Latest SPHERA FUNDS MANAGEMENT LTD. Stock Portfolio

$733Million– No. of Holdings #110

SPHERA FUNDS MANAGEMENT LTD. Performance:

2024 Q2: -7.06%YTD: 4.37%2023: 6.79%

Performance for 2024 Q2 is -7.06%, and YTD is 4.37%, and 2023 is 6.79%.

About SPHERA FUNDS MANAGEMENT LTD. and 13F Hedge Fund Stock Holdings

SPHERA FUNDS MANAGEMENT LTD. is a hedge fund based in NEW YORK, NY. On 31-Mar-2022, the fund reported that it had an AUM (Regulated Assets under Management) of $789.8 Millions. In it's latest 13F Holdings report, SPHERA FUNDS MANAGEMENT LTD. reported an equity portfolio of $733.2 Millions as of 30 Jun, 2024.

The top stock holdings of SPHERA FUNDS MANAGEMENT LTD. are BBIO, , CYTK. The fund has invested 3.1% of it's portfolio in BRIDGEBIO PHARMA INC and 3% of portfolio in SANOFI.

The fund managers got completely rid off PERSPECTIVE THERAPEUTICS INC, FUSION PHARMACEUTICALS INC (FUSN) and INCYTE CORP (INCY) stocks. They significantly reduced their stock positions in CAMTEK LTD, AMYLYX PHARMACEUTICALS INC (AMLX) and GOSSAMER BIO INC (GOSS). SPHERA FUNDS MANAGEMENT LTD. opened new stock positions in SKYE BIOSCIENCE INC (SKYE), ASML HOLDING N V and SALESFORCE INC (CRM). The fund showed a lot of confidence in some stocks as they added substantially to BROADCOM INC (AVGO), APPLE INC (AAPL) and ACADIA PHARMACEUTICALS INC (ACAD).

SPHERA FUNDS MANAGEMENT LTD. Equity Portfolio Value

Last Reported on: 14 Aug, 2024

SPHERA FUNDS MANAGEMENT LTD. Annual Return Estimates Vs S&P 500

Our best estimate is that SPHERA FUNDS MANAGEMENT LTD. made a return of -7.06% in the last quarter. In trailing 12 months, it's portfolio return was 13.87%.

New Buys

Ticker	$ Bought
skye bioscience inc	10,399,500
asml holding n v	10,126,000
salesforce inc	8,638,560
perspective therapeutics inc	7,845,480
ionis pharmaceuticals inc	6,683,740
palo alto networks inc	6,102,180
micron technology inc	4,866,610
lam research corp	3,939,940

New stocks bought by SPHERA FUNDS MANAGEMENT LTD.

Additions

Ticker	% Inc.
broadcom inc	1,834
apple inc	251
acadia pharmaceuticals inc	162
cargo therapeutics inc	107
amazon com inc	86.35
rezolute inc	71.36
praxis precision medicines i	60.00
bridgebio pharma inc	55.31

Additions to existing portfolio by SPHERA FUNDS MANAGEMENT LTD.

Reductions

Ticker	% Reduced
camtek ltd	-97.41
amylyx pharmaceuticals inc	-86.51
gossamer bio inc	-78.37
global e online ltd	-67.96
teva pharmaceutical inds ltd	-58.23
wix com ltd	-52.39
sentinelone inc	-48.48
jfrog ltd	-47.46

SPHERA FUNDS MANAGEMENT LTD. reduced stake in above stock

Sold off

Ticker	$ Sold
perspective therapeutics inc	-14,807,900
fusion pharmaceuticals inc	-9,573,550
geron corp	-1,268,380
incyte corp	-5,102,000
alpine immune sciences inc	-1,777,500
solaredge technologies inc	-2,851,620
nova ltd	-6,227,100
corbus pharmaceuticals hldgs	-1,373,400

SPHERA FUNDS MANAGEMENT LTD. got rid off the above stocks

Sector Distribution

SPHERA FUNDS MANAGEMENT LTD. has about 51.3% of it's holdings in Healthcare sector.

Sector	%
Healthcare	51.3
Others	27.1
Technology	14.7
Consumer Cyclical	3.2
Communication Services	3.1

Market Cap. Distribution

SPHERA FUNDS MANAGEMENT LTD. has about 31.7% of it's portfolio invested in the large-cap and mega-cap stocks.

Category	%
UNALLOCATED	27.9
MEGA-CAP	18.6
MID-CAP	17.8
SMALL-CAP	15.2
LARGE-CAP	13.1
MICRO-CAP	6.5

Stocks belong to which Index?

About 54.2% of the stocks held by SPHERA FUNDS MANAGEMENT LTD. either belong to S&P 500 or RUSSELL 2000 index.

Index	%
Others	45.8
RUSSELL 2000	27.2
S&P 500	27

Top 5 Winners (%)		%
INSM	insmed inc	151.9 %
RZLT	rezolute inc	48.7 %
MRUS	merus n v	31.1 %
SRPT	sarepta therapeutics inc	22.5 %
VIGL	vigil neuroscience inc	16.8 %

Top 5 Winners ($)		$
TEVA	teva pharmaceutical inds ltd	4.0 M
SRPT	sarepta therapeutics inc	2.4 M
RZLT	rezolute inc	2.4 M
MRUS	merus n v	2.1 M
AAPL	apple inc	1.7 M

Top 5 Losers (%)		%
NVDA	nvidia corporation	-85.8 %
HOWL	werewolf therapeutics inc	-62.4 %
VTYX	ventyx biosciences inc	-57.8 %
ELEV	elevation oncology inc	-43.2 %
INZY	inozyme pharma inc	-40.3 %

Top 5 Losers ($)		$
NVDA	nvidia corporation	-15.0 M
CYTK	cytokinetics inc	-5.1 M
INZY	inozyme pharma inc	-4.4 M
PRAX	praxis precision medicines i	-4.1 M
BBIO	bridgebio pharma inc	-4.0 M

SPHERA FUNDS MANAGEMENT LTD. Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of SPHERA FUNDS MANAGEMENT LTD.

SPHERA FUNDS MANAGEMENT LTD. has 110 stocks in it's portfolio. About 24% of the portfolio is in top 10 stocks. NVDA proved to be the most loss making stock for the portfolio. TEVA was the most profitable stock for SPHERA FUNDS MANAGEMENT LTD. last quarter.

Last Reported on: 14 Aug, 2024

Ticker	Namesorted ascending	% Portfolio	Shares Held	$ Value	Type	% Change
AAPL	apple inc	1.77	61,500	12,953,100	added	251

ABBV	abbvie inc	0.89	38,000	6,517,760	unchanged	0.00

ACAD	acadia pharmaceuticals inc	0.73	327,539	5,322,510	added	162

ADCT	adc therapeutics sa	0.30	685,547	2,166,330	new

ADI	analog devices inc	0.41	13,000	2,967,380	new

AKRO	akero therapeutics inc	0.45	141,620	3,322,400	reduced	-11.73

ALEC	alector inc	0.38	610,000	2,769,400	added	8.93

ALPN	alpine immune sciences inc	0.00	0.00	0.00	sold off	-100

AMAT	applied matls inc	0.79	24,604	5,806,300	reduced	-23.11

AMD	advanced micro devices inc	0.00	0.00	0.00	sold off	-100

AMLX	amylyx pharmaceuticals inc	0.01	36,050	68,495	reduced	-86.51

AMZN	amazon com inc	2.67	101,432	19,601,700	added	86.35

APLT	applied therapeutics inc	0.43	674,268	3,148,830	added	8.92

APRE	aprea therapeutics inc	0.15	270,000	1,098,900	unchanged	0.00

ARBE	arbe robotics ltd	0.01	43,165	82,445	unchanged	0.00

ARWR	arrowhead pharmaceuticals in	0.17	48,175	1,252,070	new

ATXS	astria therapeutics inc	0.20	162,842	1,481,860	added	44.31

AVGO	broadcom inc	0.42	193,600	3,108,310	added	1,834

BBIO	bridgebio pharma inc	3.14	910,070	23,052,100	added	55.31

BIIB	biogen inc	1.50	47,412	10,991,000	reduced	-32.89