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Latest HighVista Strategies LLC Stock Portfolio

$438Million | No. of Holdings #146

HighVista Strategies LLC Performance

2026 Q2+18.24%
YTD+18.97%
2025+42.99%

About HighVista Strategies LLC and 13F Hedge Fund Stock Holdings

HighVista Strategies LLC is a hedge fund based in Boston, MA. On 2026-08-14, the fund reported it's updated stock portfolio. In the 13F Holdings report, HighVista Strategies LLC reported an equity portfolio of $438.6 Millions as of 30 Jun, 2026. <br><br> The top stock holdings of HighVista Strategies LLC are DBC, , RVMD. The fund has invested 6.4% of it's portfolio in INVESCO DB COMMDY INDX TRCK and 3.4% of portfolio in ABIVAX SA. <br><br> The fund managers got completely rid off TERNS PHARMACEUTICALS INC (TERN), NUVALENT INC (NUVL) and SOLENO THERAPEUTICS INC (SLNO) stocks. They significantly reduced their stock positions in BRIDGEBIO PHARMA INC (BBIO), MICRON TECHNOLOGY INC (MU) and MICROSOFT CORP (MSFT). HighVista Strategies LLC opened new stock positions in C4 THERAPEUTICS INC (CCCC), RELMADA THERAPEUTICS INC (RLMD) and TEXAS INSTRS INC (TXN). The fund showed a lot of confidence in some stocks as they added substantially to QXO INC (SSNT), TALEN ENERGY CORP and TANGO THERAPEUTICS INC (TNGX).
HighVista Strategies LLC Equity Portfolio Value
Last Reported on: 14 Aug, 2026
$438Million
  as of Aug 14, 2026

HighVista Strategies LLC Annual Return Estimates Vs S&P 500

Our best estimate is that HighVista Strategies LLC made a return of 18.24% in the last quarter. In trailing 12 months, it's portfolio return was 67.72%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
c4 therapeutics inc6,295,800
relmada therapeutics inc3,084,930
texas instrs inc1,937,460
dnow inc1,723,710
nucor corp1,692,900
usa today co inc1,611,680
calumet inc1,584,880
qnity electronics inc1,584,110
New stocks bought by HighVista Strategies LLC

Additions

Ticker% Inc.
qxo inc209
talen energy corp161
tango therapeutics inc149
alkermes plc144
travere therapeutics inc137
avalo therapeutics inc109
enliven therapeutics inc88.59
mineralys therapeutics inc84.03
Additions to existing portfolio by HighVista Strategies LLC

Reductions

Ticker% Reduced
bridgebio pharma inc-73.45
micron technology inc-66.84
microsoft corp-62.63
constellation energy corp-56.71
lumentum hldgs inc-51.33
banco bradesco s a-50.48
xencor inc-49.44
oruka therapeutics inc-46.9
HighVista Strategies LLC reduced stake in above stock

Sold off

Ticker$ Sold
rlx technology inc-685,740
avantor inc-1,462,160
soleno therapeutics inc-5,531,800
terns pharmaceuticals inc-6,026,260
cleveland-cliffs inc new-865,905
bridgebio oncology therapeut-699,774
nokia corp-569,425
petroleo brasileiro s a-1,113,750
HighVista Strategies LLC got rid off the above stocks

Sector Distribution

HighVista Strategies LLC has about 49.6% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
  • Technology
  • Industrials
  • Financial Services
  • Utilities
  • Consumer Cyclical
  • Communication Services
Sector%
Healthcare49.6
Others33.1
Technology6.4
Industrials3.5
Financial Services1.8
Utilities1.4
Consumer Cyclical1.4
Communication Services1.2

Market Cap. Distribution

HighVista Strategies LLC has about 21.5% of it's portfolio invested in the large-cap and mega-cap stocks.

  • MID-CAP
  • UNALLOCATED
  • LARGE-CAP
  • SMALL-CAP
  • MEGA-CAP
Category%
MID-CAP34.2
UNALLOCATED33.1
LARGE-CAP16.9
SMALL-CAP11.1
MEGA-CAP4.6

Stocks belong to which Index?

About 51.2% of the stocks held by HighVista Strategies LLC either belong to S&P 500 or RUSSELL 2000 index.

  • Others
  • RUSSELL 2000
  • S&P 500
Index%
Others48.8
RUSSELL 200040.9
S&P 50010.3
Top 5 Winners (%)%
MU
micron technology inc
160.9 %
CMPS
compass pathways plc
152.3 %
STX
seagate technology hldngs pl
120.3 %
WDC
western digital corp
118.7 %
definium therapeutics inc
111.9 %
Top 5 Winners ($)$
RVMD
revolution medicines inc
6.1 M
definium therapeutics inc
6.0 M
AGLE
spyre therapeutics inc
4.3 M
LQDA
liquidia corporation
4.1 M
RLAY
relay therapeutics inc
4.1 M
Top 5 Losers (%)%
INSM
insmed inc
-32.2 %
IVA
inventiva sa
-28.9 %
PDD
pdd holdings inc
-22.8 %
CTMX
cytomx therapeutics inc.
-16.1 %
EDU
new oriental ed & technology
-15.7 %
Top 5 Losers ($)$
DBC
invesco db commdy indx trck
-2.4 M
INSM
insmed inc
-1.6 M
IVA
inventiva sa
-1.3 M
TYRA
tyra biosciences inc
-1.0 M
TARS
tarsus pharmaceuticals inc
-0.5 M

HighVista Strategies LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of HighVista Strategies LLC

HighVista Strategies LLC has 146 stocks in it's portfolio. About 28.2% of the portfolio is in top 10 stocks. DBC proved to be the most loss making stock for the portfolio. RVMD was the most profitable stock for HighVista Strategies LLC last quarter.

$438.60MTotal Value
185Positions
14 Aug, 2026Last Reported
Current holdings of Current Stock Holdings of HighVista Strategies LLC, last reported on 14 Aug, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change
ARGX
Argenx Se

Argenx Se

ARGX
HighVista Strategies LLC's holding in Argenx Se over time
0.96%4,561
$4.23M
0.96%
decreased 7.26 percentreduced
ASND
Ascendis Pharma A/S

Ascendis Pharma A/S

ASND
HighVista Strategies LLC's holding in Ascendis Pharma A/S over time
0%0.00
$0.00
0%
decreased 100 percentsold off
BBD
Banco Bradesco S A

Banco Bradesco S A

BBD
HighVista Strategies LLC's holding in Banco Bradesco S A over time
0.08%103,132
$357.9K
0.08%
decreased 50.48 percentreduced