Latest PERCEPTIVE ADVISORS LLC Stock Portfolio
PERCEPTIVE ADVISORS LLC Performance:
2025 Q3: 9.64%YTD: 11.22%2024: -1.75%
Performance for 2025 Q3 is 9.64%, and YTD is 11.22%, and 2024 is -1.75%.
About PERCEPTIVE ADVISORS LLC and 13F Hedge Fund Stock Holdings
In it's latest 13F Holdings report, PERCEPTIVE ADVISORS LLC reported an equity portfolio of $3.5 Billions as of 30 Sep, 2025.
The top stock holdings of PERCEPTIVE ADVISORS LLC are RYTM, , ACLX. The fund has invested 8.3% of it's portfolio in RHYTHM PHARMACEUTICALS INC and 6.2% of portfolio in ASCENDIS PHARMA A/S.
The fund managers got completely rid off SOLENO THERAPEUTICS INC (SLNO), EVOLUS INC (EOLS) and INSULET CORP (PODD) stocks. They significantly reduced their stock positions in VERONA PHARMA PLC (VRNA), BETA BIONICS INC and DYNE THERAPEUTICS INC (DYN). PERCEPTIVE ADVISORS LLC opened new stock positions in ABIVAX SA, EXACT SCIENCES CORP (EXAS) and IRHYTHM TECHNOLOGIES INC (IRTC). The fund showed a lot of confidence in some stocks as they added substantially to RHYTHM PHARMACEUTICALS INC (RYTM), PENUMBRA INC (PEN) and TRAVERE THERAPEUTICS INC (TVTX).
The top stock holdings of PERCEPTIVE ADVISORS LLC are RYTM, , ACLX. The fund has invested 8.3% of it's portfolio in RHYTHM PHARMACEUTICALS INC and 6.2% of portfolio in ASCENDIS PHARMA A/S.
The fund managers got completely rid off SOLENO THERAPEUTICS INC (SLNO), EVOLUS INC (EOLS) and INSULET CORP (PODD) stocks. They significantly reduced their stock positions in VERONA PHARMA PLC (VRNA), BETA BIONICS INC and DYNE THERAPEUTICS INC (DYN). PERCEPTIVE ADVISORS LLC opened new stock positions in ABIVAX SA, EXACT SCIENCES CORP (EXAS) and IRHYTHM TECHNOLOGIES INC (IRTC). The fund showed a lot of confidence in some stocks as they added substantially to RHYTHM PHARMACEUTICALS INC (RYTM), PENUMBRA INC (PEN) and TRAVERE THERAPEUTICS INC (TVTX).
PERCEPTIVE ADVISORS LLC Annual Return Estimates Vs S&P 500
Our best estimate is that PERCEPTIVE ADVISORS LLC made a return of 9.64% in the last quarter. In trailing 12 months, it's portfolio return was 4.32%.
New Buys
| Ticker | $ Bought |
|---|---|
| abivax sa | 32,992,800 |
| exact sciences corp | 25,466,800 |
| palvella therapeutics inc ne | 24,768,400 |
| oruka therapeutics inc | 24,384,000 |
| irhythm technologies inc | 21,154,800 |
| engene holdings inc | 14,324,100 |
| rapport therapeutics inc | 11,996,500 |
| kodiak sciences inc | 10,388,000 |
New stocks bought by PERCEPTIVE ADVISORS LLC
Additions
Additions to existing portfolio by PERCEPTIVE ADVISORS LLC
Reductions
| Ticker | % Reduced |
|---|---|
| verona pharma plc | -90.48 |
| beta bionics inc | -82.56 |
| dyne therapeutics inc | -75.95 |
| viking therapeutics inc | -72.26 |
| artivion inc | -27.69 |
| immunovant inc | -25.73 |
| axsome therapeutics inc | -25.00 |
| spyre therapeutics inc | -19.61 |
PERCEPTIVE ADVISORS LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| evolus inc | -22,793,300 |
| athira pharma inc | -1,631,700 |
| soleno therapeutics inc | -36,062,200 |
| helix acquisition corp ii | -4,226,760 |
| ultragenyx pharmaceutical in | -9,817,200 |
| biodesix inc | -613,034 |
| charles riv labs intl inc | -15,173,000 |
| globus med inc | -5,223,270 |
PERCEPTIVE ADVISORS LLC got rid off the above stocks
Sector Distribution
PERCEPTIVE ADVISORS LLC has about 77.5% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 77.5 |
| Others | 22.5 |
Market Cap. Distribution
PERCEPTIVE ADVISORS LLC has about 7% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| MID-CAP | 36.3 |
| SMALL-CAP | 26.7 |
| UNALLOCATED | 22.5 |
| LARGE-CAP | 7 |
| MICRO-CAP | 6.9 |
Stocks belong to which Index?
About 54.4% of the stocks held by PERCEPTIVE ADVISORS LLC either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| RUSSELL 2000 | 52.8 |
| Others | 45.6 |
| S&P 500 | 1.6 |
PERCEPTIVE ADVISORS LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of PERCEPTIVE ADVISORS LLC
PERCEPTIVE ADVISORS LLC has 90 stocks in it's portfolio. About 44.9% of the portfolio is in top 10 stocks. RYTM proved to be the most loss making stock for the portfolio. VRNA was the most profitable stock for PERCEPTIVE ADVISORS LLC last quarter.
Last Reported on: 14 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ACLX | arcellx inc | 5.85 | 2,468,350 | 202,652,000 | reduced | -0.39 | ||
| ADMA | adma biologics inc | 0.49 | 1,153,470 | 16,909,800 | reduced | -11.51 | ||
| AGLE | spyre therapeutics inc | 0.60 | 1,229,440 | 20,605,500 | reduced | -19.61 | ||
| AKRO | akero therapeutics inc | 1.56 | 1,135,770 | 53,926,200 | added | 24.01 | ||
| ALDX | aldeyra therapeutics inc | 0.79 | 5,222,310 | 27,260,500 | added | 28.89 | ||
| AMLX | amylyx pharmaceuticals inc | 3.51 | 8,952,360 | 121,663,000 | added | 13.29 | ||
| AORT | artivion inc | 2.47 | 2,020,000 | 85,526,800 | reduced | -27.69 | ||
| APYX | apyx medical corporation | 0.01 | 150,000 | 321,000 | unchanged | 0.00 | ||
| AQST | aquestive therapeutics inc | 0.61 | 3,760,100 | 21,019,000 | added | 71.66 | ||
| ATHA | athira pharma inc | 0.06 | 540,296 | 2,236,820 | new | |||
| ATHA | athira pharma inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ATXS | astria therapeutics inc | 1.36 | 6,485,420 | 47,213,900 | unchanged | 0.00 | ||
| AVTX | avalo therapeutics inc | 0.05 | 139,667 | 1,775,170 | unchanged | 0.00 | ||
| AXSM | axsome therapeutics inc | 0.52 | 148,900 | 18,083,900 | reduced | -25.00 | ||
| BDSX | biodesix | 0.02 | 108,694 | 820,639 | new | |||
| BDSX | biodesix inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| BSX | boston scientific corp | 0.87 | 310,000 | 30,265,300 | added | 10.71 | ||
| CELC | celcuity inc | 4.22 | 2,956,320 | 146,042,000 | added | 81.01 | ||
| CELC | celcuity inc | 0.25 | 6,500,000 | 8,723,790 | new | |||
| CNTA | centessa pharmaceuticals plc | 2.17 | 3,100,900 | 75,196,900 | added | 170 | ||