Latest Partner Fund Management, L.P. Stock Portfolio
Partner Fund Management, L.P. Performance:
2025 Q3: 4.34%YTD: 12.45%2024: -0.35%
Performance for 2025 Q3 is 4.34%, and YTD is 12.45%, and 2024 is -0.35%.
About Partner Fund Management, L.P. and 13F Hedge Fund Stock Holdings
PFM Health Sciences, LP is a hedge fund based in SAN FRANCISCO, CA. On 06-Sep-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $3.3 Billions. In it's latest 13F Holdings report, PFM Health Sciences, LP reported an equity portfolio of $1.3 Billions as of 30 Sep, 2025.
The top stock holdings of PFM Health Sciences, LP are LLY, THC, AXSM. The fund has invested 13.2% of it's portfolio in ELI LILLY & CO and 7.2% of portfolio in TENET HEALTHCARE CORP.
The fund managers got completely rid off DANAHER CORPORATION (DHR), MOLINA HEALTHCARE INC (MOH) and ALNYLAM PHARMACEUTICALS INC (ALNY) stocks. They significantly reduced their stock positions in HUMANA INC (HUM), UNIQURE NV (QURE) and TEVA PHARMACEUTICAL INDS LTD (TEVA). PFM Health Sciences, LP opened new stock positions in UNIVERSAL HLTH SVCS INC (UHS), CENTENE CORP DEL (CNC) and MERCK & CO INC (MRK). The fund showed a lot of confidence in some stocks as they added substantially to VIKING THERAPEUTICS INC (VKTX), NEUROCRINE BIOSCIENCES INC (NBIX) and NEOGENOMICS INC (NEO).
The top stock holdings of PFM Health Sciences, LP are LLY, THC, AXSM. The fund has invested 13.2% of it's portfolio in ELI LILLY & CO and 7.2% of portfolio in TENET HEALTHCARE CORP.
The fund managers got completely rid off DANAHER CORPORATION (DHR), MOLINA HEALTHCARE INC (MOH) and ALNYLAM PHARMACEUTICALS INC (ALNY) stocks. They significantly reduced their stock positions in HUMANA INC (HUM), UNIQURE NV (QURE) and TEVA PHARMACEUTICAL INDS LTD (TEVA). PFM Health Sciences, LP opened new stock positions in UNIVERSAL HLTH SVCS INC (UHS), CENTENE CORP DEL (CNC) and MERCK & CO INC (MRK). The fund showed a lot of confidence in some stocks as they added substantially to VIKING THERAPEUTICS INC (VKTX), NEUROCRINE BIOSCIENCES INC (NBIX) and NEOGENOMICS INC (NEO).
Partner Fund Management, L.P. Annual Return Estimates Vs S&P 500
Our best estimate is that PFM Health Sciences, LP made a return of 4.34% in the last quarter. In trailing 12 months, it's portfolio return was 2.84%.
New Buys
| Ticker | $ Bought |
|---|---|
| universal hlth svcs inc | 23,768,200 |
| centene corp del | 20,493,200 |
| merck & co inc | 19,846,800 |
| elevance health inc formerly | 19,637,900 |
| adma biologics inc | 17,313,600 |
| revolution medicines inc | 15,460,900 |
| vera therapeutics inc | 14,927,700 |
| veeva sys inc | 12,364,200 |
New stocks bought by Partner Fund Management, L.P.
Additions
| Ticker | % Inc. |
|---|---|
| viking therapeutics inc | 386 |
| neurocrine biosciences inc | 346 |
| neogenomics inc | 186 |
| united therapeutics corp del | 162 |
| structure therapeutics inc | 103 |
| centessa pharmaceuticals plc | 93.12 |
| icon plc | 51.6 |
| cencora inc | 51.06 |
Additions to existing portfolio by Partner Fund Management, L.P.
Reductions
| Ticker | % Reduced |
|---|---|
| humana inc | -96.67 |
| uniqure nv | -73.41 |
| teva pharmaceutical inds ltd | -71.2 |
| arcutis biotherapeutics inc | -60.96 |
| indivior plc | -58.59 |
| ascendis pharma a/s | -49.93 |
| amylyx pharmaceuticals inc | -40.44 |
| soleno therapeutics inc | -40.23 |
Partner Fund Management, L.P. reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| io biotech inc | -2,741,180 |
| erasca inc | -1,361,720 |
| hologic inc | -13,813,000 |
| biomarin pharmaceutical inc | -9,802,200 |
| danaher corporation | -31,885,500 |
| masimo corp | -15,888,500 |
| sagimet biosciences inc | -685,800 |
| molina healthcare inc | -25,541,600 |
Partner Fund Management, L.P. got rid off the above stocks
Sector Distribution
PFM Health Sciences, LP has about 87.4% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 87.4 |
| Others | 12.5 |
Market Cap. Distribution
PFM Health Sciences, LP has about 58% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| LARGE-CAP | 41.3 |
| MID-CAP | 22.3 |
| MEGA-CAP | 16.7 |
| UNALLOCATED | 10.3 |
| SMALL-CAP | 6.2 |
| MICRO-CAP | 3.3 |
Stocks belong to which Index?
About 61.2% of the stocks held by PFM Health Sciences, LP either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| S&P 500 | 40.2 |
| Others | 38.8 |
| RUSSELL 2000 | 21 |
Partner Fund Management, L.P. Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of Partner Fund Management, L.P.
PFM Health Sciences, LP has 66 stocks in it's portfolio. About 45.9% of the portfolio is in top 10 stocks. ISRG proved to be the most loss making stock for the portfolio. THC was the most profitable stock for PFM Health Sciences, LP last quarter.
Last Reported on: 14 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ABBV | abbvie inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| ABC | cencora inc | 1.93 | 80,493 | 25,156,500 | added | 51.06 | ||
| ADMA | adma biologics inc | 1.33 | 1,181,010 | 17,313,600 | new | |||
| AKRO | akero therapeutics inc | 0.91 | 248,079 | 11,778,800 | reduced | -6.8 | ||
| ALNY | alnylam pharmaceuticals inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AMLX | amylyx pharmaceuticals inc | 0.46 | 436,156 | 5,927,360 | reduced | -40.44 | ||
| AMRX | amneal pharmaceuticals inc | 0.27 | 355,818 | 3,561,740 | new | |||
| ARQT | arcutis biotherapeutics inc | 0.52 | 360,460 | 6,794,670 | reduced | -60.96 | ||
| AXSM | axsome therapeutics inc | 4.95 | 530,332 | 64,408,800 | added | 9.78 | ||
| BBIO | bridgebio pharma inc | 1.31 | 327,174 | 16,993,400 | reduced | -37.3 | ||
| BMRN | biomarin pharmaceutical inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| BPMC | blueprint medicines corp | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| BSX | boston scientific corp | 0.22 | 28,648 | 2,796,900 | new | |||
| CMPS | compass pathways plc | 0.73 | 1,662,840 | 9,528,050 | reduced | -6.54 | ||
| CNC | centene corp del | 1.58 | 574,360 | 20,493,200 | new | |||
| CNTA | centessa pharmaceuticals plc | 1.24 | 666,196 | 16,155,300 | added | 93.12 | ||
| COO | cooper cos inc | 0.39 | 74,363 | 5,098,330 | new | |||
| CRBU | caribou biosciences inc | 0.24 | 1,358,830 | 3,166,080 | unchanged | 0.00 | ||
| CVS | cvs health corp | 2.01 | 346,679 | 26,136,100 | reduced | -27.63 | ||
| DHR | danaher corporation | 0.00 | 0.00 | 0.00 | sold off | -100 | ||