Latest HighVista Strategies LLC Stock Portfolio

$362Million– No. of Holdings #155

HighVista Strategies LLC Performance:

2026 Q1: 0.62%YTD: 0.62%2025: 42.99%

Performance for 2026 Q1 is 0.62%, and YTD is 0.62%, and 2025 is 42.99%.

About HighVista Strategies LLC and 13F Hedge Fund Stock Holdings

HighVista Strategies LLC is a hedge fund based in Boston, MA. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, HighVista Strategies LLC reported an equity portfolio of $362.2 Millions as of 31 Mar, 2026.

The top stock holdings of HighVista Strategies LLC are DBC, , PRAX. The fund has invested 8.4% of it's portfolio in INVESCO DB COMMDY INDX TRCK and 3.5% of portfolio in ABIVAX SA.

The fund managers got completely rid off CIDARA THERAPEUTICS INC (CDTX), ARCELLX INC (ACLX) and AGIOS PHARMACEUTICALS INC (AGIO) stocks. They significantly reduced their stock positions in CENTESSA PHARMACEUTICALS PLC (CNTA), BRIDGEBIO ONCOLOGY THERAPEUT and VIRIDIAN THERAPEUTICS INC (VRDN). HighVista Strategies LLC opened new stock positions in ORUKA THERAPEUTICS INC, MOONLAKE IMMUNOTHERAPEUTICS (MLTX) and NURIX THERAPEUTICS INC (NRIX). The fund showed a lot of confidence in some stocks as they added substantially to TYRA BIOSCIENCES INC (TYRA), DYNE THERAPEUTICS INC (DYN) and ALKERMES PLC (ALKS).

HighVista Strategies LLC Equity Portfolio Value

Last Reported on: 15 May, 2026

HighVista Strategies LLC Annual Return Estimates Vs S&P 500

Our best estimate is that HighVista Strategies LLC made a return of 0.62% in the last quarter. In trailing 12 months, it's portfolio return was 53.93%.

Performance
S&P 500

New Buys

Ticker	$ Bought
oruka therapeutics inc	3,870,580
moonlake immunotherapeutics	3,615,320
definium therapeutics inc	3,512,680
nurix therapeutics inc	3,511,460
inventiva sa	3,416,950
erasca inc	2,929,700
xenon pharmaceuticals inc	2,852,260
vera therapeutics inc	2,785,570

New stocks bought by HighVista Strategies LLC

Additions

Ticker	% Inc.
tyra biosciences inc	274
dyne therapeutics inc	206
alkermes plc	177
unity software inc	118
coupang inc	85.69
axsome therapeutics inc.	83.6
immunocore hldgs plc	77.88
celldex therapeutics inc new	72.56

Additions to existing portfolio by HighVista Strategies LLC

Reductions

Ticker	% Reduced
centessa pharmaceuticals plc	-86.59
bridgebio oncology therapeut	-65.9
viridian therapeutics inc	-63.96
mineralys therapeutics inc	-62.44
rhythm pharmaceuticals inc	-60.82
apogee therapeutics inc	-59.92
xoma royalty corporation	-58.54
qxo inc	-55.18

HighVista Strategies LLC reduced stake in above stock

Sold off

Ticker	$ Sold
compass therapeutics inc	-1,318,510
apellis pharmaceuticals inc	-3,787,490
agios pharmaceuticals inc	-4,019,360
orthofix med inc	-1,289,340
acadia healthcare company in	-1,158,330
septerna inc	-2,193,650
arcellx inc	-4,890,130
avidity biosciences inc	-2,886,640

HighVista Strategies LLC got rid off the above stocks

Sector Distribution

HighVista Strategies LLC has about 48% of it's holdings in Healthcare sector.

Healthcare
Others
Technology
Industrials
Consumer Cyclical
Financial Services
Utilities

Sector	%
Healthcare	48
Others	32.4
Technology	7.9
Industrials	4
Consumer Cyclical	2.1
Financial Services	1.5
Utilities	1.4

Market Cap. Distribution

HighVista Strategies LLC has about 22.8% of it's portfolio invested in the large-cap and mega-cap stocks.

UNALLOCATED
MID-CAP
LARGE-CAP
SMALL-CAP
MEGA-CAP
MICRO-CAP

Category	%
UNALLOCATED	32.4
MID-CAP	29.8
LARGE-CAP	17.2
SMALL-CAP	13.3
MEGA-CAP	5.6
MICRO-CAP	1.6

Stocks belong to which Index?

About 48.9% of the stocks held by HighVista Strategies LLC either belong to S&P 500 or RUSSELL 2000 index.

Others
RUSSELL 2000
S&P 500

Index	%
Others	51
RUSSELL 2000	37.3
S&P 500	11.6

Top 5 Winners (%)		%
	enliven therapeutics inc	145.7 %
	dianthus therapeutics inc	89.9 %
LITE	lumentum hldgs inc	78.1 %
AGX	argan inc	73.8 %
CIEN	ciena corp	65.0 %

Top 5 Winners ($)		$
DBC	invesco db commdy indx trck	7.0 M
AGLE	spyre therapeutics inc	3.0 M
	enliven therapeutics inc	1.9 M
	dianthus therapeutics inc	1.8 M
TERN	terns pharmaceuticals inc	1.8 M

Top 5 Losers (%)		%
U	unity software inc	-42.5 %
	reddit inc	-38.5 %
WDAY	workday inc	-36.8 %
SE	sea ltd	-35.1 %
BZ	kanzhun limited	-33.9 %

Top 5 Losers ($)		$
	structure therapeutics inc	-3.4 M
VRDN	viridian therapeutics inc	-2.9 M
	abivax sa	-2.2 M
SLNO	soleno therapeutics inc	-1.9 M
OLMA	olema pharmaceuticals inc	-1.8 M

HighVista Strategies LLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of HighVista Strategies LLC

HighVista Strategies LLC has 155 stocks in it's portfolio. About 27.2% of the portfolio is in top 10 stocks. proved to be the most loss making stock for the portfolio. DBC was the most profitable stock for HighVista Strategies LLC last quarter.

Last Reported on: 15 May, 2026

Ticker	Namesorted ascending	% Portfolio	Shares Held	$ Value	Type	% Change
ACHC	acadia healthcare company in	0.00	0.00	0.00	sold off	-100

ACLX	arcellx inc	0.00	0.00	0.00	sold off	-100

AFRM	affirm hldgs inc	0.00	0.00	0.00	sold off	-100

AGIO	agios pharmaceuticals inc	0.00	0.00	0.00	sold off	-100

AGLE	spyre therapeutics inc	2.04	146,264	7,377,560	reduced	-22.29

AGX	argan inc	0.28	1,896	1,032,660	unchanged	0.00

ALC	alcon ag	0.00	0.00	0.00	sold off	-100

ALKS	alkermes plc	0.72	73,189	2,587,960	added	177

ALV	autoliv inc	0.00	0.00	0.00	sold off	-100

AMLX	amylyx pharmaceuticals inc	1.35	352,085	4,893,980	added	47.43

AMZN	amazon com inc	1.29	22,397	4,664,620	added	28.74

APG	api group corp	0.30	26,658	1,080,180	reduced	-13.89

APH	amphenol corp	0.34	9,781	1,235,830	added	38.13

APLS	apellis pharmaceuticals inc	0.00	0.00	0.00	sold off	-100

APP	applovin corp	0.00	0.00	0.00	sold off	-100

ARGX	argenx se	0.99	4,918	3,591,370	added	37.07

ASMB	assembly biosciences inc	0.57	74,735	2,073,900	new

ASND	ascendis pharma a/s	0.36	5,781	1,322,290	added	57.95

AVGO	broadcom inc	0.48	5,599	1,732,950	reduced	-0.71

AVTR	avantor inc	0.40	186,500	1,462,160	new