Latest JANUS HENDERSON GROUP PLC Stock Portfolio

JANUS HENDERSON GROUP PLC Performance:

2025 Q4: 2.31%YTD: 16.05%2024: 29.83%

Performance for 2025 Q4 is 2.31%, and YTD is 16.05%, and 2024 is 29.83%.

About JANUS HENDERSON GROUP PLC and 13F Hedge Fund Stock Holdings

On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, JANUS HENDERSON GROUP PLC reported an equity portfolio of $223.3 Billions as of 31 Dec, 2025.

The top stock holdings of JANUS HENDERSON GROUP PLC are NVDA, MSFT, AMZN. The fund has invested 6.9% of it's portfolio in NVIDIA CORPORATION and 5.8% of portfolio in MICROSOFT CORP.

The fund managers got completely rid off AKERO THERAPEUTICS INC (AKRO), METSERA INC and AMDOCS LTD (DOX) stocks. They significantly reduced their stock positions in LINEAGE INC, GODADDY INC (GDDY) and ALIGHT INC (ALIT). JANUS HENDERSON GROUP PLC opened new stock positions in TOTALENERGIES SE, TERNS PHARMACEUTICALS INC (TERN) and ALIBABA GROUP HLDG LTD (BABA). The fund showed a lot of confidence in some stocks as they added substantially to MOONLAKE IMMUNOTHERAPEUTICS (MLTX), SPYRE THERAPEUTICS INC (AGLE) and MIND MEDICINE MINDMED INC (MNMD).

JANUS HENDERSON GROUP PLC Annual Return Estimates Vs S&P 500

Our best estimate is that JANUS HENDERSON GROUP PLC made a return of 2.31% in the last quarter. In trailing 12 months, it's portfolio return was 16.05%.

Performance
S&P 500

New Buys

Ticker	$ Bought
totalenergies se	591,357,000
medline inc	443,712,000
terns pharmaceuticals inc	136,496,000
alibaba group hldg ltd	81,753,800
eyepoint inc	53,657,600
magnum ice cream co nv	47,696,400
bicara therapeutics inc	44,484,100
upstream bio inc	41,422,900

New stocks bought by JANUS HENDERSON GROUP PLC

Additions

Ticker	% Inc.
spyre therapeutics inc	13,969
biocryst pharmaceuticals inc	7,807
mineralys therapeutics inc	6,012
adma biologics inc	3,906
cipher mining inc	3,718
coinbase global inc	2,597
bright horizons fam sol in d	2,536
krystal biotech inc	2,078

Additions to existing portfolio by JANUS HENDERSON GROUP PLC

Reductions

Ticker	% Reduced
autodesk inc	-88.72
marsh & mclennan cos inc	-77.35
avadel pharmaceuticals plc	-75.45
suncor energy inc new	-70.6
synopsys inc	-52.41
avidity biosciences inc	-52.22
donaldson inc	-52.05
teck resources ltd	-50.95

JANUS HENDERSON GROUP PLC reduced stake in above stock

Sold off

None of the stocks were completely sold off by JANUS HENDERSON GROUP PLC

Sector Distribution

JANUS HENDERSON GROUP PLC has about 33.6% of it's holdings in Technology sector.

Sector	%
Technology	33.6
Healthcare	16.4
Others	11.8
Financial Services	8.8
Consumer Cyclical	8.6
Communication Services	7.6
Industrials	7.4
Consumer Defensive	1.5
Real Estate	1.3

Market Cap. Distribution

JANUS HENDERSON GROUP PLC has about 79.2% of it's portfolio invested in the large-cap and mega-cap stocks.

Category	%
MEGA-CAP	41.8
LARGE-CAP	37.4
UNALLOCATED	11.7
MID-CAP	7.4
SMALL-CAP	1.4

Stocks belong to which Index?

About 75% of the stocks held by JANUS HENDERSON GROUP PLC either belong to S&P 500 or RUSSELL 2000 index.

Index	%
S&P 500	66.7
Others	25
RUSSELL 2000	8.3

Top 5 Winners (%)		%
PRAX	praxis precision medicines i	316.5 %
WVE	wave life sciences ltd	131.7 %
	structure therapeutics inc	127.1 %
COGT	cogent biosciences inc	102.7 %
NUVB	nuvation bio inc	100.8 %

Top 5 Winners ($)		$
GOOG	alphabet inc	1685.5 M
LLY	eli lilly & co	1379.1 M
PRAX	praxis precision medicines i	725.6 M
AAPL	apple inc	450.0 M
RVMD	revolution medicines inc	389.9 M

Top 5 Losers (%)		%
IJR	ishares tr	-100.0 %
RGR	sturm ruger & co inc	-63.7 %
AVXL	anavex life sciences corp	-59.9 %
TPL	texas pacific land corporati	-59.6 %
ASPN	aspen aerogels inc	-59.3 %

Top 5 Losers ($)		$
ORCL	oracle corp	-1223.2 M
MSFT	microsoft corp	-1010.5 M
META	meta platforms inc	-536.1 M
NFLX	netflix inc	-342.7 M
ETN	eaton corp plc	-274.0 M

JANUS HENDERSON GROUP PLC Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of JANUS HENDERSON GROUP PLC

JANUS HENDERSON GROUP PLC has 2402 stocks in it's portfolio. About 32.6% of the portfolio is in top 10 stocks. ORCL proved to be the most loss making stock for the portfolio. GOOG was the most profitable stock for JANUS HENDERSON GROUP PLC last quarter.

Last Reported on: 17 Feb, 2026

Ticker	Namesorted ascending	% Portfolio	Shares Held	$ Value	Type	% Change
AAPL	apple inc	3.32	27,341,800	7,403,750,000	reduced	-3.52

ABBV	abbvie inc	0.66	6,402,650	1,462,860,000	added	29.77

ABC	cencora inc	0.06	397,102	134,123,000	reduced	-0.92

ABT	abbott labs	0.42	7,451,540	933,602,000	added	14.66

ACLX	arcellx inc	0.03	919,578	59,957,600	reduced	-9.3

ACMR	acm resh inc	0.02	1,082,980	42,739,900	added	1,406

ACN	accenture plc ireland	0.07	545,163	146,277,000	reduced	-50.8

ADBE	adobe inc	0.11	680,924	238,310,000	added	35.7

ADC	agree rlty corp	0.04	1,252,680	90,227,800	reduced	-9.64

ADGI	invivyd inc	0.04	32,543,100	80,869,700	added	28.21

ADI	analog devices inc	0.14	1,127,270	305,717,000	reduced	-6.34

ADMA	adma biologics inc	0.03	3,936,420	71,820,000	added	3,906

ADSK	autodesk inc	0.03	232,739	68,909,300	reduced	-88.72

AEE	ameren corp	0.22	4,823,990	481,724,000	added	2.11

AGLE	spyre therapeutics inc	0.03	1,829,010	59,918,300	added	13,969

AGT	ishares tr	0.06	2,446,230	122,336,000	added	33.8

AJG	gallagher arthur j & co	0.22	1,869,560	483,868,000	added	14.68

ALKT	alkami technology inc	0.03	3,208,440	74,019,200	added	40.27

ALLY	ally finl inc	0.02	998,715	45,230,000	reduced	-27.21

ALNY	alnylam pharmaceuticals inc	0.02	136,425	54,251,800	added	0.42