Latest Avidity Partners Management LP Stock Portfolio

Avidity Partners Management LP Performance:

2025 Q4: 8.21%YTD: 19.16%2024: -1.81%

Performance for 2025 Q4 is 8.21%, and YTD is 19.16%, and 2024 is -1.81%.

About Avidity Partners Management LP and 13F Hedge Fund Stock Holdings

Avidity Partners Management LP is a hedge fund based in Dallas, TX. On 2026-02-13, the fund reported it's updated stock portfolio. In the 13F Holdings report, Avidity Partners Management LP reported an equity portfolio of $346.7 Millions as of 31 Dec, 2025.

The top stock holdings of Avidity Partners Management LP are , , AVTE. The fund has invested 25% of it's portfolio in DIANTHUS THERAPEUTICS INC and 17.6% of portfolio in CG ONCOLOGY INC.

The fund managers got completely rid off BRISTOL-MYERS SQUIBB CO (BMY), METSERA INC and UNITEDHEALTH GROUP INC (UNH) stocks. They significantly reduced their stock positions in NATERA INC (NTRA), DANAHER CORPORATION (DHR) and THERMO FISHER SCIENTIFIC INC (TMO). Avidity Partners Management LP opened new stock positions in ALNYLAM PHARMACEUTICALS INC (ALNY), ICON PLC (ICLR) and AGILENT TECHNOLOGIES INC (A). The fund showed a lot of confidence in some stocks as they added substantially to REPLIGEN CORP (RGEN), MCKESSON CORP (MCK) and INSMED INC (INSM).

Avidity Partners Management LP Annual Return Estimates Vs S&P 500

Our best estimate is that Avidity Partners Management LP made a return of 8.21% in the last quarter. In trailing 12 months, it's portfolio return was 19.16%.

Performance
S&P 500

New Buys

Ticker	$ Bought
alnylam pharmaceuticals inc	8,350,650
icon plc	6,031,480
agilent technologies inc	5,646,900
centene corp del	4,913,310
novo-nordisk a s	3,424,220
waters corp	3,076,620
acadia healthcare company in	2,398,110
integer hldgs corp	2,337,210

New stocks bought by Avidity Partners Management LP

Additions

Ticker	% Inc.
repligen corp	115
mckesson corp	64.14
insmed inc	52.59
jade biosciences inc	24.27
perspective therapeutics inc	7.24

Additions to existing portfolio by Avidity Partners Management LP

Reductions

Ticker	% Reduced
natera inc	-83.24
danaher corporation	-68.92
thermo fisher scientific inc	-64.55
genmab a/s	-62.92
cencora inc	-50.53
pfizer inc	-44.43
medtronic plc	-43.55
context therapeutics inc	-38.71

Avidity Partners Management LP reduced stake in above stock

Sold off

Ticker	$ Sold
arvinas inc	-5,950,050
carlsmed inc	-4,310,400
wave life sciences ltd	-2,177,700
bristol-myers squibb co	-11,617,800
arcutis biotherapeutics inc	-4,041,440
metsera inc	-7,352,360
beam therapeutics inc	-2,718,240
immuneering corp	-636,300

Avidity Partners Management LP got rid off the above stocks

Sector Distribution

Avidity Partners Management LP has about 57.8% of it's holdings in Others sector.

Sector	%
Others	57.8
Healthcare	42.2

Market Cap. Distribution

Avidity Partners Management LP has about 27.2% of it's portfolio invested in the large-cap and mega-cap stocks.

Category	%
UNALLOCATED	56.9
LARGE-CAP	27.2
SMALL-CAP	7.9
MID-CAP	4.5
MICRO-CAP	3.1

Stocks belong to which Index?

About 27.8% of the stocks held by Avidity Partners Management LP either belong to S&P 500 or RUSSELL 2000 index.

Index	%
Others	72.2
S&P 500	17.2
RUSSELL 2000	10.6

Top 5 Winners (%)		%
AVTE	jade biosciences inc	66.0 %
	oruka therapeutics inc	57.6 %
TEVA	teva pharmaceutical inds ltd	49.5 %
CNTX	context therapeutics inc	41.7 %
PHAT	phathom pharmaceuticals inc	34.3 %

Top 5 Winners ($)		$
AVTE	jade biosciences inc	8.6 M
	oruka therapeutics inc	7.3 M
TEVA	teva pharmaceutical inds ltd	5.1 M
	dianthus therapeutics inc	4.9 M
CNTX	context therapeutics inc	3.6 M

Top 5 Losers (%)		%
IMUX	immunic inc	-39.5 %
	enliven therapeutics inc	-24.8 %
	perspective therapeutics inc	-19.3 %
SCYX	scynexis inc	-14.5 %
EHC	encompass health corp	-14.4 %

Top 5 Losers ($)		$
	perspective therapeutics inc	-2.1 M
IMUX	immunic inc	-1.6 M
EHC	encompass health corp	-0.8 M
	enliven therapeutics inc	-0.7 M
SCYX	scynexis inc	-0.4 M

Avidity Partners Management LP Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Avidity Partners Management LP

Avidity Partners Management LP has 39 stocks in it's portfolio. About 71.9% of the portfolio is in top 10 stocks. proved to be the most loss making stock for the portfolio. AVTE was the most profitable stock for Avidity Partners Management LP last quarter.

Last Reported on: 13 Feb, 2026

Ticker	Namesorted ascending	% Portfolio	Shares Held	$ Value	Type	% Change
A	agilent technologies inc	1.63	41,500	5,646,900	new

ABBV	abbvie inc	0.00	0.00	0.00	sold off	-100

ABC	cencora inc	0.92	9,400	3,174,850	reduced	-50.53

ACAD	acadia pharmaceuticals inc	0.82	106,900	2,855,300	reduced	-25.76

ACHC	acadia healthcare company in	0.69	169,000	2,398,110	new

AKRO	akero therapeutics inc	0.00	0.00	0.00	sold off	-100

ALNY	alnylam pharmaceuticals inc	2.41	21,000	8,350,650	new

ARQT	arcutis biotherapeutics inc	0.00	0.00	0.00	sold off	-100

ARVN	arvinas inc	0.00	0.00	0.00	sold off	-100

ASND	ascendis pharma a/s	0.00	0.00	0.00	sold off	-100

AVTE	jade biosciences inc	6.23	1,400,710	21,612,900	added	24.27

BEAM	beam therapeutics inc	0.00	0.00	0.00	sold off	-100

BMY	bristol-myers squibb co	0.00	0.00	0.00	sold off	-100

BSX	boston scientific corp	3.15	114,500	10,917,600	reduced	-30.31

CI	the cigna group	0.92	11,600	3,192,670	reduced	-30.12

CNC	centene corp del	1.42	119,400	4,913,310	new

CNTX	context therapeutics inc	2.33	5,504,860	8,092,140	reduced	-38.71

CORT	corcept therapeutics inc	0.22	22,000	765,600	new

DHR	danaher corporation	1.12	17,000	3,891,640	reduced	-68.92

EHC	encompass health corp	0.97	31,600	3,354,020	reduced	-24.58