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Latest Avidity Partners Management LP Stock Portfolio

$935Million– No. of Holdings #52

Avidity Partners Management LP Performance:
2026 Q1: 33.6%YTD: 33.6%2025: 19.16%
Performance for 2026 Q1 is 33.6%, and YTD is 33.6%, and 2025 is 19.16%.

About Avidity Partners Management LP and 13F Hedge Fund Stock Holdings

Avidity Partners Management LP is a hedge fund based in Dallas, TX. On 2026-05-28, the fund reported it's updated stock portfolio. In the 13F Holdings report, Avidity Partners Management LP reported an equity portfolio of $935.7 Millions as of 31 Mar, 2026.

The top stock holdings of Avidity Partners Management LP are , , . The fund has invested 38.6% of it's portfolio in DIANTHUS THERAPEUTICS INC and 9.6% of portfolio in ORUKA THERAPEUTICS INC.

The fund managers got completely rid off ALNYLAM PHARMACEUTICALS INC (ALNY), MCKESSON CORP (MCK) and AGILENT TECHNOLOGIES INC (A) stocks. They significantly reduced their stock positions in ACADIA PHARM (ACAD), KENVUE INC ORD and CENTENE CORP (CNC). Avidity Partners Management LP opened new stock positions in AKTIS ONCOLOGY INC, VIR BIOTECHNOLOGY INC (VIR) and DEXCOM (DXCM). The fund showed a lot of confidence in some stocks as they added substantially to PALVELLA THERAPEUTICS INC, KARYOPHARM THERAPEUTICS INC (KPTI) and REPLIGEN CORP (RGEN).
Avidity Partners Management LP Equity Portfolio Value
Last Reported on: 28 May, 2026

Avidity Partners Management LP Annual Return Estimates Vs S&P 500

Our best estimate is that Avidity Partners Management LP made a return of 33.6% in the last quarter. In trailing 12 months, it's portfolio return was 76.68%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
aktis oncology inc17,168,300
vir biotechnology inc14,838,200
dexcom11,607,000
tenax therapeutics inc6,939,180
humana inc5,911,000
gilead sciences inc5,404,200
satellos bioscience inc5,265,900
tempus ai inc4,736,700
New stocks bought by Avidity Partners Management LP

Additions

Ticker% Inc.
palvella therapeutics inc625
karyopharm therapeutics inc589
enliven therapeutics inc470
perspective therapeutics inc276
repligen corp209
corcept thera172
encompass health corp165
phathom pharmaceuticals inc142
Additions to existing portfolio by Avidity Partners Management LP

Reductions

Ticker% Reduced
acadia pharm-75.74
kenvue inc ord-57.04
centene corp-41.37
cg oncology inc-12.48
icon plc-3.32
Avidity Partners Management LP reduced stake in above stock

Sold off

Ticker$ Sold
pfizer inc-5,069,640
acadia healthcare company in-2,398,110
novo-nordisk a s-3,424,220
agilent technologies inc-5,646,900
integer hldgs corp-2,337,210
alnylam pharmaceuticals inc-8,350,650
insmed inc-3,080,510
danaher corporation-3,891,640
Avidity Partners Management LP got rid off the above stocks

Sector Distribution

Avidity Partners Management LP has about 72.8% of it's holdings in Others sector.

  • Others
  • Healthcare
Sector%
Others72.8
Healthcare26.7

Market Cap. Distribution

Avidity Partners Management LP has about 9.9% of it's portfolio invested in the large-cap and mega-cap stocks.

  • UNALLOCATED
  • LARGE-CAP
  • SMALL-CAP
  • MICRO-CAP
  • MID-CAP
Category%
UNALLOCATED72.8
LARGE-CAP9.9
SMALL-CAP9.1
MICRO-CAP4.9
MID-CAP2.8

Stocks belong to which Index?

About 15.7% of the stocks held by Avidity Partners Management LP either belong to S&P 500 or RUSSELL 2000 index.

  • Others
  • RUSSELL 2000
  • S&P 500
Index%
Others84.3
RUSSELL 20009.9
S&P 5005.8
Top 5 Winners (%)%
IMUX
immunic inc
142.0 %
dianthus therapeutics inc
63.9 %
cg oncology inc
59.1 %
enliven therapeutics inc
56.9 %
oruka therapeutics inc
53.1 %
Top 5 Winners ($)$
dianthus therapeutics inc
140.9 M
cg oncology inc
36.1 M
oruka therapeutics inc
31.0 M
enliven therapeutics inc
11.7 M
perspective therapeutics inc
9.8 M
Top 5 Losers (%)%
ICLR
icon plc
-36.5 %
BSX
boston scientific corporation
-36.4 %
PHAT
phathom pharmaceuticals inc
-25.6 %
RGEN
repligen corp
-20.4 %
CNC
centene corp
-16.2 %
Top 5 Losers ($)$
RGEN
repligen corp
-4.7 M
BSX
boston scientific corporation
-4.1 M
ICLR
icon plc
-2.2 M
PHAT
phathom pharmaceuticals inc
-1.9 M
MDT
medtronic inc
-1.9 M

Avidity Partners Management LP Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Avidity Partners Management LP

Avidity Partners Management LP has 52 stocks in it's portfolio. About 80.6% of the portfolio is in top 10 stocks. RGEN proved to be the most loss making stock for the portfolio. was the most profitable stock for Avidity Partners Management LP last quarter.

Last Reported on: 28 May, 2026
TickerNamesorted ascending% PortfolioShares Held$ ValueType% ChangeOptions