Latest HighVista Strategies LLC Stock Portfolio

HighVista Strategies LLC Performance:

2025 Q4: 20.22%YTD: 42.99%2024: 5.47%

Performance for 2025 Q4 is 20.22%, and YTD is 42.99%, and 2024 is 5.47%.

About HighVista Strategies LLC and 13F Hedge Fund Stock Holdings

HighVista Strategies LLC is a hedge fund based in Boston, MA. On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, HighVista Strategies LLC reported an equity portfolio of $388.3 Millions as of 31 Dec, 2025.

The top stock holdings of HighVista Strategies LLC are DBC, , COGT. The fund has invested 6.1% of it's portfolio in INVESCO DB COMMDY INDX TRCK and 3.5% of portfolio in STRUCTURE THERAPEUTICS INC.

The fund managers got completely rid off MERUS N V (MRUS), AKERO THERAPEUTICS INC (AKRO) and XENON PHARMACEUTICALS INC (XENE) stocks. They significantly reduced their stock positions in SANDISK CORP, ARGAN INC (AGX) and PRAXIS PRECISION MEDICINES I (PRAX). HighVista Strategies LLC opened new stock positions in TERNS PHARMACEUTICALS INC (TERN), MAZE THERAPEUTICS INC and PHARVARIS N V (PHVS). The fund showed a lot of confidence in some stocks as they added substantially to SOLENO THERAPEUTICS INC (SLNO), AVALO THERAPEUTICS INC (AVTX) and OCULAR THERAPEUTIX INC (OCUL).

HighVista Strategies LLC Annual Return Estimates Vs S&P 500

Our best estimate is that HighVista Strategies LLC made a return of 20.22% in the last quarter. In trailing 12 months, it's portfolio return was 42.99%.

Performance
S&P 500

New Buys

Ticker	$ Bought
terns pharmaceuticals inc	7,088,660
maze therapeutics inc	7,057,720
pharvaris n v	4,505,770
stoke therapeutics inc	3,667,210
compass pathways plc	3,442,640
lb pharmaceuticals inc	3,118,780
palisade bio inc	3,055,070
transdigm group inc	2,892,420

New stocks bought by HighVista Strategies LLC

Additions

Ticker	% Inc.
soleno therapeutics inc	622
avalo therapeutics inc	244
ocular therapeutix inc	222
relay therapeutics inc	126
tarsus pharmaceuticals inc	115
booking holdings inc	54.78
sea ltd	44.91
alcon ag	32.79

Additions to existing portfolio by HighVista Strategies LLC

Reductions

Ticker	% Reduced
sandisk corp	-90.77
argan inc	-73.3
praxis precision medicines i	-72.8
enliven therapeutics inc	-68.15
cidara therapeutics inc	-67.66
lumentum hldgs inc	-66.6
compania de minas buenaventu	-64.25
banco bradesco s a	-63.42

HighVista Strategies LLC reduced stake in above stock

Sold off

Ticker	$ Sold
evolus inc	-1,387,790
dynavax technologies corp	-1,914,990
avantor inc	-2,151,550
merus n v	-12,552,200
corbus pharmaceuticals hldgs	-1,493,040
akero therapeutics inc	-5,226,550
roivant sciences ltd	-1,495,720
adma biologics inc	-1,394,340

HighVista Strategies LLC got rid off the above stocks

Sector Distribution

HighVista Strategies LLC has about 52.2% of it's holdings in Healthcare sector.

Sector	%
Healthcare	52.2
Others	28.9
Technology	7
Industrials	4.1
Financial Services	2
Consumer Cyclical	1.9
Utilities	1.5
Communication Services	1.1

Market Cap. Distribution

HighVista Strategies LLC has about 24.9% of it's portfolio invested in the large-cap and mega-cap stocks.

Category	%
MID-CAP	34
UNALLOCATED	28.9
LARGE-CAP	19.9
SMALL-CAP	10
MEGA-CAP	5
MICRO-CAP	2.2

Stocks belong to which Index?

About 53.1% of the stocks held by HighVista Strategies LLC either belong to S&P 500 or RUSSELL 2000 index.

Index	%
Others	46.9
RUSSELL 2000	42.3
S&P 500	10.8

Top 5 Winners (%)		%
PRAX	praxis precision medicines i	290.1 %
	structure therapeutics inc	134.8 %
COGT	cogent biosciences inc	127.3 %
OLMA	olema pharmaceuticals inc	120.6 %
AGLE	spyre therapeutics inc	89.4 %

Top 5 Winners ($)		$
PRAX	praxis precision medicines i	14.6 M
	structure therapeutics inc	8.9 M
COGT	cogent biosciences inc	8.5 M
	abivax sa	6.4 M
CDTX	cidara therapeutics inc	5.9 M

Top 5 Losers (%)		%
RBLX	roblox corp	-40.9 %
JANX	janux therapeutics inc	-38.1 %
XOMA	xoma royalty corporation	-30.3 %
AGIO	agios pharmaceuticals inc	-28.3 %
CPNG	coupang inc	-26.4 %

Top 5 Losers ($)		$
AGIO	agios pharmaceuticals inc	-2.2 M
SLNO	soleno therapeutics inc	-1.6 M
ACLX	arcellx inc	-1.4 M
XOMA	xoma royalty corporation	-1.3 M
	enliven therapeutics inc	-0.9 M

HighVista Strategies LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of HighVista Strategies LLC

HighVista Strategies LLC has 144 stocks in it's portfolio. About 28.1% of the portfolio is in top 10 stocks. AGIO proved to be the most loss making stock for the portfolio. PRAX was the most profitable stock for HighVista Strategies LLC last quarter.

Last Reported on: 17 Feb, 2026

Ticker	Namesorted ascending	% Portfolio	Shares Held	$ Value	Type	% Change
ACHC	acadia healthcare company in	0.30	81,630	1,158,330	new

ACLX	arcellx inc	1.26	75,002	4,890,130	reduced	-22.02

ADMA	adma biologics inc	0.00	0.00	0.00	sold off	-100

AFRM	affirm hldgs inc	0.25	13,086	973,991	added	4.69

AGIO	agios pharmaceuticals inc	1.03	147,662	4,019,360	reduced	-24.39

AGLE	spyre therapeutics inc	1.59	188,206	6,165,630	reduced	-12.77

AGX	argan inc	0.15	1,896	594,055	reduced	-73.3

AKRO	akero therapeutics inc	0.00	0.00	0.00	sold off	-100

ALC	alcon ag	0.17	10,440	660,643	added	32.79

ALKS	alkermes plc	0.19	26,401	738,700	reduced	-40.11

ALV	autoliv inc	0.16	5,243	622,344	reduced	-39.74

AMD	advanced micro devices inc	0.00	0.00	0.00	sold off	-100

AMLX	amylyx pharmaceuticals inc	0.74	238,812	2,884,850	new

AMZN	amazon com inc	1.03	17,397	4,015,580	reduced	-34.08

APG	api group corp	0.30	30,958	1,184,450	reduced	-34.62

APH	amphenol corp new	0.25	7,081	956,926	reduced	-54.02

APLS	apellis pharmaceuticals inc	0.98	150,776	3,787,490	added	3.46

APP	applovin corp	0.43	2,482	1,672,420	new

ARGX	argenx se	0.78	3,588	3,017,330	reduced	-11.8

ASND	ascendis pharma a/s	0.20	3,660	780,458	reduced	-48.32