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Latest Rock Springs Capital Management LP Stock Portfolio

$1.70Billion– No. of Holdings #101

Rock Springs Capital Management LP Performance:
2026 Q1: -4.57%YTD: -4.57%2025: 36.21%
Performance for 2026 Q1 is -4.57%, and YTD is -4.57%, and 2025 is 36.21%.

About Rock Springs Capital Management LP and 13F Hedge Fund Stock Holdings

Rock Springs Capital Management LP is a hedge fund based in Baltimore, MD. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, Rock Springs Capital Management LP reported an equity portfolio of $1.7 Billions as of 31 Mar, 2026.

The top stock holdings of Rock Springs Capital Management LP are RVMD, LLY, MDGL. The fund has invested 6.9% of it's portfolio in REVOLUTION MEDICINES INC and 5.3% of portfolio in ELI LILLY & CO.

The fund managers got completely rid off EXACT SCIENCES CORP (EXAS), CIDARA THERAPEUTICS INC (CDTX) and RAPT THERAPEUTICS INC (RAPT) stocks. They significantly reduced their stock positions in AMICUS THERAPEUTIC (FOLD), SPDR SERIES TRUST (BIL) and EDWARDS LIFESCIENCES CORP (EW). Rock Springs Capital Management LP opened new stock positions in MINIMED GROUP INC, STRYKER CORPORATION (SYK) and NOVO-NORDISK A S (NVO). The fund showed a lot of confidence in some stocks as they added substantially to JAZZ PHARMACEUTICALS PLC (JAZZ), PTC THERAPEUTICS INC (PTCT) and HEARTFLOW INC.
Rock Springs Capital Management LP Equity Portfolio Value
Last Reported on: 15 May, 2026

Rock Springs Capital Management LP Annual Return Estimates Vs S&P 500

Our best estimate is that Rock Springs Capital Management LP made a return of -4.57% in the last quarter. In trailing 12 months, it's portfolio return was 38.05%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
minimed group inc15,740,600
indivior pharmaceuticals inc6,096,000
stryker corporation4,863,130
novo-nordisk a s3,307,500
viking therapeutics inc3,123,840
century therapeutics inc2,947,820
cvs health corp2,872,800
dianthus therapeutics inc2,245,450
New stocks bought by Rock Springs Capital Management LP

Additions

Ticker% Inc.
jazz pharmaceuticals plc228
ptc therapeutics inc161
heartflow inc106
olema pharmaceuticals inc73.43
alkermes plc32.15
unitedhealth group inc29.9
boston scientific corp29.13
vaxcyte inc28.19
Additions to existing portfolio by Rock Springs Capital Management LP

Reductions

Ticker% Reduced
amicus therapeutic-98.91
spdr series trust-86.49
edwards lifesciences corp-64.97
gossamer bio inc-50.73
acadia healthcare company in-37.08
travere therapeutics inc-33.13
surgery partners inc-32.9
phreesia inc-31.51
Rock Springs Capital Management LP reduced stake in above stock

Sold off

Ticker$ Sold
gossamer bio inc-6,559,040
exact sciences corp-61,118,800
agilon health inc-4,476,550
agilon health inc-4,476,550
rapt therapeutics inc-7,239,070
theravance biopharma inc-3,906,100
cidara therapeutics inc-45,255,500
mersana therapeutics inc-4,414,310
Rock Springs Capital Management LP got rid off the above stocks

Sector Distribution

Rock Springs Capital Management LP has about 80.4% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
Sector%
Healthcare80.4
Others19.6

Market Cap. Distribution

Rock Springs Capital Management LP has about 37.8% of it's portfolio invested in the large-cap and mega-cap stocks.

  • LARGE-CAP
  • MID-CAP
  • UNALLOCATED
  • SMALL-CAP
  • MEGA-CAP
Category%
LARGE-CAP31.6
MID-CAP30.8
UNALLOCATED19.6
SMALL-CAP11.2
MEGA-CAP6.2

Stocks belong to which Index?

About 64.8% of the stocks held by Rock Springs Capital Management LP either belong to S&P 500 or RUSSELL 2000 index.

  • RUSSELL 2000
  • Others
  • S&P 500
Index%
RUSSELL 200051.1
Others35.2
S&P 50013.7
Top 5 Winners (%)%
ERAS
erasca inc
253.5 %
enliven therapeutics inc
148.0 %
TNGX
tango therapeutics inc
136.1 %
ACLX
arcellx inc
76.1 %
APLS
apellis pharmaceuticals inc
56.6 %
Top 5 Winners ($)$
RVMD
revolution medicines inc
22.4 M
enliven therapeutics inc
19.3 M
ERAS
erasca inc
12.8 M
MIRM
mirum pharmaceuticals inc
10.5 M
XENE
xenon pharmaceuticals inc
10.3 M
Top 5 Losers (%)%
GOSS
gossamer bio inc
-66.7 %
JSPR
jasper therapeutics inc
-52.1 %
ATEC
alphatec hldgs inc
-46.5 %
zenas biopharma inc
-46.2 %
INSP
inspire med sys inc
-44.0 %
Top 5 Losers ($)$
LLY
eli lilly & co
-15.8 M
TVTX
travere therapeutics inc
-15.7 M
BSX
boston scientific corp
-14.9 M
structure therapeutics inc
-14.8 M
IRTC
irhythm holdings inc
-14.8 M

Rock Springs Capital Management LP Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Rock Springs Capital Management LP

Rock Springs Capital Management LP has 101 stocks in it's portfolio. About 40.6% of the portfolio is in top 10 stocks. LLY proved to be the most loss making stock for the portfolio. RVMD was the most profitable stock for Rock Springs Capital Management LP last quarter.

Last Reported on: 15 May, 2026
TickerNamesorted ascending% PortfolioShares Held$ ValueType% ChangeOptions