Latest HighVista Strategies LLC Stock Portfolio
HighVista Strategies LLC Performance:
2025 Q3: 10.07%YTD: 11.29%2024: 4.91%
Performance for 2025 Q3 is 10.07%, and YTD is 11.29%, and 2024 is 4.91%.
About HighVista Strategies LLC and 13F Hedge Fund Stock Holdings
HighVista Strategies LLC is a hedge fund based in BOSTON, MA. On 27-Jun-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $4.9 Billions. In it's latest 13F Holdings report, HighVista Strategies LLC reported an equity portfolio of $408 Millions as of 30 Sep, 2025.
The top stock holdings of HighVista Strategies LLC are DBC, , MRUS. The fund has invested 7.9% of it's portfolio in INVESCO DB COMMDY INDX TRCK and 3.8% of portfolio in ABIVAX SA.
The fund managers got completely rid off ANSYS INC (ANSS), JUNIPER NETWORKS INC (JNPR) and HESS CORP (HES) stocks. They significantly reduced their stock positions in WESTERN DIGITAL CORP (WDC), SEAGATE TECHNOLOGY HLDNGS PL (STX) and GE VERNOVA INC. HighVista Strategies LLC opened new stock positions in CIDARA THERAPEUTICS INC (CDTX), ALPHABET INC (GOOG) and CRH PLC (CRH). The fund showed a lot of confidence in some stocks as they added substantially to GH RESEARCH PLC, INSMED INC (INSM) and EVOLUS INC (EOLS).
The top stock holdings of HighVista Strategies LLC are DBC, , MRUS. The fund has invested 7.9% of it's portfolio in INVESCO DB COMMDY INDX TRCK and 3.8% of portfolio in ABIVAX SA.
The fund managers got completely rid off ANSYS INC (ANSS), JUNIPER NETWORKS INC (JNPR) and HESS CORP (HES) stocks. They significantly reduced their stock positions in WESTERN DIGITAL CORP (WDC), SEAGATE TECHNOLOGY HLDNGS PL (STX) and GE VERNOVA INC. HighVista Strategies LLC opened new stock positions in CIDARA THERAPEUTICS INC (CDTX), ALPHABET INC (GOOG) and CRH PLC (CRH). The fund showed a lot of confidence in some stocks as they added substantially to GH RESEARCH PLC, INSMED INC (INSM) and EVOLUS INC (EOLS).
HighVista Strategies LLC Annual Return Estimates Vs S&P 500
Our best estimate is that HighVista Strategies LLC made a return of 10.07% in the last quarter. In trailing 12 months, it's portfolio return was 8.96%.
New Buys
| Ticker | $ Bought |
|---|---|
| cidara therapeutics inc | 6,789,770 |
| alphabet inc | 2,386,790 |
| crh plc | 2,330,740 |
| avantor inc | 2,151,550 |
| clean harbors inc | 2,114,600 |
| lumentum hldgs inc | 2,103,350 |
| flowserve corp | 2,071,130 |
| capital one finl corp | 2,056,500 |
New stocks bought by HighVista Strategies LLC
Additions
| Ticker | % Inc. |
|---|---|
| gh research plc | 362 |
| insmed inc | 330 |
| evolus inc | 289 |
| abivax sa | 260 |
| dianthus therapeutics inc | 241 |
| edgewise therapeutics inc | 198 |
| agios pharmaceuticals inc | 178 |
| structure therapeutics inc | 172 |
Additions to existing portfolio by HighVista Strategies LLC
Reductions
| Ticker | % Reduced |
|---|---|
| western digital corp | -71.85 |
| seagate technology hldngs pl | -68.79 |
| ge vernova inc | -58.75 |
| core scientific inc new | -58.22 |
| booking holdings inc | -56.02 |
| 3m co | -47.22 |
| coupang inc | -44.07 |
| sea ltd | -42.5 |
HighVista Strategies LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| cleveland-cliffs inc new | -1,942,560 |
| perspective therapeutics inc | -475,924 |
| geron corp | -187,123 |
| lyft inc | -1,982,610 |
| juniper networks inc | -4,579,970 |
| 89bio inc | -467,756 |
| amedisys inc | -3,861,810 |
| rexford indl rlty inc | -1,287,630 |
HighVista Strategies LLC got rid off the above stocks
Sector Distribution
HighVista Strategies LLC has about 46% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 46 |
| Others | 28 |
| Technology | 11 |
| Industrials | 4.8 |
| Financial Services | 3 |
| Consumer Cyclical | 2.7 |
| Communication Services | 1.7 |
| Utilities | 1.1 |
| Basic Materials | 1.1 |
Market Cap. Distribution
HighVista Strategies LLC has about 21% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| MID-CAP | 31.2 |
| UNALLOCATED | 28.8 |
| SMALL-CAP | 15.6 |
| LARGE-CAP | 12.5 |
| MEGA-CAP | 8.5 |
| MICRO-CAP | 3.3 |
Stocks belong to which Index?
About 52.6% of the stocks held by HighVista Strategies LLC either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| Others | 47.4 |
| RUSSELL 2000 | 37.1 |
| S&P 500 | 15.5 |
HighVista Strategies LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of HighVista Strategies LLC
HighVista Strategies LLC has 147 stocks in it's portfolio. About 29.1% of the portfolio is in top 10 stocks. MLTX proved to be the most loss making stock for the portfolio. MRUS was the most profitable stock for HighVista Strategies LLC last quarter.
Last Reported on: 14 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ACLX | arcellx inc | 1.94 | 96,177 | 7,896,130 | added | 169 | ||
| ADBE | adobe inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ADMA | adma biologics inc | 0.34 | 95,112 | 1,394,340 | new | |||
| AFRM | affirm hldgs inc | 0.22 | 12,500 | 913,500 | new | |||
| AGIO | agios pharmaceuticals inc | 1.92 | 195,298 | 7,839,260 | added | 178 | ||
| AGLE | spyre therapeutics inc | 0.89 | 215,746 | 3,615,900 | added | 91.26 | ||
| AGX | argan inc | 0.47 | 7,100 | 1,917,360 | added | 24.56 | ||
| AKRO | akero therapeutics inc | 1.28 | 110,079 | 5,226,550 | added | 83.49 | ||
| ALKS | alkermes plc | 0.32 | 44,081 | 1,322,430 | reduced | -16.74 | ||
| ALV | autoliv inc | 0.26 | 8,700 | 1,074,450 | added | 2.35 | ||
| AMD | advanced micro devices inc | 0.68 | 17,200 | 2,782,790 | added | 11.69 | ||
| AMED | amedisys inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AMZN | amazon com inc | 1.42 | 26,393 | 5,795,110 | added | 39.7 | ||
| ANSS | ansys inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| APG | api group corp | 0.40 | 47,350 | 1,627,420 | added | 88.27 | ||
| APH | amphenol corp new | 0.47 | 15,400 | 1,905,750 | reduced | -18.95 | ||
| APLS | apellis pharmaceuticals inc | 0.81 | 145,729 | 3,297,850 | added | 68.16 | ||
| AURA | aura biosciences inc | 0.04 | 27,174 | 167,935 | new | |||
| AVGO | broadcom inc | 0.82 | 10,200 | 3,365,080 | reduced | -20.31 | ||
| AVTR | avantor inc | 0.53 | 172,400 | 2,151,550 | new | |||