Latest Prosight Management, LP Stock Portfolio

Prosight Management, LP Performance:

2025 Q4: 3.45%YTD: 7.64%2024: -20.31%

Performance for 2025 Q4 is 3.45%, and YTD is 7.64%, and 2024 is -20.31%.

About Prosight Management, LP and 13F Hedge Fund Stock Holdings

On 2026-02-13, the fund reported it's updated stock portfolio. In the 13F Holdings report, Prosight Management, LP reported an equity portfolio of $483.9 Millions as of 31 Dec, 2025.

The top stock holdings of Prosight Management, LP are PRCT, GLPG, JANX. The fund has invested 9% of it's portfolio in PROCEPT BIOROBOTICS CORP and 7.3% of portfolio in GALAPAGOS NV.

The fund managers got completely rid off INTUITIVE SURGICAL INC (ISRG), DEXCOM INC (DXCM) and BIOHAVEN LTD stocks. They significantly reduced their stock positions in BRIDGEBIO PHARMA INC (BBIO), IMMUNOVANT INC (IMVT) and SHATTUCK LABS INC (STTK). Prosight Management, LP opened new stock positions in NEKTAR THERAPEUTICS (NKTR), VEEVA SYS INC (VEEV) and PHREESIA INC (PHR). The fund showed a lot of confidence in some stocks as they added substantially to PLIANT THERAPEUTICS INC (PLRX), PROCEPT BIOROBOTICS CORP (PRCT) and TRUEBLUE INC (TBI).

Prosight Management, LP Annual Return Estimates Vs S&P 500

Our best estimate is that Prosight Management, LP made a return of 3.45% in the last quarter. In trailing 12 months, it's portfolio return was 7.64%.

Performance
S&P 500

New Buys

Ticker	$ Bought
nektar therapeutics	23,449,900
veeva sys inc	20,120,400
phreesia inc	16,533,400
avantor inc	10,296,800
labcorp holdings inc	8,663,390
genedx holdings corp	7,153,300
alnylam pharmaceuticals inc	6,803,390
terns pharmaceuticals inc	3,838,000

New stocks bought by Prosight Management, LP

Additions

Ticker	% Inc.
pliant therapeutics inc	7,493
procept biorobotics corp	1,692
trueblue inc	456
onkure therapeutics inc	204
janux therapeutics inc	176
boston scientific corp	175
corbus pharmaceuticals hldgs	99.15
concentra group holdings par	46.07

Additions to existing portfolio by Prosight Management, LP

Reductions

Ticker	% Reduced
bridgebio pharma inc	-88.66
immunovant inc	-65.15
shattuck labs inc	-56.31
orthopediatrics corp	-55.71
roivant sciences ltd	-53.04
caredx inc	-50.4
rocket pharmaceuticals inc	-41.33
tectonic therapeutic inc	-38.04

Prosight Management, LP reduced stake in above stock

Sold off

Ticker	$ Sold
biohaven ltd	-9,006,000
cytomx therapeutics inc	-1,801,710
sight sciences inc	-1,513,400
acadia healthcare company in	-6,190,000
dexcom inc	-13,136,200
twist bioscience corp	-2,110,500
intuitive surgical inc	-21,785,000
akero therapeutics inc	-1,855,140

Prosight Management, LP got rid off the above stocks

Sector Distribution

Prosight Management, LP has about 67.7% of it's holdings in Healthcare sector.

Sector	%
Healthcare	67.7
Others	28.3
Basic Materials	2.1
	1.5

Market Cap. Distribution

Prosight Management, LP has about 13% of it's portfolio invested in the large-cap and mega-cap stocks.

Category	%
SMALL-CAP	39.7
UNALLOCATED	28.3
MID-CAP	14.8
LARGE-CAP	13
MICRO-CAP	4.3

Stocks belong to which Index?

About 54.7% of the stocks held by Prosight Management, LP either belong to S&P 500 or RUSSELL 2000 index.

Index	%
RUSSELL 2000	50.6
Others	45.3
S&P 500	4.1

Top 5 Winners (%)		%
FOLD	amicus therapeutics inc	67.5 %
ZYME	zymeworks inc	46.2 %
IMVT	immunovant inc	38.9 %
STTK	shattuck labs inc	37.9 %
ROIV	roivant sciences ltd	31.9 %

Top 5 Winners ($)		$
FOLD	amicus therapeutics inc	9.1 M
ROIV	roivant sciences ltd	6.4 M
ZYME	zymeworks inc	5.9 M
STTK	shattuck labs inc	4.9 M
SNDX	syndax pharmaceuticals inc	4.7 M

Top 5 Losers (%)		%
JANX	janux therapeutics inc	-34.4 %
CRBP	corbus pharmaceuticals hldgs	-29.4 %
TBI	trueblue inc	-17.0 %
ADCT	adc therapeutics sa	-11.1 %
PLRX	pliant therapeutics inc	-9.7 %

Top 5 Losers ($)		$
JANX	janux therapeutics inc	-17.3 M
ADCT	adc therapeutics sa	-3.7 M
PRCT	procept biorobotics corp	-3.1 M
CRBP	corbus pharmaceuticals hldgs	-2.3 M
GLPG	galapagos nv	-2.2 M

Prosight Management, LP Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of Prosight Management, LP

Prosight Management, LP has 38 stocks in it's portfolio. About 57.2% of the portfolio is in top 10 stocks. JANX proved to be the most loss making stock for the portfolio. FOLD was the most profitable stock for Prosight Management, LP last quarter.

Last Reported on: 13 Feb, 2026

Ticker	Namesorted ascending	% Portfolio	Shares Held	$ Value	Type	% Change
ACET	adicet bio inc	0.44	250,244	2,107,050	new

ACHC	acadia healthcare company in	0.00	0.00	0.00	sold off	-100

ADCT	adc therapeutics sa	6.18	8,477,340	29,925,000	added	13.45

AKRO	akero therapeutics inc	0.00	0.00	0.00	sold off	-100

ALGN	align technology inc	0.00	0.00	0.00	sold off	-100

ALNY	alnylam pharmaceuticals inc	1.41	17,109	6,803,390	new

ALRN	rein therapeutics inc	0.11	442,600	513,416	reduced	-22.06

ARGX	argenx se	0.00	0.00	0.00	sold off	-100

AVTR	avantor inc	2.13	898,499	10,296,800	new

BBIO	bridgebio pharma inc	0.47	30,000	2,294,700	reduced	-88.66

BSX	boston scientific corp	4.14	210,000	20,023,500	added	175

CDNA	caredx inc	0.97	250,000	4,710,000	reduced	-50.4

CRBP	corbus pharmaceuticals hldgs	1.15	683,872	5,566,720	added	99.15

CRNX	crinetics pharmaceuticals in	2.53	262,904	12,238,200	reduced	-20.01

CTMX	cytomx therapeutics inc	0.00	0.00	0.00	sold off	-100

DXCM	dexcom inc	0.00	0.00	0.00	sold off	-100

FOLD	amicus therapeutics inc	3.38	1,150,000	16,376,000	reduced	-32.73

GLPG	galapagos nv	7.26	1,074,110	35,123,500	reduced	-6.6

ICLR	icon plc	4.14	110,000	20,044,200	added	0.46

IMVT	immunovant inc	1.28	243,404	6,187,330	reduced	-65.15