Latest GREAT POINT PARTNERS LLC Stock Portfolio
GREAT POINT PARTNERS LLC Performance:
2025 Q4: 4.45%YTD: 43.33%2024: -9.58%
Performance for 2025 Q4 is 4.45%, and YTD is 43.33%, and 2024 is -9.58%.
About GREAT POINT PARTNERS LLC and 13F Hedge Fund Stock Holdings
GREAT POINT PARTNERS LLC is a hedge fund based in Greenwich, CT. On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, GREAT POINT PARTNERS LLC reported an equity portfolio of $308.4 Millions as of 31 Dec, 2025.
The top stock holdings of GREAT POINT PARTNERS LLC are , AMLX, . The fund has invested 9.2% of it's portfolio in APOGEE THERAPEUTICS INC and 6.8% of portfolio in AMYLYX PHARMACEUTICALS INC.
The fund managers got completely rid off ASCENDIS PHARMA A/S SPONSORED ADR (ASND), ABIVAX SA SPONSORED ADS and CYTOKINETICS INC COM NEW (CYTK) stocks. They significantly reduced their stock positions in REZOLUTE INC (RZLT), PHARVARIS N V (PHVS) and NEKTAR THERAPEUTICS (NKTR). GREAT POINT PARTNERS LLC opened new stock positions in DISC MEDICINE INC, RAPT THERAPEUTICS INC (RAPT) and VOR BIOPHARMA INC (VOR). The fund showed a lot of confidence in some stocks as they added substantially to SOLENO THERAPEUTICS INC (SLNO), IMMUNOVANT INC (IMVT) and DIANTHUS THERAPEUTICS INC.
The top stock holdings of GREAT POINT PARTNERS LLC are , AMLX, . The fund has invested 9.2% of it's portfolio in APOGEE THERAPEUTICS INC and 6.8% of portfolio in AMYLYX PHARMACEUTICALS INC.
The fund managers got completely rid off ASCENDIS PHARMA A/S SPONSORED ADR (ASND), ABIVAX SA SPONSORED ADS and CYTOKINETICS INC COM NEW (CYTK) stocks. They significantly reduced their stock positions in REZOLUTE INC (RZLT), PHARVARIS N V (PHVS) and NEKTAR THERAPEUTICS (NKTR). GREAT POINT PARTNERS LLC opened new stock positions in DISC MEDICINE INC, RAPT THERAPEUTICS INC (RAPT) and VOR BIOPHARMA INC (VOR). The fund showed a lot of confidence in some stocks as they added substantially to SOLENO THERAPEUTICS INC (SLNO), IMMUNOVANT INC (IMVT) and DIANTHUS THERAPEUTICS INC.
GREAT POINT PARTNERS LLC Annual Return Estimates Vs S&P 500
Our best estimate is that GREAT POINT PARTNERS LLC made a return of 4.45% in the last quarter. In trailing 12 months, it's portfolio return was 43.33%.
- Performance
- S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| disc medicine inc | 19,852,500 |
| rapt therapeutics inc | 19,684,800 |
| vor biopharma inc | 17,921,000 |
| kalvista pharmaceuticals inc | 11,073,000 |
| contineum therapeutics inc | 9,144,000 |
| fulcrum therapeutics inc | 9,048,000 |
| ultragenyx pharmaceutical in | 6,900,000 |
| cullinan therapeutics inc | 6,562,230 |
New stocks bought by GREAT POINT PARTNERS LLC
Additions
| Ticker | % Inc. |
|---|---|
| soleno therapeutics inc | 77.78 |
| immunovant inc | 50.00 |
| dianthus therapeutics inc | 31.68 |
| jade biosciences inc | 27.45 |
| apogee therapeutics inc | 23.03 |
| amylyx pharmaceuticals inc | 2.94 |
Additions to existing portfolio by GREAT POINT PARTNERS LLC
Reductions
| Ticker | % Reduced |
|---|---|
| rezolute inc | -61.18 |
| pharvaris n v | -46.62 |
| nektar therapeutics | -29.76 |
| neurogene inc | -21.67 |
GREAT POINT PARTNERS LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| taysha gene therapies inc com shs | -4,905,000 |
| pliant therapeutics inc | -1,258,000 |
| absci corporation | -2,421,170 |
| dbv technologies s a sponsored ads | -3,785,940 |
| xenon pharmaceuticals inc | -8,030,000 |
| cytokinetics inc com new | -8,244,000 |
| abivax sa sponsored ads | -12,735,000 |
| legend biotech corp sponsored ads | -3,699,930 |
GREAT POINT PARTNERS LLC got rid off the above stocks
Sector Distribution
GREAT POINT PARTNERS LLC has about 56.4% of it's holdings in Healthcare sector.
- Healthcare
- Others
| Sector | % |
|---|---|
| Healthcare | 56.4 |
| Others | 43.6 |
Market Cap. Distribution
GREAT POINT PARTNERS LLC has about 0% of it's portfolio invested in the large-cap and mega-cap stocks.
- UNALLOCATED
- SMALL-CAP
- MID-CAP
- MICRO-CAP
| Category | % |
|---|---|
| UNALLOCATED | 43.6 |
| SMALL-CAP | 32.7 |
| MID-CAP | 12.2 |
| MICRO-CAP | 11.5 |
Stocks belong to which Index?
About 35.9% of the stocks held by GREAT POINT PARTNERS LLC either belong to S&P 500 or RUSSELL 2000 index.
- Others
- RUSSELL 2000
| Index | % |
|---|---|
| Others | 64.1 |
| RUSSELL 2000 | 35.9 |
GREAT POINT PARTNERS LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of GREAT POINT PARTNERS LLC
GREAT POINT PARTNERS LLC has 29 stocks in it's portfolio. About 62% of the portfolio is in top 10 stocks. RZLT proved to be the most loss making stock for the portfolio. was the most profitable stock for GREAT POINT PARTNERS LLC last quarter.
Last Reported on: 17 Feb, 2026| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ABSI | absci corporation | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AKRO | akero therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AMLX | amylyx pharmaceuticals inc | 6.85 | 1,750,000 | 21,140,000 | added | 2.94 | ||
| ASND | ascendis pharma a/s sponsored adr | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AVTE | jade biosciences inc | 4.03 | 806,273 | 12,440,800 | added | 27.45 | ||
| AVTX | avalo therapeutics inc | 0.73 | 124,666 | 2,263,940 | new | |||
| CGEM | cullinan therapeutics inc | 2.13 | 634,032 | 6,562,230 | new | |||
| CNTX | context therapeutics inc | 2.23 | 4,683,710 | 6,885,060 | unchanged | 0.00 | ||
| CYTK | cytokinetics inc com new | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| DBVT | dbv technologies s a sponsored ads | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ELYM | climb bio inc | 1.27 | 979,534 | 3,918,140 | new | |||
| FULC | fulcrum therapeutics inc | 2.93 | 800,000 | 9,048,000 | new | |||
| IMVT | immunovant inc | 6.18 | 750,000 | 19,065,000 | added | 50.00 | ||
| IONS | ionis pharmaceuticals inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| KALV | kalvista pharmaceuticals inc | 3.59 | 685,632 | 11,073,000 | new | |||
| LEGN | legend biotech corp sponsored ads | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| NKTR | nektar therapeutics | 2.89 | 210,732 | 8,909,750 | reduced | -29.76 | ||
| PHVS | pharvaris n v | 0.74 | 82,800 | 2,297,700 | reduced | -46.62 | ||
| PLRX | pliant therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| RAPT | rapt therapeutics inc | 6.38 | 581,187 | 19,684,800 | new | |||