Latest SPHERA FUNDS MANAGEMENT LTD. Stock Portfolio
SPHERA FUNDS MANAGEMENT LTD. Performance:
2025 Q3: 16.89%YTD: 4.34%2024: -0.58%
Performance for 2025 Q3 is 16.89%, and YTD is 4.34%, and 2024 is -0.58%.
About SPHERA FUNDS MANAGEMENT LTD. and 13F Hedge Fund Stock Holdings
SPHERA FUNDS MANAGEMENT LTD. is a hedge fund based in NEW YORK, NY. On 31-Mar-2022, the fund reported that it had an AUM (Regulated Assets under Management) of $789.8 Millions. In it's latest 13F Holdings report, SPHERA FUNDS MANAGEMENT LTD. reported an equity portfolio of $474.1 Millions as of 30 Sep, 2025.
The top stock holdings of SPHERA FUNDS MANAGEMENT LTD. are TEVA, , TSEM. The fund has invested 6.4% of it's portfolio in TEVA PHARMACEUTICAL INDS LTD and 4.8% of portfolio in NICE LTD.
The fund managers got completely rid off NVIDIA CORPORATION (NVDA), MICROSOFT CORP (MSFT) and AVIDITY BIOSCIENCES INC (RNA) stocks. They significantly reduced their stock positions in ARROWHEAD PHARMACEUTICALS IN (ARWR), PROMIS NEUROSCIENCES INC (PMN) and 89BIO INC (ETNB). SPHERA FUNDS MANAGEMENT LTD. opened new stock positions in NICE LTD, INVESCO QQQ TR (QQQ) and CELLEBRITE DI LTD (CLBT). The fund showed a lot of confidence in some stocks as they added substantially to JASPER THERAPEUTICS INC (JSPR), ULTRAGENYX PHARMACEUTICAL IN (RARE) and CORVUS PHARMACEUTICALS INC (CRVS).
The top stock holdings of SPHERA FUNDS MANAGEMENT LTD. are TEVA, , TSEM. The fund has invested 6.4% of it's portfolio in TEVA PHARMACEUTICAL INDS LTD and 4.8% of portfolio in NICE LTD.
The fund managers got completely rid off NVIDIA CORPORATION (NVDA), MICROSOFT CORP (MSFT) and AVIDITY BIOSCIENCES INC (RNA) stocks. They significantly reduced their stock positions in ARROWHEAD PHARMACEUTICALS IN (ARWR), PROMIS NEUROSCIENCES INC (PMN) and 89BIO INC (ETNB). SPHERA FUNDS MANAGEMENT LTD. opened new stock positions in NICE LTD, INVESCO QQQ TR (QQQ) and CELLEBRITE DI LTD (CLBT). The fund showed a lot of confidence in some stocks as they added substantially to JASPER THERAPEUTICS INC (JSPR), ULTRAGENYX PHARMACEUTICAL IN (RARE) and CORVUS PHARMACEUTICALS INC (CRVS).
SPHERA FUNDS MANAGEMENT LTD. Annual Return Estimates Vs S&P 500
Our best estimate is that SPHERA FUNDS MANAGEMENT LTD. made a return of 16.89% in the last quarter. In trailing 12 months, it's portfolio return was 0.92%.
New Buys
| Ticker | $ Bought |
|---|---|
| nice ltd | 22,788,400 |
| invesco qqq tr | 13,784,500 |
| cellebrite di ltd | 5,539,510 |
| solaredge technologies inc | 5,332,890 |
| rapport therapeutics inc | 4,678,730 |
| varonis sys inc | 4,247,030 |
| mediwound ltd | 3,338,560 |
| soleno therapeutics inc | 2,812,570 |
New stocks bought by SPHERA FUNDS MANAGEMENT LTD.
Additions
| Ticker | % Inc. |
|---|---|
| jasper therapeutics inc | 4,190 |
| ultragenyx pharmaceutical in | 252 |
| corvus pharmaceuticals inc | 122 |
| climb bio inc | 107 |
| dyne therapeutics inc | 92.63 |
| advanced micro devices inc | 87.52 |
| structure therapeutics inc | 81.31 |
| ceva inc | 65.75 |
Additions to existing portfolio by SPHERA FUNDS MANAGEMENT LTD.
Reductions
| Ticker | % Reduced |
|---|---|
| arrowhead pharmaceuticals in | -93.84 |
| promis neurosciences inc | -84.46 |
| 89bio inc | -80.71 |
| syndax pharmaceuticals inc | -75.33 |
| ormat technologies inc | -62.82 |
| pharvaris n v | -61.47 |
| amazon com inc | -57.58 |
| maze therapeutics inc | -56.7 |
SPHERA FUNDS MANAGEMENT LTD. reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| ormat technologies inc | -5,609,900 |
| chemomab therapeutics ltd | -856,136 |
| nano dimension ltd | -1,162,380 |
| vistagen therapeutics inc | -895,878 |
| elevation oncology inc | -120,615 |
| intellia therapeutics inc | -1,207,960 |
| avidity biosciences inc | -3,578,400 |
| kezar life sciences inc | -268,109 |
SPHERA FUNDS MANAGEMENT LTD. got rid off the above stocks
Sector Distribution
SPHERA FUNDS MANAGEMENT LTD. has about 51.4% of it's holdings in Healthcare sector.
| Sector | % |
|---|---|
| Healthcare | 51.4 |
| Others | 42.4 |
| Technology | 4.1 |
Market Cap. Distribution
SPHERA FUNDS MANAGEMENT LTD. has about 20.3% of it's portfolio invested in the large-cap and mega-cap stocks.
| Category | % |
|---|---|
| UNALLOCATED | 42.4 |
| MID-CAP | 16.1 |
| SMALL-CAP | 11.9 |
| LARGE-CAP | 11.7 |
| MEGA-CAP | 8.6 |
| MICRO-CAP | 7.3 |
| NANO-CAP | 2.1 |
Stocks belong to which Index?
About 37% of the stocks held by SPHERA FUNDS MANAGEMENT LTD. either belong to S&P 500 or RUSSELL 2000 index.
| Index | % |
|---|---|
| Others | 63 |
| RUSSELL 2000 | 22.8 |
| S&P 500 | 14.2 |
SPHERA FUNDS MANAGEMENT LTD. Holdings Map
This heatmap illustrates the top 50 positions within the fund's portfolio.
Current Stock Holdings of SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. has 100 stocks in it's portfolio. About 32.8% of the portfolio is in top 10 stocks. RARE proved to be the most loss making stock for the portfolio. SNDX was the most profitable stock for SPHERA FUNDS MANAGEMENT LTD. last quarter.
Last Reported on: 14 Nov, 2025| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options | |
|---|---|---|---|---|---|---|---|---|
| ABBV | abbvie inc | 1.23 | 25,256 | 5,847,770 | unchanged | 0.00 | ||
| ACAD | acadia pharmaceuticals inc | 0.67 | 148,900 | 3,177,530 | reduced | -14.87 | ||
| AMAT | applied matls inc | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| AMD | advanced micro devices inc | 0.53 | 15,470 | 2,502,890 | added | 87.52 | ||
| AMGN | amgen inc | 0.57 | 9,500 | 2,680,900 | unchanged | 0.00 | ||
| AMZN | amazon com inc | 0.64 | 13,760 | 3,021,280 | reduced | -57.58 | ||
| ANNX | annexon inc | 1.15 | 1,794,390 | 5,472,880 | added | 1.7 | ||
| APLS | apellis pharmaceuticals inc | 0.30 | 63,660 | 1,440,630 | reduced | -44.33 | ||
| APLT | applied therapeutics inc | 0.01 | 50,000 | 30,245 | unchanged | 0.00 | ||
| APRE | aprea therapeutics inc | 0.08 | 270,000 | 398,250 | unchanged | 0.00 | ||
| ARWR | arrowhead pharmaceuticals in | 0.09 | 12,496 | 430,987 | reduced | -93.84 | ||
| ATXS | astria therapeutics inc | 0.39 | 251,225 | 1,828,920 | reduced | -2.4 | ||
| AVGO | broadcom inc | 0.46 | 6,555 | 2,162,560 | new | |||
| BBIO | bridgebio pharma inc | 0.45 | 40,746 | 2,116,350 | reduced | -53.22 | ||
| BIIB | biogen inc | 2.44 | 82,738 | 11,589,900 | unchanged | 0.00 | ||
| BMY | bristol-myers squibb co | 0.17 | 17,500 | 789,250 | unchanged | 0.00 | ||
| CDTX | cidara therapeutics inc | 1.53 | 75,743 | 7,253,150 | reduced | -45.11 | ||
| CEVA | ceva inc | 0.45 | 81,085 | 2,141,460 | added | 65.75 | ||
| CGNT | cognyte software ltd | 0.00 | 0.00 | 0.00 | sold off | -100 | ||
| CLBT | cellebrite di ltd | 1.17 | 298,948 | 5,539,510 | new | |||