Latest TCG Crossover Management, LLC Stock Portfolio

TCG Crossover Management, LLC Performance:

2025 Q4: 33.58%YTD: 130.69%2024: -19.85%

Performance for 2025 Q4 is 33.58%, and YTD is 130.69%, and 2024 is -19.85%.

About TCG Crossover Management, LLC and 13F Hedge Fund Stock Holdings

On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, TCG Crossover Management, LLC reported an equity portfolio of $3 Billions as of 31 Dec, 2025.

The top stock holdings of TCG Crossover Management, LLC are , COGT, . The fund has invested 31.7% of it's portfolio in ABIVAX SA AMERICAN DEPOSITARY SHARES and 6.9% of portfolio in COGENT BIOSCIENCES INC.

The fund managers got completely rid off TOURMALINE BIO INC, ASTRIA THERAPEUTICS INC (ATXS) and ADVERUM BIOTECHNOLOGIES INC (ADVM) stocks. They significantly reduced their stock positions in UPSTREAM BIO INC, AGIOS PHARMACEUTICALS INC (AGIO) and COGENT BIOSCIENCES INC (COGT). TCG Crossover Management, LLC opened new stock positions in MONTE ROSA THERAPEUTICS INC (GLUE), BIOHAVEN LTD and IMMUNOVANT INC (IMVT). The fund showed a lot of confidence in some stocks as they added substantially to ADC THERAPEUTICS SA (ADCT), ENTRADA THERAPEUTICS INC (TRDA) and RELAY THERAPEUTICS INC (RLAY).

TCG Crossover Management, LLC Annual Return Estimates Vs S&P 500

Our best estimate is that TCG Crossover Management, LLC made a return of 33.58% in the last quarter. In trailing 12 months, it's portfolio return was 130.69%.

Performance
S&P 500

New Buys

Ticker	$ Bought
monte rosa therapeutics inc	72,475,300
biohaven ltd	52,287,600
immunovant inc	42,220,900
janux therapeutics inc	24,696,700
alector inc	15,600,000
maze therapeutics inc	7,201,200
mirum pharmaceuticals inc	4,901,250
athira pharma, inc.	3,348,510

New stocks bought by TCG Crossover Management, LLC

Additions

Ticker	% Inc.
adc therapeutics sa	719
entrada therapeutics inc	257
relay therapeutics inc	77.88
spyre therapeutics inc	72.69
arvinas holding co llc	64.85
rapt therapeutics inc	57.82
tango therapeutics inc	49.51
centessa pharmaceuticals plc	36.67

Additions to existing portfolio by TCG Crossover Management, LLC

Reductions

Ticker	% Reduced
upstream bio inc	-64.86
agios pharmaceuticals inc	-17.36
cogent biosciences inc	-13.68
structure therapeutics inc	-13.37
monopar therapeutics inc	-7.25
ocular therapeutix inc	-6.16
lb pharmaceuticals inc	0.00

TCG Crossover Management, LLC reduced stake in above stock

Sold off

Ticker	$ Sold
astria therapeutics inc	-20,106,300
adverum biotechnologies inc	-7,556,830
tourmaline bio inc	-62,742,600
pepgen inc	-5,544,000
disc medicine inc	-30,744,200

TCG Crossover Management, LLC got rid off the above stocks

Sector Distribution

TCG Crossover Management, LLC has about 52.1% of it's holdings in Healthcare sector.

Sector	%
Healthcare	52.1
Others	47.9

Market Cap. Distribution

TCG Crossover Management, LLC has about 1.2% of it's portfolio invested in the large-cap and mega-cap stocks.

Category	%
UNALLOCATED	47.9
SMALL-CAP	31
MID-CAP	19
LARGE-CAP	1.2

Stocks belong to which Index?

About 43.8% of the stocks held by TCG Crossover Management, LLC either belong to S&P 500 or RUSSELL 2000 index.

Index	%
Others	56.2
RUSSELL 2000	43.8

Top 5 Winners (%)		%
VTYX	ventyx biosciences inc	190.3 %
	structure therapeutics inc	138.5 %
COGT	cogent biosciences inc	137.3 %
TYRA	tyra biosciences inc	87.9 %
	mbx biosciences inc	80.2 %

Top 5 Winners ($)		$
	abivax sa american depositary shares	355.3 M
COGT	cogent biosciences inc	134.0 M
	structure therapeutics inc	41.2 M
TYRA	tyra biosciences inc	35.6 M
DYN	dyne therapeutics inc	31.9 M

Top 5 Losers (%)		%
	korro bio inc	-83.3 %
VSTA	vistagen therapeutics inc	-81.3 %
AGIO	agios pharmaceuticals inc	-29.4 %
MNPR	monopar therapeutics inc	-19.3 %
AMLX	amylyx pharmaceuticals inc	-11.1 %

Top 5 Losers ($)		$
AGIO	agios pharmaceuticals inc	-16.9 M
	korro bio inc	-16.6 M
AMLX	amylyx pharmaceuticals inc	-9.4 M
VSTA	vistagen therapeutics inc	-7.7 M
ADCT	adc therapeutics sa	-3.0 M

TCG Crossover Management, LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of TCG Crossover Management, LLC

TCG Crossover Management, LLC has 43 stocks in it's portfolio. About 64.3% of the portfolio is in top 10 stocks. AGIO proved to be the most loss making stock for the portfolio. was the most profitable stock for TCG Crossover Management, LLC last quarter.

Last Reported on: 17 Feb, 2026

Ticker	Namesorted ascending	% Portfolio	Shares Held	$ Value	Type	% Change
ADCT	adc therapeutics sa	1.33	11,390,200	40,207,300	added	719

ADVM	adverum biotechnologies inc	0.00	0.00	0.00	sold off	-100

AGIO	agios pharmaceuticals inc	1.06	1,181,840	32,169,700	reduced	-17.36

AGLE	spyre therapeutics inc	2.06	1,900,580	62,263,100	added	72.69

ALEC	alector inc	0.52	10,000,000	15,600,000	new

AMLX	amylyx pharmaceuticals inc	2.50	6,243,810	75,425,200	unchanged	0.00

ARVN	arvinas holding co llc	1.05	2,666,220	31,621,300	added	64.85

ATHA	athira pharma, inc.	0.11	464,398	3,348,510	new

ATXS	astria therapeutics inc	0.00	0.00	0.00	sold off	-100

AVTX	avalo therapeutics inc	0.29	483,000	8,771,280	unchanged	0.00

CNTA	centessa pharmaceuticals plc	3.55	4,286,480	107,205,000	added	36.67

COGT	cogent biosciences inc	6.90	5,868,160	208,437,000	reduced	-13.68

DYN	dyne therapeutics inc	2.99	4,615,140	90,272,200	unchanged	0.00

EYPT	eyepoint pharmaceuticals inc	2.16	3,572,340	65,266,600	unchanged	0.00

FULC	fulcrum therapeutics inc	1.97	5,250,000	59,377,500	unchanged	0.00

GLUE	monte rosa therapeutics inc	2.40	4,622,150	72,475,300	new

IMVT	immunovant inc	1.40	1,660,930	42,220,900	new

JANX	janux therapeutics inc	0.82	1,789,620	24,696,700	new

KOD	kodiak sciences inc	1.34	1,445,540	40,417,200	added	26.19

LQDA	liquidia technologies inc	1.95	1,710,080	58,980,800	unchanged	0.00