Latest PERCEPTIVE ADVISORS LLC Stock Portfolio
PERCEPTIVE ADVISORS LLC Performance:
2025 Q4: 545.62%YTD: 57.06%2024: 1.69%
Performance for 2025 Q4 is 545.62%, and YTD is 57.06%, and 2024 is 1.69%.
About PERCEPTIVE ADVISORS LLC and 13F Hedge Fund Stock Holdings
On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, PERCEPTIVE ADVISORS LLC reported an equity portfolio of $5.6 Billions as of 31 Dec, 2025.
The top stock holdings of PERCEPTIVE ADVISORS LLC are PRAX, CELC, RYTM. The fund has invested 10.5% of it's portfolio in PRAXIS PRECISION MEDICINES I and 5.6% of portfolio in CELCUITY INC.
The fund managers got completely rid off MERUS N V (MRUS), INSMED INC (INSM) and VERONA PHARMA PLC (VRNA) stocks. They significantly reduced their stock positions in RHYTHM PHARMACEUTICALS INC (RYTM), AQUESTIVE THERAPEUTICS INC (AQST) and KYMERA THERAPEUTICS INC (KYMR). PERCEPTIVE ADVISORS LLC opened new stock positions in INVIVYD INC (ADGI), DANAHER CORPORATION (DHR) and CIDARA THERAPEUTICS INC (CDTX). The fund showed a lot of confidence in some stocks as they added substantially to ALTO NEUROSCIENCE INC, BELITE BIO INC (BLTE) and DYNE THERAPEUTICS INC (DYN).
The top stock holdings of PERCEPTIVE ADVISORS LLC are PRAX, CELC, RYTM. The fund has invested 10.5% of it's portfolio in PRAXIS PRECISION MEDICINES I and 5.6% of portfolio in CELCUITY INC.
The fund managers got completely rid off MERUS N V (MRUS), INSMED INC (INSM) and VERONA PHARMA PLC (VRNA) stocks. They significantly reduced their stock positions in RHYTHM PHARMACEUTICALS INC (RYTM), AQUESTIVE THERAPEUTICS INC (AQST) and KYMERA THERAPEUTICS INC (KYMR). PERCEPTIVE ADVISORS LLC opened new stock positions in INVIVYD INC (ADGI), DANAHER CORPORATION (DHR) and CIDARA THERAPEUTICS INC (CDTX). The fund showed a lot of confidence in some stocks as they added substantially to ALTO NEUROSCIENCE INC, BELITE BIO INC (BLTE) and DYNE THERAPEUTICS INC (DYN).
PERCEPTIVE ADVISORS LLC Annual Return Estimates Vs S&P 500
Our best estimate is that PERCEPTIVE ADVISORS LLC made a return of 545.62% in the last quarter. In trailing 12 months, it's portfolio return was 57.06%.
- Performance
- S&P 500
New Buys
| Ticker | $ Bought |
|---|---|
| invivyd inc | 53,809,400 |
| danaher corporation | 45,784,000 |
| cidara therapeutics inc | 36,475,800 |
| disc medicine inc | 35,793,500 |
| jazz pharmaceuticals plc | 28,900,000 |
| palisade bio inc | 28,317,500 |
| axogen inc | 25,664,900 |
| x4 pharmaceuticals inc | 25,257,800 |
New stocks bought by PERCEPTIVE ADVISORS LLC
Additions
| Ticker | % Inc. |
|---|---|
| alto neuroscience inc | 1,048 |
| belite bio inc | 732 |
| dyne therapeutics inc | 543 |
| rapt therapeutics inc | 349 |
| athira pharma inc | 244 |
| boston scientific corp | 215 |
| engene holdings inc | 179 |
| exact sciences corp | 157 |
Additions to existing portfolio by PERCEPTIVE ADVISORS LLC
Reductions
| Ticker | % Reduced |
|---|---|
| rhythm pharmaceuticals inc | -99.39 |
| aquestive therapeutics inc | -80.13 |
| kymera therapeutics inc | -58.81 |
| corvus pharmaceuticals inc | -51.87 |
| krystal biotech inc | -50.00 |
| penumbra inc | -49.88 |
| arcellx inc | -40.61 |
| palvella therapeutics inc ne | -32.6 |
PERCEPTIVE ADVISORS LLC reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| trinity biotech plc | -1,861,600 |
| merus n v | -127,394,000 |
| pyxis oncology inc | -2,615,840 |
| akero therapeutics inc | -53,926,200 |
| insmed inc | -101,114,000 |
| scpharmaceuticals inc | -3,306,420 |
| verona pharma plc | -55,925,400 |
| janux therapeutics inc | -7,153,250 |
PERCEPTIVE ADVISORS LLC got rid off the above stocks
Sector Distribution
PERCEPTIVE ADVISORS LLC has about 74% of it's holdings in Healthcare sector.
- Healthcare
- Others
| Sector | % |
|---|---|
| Healthcare | 74 |
| Others | 25 |
Market Cap. Distribution
PERCEPTIVE ADVISORS LLC has about 12.2% of it's portfolio invested in the large-cap and mega-cap stocks.
- MID-CAP
- UNALLOCATED
- SMALL-CAP
- LARGE-CAP
- MICRO-CAP
| Category | % |
|---|---|
| MID-CAP | 46.3 |
| UNALLOCATED | 25 |
| SMALL-CAP | 14.1 |
| LARGE-CAP | 12.2 |
| MICRO-CAP | 2.1 |
Stocks belong to which Index?
About 48.6% of the stocks held by PERCEPTIVE ADVISORS LLC either belong to S&P 500 or RUSSELL 2000 index.
- Others
- RUSSELL 2000
- S&P 500
| Index | % |
|---|---|
| Others | 51.4 |
| RUSSELL 2000 | 44.1 |
| S&P 500 | 4.5 |
PERCEPTIVE ADVISORS LLC Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of PERCEPTIVE ADVISORS LLC
PERCEPTIVE ADVISORS LLC has 111 stocks in it's portfolio. About 41.5% of the portfolio is in top 10 stocks. ACLX proved to be the most loss making stock for the portfolio. RYTM was the most profitable stock for PERCEPTIVE ADVISORS LLC last quarter.
Last Reported on: 17 Feb, 2026| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ACLX | arcellx inc | 1.70 | 1,466,070 | 95,587,800 | reduced | -40.61 | ||
| ADGI | invivyd inc | 0.96 | 21,785,200 | 53,809,400 | new | |||
| ADMA | adma biologics inc | 0.29 | 883,468 | 16,114,500 | reduced | -23.41 | ||
| AGLE | spyre therapeutics inc | 1.79 | 3,069,220 | 100,548,000 | added | 149 | ||
| AKRO | akero therapeutics inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ALDX | aldeyra therapeutics inc | 0.39 | 4,185,630 | 21,681,600 | reduced | -19.85 | ||
| AMLX | amylyx pharmaceuticals inc | 1.78 | 8,284,880 | 100,081,000 | reduced | -7.46 | ||
| AORT | artivion inc | 1.40 | 1,722,290 | 78,553,600 | reduced | -14.74 | ||
| APYX | apyx medical corporation | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AQST | aquestive therapeutics inc | 0.09 | 747,193 | 4,826,870 | reduced | -80.13 | ||
| ASND | ascendis pharma a/s | 4.11 | 1,081,420 | 230,602,000 | reduced | -0.65 | ||
| ATHA | athira pharma inc | 0.25 | 1,859,320 | 14,075,100 | added | 244 | ||
| ATXS | astria therapeutics inc | 1.51 | 6,485,420 | 84,894,100 | unchanged | 0.00 | ||
| AVTX | avalo therapeutics inc | 0.04 | 139,667 | 2,536,350 | unchanged | 0.00 | ||
| AXGN | axogen inc | 0.46 | 784,140 | 25,664,900 | new | |||
| AXSM | axsome therapeutics inc | 0.48 | 148,900 | 27,195,100 | unchanged | 0.00 | ||
| BCRX | biocryst pharmaceuticals inc | 0.44 | 3,162,530 | 24,667,700 | new | |||
| BDSX | biodesix | 0.01 | 108,694 | 739,119 | unchanged | 0.00 | ||
| BIIB | biogen inc | 0.39 | 124,000 | 21,822,800 | new | |||
| BLTE | belite bio inc | 1.18 | 414,239 | 66,261,700 | added | 732 | ||