Latest ADAGE CAPITAL PARTNERS GP, L.L.C. Stock Portfolio

ADAGE CAPITAL PARTNERS GP, L.L.C. Performance:

2025 Q4: 4.01%YTD: 16.94%2024: 21.82%

Performance for 2025 Q4 is 4.01%, and YTD is 16.94%, and 2024 is 21.82%.

About ADAGE CAPITAL PARTNERS GP, L.L.C. and 13F Hedge Fund Stock Holdings

On 2026-02-17, the fund reported it's updated stock portfolio. In the 13F Holdings report, ADAGE CAPITAL PARTNERS GP, L.L.C. reported an equity portfolio of $66.1 Billions as of 31 Dec, 2025.

The top stock holdings of ADAGE CAPITAL PARTNERS GP, L.L.C. are NVDA, AAPL, MSFT. The fund has invested 6.3% of it's portfolio in NVIDIA CORPORATION and 5.4% of portfolio in APPLE INC.

The fund managers got completely rid off 89BIO INC (ETNB), SOLENO THERAPEUTICS INC (SLNO) and DUKE ENERGY CORP NEW (DUK) stocks. They significantly reduced their stock positions in ACADIA PHARMACEUTICALS INC (ACAD), OSCAR HEALTH INC (OSCR) and INGERSOLL RAND INC (IR). ADAGE CAPITAL PARTNERS GP, L.L.C. opened new stock positions in DOMINION ENERGY INC (D), EXACT SCIENCES CORP (EXAS) and HESS MIDSTREAM LP (HESM). The fund showed a lot of confidence in some stocks as they added substantially to OMNICOM GROUP INC (OMC), APPLIED INDL TECHNOLOGIES IN (AIT) and BEST BUY INC (BBY).

ADAGE CAPITAL PARTNERS GP, L.L.C. Annual Return Estimates Vs S&P 500

Our best estimate is that ADAGE CAPITAL PARTNERS GP, L.L.C. made a return of 4.01% in the last quarter. In trailing 12 months, it's portfolio return was 16.94%.

Performance
S&P 500

New Buys

Ticker	$ Bought
dominion energy inc	125,495,000
exact sciences corp	108,399,000
hess midstream lp	92,287,500
core natural resources inc	86,297,200
acuity inc	78,249,300
consolidated edison inc	67,124,800
aptiv plc	57,075,100
carvana co	53,892,000

New stocks bought by ADAGE CAPITAL PARTNERS GP, L.L.C.

Additions

Ticker	% Inc.
omnicom group inc	5,465
applied indl technologies in	4,933
best buy inc	1,514
ryan specialty holdings inc	1,510
glaukos corp	774
stanley black & decker inc	698
assurant inc	676
dexcom inc	666

Additions to existing portfolio by ADAGE CAPITAL PARTNERS GP, L.L.C.

Reductions

Ticker	% Reduced
union pac corp	-81.31
insmed inc	-76.05
eversource energy	-73.44
protagonist therapeutics inc	-67.58
delta air lines inc del	-64.45
praxis precision medicines i	-59.34
amylyx pharmaceuticals inc	-59.26
astrazeneca plc	-55.73

ADAGE CAPITAL PARTNERS GP, L.L.C. reduced stake in above stock

Sold off

None of the stocks were completely sold off by ADAGE CAPITAL PARTNERS GP, L.L.C.

Sector Distribution

ADAGE CAPITAL PARTNERS GP, L.L.C. has about 28.8% of it's holdings in Technology sector.

Sector	%
Technology	28.8
Healthcare	14.4
Financial Services	9.5
Communication Services	8.8
Consumer Cyclical	8.7
Industrials	8.1
Others	7.5
Energy	4.2
Consumer Defensive	3.7
Utilities	2.6
Real Estate	2.3
Basic Materials	1.4

Market Cap. Distribution

ADAGE CAPITAL PARTNERS GP, L.L.C. has about 82.3% of it's portfolio invested in the large-cap and mega-cap stocks.

Category	%
MEGA-CAP	48.9
LARGE-CAP	33.4
MID-CAP	7.7
UNALLOCATED	7.6
SMALL-CAP	2.1

Stocks belong to which Index?

About 84.1% of the stocks held by ADAGE CAPITAL PARTNERS GP, L.L.C. either belong to S&P 500 or RUSSELL 2000 index.

Index	%
S&P 500	76.5
Others	16
RUSSELL 2000	7.6

Top 5 Winners (%)		%
PRAX	praxis precision medicines i	320.8 %
TERN	terns pharmaceuticals inc	228.9 %
RVMD	revolution medicines inc	213.4 %
BAER	bridger aerospace grp hldgs	159.0 %
	schmid group n.v.	119.3 %

Top 5 Winners ($)		$
PRAX	praxis precision medicines i	403.6 M
GOOG	alphabet inc	368.5 M
GOOG	alphabet inc	298.6 M
LLY	eli lilly & co	255.4 M
AAPL	apple inc	229.1 M

Top 5 Losers (%)		%
	classover hldgs inc	-85.0 %
STRC	palladyne ai corp	-69.5 %
APLT	applied therapeutics inc	-64.6 %
ENSC	ensysce biosciences inc	-54.2 %
STRC	palladyne ai corp	-50.4 %

Top 5 Losers ($)		$
MSFT	microsoft corp	-230.1 M
META	meta platforms inc	-149.1 M
ORCL	oracle corp	-148.4 M
NFLX	netflix inc	-101.1 M
HD	home depot inc	-67.9 M

ADAGE CAPITAL PARTNERS GP, L.L.C. Holdings Map

This heatmap illustrates the top 50 positions within the fund's portfolio.

Current Stock Holdings of ADAGE CAPITAL PARTNERS GP, L.L.C.

ADAGE CAPITAL PARTNERS GP, L.L.C. has 902 stocks in it's portfolio. About 31.5% of the portfolio is in top 10 stocks. MSFT proved to be the most loss making stock for the portfolio. PRAX was the most profitable stock for ADAGE CAPITAL PARTNERS GP, L.L.C. last quarter.

Last Reported on: 17 Feb, 2026

Ticker	Namesorted ascending	% Portfolio	Shares Held	$ Value	Type	% Change
AAPL	apple inc	5.44	13,226,600	3,595,770,000	reduced	-1.05

ABBV	abbvie inc	0.52	1,508,720	344,726,000	reduced	-18.22

ABC	cencora inc	0.10	193,500	65,354,600	added	9.76

ABNB	airbnb inc	0.06	313,000	42,480,400	reduced	-10.72

ABT	abbott labs	0.32	1,681,200	210,638,000	reduced	-26.81

ABUS	arbutus biopharma corp	0.03	4,339,940	20,875,100	reduced	-13.46

ACGL	arch cap group ltd	0.05	326,000	31,269,900	added	489

ACN	accenture plc ireland	0.22	534,822	143,493,000	reduced	-2.12

ADBE	adobe inc	0.19	352,878	123,504,000	reduced	-3.53

ADI	analog devices inc	0.16	381,414	103,439,000	added	2.94

ADM	archer daniels midland co	0.04	433,892	24,944,500	reduced	-0.8

ADP	automatic data processing in	0.10	243,176	62,552,200	added	2.01

ADSK	autodesk inc	0.07	167,289	49,519,200	reduced	-1.36

AFG	american finl group inc ohio	0.07	320,694	43,832,500	new

AFL	aflac inc	0.07	425,874	46,961,100	added	15.67

AIG	american intl group inc	0.06	487,138	41,674,700	reduced	-35.24

AIT	applied indl technologies in	0.10	264,575	67,934,900	added	4,933

AIZ	assurant inc	0.09	240,240	57,861,800	added	676

AJG	gallagher arthur j & co	0.06	159,803	41,355,400	reduced	-45.48

ALB	albemarle corp	0.04	161,279	22,811,300	added	401