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Latest SPHERA FUNDS MANAGEMENT LTD. Stock Portfolio

$629Million– No. of Holdings #91

SPHERA FUNDS MANAGEMENT LTD. Performance:
2026 Q1: 4.8%YTD: 4.8%2025: 22.51%
Performance for 2026 Q1 is 4.8%, and YTD is 4.8%, and 2025 is 22.51%.

About SPHERA FUNDS MANAGEMENT LTD. and 13F Hedge Fund Stock Holdings

SPHERA FUNDS MANAGEMENT LTD. is a hedge fund based in New York, NY. On 2026-05-15, the fund reported it's updated stock portfolio. In the 13F Holdings report, SPHERA FUNDS MANAGEMENT LTD. reported an equity portfolio of $629.7 Millions as of 31 Mar, 2026.

The top stock holdings of SPHERA FUNDS MANAGEMENT LTD. are , TEVA, TSEM. The fund has invested 5.8% of it's portfolio in MINERALYS THERAPEUTICS INC and 5.4% of portfolio in TEVA PHARMACEUTICAL INDS LTD.

The fund managers got completely rid off ASTRAZENECA PLC (AZN), ANNEXON INC (ANNX) and ASTRIA THERAPEUTICS INC (ATXS) stocks. They significantly reduced their stock positions in PRECISION BIOSCIENCES INC (DTIL), SOLAREDGE TECHNOLOGIES INC (SEDG) and BIOAGE LABS INC. SPHERA FUNDS MANAGEMENT LTD. opened new stock positions in ASTRAZENECA PLC, CELLEBRITE DI LTD (CLBT) and PALO ALTO NETWORKS INC (PANW). The fund showed a lot of confidence in some stocks as they added substantially to PROMIS NEUROSCIENCES INC (PMN), PALISADE BIO INC (PALI) and PRELUDE THERAPEUTICS INC (PRLD).
SPHERA FUNDS MANAGEMENT LTD. Equity Portfolio Value
Last Reported on: 15 May, 2026

SPHERA FUNDS MANAGEMENT LTD. Annual Return Estimates Vs S&P 500

Our best estimate is that SPHERA FUNDS MANAGEMENT LTD. made a return of 4.8% in the last quarter. In trailing 12 months, it's portfolio return was 48.46%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
astrazeneca plc12,332,200
cellebrite di ltd8,702,360
palo alto networks inc8,464,900
ormat technologies inc7,638,540
xenon pharmaceuticals inc7,385,050
amazon com inc6,652,140
applied optoelectronics inc6,208,910
biohaven ltd5,025,240
New stocks bought by SPHERA FUNDS MANAGEMENT LTD.

Additions

Ticker% Inc.
promis neurosciences inc2,657
palisade bio inc841
prelude therapeutics inc354
maze therapeutics inc216
mineralys therapeutics inc198
madrigal pharmaceuticals inc173
ultragenyx pharmaceutical in169
bridgebio pharma inc127
Additions to existing portfolio by SPHERA FUNDS MANAGEMENT LTD.

Reductions

Ticker% Reduced
precision biosciences inc-89.9
solaredge technologies inc-73.12
bioage labs inc-64.4
dyne therapeutics inc-59.13
cytokinetics inc-56.59
climb bio inc-55.03
evommune inc-52.91
oric pharmaceuticals inc-46.47
SPHERA FUNDS MANAGEMENT LTD. reduced stake in above stock

Sold off

Ticker$ Sold
tenaya therapeutics inc-1,067,250
annexon inc-6,607,380
protara therapeutics inc-3,464,500
jasper therapeutics inc-888,284
taysha gene therapies inc-2,024,800
astria therapeutics inc-4,656,440
perspective therapeutics inc-962,426
mereo biopharma group plc-106,425
SPHERA FUNDS MANAGEMENT LTD. got rid off the above stocks

Sector Distribution

SPHERA FUNDS MANAGEMENT LTD. has about 56.5% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
  • Technology
  • Utilities
  • Consumer Cyclical
Sector%
Healthcare56.5
Others37
Technology4
Utilities1.3
Consumer Cyclical1.2

Market Cap. Distribution

SPHERA FUNDS MANAGEMENT LTD. has about 24.2% of it's portfolio invested in the large-cap and mega-cap stocks.

  • UNALLOCATED
  • LARGE-CAP
  • SMALL-CAP
  • MID-CAP
  • MEGA-CAP
  • MICRO-CAP
Category%
UNALLOCATED37
LARGE-CAP18.2
SMALL-CAP17.1
MID-CAP15.6
MEGA-CAP6
MICRO-CAP5

Stocks belong to which Index?

About 41.9% of the stocks held by SPHERA FUNDS MANAGEMENT LTD. either belong to S&P 500 or RUSSELL 2000 index.

  • Others
  • RUSSELL 2000
  • S&P 500
Index%
Others58.1
RUSSELL 200028.5
S&P 50013.4
Top 5 Winners (%)%
enliven therapeutics inc
129.5 %
TNGX
tango therapeutics inc
111.0 %
ELDN
eledon pharmaceuticals inc
95.2 %
CRVS
corvus pharmaceuticals inc
72.4 %
STTK
shattuck labs inc
57.8 %
Top 5 Winners ($)$
TSEM
tower semiconductor ltd
7.8 M
NVMI
nova ltd
5.4 M
TNGX
tango therapeutics inc
5.4 M
enliven therapeutics inc
4.5 M
APLS
apellis pharmaceuticals inc
3.5 M
Top 5 Losers (%)%
WVE
wave life sciences ltd
-54.0 %
CYBN
cybin inc
-39.3 %
VSTM
verastem inc
-31.4 %
structure therapeutics inc
-28.6 %
NVO
novo-nordisk a s
-27.4 %
Top 5 Losers ($)$
mineralys therapeutics inc
-8.2 M
WVE
wave life sciences ltd
-4.7 M
CYBN
cybin inc
-3.1 M
SLNO
soleno therapeutics inc
-2.3 M
maze therapeutics inc
-1.7 M

SPHERA FUNDS MANAGEMENT LTD. Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of SPHERA FUNDS MANAGEMENT LTD.

SPHERA FUNDS MANAGEMENT LTD. has 91 stocks in it's portfolio. About 34.5% of the portfolio is in top 10 stocks. proved to be the most loss making stock for the portfolio. TSEM was the most profitable stock for SPHERA FUNDS MANAGEMENT LTD. last quarter.

Last Reported on: 15 May, 2026
TickerNamesorted ascending% PortfolioShares Held$ ValueType% ChangeOptions