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Latest Rock Springs Capital Management LP Stock Portfolio

$2.05Billion | No. of Holdings #105

Rock Springs Capital Management LP Performance

2026 Q2+15.95%
YTD+10.65%
2025+36.21%

About Rock Springs Capital Management LP and 13F Hedge Fund Stock Holdings

Rock Springs Capital Management LP is a hedge fund based in Baltimore, MD. On 2026-08-14, the fund reported it's updated stock portfolio. In the 13F Holdings report, Rock Springs Capital Management LP reported an equity portfolio of $2 Billions as of 30 Jun, 2026. <br><br> The top stock holdings of Rock Springs Capital Management LP are RVMD, TVTX, LLY. The fund has invested 10.1% of it's portfolio in REVOLUTION MEDICINES INC and 6% of portfolio in TRAVERE THERAPEUTICS INC. <br><br> The fund managers got completely rid off ASCENDIS PHARMA A/S (ASND), ARCELLX INC (ACLX) and CENTESSA PHARMACEUTICALS PLC (CNTA) stocks. They significantly reduced their stock positions in MOONLAKE IMMUNOTHERAPEUTICS (MLTX), VIKING THERAPEUTICS INC (VKTX) and SURGERY PARTNERS INC (SGRY). Rock Springs Capital Management LP opened new stock positions in ASCENDIS PHARMA A/S, OMEROS CORP (OMER) and TREVI THERAPEUTICS INC (TRVI). The fund showed a lot of confidence in some stocks as they added substantially to AGILON HEALTH INC (AGL), CYTOKINETICS INC (CYTK) and ORUKA THERAPEUTICS INC.
Rock Springs Capital Management LP Equity Portfolio Value
Last Reported on: 14 Aug, 2026
$2.05Billion
  as of Aug 14, 2026

Rock Springs Capital Management LP Annual Return Estimates Vs S&P 500

Our best estimate is that Rock Springs Capital Management LP made a return of 15.95% in the last quarter. In trailing 12 months, it's portfolio return was 53.57%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
ascendis pharma a/s45,009,000
avalyn pharmaceuticals inc21,823,300
hemab therapeutics hldgs inc21,135,600
parabilis medicines inc15,820,600
omeros corp6,832,920
definium therapeutics inc6,735,520
mobia med inc5,603,880
trevi therapeutics inc4,849,000
New stocks bought by Rock Springs Capital Management LP

Additions

Ticker% Inc.
agilon health inc2,425
agilon health inc2,425
cytokinetics inc314
oruka therapeutics inc192
stryker corporation95.95
inspire med sys inc85.13
biocryst pharmaceuticals inc75.59
travere therapeutics inc47.44
Additions to existing portfolio by Rock Springs Capital Management LP

Reductions

Ticker% Reduced
moonlake immunotherapeutics-82.66
viking therapeutics inc-73.44
surgery partners inc-59.62
argenx se-46.45
enliven therapeutics inc-43.78
agios pharmaceuticals inc-33.36
omada health inc-31.05
novo-nordisk a s-29.44
Rock Springs Capital Management LP reduced stake in above stock

Sold off

Ticker$ Sold
gossamer bio inc-528,718
centessa pharmaceuticals plc-13,974,600
soleno therapeutics inc-8,612,830
ascendis pharma a/s-44,373,600
arcellx inc-19,503,200
apellis pharmaceuticals inc-6,547,430
terns pharmaceuticals inc-5,996,800
acadia healthcare company in-1,765,940
Rock Springs Capital Management LP got rid off the above stocks

Sector Distribution

Rock Springs Capital Management LP has about 79.8% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
Sector%
Healthcare79.8
Others20.2

Market Cap. Distribution

Rock Springs Capital Management LP has about 35.8% of it's portfolio invested in the large-cap and mega-cap stocks.

  • MID-CAP
  • LARGE-CAP
  • UNALLOCATED
  • SMALL-CAP
  • MEGA-CAP
Category%
MID-CAP34.8
LARGE-CAP28.6
UNALLOCATED20.2
SMALL-CAP9
MEGA-CAP7.2

Stocks belong to which Index?

About 65.6% of the stocks held by Rock Springs Capital Management LP either belong to S&P 500 or RUSSELL 2000 index.

  • RUSSELL 2000
  • Others
  • S&P 500
Index%
RUSSELL 200053.3
Others34.3
S&P 50012.3
Top 5 Winners (%)%
EVH
evolent health inc
133.2 %
RVMD
revolution medicines inc
88.6 %
CORT
corcept therapeutics inc
83.6 %
mbx biosciences inc
82.3 %
TVTX
travere therapeutics inc
66.8 %
Top 5 Winners ($)$
RVMD
revolution medicines inc
104.2 M
TVTX
travere therapeutics inc
49.6 M
LLY
eli lilly & co
27.6 M
MIRM
mirum pharmaceuticals inc
19.9 M
RYTM
rhythm pharmaceuticals inc
16.6 M
Top 5 Losers (%)%
CMPX
compass therapeutics inc
-57.8 %
JSPR
jasper therapeutics inc
-52.0 %
lenz therapeutics inc
-37.9 %
INSM
insmed inc
-33.3 %
BSX
boston scientific corp
-31.7 %
Top 5 Losers ($)$
INSM
insmed inc
-19.2 M
AGL
agilon health inc
-12.4 M
AGL
agilon health inc
-12.4 M
CMPX
compass therapeutics inc
-10.6 M
BSX
boston scientific corp
-10.5 M

Rock Springs Capital Management LP Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Rock Springs Capital Management LP

Rock Springs Capital Management LP has 105 stocks in it's portfolio. About 44% of the portfolio is in top 10 stocks. INSM proved to be the most loss making stock for the portfolio. RVMD was the most profitable stock for Rock Springs Capital Management LP last quarter.

$2.05BTotal Value
117Positions
14 Aug, 2026Last Reported
Current holdings of Current Stock Holdings of Rock Springs Capital Management LP, last reported on 14 Aug, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change
ARGX
Argenx Se

Argenx Se

ARGX
Rock Springs Capital Management LP's holding in Argenx Se over time
2.39%52,750
$48.94M
2.39%
decreased 46.45 percentreduced
ASND
Ascendis Pharma A/S

Ascendis Pharma A/S

ASND
Rock Springs Capital Management LP's holding in Ascendis Pharma A/S over time
0%0.00
$0.00
0%
decreased 100 percentsold off