Latest Avidity Partners Management LP Stock Portfolio
$935Million | No. of Holdings #52
Avidity Partners Management LP Performance
2026 Q1+33.60%
YTD+33.60%
2025+19.16%
About Avidity Partners Management LP and 13F Hedge Fund Stock Holdings
Avidity Partners Management LP is a hedge fund based in Dallas, TX. On 2026-05-28, the fund reported it's updated stock portfolio. In the 13F Holdings report, Avidity Partners Management LP reported an equity portfolio of $935.7 Millions as of 31 Mar, 2026. <br><br> The top stock holdings of Avidity Partners Management LP are , , . The fund has invested 38.6% of it's portfolio in DIANTHUS THERAPEUTICS INC and 9.6% of portfolio in ORUKA THERAPEUTICS INC. <br><br> The fund managers got completely rid off ALNYLAM PHARMACEUTICALS INC (ALNY), MCKESSON CORP (MCK) and AGILENT TECHNOLOGIES INC (A) stocks. They significantly reduced their stock positions in ACADIA PHARM (ACAD), KENVUE INC ORD and CENTENE CORP (CNC). Avidity Partners Management LP opened new stock positions in AKTIS ONCOLOGY INC, VIR BIOTECHNOLOGY INC (VIR) and DEXCOM (DXCM). The fund showed a lot of confidence in some stocks as they added substantially to PALVELLA THERAPEUTICS INC, KARYOPHARM THERAPEUTICS INC (KPTI) and REPLIGEN CORP (RGEN).
Avidity Partners Management LP Equity Portfolio Value
Last Reported on: 28 May, 2026
$935Million
as of May 28, 2026Avidity Partners Management LP Annual Return Estimates Vs S&P 500
Our best estimate is that Avidity Partners Management LP made a return of 33.6% in the last quarter. In trailing 12 months, it's portfolio return was 76.68%.
- Performance
- S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| aktis oncology inc | 17,168,300 |
| vir biotechnology inc | 14,838,200 |
| dexcom | 11,607,000 |
| tenax therapeutics inc | 6,939,180 |
| humana inc | 5,911,000 |
| gilead sciences inc | 5,404,200 |
| satellos bioscience inc | 5,265,900 |
| tempus ai inc | 4,736,700 |
New stocks bought by Avidity Partners Management LP
Additions
| Ticker | % Inc. |
|---|---|
| palvella therapeutics inc | 625 |
| karyopharm therapeutics inc | 589 |
| enliven therapeutics inc | 470 |
| perspective therapeutics inc | 276 |
| repligen corp | 209 |
| corcept thera | 172 |
| encompass health corp | 165 |
| phathom pharmaceuticals inc | 142 |
Additions to existing portfolio by Avidity Partners Management LP
Reductions
| Ticker | % Reduced |
|---|---|
| acadia pharm | -75.74 |
| kenvue inc ord | -57.04 |
| centene corp | -41.37 |
| cg oncology inc | -12.48 |
| icon plc | -3.32 |
Avidity Partners Management LP reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| pfizer inc | -5,069,640 |
| acadia healthcare company in | -2,398,110 |
| novo-nordisk a s | -3,424,220 |
| agilent technologies inc | -5,646,900 |
| integer hldgs corp | -2,337,210 |
| alnylam pharmaceuticals inc | -8,350,650 |
| insmed inc | -3,080,510 |
| danaher corporation | -3,891,640 |
Avidity Partners Management LP got rid off the above stocks
Sector Distribution
Avidity Partners Management LP has about 72.8% of it's holdings in Others sector.
- Others
- Healthcare
| Sector | % |
|---|---|
| Others | 72.8 |
| Healthcare | 26.7 |
Market Cap. Distribution
Avidity Partners Management LP has about 9.9% of it's portfolio invested in the large-cap and mega-cap stocks.
- UNALLOCATED
- LARGE-CAP
- SMALL-CAP
- MICRO-CAP
- MID-CAP
| Category | % |
|---|---|
| UNALLOCATED | 72.8 |
| LARGE-CAP | 9.9 |
| SMALL-CAP | 9.1 |
| MICRO-CAP | 4.9 |
| MID-CAP | 2.8 |
Stocks belong to which Index?
About 15.7% of the stocks held by Avidity Partners Management LP either belong to S&P 500 or RUSSELL 2000 index.
- Others
- RUSSELL 2000
- S&P 500
| Index | % |
|---|---|
| Others | 84.3 |
| RUSSELL 2000 | 9.9 |
| S&P 500 | 5.8 |
| Top 5 Winners (%) | % | |
|---|---|---|
| IMUX | immunic inc | 142.0 % |
dianthus therapeutics inc | 63.9 % | |
cg oncology inc | 59.1 % | |
enliven therapeutics inc | 56.9 % | |
oruka therapeutics inc | 53.1 % | |
| Top 5 Winners ($) | $ | |
|---|---|---|
dianthus therapeutics inc | 140.9 M | |
cg oncology inc | 36.1 M | |
oruka therapeutics inc | 31.0 M | |
enliven therapeutics inc | 11.7 M | |
perspective therapeutics inc | 9.8 M | |
Avidity Partners Management LP Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Avidity Partners Management LP
Avidity Partners Management LP has 52 stocks in it's portfolio. About 80.6% of the portfolio is in top 10 stocks. RGEN proved to be the most loss making stock for the portfolio. was the most profitable stock for Avidity Partners Management LP last quarter.
$935.70MTotal Value
67.00Positions
28 May, 2026Last Reported
| Expand | Holdingsorted ascending | % Portfolio | Shares Held | $ Value | % Change |
|---|---|---|---|---|---|
 Agilent Technologies Inc Avidity Partners Management LP's holding in Agilent Technologies Inc over time | 0% | 0.00 | $0.00 0% | 100%decreased 100 percentsold off | |
 Cencora Inc Cencora IncABC Avidity Partners Management LP's holding in Cencora Inc over time | 0% | 0.00 | $0.00 0% | 100%decreased 100 percentsold off | |
 Abbott Laboratories Avidity Partners Management LP's holding in Abbott Laboratories over time | 0.1% | 10,000 | $907.9K 0.1% | Newnew position | |
 Arbutus Biopharma Corp Avidity Partners Management LP's holding in Arbutus Biopharma Corp over time | 0.12% | 250,000 | $1.09M 0.12% | Newnew position | |
 Acadia Pharm Acadia PharmACAD Avidity Partners Management LP's holding in Acadia Pharm over time | 0.06% | 25,934 | $579.8K 0.06% | 75.74%decreased 75.74 percentreduced | |
 Acadia Healthcare Company In Avidity Partners Management LP's holding in Acadia Healthcare Company In over time | 0% | 0.00 | $0.00 0% | 100%decreased 100 percentsold off | |
 Alnylam Pharmaceuticals Inc Avidity Partners Management LP's holding in Alnylam Pharmaceuticals Inc over time | 0% | 0.00 | $0.00 0% | 100%decreased 100 percentsold off | |
 Jade Biosciences Inc Avidity Partners Management LP's holding in Jade Biosciences Inc over time | 5.76% | 2,801,420 | $53.86M 5.76% | 100%increased 100 percentadded | |
 Bridgebio Pharma Inc Avidity Partners Management LP's holding in Bridgebio Pharma Inc over time | 0.08% | 10,000 | $711.1K 0.08% | Newnew position | |
 Boston Scientific Corporation Avidity Partners Management LP's holding in Boston Scientific Corporation over time | 0.77% | 120,000 | $7.22M 0.77% | 4.8%increased 4.8 percentadded | |
 The Cigna Group Avidity Partners Management LP's holding in The Cigna Group over time | 0% | 0.00 | $0.00 0% | 100%decreased 100 percentsold off | |
 Centene Corp Centene CorpCNC Avidity Partners Management LP's holding in Centene Corp over time | 0.24% | 70,000 | $2.29M 0.24% | 41.37%decreased 41.37 percentreduced | |
 Context Therapeutics Inc Avidity Partners Management LP's holding in Context Therapeutics Inc over time | 2.66% | 9,996,530 | $24.89M 2.66% | 81.59%increased 81.59 percentadded | |
 Corcept Thera Corcept TheraCORT Avidity Partners Management LP's holding in Corcept Thera over time | 0.28% | 60,000 | $2.60M 0.28% | 172.73%increased 172.73 percentadded | |
 Charles Riv Labs Intl Inc Avidity Partners Management LP's holding in Charles Riv Labs Intl Inc over time | 0.18% | 10,000 | $1.67M 0.18% | Newnew position | |
 Corvus Pharmaceuticals Inc Avidity Partners Management LP's holding in Corvus Pharmaceuticals Inc over time | 0.37% | 230,000 | $3.43M 0.37% | Newnew position | |
 Danaher Corporation Avidity Partners Management LP's holding in Danaher Corporation over time | 0% | 0.00 | $0.00 0% | 100%decreased 100 percentsold off | |
| 1.24% | 190,000 | $11.61M 1.24% | Newnew position | ||
 Encompass Health Corp Avidity Partners Management LP's holding in Encompass Health Corp over time | 0.88% | 84,000 | $8.26M 0.88% | 165.82%increased 165.82 percentadded | |
 Gilead Sciences Inc Avidity Partners Management LP's holding in Gilead Sciences Inc over time | 0.58% | 40,000 | $5.40M 0.58% | Newnew position | |
