Latest DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) Stock Portfolio

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) Performance:

2025 Q4: 22.97%YTD: 33.28%2024: 4.15%

Performance for 2025 Q4 is 22.97%, and YTD is 33.28%, and 2024 is 4.15%.

About DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) and 13F Hedge Fund Stock Holdings

DEERFIELD MANAGEMENT COMPANY, L.P. is a hedge fund based in New York, NY. On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, DEERFIELD MANAGEMENT COMPANY, L.P. reported an equity portfolio of $7.8 Billions as of 31 Dec, 2025.

The top stock holdings of DEERFIELD MANAGEMENT COMPANY, L.P. are NUVL, COGT, PRAX. The fund has invested 22.2% of it's portfolio in NUVALENT INC and 4.1% of portfolio in COGENT BIOSCIENCES INC.

The fund managers got completely rid off MERUS N V (MRUS), BRISTOL-MYERS SQUIBB CO (BMY) and MERCK & CO INC (MRK) stocks. They significantly reduced their stock positions in INTEGRA LIFESCIENCES HLDGS C (IART), CONMED CORP (CNMD) and INTUITIVE SURGICAL INC (ISRG). DEERFIELD MANAGEMENT COMPANY, L.P. opened new stock positions in STOKE THERAPEUTICS INC (STOK), LANTHEUS HLDGS INC (LNTH) and BELITE BIO INC (BLTE). The fund showed a lot of confidence in some stocks as they added substantially to LABCORP HOLDINGS INC, ACADIA HEALTHCARE COMPANY IN (ACHC) and INSULET CORP (PODD).

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) Annual Return Estimates Vs S&P 500

Our best estimate is that DEERFIELD MANAGEMENT COMPANY, L.P. made a return of 22.97% in the last quarter. In trailing 12 months, it's portfolio return was 33.28%.

Performance
S&P 500

New Buys

Ticker	$ Bought
brookdale sr living inc	427,494,000
alignment healthcare inc	92,553,500
stoke therapeutics inc	57,877,900
lantheus hldgs inc	55,103,300
belite bio inc	37,400,700
tango therapeutics inc	25,755,500
compass therapeutics inc	19,364,200
kyverna therapeutics inc	18,800,000

New stocks bought by DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)

Additions

Ticker	% Inc.
labcorp holdings inc	1,207
acadia healthcare company in	280
insulet corp	136
celcuity inc	133
healthequity inc	129
edwards lifesciences corp	115
tandem diabetes care inc	113
structure therapeutics inc	105

Additions to existing portfolio by DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)

Reductions

Ticker	% Reduced
integra lifesciences hldgs c	-95.07
conmed corp	-93.09
intuitive surgical inc	-91.12
cullinan therapeutics inc	-86.81
repligen corp	-82.97
cooper cos inc	-81.94
ufp technologies inc	-72.68
revvity inc	-69.22

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) reduced stake in above stock

Sold off

Ticker	$ Sold
tandem diabetes care inc	-87,142,700
docgo inc	-6,286,880
neogenomics inc	-34,333,400
pfizer inc	-84,180,600
merus n v	-286,867,000
bristol-myers squibb co	-105,433,000
zenas biopharma inc	-34,697,300
elutia inc	-1,221,000

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) got rid off the above stocks

Sector Distribution

DEERFIELD MANAGEMENT COMPANY, L.P. has about 86.5% of it's holdings in Healthcare sector.

Sector	%
Healthcare	86.5
Others	11.7
	1.3

Market Cap. Distribution

DEERFIELD MANAGEMENT COMPANY, L.P. has about 19.9% of it's portfolio invested in the large-cap and mega-cap stocks.

Category	%
MID-CAP	51
LARGE-CAP	19.9
SMALL-CAP	15.5
UNALLOCATED	11.7
MICRO-CAP	1.9

Stocks belong to which Index?

About 68.7% of the stocks held by DEERFIELD MANAGEMENT COMPANY, L.P. either belong to S&P 500 or RUSSELL 2000 index.

Index	%
RUSSELL 2000	59.3
Others	31.3
S&P 500	9.4

Top 5 Winners (%)		%
PRAX	praxis precision medicines i	380.3 %
COGT	cogent biosciences inc	147.3 %
	calcimedica inc	114.3 %
AGLE	spyre therapeutics inc	83.5 %
	structure therapeutics inc	79.8 %

Top 5 Winners ($)		$
NUVL	nuvalent inc	248.6 M
PRAX	praxis precision medicines i	210.8 M
COGT	cogent biosciences inc	191.5 M
RVMD	revolution medicines inc	107.8 M
VERA	vera therapeutics inc	83.1 M

Top 5 Losers (%)		%
BFLY	butterfly network inc	-61.4 %
ALEC	alector inc	-47.3 %
ACHC	acadia healthcare company in	-32.0 %
	omada health inc	-28.6 %
LEGN	legend biotech corp	-27.3 %

Top 5 Losers ($)		$
LEGN	legend biotech corp	-48.3 M
ACHC	acadia healthcare company in	-30.2 M
CERT	certara inc	-24.8 M
PHR	phreesia inc	-10.3 M
EMBC	embecta corp	-6.0 M

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)

DEERFIELD MANAGEMENT COMPANY, L.P. has 141 stocks in it's portfolio. About 48.8% of the portfolio is in top 10 stocks. LEGN proved to be the most loss making stock for the portfolio. NUVL was the most profitable stock for DEERFIELD MANAGEMENT COMPANY, L.P. last quarter.

Last Reported on: 17 Feb, 2026

Ticker	Namesorted ascending	% Portfolio	Shares Held	$ Value	Type	% Change
ABBV	abbvie inc	0.01	2,014	460,179	new

ABEO	abeona therapeutics inc	0.00	40,000	210,800	new

ABT	abbott labs	0.02	11,449	1,434,440	new

ACHC	acadia healthcare company in	0.82	4,520,000	64,138,800	added	280

ADPT	adaptive biotechnologies cor	0.00	0.00	0.00	sold off	-100

ADUS	addus homecare corp	0.02	15,871	1,704,390	new

AGLE	spyre therapeutics inc	0.30	710,626	23,280,100	added	15.8

AHCO	adapthealth corp	1.46	11,477,700	114,318,000	unchanged	0.00

ALEC	alector inc	0.02	1,055,190	1,646,100	unchanged	0.00

ALGN	align technology inc	0.02	11,000	1,717,650	reduced	-66.45

ALHC	alignment healthcare inc	1.18	61,000,000	92,553,500	new

ALHC	alignment healthcare inc	0.04	164,345	3,245,810	added	59.65

ALNY	alnylam pharmaceuticals inc	0.34	67,935	27,014,400	unchanged	0.00

AMPH	amphastar pharmaceuticals in	0.00	14,852	397,737	new

ANNX	annexon inc	0.04	583,913	2,931,240	unchanged	0.00

ARVN	arvinas inc	0.01	68,057	807,156	new

ARWR	arrowhead pharmaceuticals in	1.55	1,832,950	121,689,000	added	84.59

ATEC	alphatec hldgs inc	0.01	57,277	1,205,110	reduced	-12.24

ATRC	atricure inc	0.03	52,076	2,060,130	reduced	-40.53

AVNS	avanos med inc	0.02	167,061	1,876,100	added	35.93