Latest GREAT POINT PARTNERS LLC Stock Portfolio
GREAT POINT PARTNERS LLC Performance:
2025 Q3: 29.83%YTD: 21.06%2024: -4.9%
Performance for 2025 Q3 is 29.83%, and YTD is 21.06%, and 2024 is -4.9%.
About GREAT POINT PARTNERS LLC and 13F Hedge Fund Stock Holdings
GREAT POINT PARTNERS LLC is a hedge fund based in GREENWICH, CT. On 31-Mar-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $1.9 Billions. In it's latest 13F Holdings report, GREAT POINT PARTNERS LLC reported an equity portfolio of $242.5 Millions as of 30 Sep, 2025.
The top stock holdings of GREAT POINT PARTNERS LLC are AMLX, RZLT, NKTR. The fund has invested 9.5% of it's portfolio in AMYLYX PHARMACEUTICALS INC and 9.5% of portfolio in REZOLUTE INC COM NEW.
The fund managers got completely rid off AKEBIA THERAPEUTICS INC (AKBA), EVOLUS INC (EOLS) and ARCELLX INC (ACLX) stocks. They significantly reduced their stock positions in ABIVAX SA SPONSORED ADS, IONIS PHARMACEUTICALS INC (IONS) and REZOLUTE INC COM NEW (RZLT). GREAT POINT PARTNERS LLC opened new stock positions in NEKTAR THERAPEUTICS COM NEW (NKTR), SOLENO THERAPEUTICS INC (SLNO) and ASCENDIS PHARMA A/S SPONSORED ADR. The fund showed a lot of confidence in some stocks as they added substantially to IMMUNOVANT INC (IMVT), JADE BIOSCIENCES INC COM NEW (AVTE) and ZURA BIO LTD CLASS A ORD SHS.
The top stock holdings of GREAT POINT PARTNERS LLC are AMLX, RZLT, NKTR. The fund has invested 9.5% of it's portfolio in AMYLYX PHARMACEUTICALS INC and 9.5% of portfolio in REZOLUTE INC COM NEW.
The fund managers got completely rid off AKEBIA THERAPEUTICS INC (AKBA), EVOLUS INC (EOLS) and ARCELLX INC (ACLX) stocks. They significantly reduced their stock positions in ABIVAX SA SPONSORED ADS, IONIS PHARMACEUTICALS INC (IONS) and REZOLUTE INC COM NEW (RZLT). GREAT POINT PARTNERS LLC opened new stock positions in NEKTAR THERAPEUTICS COM NEW (NKTR), SOLENO THERAPEUTICS INC (SLNO) and ASCENDIS PHARMA A/S SPONSORED ADR. The fund showed a lot of confidence in some stocks as they added substantially to IMMUNOVANT INC (IMVT), JADE BIOSCIENCES INC COM NEW (AVTE) and ZURA BIO LTD CLASS A ORD SHS.
GREAT POINT PARTNERS LLC Annual Return Estimates Vs S&P 500
Our best estimate is that GREAT POINT PARTNERS LLC made a return of 29.83% in the last quarter. In trailing 12 months, it's portfolio return was 13.44%.
New Buys
| Ticker | $ Bought |
|---|---|
| nektar therapeutics com new | 17,070,000 |
| soleno therapeutics inc | 15,210,000 |
| ascendis pharma a/s sponsored adr | 14,910,800 |
| apogee therapeutics inc | 12,077,900 |
| dianthus therapeutics inc | 10,459,300 |
| eupraxia pharmaceuticals inc | 7,080,000 |
| pharvaris n v | 3,869,870 |
| oruka therapeutics inc | 3,525,440 |
New stocks bought by GREAT POINT PARTNERS LLC
Additions
| Ticker | % Inc. |
|---|---|
| immunovant inc | 90.71 |
| jade biosciences inc com new | 27.01 |
| zura bio ltd class a ord shs | 20.37 |
| dbv technologies s a sponsored ads | 1.04 |
Additions to existing portfolio by GREAT POINT PARTNERS LLC
Reductions
| Ticker | % Reduced |
|---|---|
| abivax sa sponsored ads | -88.39 |
| ionis pharmaceuticals inc | -84.00 |
| legend biotech corp sponsored ads | -67.58 |
| rezolute inc com new | -19.17 |
| amylyx pharmaceuticals inc | -15.00 |
| neurogene inc | -8.04 |
GREAT POINT PARTNERS LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| promis neurosciences inc | -1,279,710 |
| akebia therapeutics inc | -7,228,730 |
| evolus inc | -6,632,290 |
| kalvista pharmaceuticals inc | -3,653,440 |
| centessa pharmaceuticals plc | -2,956,500 |
| arcellx inc | -6,585,000 |
| scholar rock hldg corp | -2,182,120 |
| helix acquisition corp ii | -312,026 |
GREAT POINT PARTNERS LLC got rid off the above stocks
Sector Distribution
GREAT POINT PARTNERS LLC has about 59% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 59 |
| Others | 41 |
Market Cap. Distribution
GREAT POINT PARTNERS LLC has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| UNALLOCATED | 41 |
| MICRO-CAP | 29.9 |
| SMALL-CAP | 13 |
| MID-CAP | 12.3 |
| NANO-CAP | 3.7 |
Stocks belong to which Index?
About 22.4% of the stocks held by GREAT POINT PARTNERS LLC either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| Others | 77.6 |
| RUSSELL 2000 | 22.4 |
GREAT POINT PARTNERS LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of GREAT POINT PARTNERS LLC
GREAT POINT PARTNERS LLC has 28 stocks in it's portfolio. About 63.3% of the portfolio is in top 10 stocks. AVTE proved to be the most loss making stock for the portfolio. RZLT was the most profitable stock for GREAT POINT PARTNERS LLC last quarter.
Last Reported on: 14 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ABSI | absci corporation | 1.00 | 796,438 | 2,421,170 | new | |||
| ACLX | arcellx inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AKBA | akebia therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AKRO | akero therapeutics inc | 2.03 | 103,848 | 4,930,700 | unchanged | 0.00 | ||
| AMLX | amylyx pharmaceuticals inc | 9.53 | 1,700,000 | 23,103,000 | reduced | -15.00 | ||
| AVTE | jade biosciences inc com new | 2.25 | 632,599 | 5,459,330 | added | 27.01 | ||
| CNTA | centessa pharmaceuticals plc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| CNTX | context therapeutics inc | 1.87 | 4,683,710 | 4,537,580 | unchanged | 0.00 | ||
| CYTK | cytokinetics inc com new | 3.40 | 150,000 | 8,244,000 | unchanged | 0.00 | ||
| DBVT | dbv technologies s a sponsored ads | 1.56 | 378,594 | 3,785,940 | added | 1.04 | ||
| EOLS | evolus inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| IMVT | immunovant inc | 3.32 | 500,000 | 8,060,000 | added | 90.71 | ||
| IONS | ionis pharmaceuticals inc | 2.16 | 80,000 | 5,233,600 | reduced | -84.00 | ||
| KALV | kalvista pharmaceuticals inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| NKTR | nektar therapeutics com new | 7.04 | 300,000 | 17,070,000 | new | |||
| PHVS | pharvaris n v | 1.60 | 155,105 | 3,869,870 | new | |||
| PLRX | pliant therapeutics inc | 0.52 | 850,000 | 1,258,000 | unchanged | 0.00 | ||
| PMN | promis neurosciences inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| RZLT | rezolute inc com new | 9.50 | 2,451,810 | 23,047,000 | reduced | -19.17 | ||
| SANA | sana biotechnology inc | 1.02 | 700,000 | 2,485,000 | new | |||