Latest ORBIMED ADVISORS LLC Stock Portfolio
ORBIMED ADVISORS LLC Performance:
2025 Q1: -5.58%YTD: -5.58%2024: 11.93%
Performance for 2025 Q1 is -5.58%, and YTD is -5.58%, and 2024 is 11.93%.
About ORBIMED ADVISORS LLC and 13F Hedge Fund Stock Holdings
ORBIMED ADVISORS LLC is a hedge fund based in NEW YORK, NY. On 29-Mar-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $18.3 Billions. In it's latest 13F Holdings report, ORBIMED ADVISORS LLC reported an equity portfolio of $4.2 Billions as of 31 Mar, 2025.
The top stock holdings of ORBIMED ADVISORS LLC are SVA, EWTX, BSX. The fund has invested 8% of it's portfolio in SINOVAC BIOTECH LTD and 7.9% of portfolio in EDGEWISE THERAPEUTICS INC.
The fund managers got completely rid off SAREPTA THERAPEUTICS INC (SRPT), MERCK & CO INC (MRK) and BIOGEN INC (BIIB) stocks. They significantly reduced their stock positions in INSMED INC (INSM), CARDIFF ONCOLOGY INC (CRDF) and TENET HEALTHCARE CORP (THC). ORBIMED ADVISORS LLC opened new stock positions in PFIZER INC (PFE), AXSOME THERAPEUTICS INC (AXSM) and SIONNA THERAPEUTICS INC. The fund showed a lot of confidence in some stocks as they added substantially to AGIOS PHARMACEUTICALS INC (AGIO), AKERO THERAPEUTICS INC (AKRO) and CG ONCOLOGY INC.
The top stock holdings of ORBIMED ADVISORS LLC are SVA, EWTX, BSX. The fund has invested 8% of it's portfolio in SINOVAC BIOTECH LTD and 7.9% of portfolio in EDGEWISE THERAPEUTICS INC.
The fund managers got completely rid off SAREPTA THERAPEUTICS INC (SRPT), MERCK & CO INC (MRK) and BIOGEN INC (BIIB) stocks. They significantly reduced their stock positions in INSMED INC (INSM), CARDIFF ONCOLOGY INC (CRDF) and TENET HEALTHCARE CORP (THC). ORBIMED ADVISORS LLC opened new stock positions in PFIZER INC (PFE), AXSOME THERAPEUTICS INC (AXSM) and SIONNA THERAPEUTICS INC. The fund showed a lot of confidence in some stocks as they added substantially to AGIOS PHARMACEUTICALS INC (AGIO), AKERO THERAPEUTICS INC (AKRO) and CG ONCOLOGY INC.
ORBIMED ADVISORS LLC Annual Return Estimates Vs S&P 500
Our best estimate is that ORBIMED ADVISORS LLC made a return of -5.58% in the last quarter. In trailing 12 months, it's portfolio return was -8.15%.
New Buys
| Ticker | $ Bought |
|---|---|
| pfizer inc | 97,564,100 |
| axsome therapeutics inc | 45,100,800 |
| sionna therapeutics inc | 38,753,900 |
| tarsus pharmaceuticals inc | 33,582,800 |
| apellis pharmaceuticals inc | 31,324,400 |
| amgen inc | 13,770,500 |
| whitehawk therapeutics inc | 7,415,480 |
| trevi therapeutics inc | 7,044,800 |
New stocks bought by ORBIMED ADVISORS LLC
Additions
| Ticker | % Inc. |
|---|---|
| agios pharmaceuticals inc | 1,119 |
| akero therapeutics inc | 172 |
| cg oncology inc | 72.73 |
| avidity biosciences inc | 62.9 |
| c4 therapeutics inc | 56.02 |
| unitedhealth group inc | 53.71 |
| thermo fisher scientific inc | 52.84 |
| edwards lifesciences corp | 33.76 |
Additions to existing portfolio by ORBIMED ADVISORS LLC
Reductions
| Ticker | % Reduced |
|---|---|
| insmed inc | -69.69 |
| cardiff oncology inc | -62.7 |
| tenet healthcare corp | -41.29 |
| vera therapeutics inc | -35.22 |
| vir biotechnology inc | -30.15 |
| intuitive surgical inc | -27.56 |
| springworks therapeutics inc | -24.29 |
| disc medicine inc | -20.75 |
ORBIMED ADVISORS LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| lyell immunopharma inc | -1,986,320 |
| geron corp | -7,674,720 |
| milestone pharmaceuticals in | -4,720,000 |
| mineralys therapeutics inc | -19,839,300 |
| sarepta therapeutics inc | -117,140,000 |
| elevation oncology inc | -529,561 |
| merck & co inc | -82,558,400 |
| neumora therapeutics inc. | -8,532,960 |
ORBIMED ADVISORS LLC got rid off the above stocks
Sector Distribution
ORBIMED ADVISORS LLC has about 74% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 74 |
| Others | 23.5 |
| 2.5 |
Market Cap. Distribution
ORBIMED ADVISORS LLC has about 40.9% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| LARGE-CAP | 30.1 |
| UNALLOCATED | 23.7 |
| SMALL-CAP | 16.1 |
| MID-CAP | 13.2 |
| MEGA-CAP | 10.8 |
| MICRO-CAP | 5.7 |
Stocks belong to which Index?
About 57.5% of the stocks held by ORBIMED ADVISORS LLC either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| Others | 42.5 |
| S&P 500 | 32 |
| RUSSELL 2000 | 25.5 |
ORBIMED ADVISORS LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC has 106 stocks in it's portfolio. About 47.7% of the portfolio is in top 10 stocks. EWTX proved to be the most loss making stock for the portfolio. BSX was the most profitable stock for ORBIMED ADVISORS LLC last quarter.
Last Reported on: 15 May, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| AADI | whitehawk therapeutics inc | 0.18 | 4,166,000 | 7,415,480 | new | |||
| ABCL | abcellera biologics inc | 0.22 | 4,180,770 | 9,323,110 | unchanged | 0.00 | ||
| ACET | adicet bio inc | 0.21 | 11,447,100 | 8,642,590 | unchanged | 0.00 | ||
| ADCT | adc therapeutics sa | 0.20 | 5,968,450 | 8,415,520 | unchanged | 0.00 | ||
| ADGI | invivyd inc | 0.01 | 933,500 | 565,048 | reduced | -18.78 | ||
| AGIO | agios pharmaceuticals inc | 0.23 | 325,500 | 9,537,150 | added | 1,119 | ||
| AKRO | akero therapeutics inc | 0.17 | 179,900 | 7,282,350 | added | 172 | ||
| ALNY | alnylam pharmaceuticals inc | 2.23 | 346,100 | 93,453,900 | reduced | -16.72 | ||
| AMGN | amgen inc | 0.33 | 44,200 | 13,770,500 | new | |||
| AMLX | amylyx pharmaceuticals inc | 0.03 | 348,000 | 1,231,920 | unchanged | 0.00 | ||
| APLS | apellis pharmaceuticals inc | 0.75 | 1,432,300 | 31,324,400 | new | |||
| AVTX | avalo therapeutics inc | 0.18 | 967,000 | 7,745,670 | unchanged | 0.00 | ||
| AXSM | axsome therapeutics inc | 1.07 | 386,700 | 45,100,800 | new | |||
| BIIB | biogen inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| BSX | boston scientific corp | 6.77 | 2,813,200 | 283,796,000 | reduced | -10.98 | ||
| CCCC | c4 therapeutics inc | 0.26 | 6,830,300 | 10,928,500 | added | 56.02 | ||
| CGEM | cullinan therapeutics inc | 0.35 | 1,923,860 | 14,563,600 | reduced | -0.96 | ||
| CMPX | compass therapeutics inc | 1.01 | 22,362,800 | 42,489,400 | unchanged | 0.00 | ||
| CRBP | corbus pharmaceuticals hldgs | 0.15 | 1,172,290 | 6,224,840 | unchanged | 0.00 | ||
| CRDF | cardiff oncology inc | 0.04 | 573,884 | 1,802,000 | reduced | -62.7 | ||