others41.9

Market Cap. Distribution

TCG Crossover Management, LLC has about 1.6% of it's portfolio invested in the large-cap and mega-cap stocks.

  • UNALLOCATED
  • SMALL-CAP
  • MID-CAP
  • MICRO-CAP
  • LARGE-CAP
Category%
UNALLOCATED41.9
SMALL-CAP27.5
MID-CAP21.9
MICRO-CAP7
LARGE-CAP1.6

Stocks belong to which Index?

About 47.2% of the stocks held by TCG Crossover Management, LLC either belong to S&P 500 or RUSSELL 2000 index.

  • Others
  • RUSSELL 2000
Index%
Others52.8
RUSSELL 200047.2
Top 5 Winners (%)%
TNGX
tango therapeutics inc
124.2 %
dianthus therapeutics inc
103.6 %
cg oncology inc
63.0 %
CNTA
centessa pharmaceuticals plc
58.8 %
AGLE
spyre therapeutics inc
54.0 %
Top 5 Winners ($)$
TNGX
tango therapeutics inc
140.5 M
cg oncology inc
96.0 M
dianthus therapeutics inc
71.6 M
CNTA
centessa pharmaceuticals plc
63.1 M
TYRA
tyra biosciences inc
36.9 M
Top 5 Losers (%)%
upstream bio inc
-41.6 %
FULC
fulcrum therapeutics inc
-32.2 %
biohaven ltd
-25.1 %
XNCR
xencor inc
-21.2 %
OCUL
ocular therapeutix inc
-19.4 %
Top 5 Losers ($)$
abivax sa american depositary shares
-159.7 M
FULC
fulcrum therapeutics inc
-19.1 M
OCUL
ocular therapeutix inc
-13.6 M
biohaven ltd
-13.1 M
structure therapeutics inc
-11.3 M

TCG Crossover Management, LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of TCG Crossover Management, LLC

TCG Crossover Management, LLC has 49 stocks in it's portfolio. About 60.9% of the portfolio is in top 10 stocks. proved to be the most loss making stock for the portfolio. TNGX was the most profitable stock for TCG Crossover Management, LLC last quarter.

Last Reported on: 15 May, 2026
TickerNamesorted ascending% PortfolioShares Held$ ValueType% ChangeOptions