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Latest SPHERA FUNDS MANAGEMENT LTD. Stock Portfolio

$766Million | No. of Holdings #96

SPHERA FUNDS MANAGEMENT LTD. Performance

2026 Q2+11.49%
YTD+16.84%
2025+22.51%

About SPHERA FUNDS MANAGEMENT LTD. and 13F Hedge Fund Stock Holdings

SPHERA FUNDS MANAGEMENT LTD. is a hedge fund based in New York, NY. On 2026-08-14, the fund reported it's updated stock portfolio. In the 13F Holdings report, SPHERA FUNDS MANAGEMENT LTD. reported an equity portfolio of $766.5 Millions as of 30 Jun, 2026. <br><br> The top stock holdings of SPHERA FUNDS MANAGEMENT LTD. are TEVA, , TSEM. The fund has invested 6.6% of it's portfolio in TEVA PHARMACEUTICAL INDS LTD and 5.2% of portfolio in MINERALYS THERAPEUTICS INC. <br><br> The fund managers got completely rid off AMICUS THERAPEUTIC (FOLD), CELLEBRITE DI LTD (CLBT) and APELLIS PHARMACEUTICALS INC (APLS) stocks. They significantly reduced their stock positions in CURIS INC (CRIS), BIOHAVEN LTD and SHATTUCK LABS INC (STTK). SPHERA FUNDS MANAGEMENT LTD. opened new stock positions in INSMED INC (INSM), RHYTHM PHARMACEUTICALS INC (RYTM) and LAM RESEARCH CORP (LRCX). The fund showed a lot of confidence in some stocks as they added substantially to CYTOKINETICS INC (CYTK), CYTOMX THERAPEUTICS INC. (CTMX) and BIOAGE LABS INC.
SPHERA FUNDS MANAGEMENT LTD. Equity Portfolio Value
Last Reported on: 14 Aug, 2026
$766Million
  as of Aug 14, 2026

SPHERA FUNDS MANAGEMENT LTD. Annual Return Estimates Vs S&P 500

Our best estimate is that SPHERA FUNDS MANAGEMENT LTD. made a return of 11.49% in the last quarter. In trailing 12 months, it's portfolio return was 60.3%.
  • Performance
  • S&P 500

New Buys

Ticker$ Bought
insmed inc12,666,500
rhythm pharmaceuticals inc8,926,810
lam research corp8,003,600
applied matls inc7,981,920
ideaya biosciences inc7,320,130
nuvectis pharma inc7,042,360
harmony biosciences hldgs in6,432,300
vistra corp4,671,650
New stocks bought by SPHERA FUNDS MANAGEMENT LTD.

Additions

Ticker% Inc.
cytokinetics inc452
cytomx therapeutics inc.299
bioage labs inc146
biomarin pharmaceutical inc134
madrigal pharmaceuticals inc92.69
verastem inc84.08
maze therapeutics inc83.67
prelude therapeutics inc82.65
Additions to existing portfolio by SPHERA FUNDS MANAGEMENT LTD.

Reductions

Ticker% Reduced
curis inc-95.04
biohaven ltd-72.32
evommune inc-71.07
shattuck labs inc-69.21
revolution medicines inc-59.35
ormat technologies inc-58.95
nova ltd-52.84
biocryst pharmaceuticals inc-51.29
SPHERA FUNDS MANAGEMENT LTD. reduced stake in above stock

Sold off

Ticker$ Sold
cellebrite di ltd-8,702,360
amicus therapeutic-8,724,830
soleno therapeutics inc-7,241,090
apellis pharmaceuticals inc-8,645,990
enphase energy inc-5,384,860
zim integrated shipping serv-2,791,780
applied optoelectronics inc-6,208,910
ishares bitcoin trust etf-2,286,180
SPHERA FUNDS MANAGEMENT LTD. got rid off the above stocks

Sector Distribution

SPHERA FUNDS MANAGEMENT LTD. has about 64.6% of it's holdings in Healthcare sector.

  • Healthcare
  • Others
  • Technology
  • Utilities
Sector%
Healthcare64.6
Others31.6
Technology2.3
Utilities1.5

Market Cap. Distribution

SPHERA FUNDS MANAGEMENT LTD. has about 29.4% of it's portfolio invested in the large-cap and mega-cap stocks.

  • UNALLOCATED
  • LARGE-CAP
  • MID-CAP
  • SMALL-CAP
  • MEGA-CAP
  • MICRO-CAP
Category%
UNALLOCATED31.6
LARGE-CAP22
MID-CAP21
SMALL-CAP15.1
MEGA-CAP7.4
MICRO-CAP2.7

Stocks belong to which Index?

About 46.3% of the stocks held by SPHERA FUNDS MANAGEMENT LTD. either belong to S&P 500 or RUSSELL 2000 index.

  • Others
  • RUSSELL 2000
  • S&P 500
Index%
Others53.7
RUSSELL 200034.6
S&P 50011.7
Top 5 Winners (%)%
CRIS
curis inc
948.8 %
ELYM
climb bio inc
79.5 %
RLAY
relay therapeutics inc
69.2 %
RVMD
revolution medicines inc
65.1 %
TRVI
trevi therapeutics inc
52.6 %
Top 5 Winners ($)$
TSEM
tower semiconductor ltd
10.8 M
CRIS
curis inc
10.4 M
RARE
ultragenyx pharmaceutical in
8.7 M
TEVA
teva pharmaceutical inds ltd
5.0 M
NVMI
nova ltd
4.3 M
Top 5 Losers (%)%
HOWL
werewolf therapeutics inc
-56.8 %
evommune inc
-27.2 %
VSTM
verastem inc
-23.0 %
WVE
wave life sciences ltd
-18.7 %
upstream bio inc
-18.6 %
Top 5 Losers ($)$
SNY
sanofi sa
-1.5 M
SNDX
syndax pharmaceuticals inc
-1.3 M
ORIC
oric pharmaceuticals inc
-1.2 M
FBRX
forte biosciences inc
-1.0 M
PFE
pfizer inc
-0.9 M

SPHERA FUNDS MANAGEMENT LTD. Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of SPHERA FUNDS MANAGEMENT LTD.

SPHERA FUNDS MANAGEMENT LTD. has 96 stocks in it's portfolio. About 33.3% of the portfolio is in top 10 stocks. SNY proved to be the most loss making stock for the portfolio. TSEM was the most profitable stock for SPHERA FUNDS MANAGEMENT LTD. last quarter.

$698.83MTotal Value
114Positions
14 Aug, 2026Last Reported
Current holdings of Current Stock Holdings of SPHERA FUNDS MANAGEMENT LTD., last reported on 14 Aug, 2026. Select a row with a linked ticker to view its historical trend.
ExpandHoldingsorted ascending% PortfolioShares Held$ Value% Change
AGNG
Global X Fds

Global X Fds

AGNG
SPHERA FUNDS MANAGEMENT LTD.'s holding in Global X Fds over time
0.58%195,900
$4.45M
0.58%
new position
ASND
Ascendis Pharma A/S

Ascendis Pharma A/S

ASND
SPHERA FUNDS MANAGEMENT LTD.'s holding in Ascendis Pharma A/S over time
0%0.00
$0.00
0%
decreased 100 percentsold off
CAMT
Camtek Ltd

Camtek Ltd

CAMT
SPHERA FUNDS MANAGEMENT LTD.'s holding in Camtek Ltd over time
0%0.00
$0.00
0%
decreased 100 percentsold off