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Latest HighVista Strategies LLC Stock Portfolio

$362Million | No. of Holdings #155

HighVista Strategies LLC Performance

2026 Q1+0.62%
YTD+0.62%
2025+42.99%

About HighVista Strategies LLC and 13F Hedge Fund Stock Holdings

HighVista Strategies LLC is a hedge fund based in Boston, MA. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, HighVista Strategies LLC reported an equity portfolio of $362.2 Millions as of 31 Mar, 2026. <br><br> The top stock holdings of HighVista Strategies LLC are DBC, , PRAX. The fund has invested 8.4% of it's portfolio in INVESCO DB COMMDY INDX TRCK and 3.5% of portfolio in ABIVAX SA. <br><br> The fund managers got completely rid off CIDARA THERAPEUTICS INC (CDTX), ARCELLX INC (ACLX) and AGIOS PHARMACEUTICALS INC (AGIO) stocks. They significantly reduced their stock positions in CENTESSA PHARMACEUTICALS PLC (CNTA), BRIDGEBIO ONCOLOGY THERAPEUT and VIRIDIAN THERAPEUTICS INC (VRDN). HighVista Strategies LLC opened new stock positions in ORUKA THERAPEUTICS INC, MOONLAKE IMMUNOTHERAPEUTICS (MLTX) and NURIX THERAPEUTICS INC (NRIX). The fund showed a lot of confidence in some stocks as they added substantially to TYRA BIOSCIENCES INC (TYRA), DYNE THERAPEUTICS INC (DYN) and ALKERMES PLC (ALKS).
HighVista Strategies LLC Equity Portfolio Value
Last Reported on: 15 May, 2026
$362Million
  as of May 15, 2026

HighVista Strategies LLC Annual Return Estimates Vs S&P 500

Our best estimate is that HighVista Strategies LLC made a return of 0.62% in the last quarter. In trailing 12 months, it's portfolio return was 53.93%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
oruka therapeutics inc3,870,580
moonlake immunotherapeutics3,615,320
definium therapeutics inc3,512,680
nurix therapeutics inc3,511,460
inventiva sa3,416,950
erasca inc2,929,700
xenon pharmaceuticals inc2,852,260
vera therapeutics inc2,785,570
New stocks bought by HighVista Strategies LLC

Additions

Ticker% Inc.
tyra biosciences inc274
dyne therapeutics inc206
alkermes plc177
unity software inc118
coupang inc85.69
axsome therapeutics inc.83.6
immunocore hldgs plc77.88
celldex therapeutics inc new72.56
Additions to existing portfolio by HighVista Strategies LLC

Reductions

Ticker% Reduced
centessa pharmaceuticals plc-86.59
bridgebio oncology therapeut-65.9
viridian therapeutics inc-63.96
mineralys therapeutics inc-62.44
rhythm pharmaceuticals inc-60.82
apogee therapeutics inc-59.92
xoma royalty corporation-58.54
qxo inc-55.18
HighVista Strategies LLC reduced stake in above stock

Sold off

Ticker$ Sold
compass therapeutics inc-1,318,510
apellis pharmaceuticals inc-3,787,490
agios pharmaceuticals inc-4,019,360
orthofix med inc-1,289,340
acadia healthcare company in-1,158,330
septerna inc-2,193,650
arcellx inc-4,890,130
avidity biosciences inc-2,886,640
HighVista Strategies LLC got rid off the above stocks

Sector Distribution

HighVista Strategies LLC has about 48% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
  • Technology
  • Industrials
  • Consumer Cyclical
  • Financial Services
  • Utilities
Sector%
Healthcare48
Others32.4
Technology7.9
Industrials4
Consumer Cyclical2.1
Financial Services1.5
Utilities1.4

Market Cap. Distribution

HighVista Strategies LLC has about 22.8% of it's portfolio invested in the large-cap and mega-cap stocks.

  • UNALLOCATED
  • MID-CAP
  • LARGE-CAP
  • SMALL-CAP
  • MEGA-CAP
  • MICRO-CAP
Category%
UNALLOCATED32.4
MID-CAP29.8
LARGE-CAP17.2
SMALL-CAP13.3
MEGA-CAP5.6
MICRO-CAP1.6

Stocks belong to which Index?

About 48.9% of the stocks held by HighVista Strategies LLC either belong to S&P 500 or RUSSELL 2000 index.

  • Others
  • RUSSELL 2000
  • S&P 500
Index%
Others51
RUSSELL 200037.3
S&P 50011.6
Top 5 Winners (%)%
enliven therapeutics inc
145.7 %
dianthus therapeutics inc
89.9 %
LITE
lumentum hldgs inc
78.1 %
AGX
argan inc
73.8 %
CIEN
ciena corp
65.0 %
Top 5 Winners ($)$
DBC
invesco db commdy indx trck
7.0 M
AGLE
spyre therapeutics inc
3.0 M
enliven therapeutics inc
1.9 M
dianthus therapeutics inc
1.8 M
TERN
terns pharmaceuticals inc
1.8 M
Top 5 Losers (%)%
U
unity software inc
-42.5 %
reddit inc
-38.5 %
WDAY
workday inc
-36.8 %
SE
sea ltd
-35.1 %
BZ
kanzhun limited
-33.9 %
Top 5 Losers ($)$
structure therapeutics inc
-3.4 M
VRDN
viridian therapeutics inc
-2.9 M
abivax sa
-2.2 M
SLNO
soleno therapeutics inc
-1.9 M
OLMA
olema pharmaceuticals inc
-1.8 M

HighVista Strategies LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of HighVista Strategies LLC

HighVista Strategies LLC has 155 stocks in it's portfolio. About 27.2% of the portfolio is in top 10 stocks. proved to be the most loss making stock for the portfolio. DBC was the most profitable stock for HighVista Strategies LLC last quarter.

$362.16MTotal Value
180Positions
15 May, 2026Last Reported
Current holdings of Current Stock Holdings of HighVista Strategies LLC, last reported on 15 May, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change
ALC
Alcon Ag

Alcon Ag

ALC
HighVista Strategies LLC's holding in Alcon Ag over time
0%0.00
$0.00
0%
decreased 100 percentsold off
ARGX
Argenx Se

Argenx Se

ARGX
HighVista Strategies LLC's holding in Argenx Se over time
0.99%4,918
$3.59M
0.99%
increased 37.07 percentadded
ASND
Ascendis Pharma A/S

Ascendis Pharma A/S

ASND
HighVista Strategies LLC's holding in Ascendis Pharma A/S over time
0.36%5,781
$1.32M
0.36%
increased 57.95 percentadded