Latest Avidity Partners Management LP Stock Portfolio
Avidity Partners Management LP Performance:
2025 Q3: 19.28%YTD: 10.12%2024: -1.81%
Performance for 2025 Q3 is 19.28%, and YTD is 10.12%, and 2024 is -1.81%.
About Avidity Partners Management LP and 13F Hedge Fund Stock Holdings
Avidity Partners Management LP is a hedge fund based in DALLAS, TX. On 31-Mar-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $9.2 Billions. In it's latest 13F Holdings report, Avidity Partners Management LP reported an equity portfolio of $439.4 Millions as of 30 Sep, 2025.
The top stock holdings of Avidity Partners Management LP are , , MDT. The fund has invested 28.7% of it's portfolio in DIANTHUS THERAPEUTICS INC and 14.7% of portfolio in CG ONCOLOGY INC.
The fund managers got completely rid off TENET HEALTHCARE CORP (THC), DEXCOM INC (DXCM) and HINGE HEALTH INC stocks. They significantly reduced their stock positions in INSMED INC (INSM), EXACT SCIENCES CORP (EXAS) and REPLIGEN CORP (RGEN). Avidity Partners Management LP opened new stock positions in MEDTRONIC PLC (MDT), BRISTOL-MYERS SQUIBB CO (BMY) and PFIZER INC (PFE). The fund showed a lot of confidence in some stocks as they added substantially to ENLIVEN THERAPEUTICS INC, ARVINAS INC (ARVN) and SCYNEXIS INC (SCYX).
The top stock holdings of Avidity Partners Management LP are , , MDT. The fund has invested 28.7% of it's portfolio in DIANTHUS THERAPEUTICS INC and 14.7% of portfolio in CG ONCOLOGY INC.
The fund managers got completely rid off TENET HEALTHCARE CORP (THC), DEXCOM INC (DXCM) and HINGE HEALTH INC stocks. They significantly reduced their stock positions in INSMED INC (INSM), EXACT SCIENCES CORP (EXAS) and REPLIGEN CORP (RGEN). Avidity Partners Management LP opened new stock positions in MEDTRONIC PLC (MDT), BRISTOL-MYERS SQUIBB CO (BMY) and PFIZER INC (PFE). The fund showed a lot of confidence in some stocks as they added substantially to ENLIVEN THERAPEUTICS INC, ARVINAS INC (ARVN) and SCYNEXIS INC (SCYX).
Avidity Partners Management LP Annual Return Estimates Vs S&P 500
Our best estimate is that Avidity Partners Management LP made a return of 19.28% in the last quarter. In trailing 12 months, it's portfolio return was -1.29%.
New Buys
| Ticker | $ Bought |
|---|---|
| medtronic plc | 18,152,700 |
| bristol-myers squibb co | 11,617,800 |
| pfizer inc | 9,335,870 |
| metsera inc | 7,352,360 |
| johnson & johnson | 4,969,260 |
| the cigna group | 4,784,950 |
| abbvie inc | 4,584,490 |
| carlsmed inc | 4,310,400 |
New stocks bought by Avidity Partners Management LP
Additions
| Ticker | % Inc. |
|---|---|
| enliven therapeutics inc | 1,141 |
| arvinas inc | 187 |
| scynexis inc | 172 |
| oruka therapeutics inc | 87.55 |
| dianthus therapeutics inc | 83.84 |
| perspective therapeutics inc | 61.09 |
| context therapeutics inc | 20.12 |
| cg oncology inc | 6.73 |
Additions to existing portfolio by Avidity Partners Management LP
Reductions
| Ticker | % Reduced |
|---|---|
| insmed inc | -80.34 |
| exact sciences corp | -79.27 |
| repligen corp | -78.12 |
| beam therapeutics inc | -72.64 |
| healthequity inc | -72.5 |
| phathom pharmaceuticals inc | -71.25 |
| akero therapeutics inc | -69.78 |
| natera inc | -64.68 |
Avidity Partners Management LP reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| organon & co | -6,195,200 |
| kezar life sciences inc | -2,301,910 |
| omada health inc | -7,147,980 |
| hinge health inc | -16,681,300 |
| intellia therapeutics inc | -2,176,160 |
| revolution medicines inc | -8,410,190 |
| dexcom inc | -18,374,500 |
| uniqure nv | -2,885,580 |
Avidity Partners Management LP got rid off the above stocks
Sector Distribution
Avidity Partners Management LP has about 56.6% of it's holdings in Others sector.
| Sector | % |
|---|---|
| Others | 56.6 |
| Healthcare | 43.4 |
Market Cap. Distribution
Avidity Partners Management LP has about 30.4% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| UNALLOCATED | 55.3 |
| LARGE-CAP | 24.7 |
| MEGA-CAP | 5.7 |
| MID-CAP | 4.3 |
| SMALL-CAP | 4 |
| MICRO-CAP | 3.7 |
| NANO-CAP | 2.4 |
Stocks belong to which Index?
About 31.6% of the stocks held by Avidity Partners Management LP either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| Others | 68.4 |
| S&P 500 | 22.8 |
| RUSSELL 2000 | 8.8 |
Avidity Partners Management LP Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Avidity Partners Management LP
Avidity Partners Management LP has 43 stocks in it's portfolio. About 66.4% of the portfolio is in top 10 stocks. BSX proved to be the most loss making stock for the portfolio. was the most profitable stock for Avidity Partners Management LP last quarter.
Last Reported on: 14 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ABBV | abbvie inc | 1.04 | 19,800 | 4,584,490 | new | |||
| ABC | cencora inc | 1.35 | 19,000 | 5,938,070 | reduced | -42.07 | ||
| ACAD | acadia pharmaceuticals inc | 0.70 | 144,000 | 3,072,960 | new | |||
| AKRO | akero therapeutics inc | 0.44 | 40,500 | 1,922,940 | reduced | -69.78 | ||
| ALT | altimmune inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ARQT | arcutis biotherapeutics inc | 0.92 | 214,400 | 4,041,440 | reduced | -20.00 | ||
| ARVN | arvinas inc | 1.35 | 698,363 | 5,950,050 | added | 187 | ||
| AVTE | jade biosciences inc | 2.21 | 1,127,190 | 9,727,620 | unchanged | 0.00 | ||
| AXSM | axsome therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| BBIO | bridgebio pharma inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| BEAM | beam therapeutics inc | 0.62 | 112,000 | 2,718,240 | reduced | -72.64 | ||
| BMY | bristol-myers squibb co | 2.64 | 257,600 | 11,617,800 | new | |||
| BSX | boston scientific corp | 3.65 | 164,300 | 16,040,600 | reduced | -48.94 | ||
| CAH | cardinal health inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| CI | the cigna group | 1.09 | 16,600 | 4,784,950 | new | |||
| CNTX | context therapeutics inc | 1.98 | 8,981,860 | 8,701,620 | added | 20.12 | ||
| DHR | danaher corporation | 2.47 | 54,700 | 10,844,800 | reduced | -39.02 | ||
| DOCS | doximity inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| DXCM | dexcom inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| EHC | encompass health corp | 1.21 | 41,900 | 5,322,140 | reduced | -43.38 | ||