Latest Sofinnova Investments, Inc. Stock Portfolio
Sofinnova Investments, Inc. Performance:
2025 Q3: 15.14%YTD: 11.31%2024: 8.13%
Performance for 2025 Q3 is 15.14%, and YTD is 11.31%, and 2024 is 8.13%.
About Sofinnova Investments, Inc. and 13F Hedge Fund Stock Holdings
In it's latest 13F Holdings report, Sofinnova Investments, Inc. reported an equity portfolio of $1.8 Billions as of 30 Sep, 2025.
The top stock holdings of Sofinnova Investments, Inc. are NTRA, GILD, VERA. The fund has invested 13.6% of it's portfolio in NATERA INC and 7.6% of portfolio in GILEAD SCIENCES INC.
The fund managers got completely rid off ELI LILLY AND CO (LLY), INOZYME PHARMA INC (INZY) and SYNDAX PHARMACEUTICALS INC (SNDX) stocks. They significantly reduced their stock positions in UNIQURE NV (QURE), CIDARA THERAPEUTICS INC (CDTX) and ANAPTYSBIO INC (ANAB). Sofinnova Investments, Inc. opened new stock positions in VERTEX PHARMACEUTICALS INC (VRTX), GLAUKOS CORP (GKOS) and CELCUITY INC (CELC). The fund showed a lot of confidence in some stocks as they added substantially to PRAXIS PRECISION MEDICINES INC (PRAX), APOGEE THERAPEUTICS INC and AXSOME THERAPEUTICS INC (AXSM).
The top stock holdings of Sofinnova Investments, Inc. are NTRA, GILD, VERA. The fund has invested 13.6% of it's portfolio in NATERA INC and 7.6% of portfolio in GILEAD SCIENCES INC.
The fund managers got completely rid off ELI LILLY AND CO (LLY), INOZYME PHARMA INC (INZY) and SYNDAX PHARMACEUTICALS INC (SNDX) stocks. They significantly reduced their stock positions in UNIQURE NV (QURE), CIDARA THERAPEUTICS INC (CDTX) and ANAPTYSBIO INC (ANAB). Sofinnova Investments, Inc. opened new stock positions in VERTEX PHARMACEUTICALS INC (VRTX), GLAUKOS CORP (GKOS) and CELCUITY INC (CELC). The fund showed a lot of confidence in some stocks as they added substantially to PRAXIS PRECISION MEDICINES INC (PRAX), APOGEE THERAPEUTICS INC and AXSOME THERAPEUTICS INC (AXSM).
Sofinnova Investments, Inc. Annual Return Estimates Vs S&P 500
Our best estimate is that Sofinnova Investments, Inc. made a return of 15.14% in the last quarter. In trailing 12 months, it's portfolio return was 7.04%.
New Buys
| Ticker | $ Bought |
|---|---|
| vertex pharmaceuticals inc | 46,164,600 |
| glaukos corp | 25,524,700 |
| celcuity inc | 12,516,700 |
| ge healthcare technologies inc | 11,346,500 |
| compass therapeutics inc | 7,101,100 |
| nektar therapeutics | 6,738,040 |
| nextcure inc | 1,304,750 |
| acadia pharmaceuticals inc | 571,912 |
New stocks bought by Sofinnova Investments, Inc.
Additions
| Ticker | % Inc. |
|---|---|
| praxis precision medicines inc | 999 |
| apogee therapeutics inc | 642 |
| axsome therapeutics inc | 320 |
| astrazeneca plc | 180 |
| disc medicine inc | 85.35 |
| exact sciences corp | 75.23 |
| united therapeutics corp | 60.85 |
| dyne therapeutics inc | 60.33 |
Additions to existing portfolio by Sofinnova Investments, Inc.
Reductions
| Ticker | % Reduced |
|---|---|
| uniqure nv | -91.22 |
| cidara therapeutics inc | -78.41 |
| anaptysbio inc | -75.37 |
| insmed inc | -66.76 |
| establishment labs hldgs inc | -61.64 |
| soleno therapeutics inc | -59.95 |
| merus n v | -58.79 |
| rhythm pharmaceuticals inc | -57.86 |
Sofinnova Investments, Inc. reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| inozyme pharma inc | -17,121,200 |
| y-mabs therapeutics inc | -9,896,190 |
| syndax pharmaceuticals inc | -14,276,400 |
| nextcure inc | -1,229,050 |
| eli lilly and co | -75,628,400 |
| metsera inc | -1,029,630 |
| structure therapeutics inc | -712,481 |
| ikena oncology inc | -512,705 |
Sofinnova Investments, Inc. got rid off the above stocks
Sector Distribution
Sofinnova Investments, Inc. has about 84.5% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 84.5 |
| Others | 15.5 |
Market Cap. Distribution
Sofinnova Investments, Inc. has about 45.5% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| LARGE-CAP | 43.4 |
| MID-CAP | 27.7 |
| UNALLOCATED | 15.5 |
| SMALL-CAP | 9.9 |
| MEGA-CAP | 2.1 |
| MICRO-CAP | 1.2 |
Stocks belong to which Index?
About 51.5% of the stocks held by Sofinnova Investments, Inc. either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| Others | 48.5 |
| RUSSELL 2000 | 28.3 |
| S&P 500 | 23.2 |
Sofinnova Investments, Inc. Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Sofinnova Investments, Inc.
Sofinnova Investments, Inc. has 55 stocks in it's portfolio. About 49.5% of the portfolio is in top 10 stocks. DXCM proved to be the most loss making stock for the portfolio. QURE was the most profitable stock for Sofinnova Investments, Inc. last quarter.
Last Reported on: 14 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ABBV | abbvie inc | 1.91 | 150,966 | 34,954,700 | reduced | -43.21 | ||
| ACAD | acadia pharmaceuticals inc | 0.03 | 26,800 | 571,912 | new | |||
| AKRO | akero therapeutics inc | 1.23 | 473,625 | 22,487,700 | reduced | -13.7 | ||
| ANAB | anaptysbio inc | 0.43 | 254,268 | 7,785,690 | reduced | -75.37 | ||
| AVTE | jade biosciences inc | 0.05 | 107,391 | 926,784 | unchanged | 0.00 | ||
| AXSM | axsome therapeutics inc | 2.61 | 393,499 | 47,790,500 | added | 320 | ||
| BBIO | bridgebio pharma inc | 2.36 | 831,847 | 43,206,100 | reduced | -16.24 | ||
| BOLT | bolt biotherapeutics inc | 0.04 | 137,721 | 732,676 | unchanged | 0.00 | ||
| BSX | boston scientific corp | 3.04 | 569,427 | 55,593,200 | added | 32.06 | ||
| CDTX | cidara therapeutics inc | 0.28 | 54,197 | 5,189,900 | reduced | -78.41 | ||
| CELC | celcuity inc | 0.68 | 253,375 | 12,516,700 | new | |||
| CMPX | compass therapeutics inc | 0.39 | 2,028,890 | 7,101,100 | new | |||
| COGT | cogent biosciences inc | 1.67 | 2,127,940 | 30,557,200 | reduced | -9.66 | ||
| DXCM | dexcom inc | 2.87 | 779,616 | 52,460,400 | added | 48.87 | ||
| DYN | dyne therapeutics inc | 0.68 | 985,828 | 12,470,700 | added | 60.33 | ||
| ESTA | establishment labs hldgs inc | 0.02 | 10,787 | 442,159 | reduced | -61.64 | ||
| EWTX | edgewise therapeutics inc | 0.46 | 520,240 | 8,438,290 | reduced | -27.43 | ||
| EXAS | exact sciences corp | 1.09 | 365,000 | 19,969,200 | added | 75.23 | ||
| GILD | gilead sciences inc | 7.60 | 1,252,310 | 139,007,000 | added | 19.23 | ||
| GKOS | glaukos corp | 1.40 | 312,994 | 25,524,700 | new | |||